R Hurd

Publications (2)6.67 Total impact

• Article: Abnormalities of antioxidant metabolism in a case of Friedreich's disease.

  W Helveston, J E Cibula, R Hurd, B M Uthman, B J Wilder
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  ABSTRACT: We report a patient with Friedreich's disease (FD) who exhibited abnormalities of antioxidant metabolism, including decreased levels of glutathione peroxidase, glutathione reductase, and selenium, and an increased lipid peroxide index. These abnormalities became normal after treatment with N-acetylcysteine, selenium, and low-dose vitamin E therapy. Treatment was associated with a decreased rate of clinical decline. FD is a neurodegenerative disorder that may be related to disturbed antioxidant metabolism; the disorder may be treatable with antioxidant compounds.
  Clinical Neuropharmacology 07/1996; 19(3):271-5. · 2.17 Impact Factor
• Article: Abnormalities of glutathione peroxidase and glutathione reductase in four patients with Friedreich's disease.

  W Helveston, R Hurd, B Uthman, B J Wilder
  Movement Disorders 02/1996; 11(1):106-7. · 4.51 Impact Factor