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ABSTRACT: Vitiligo has been found to be associated with different HLA antigens in different ethnic groups. In our previous genome-wide association study (GWAS), we identified independent association signal of rs9468925 (P = 2.21 × 10(-33), OR = 0.74) within HLA-C-HLA-B region.
To explore the association between rs9468925 polymorphism within MHC and the clinical features of generalized vitiligo.
The study, using 5566 cases and 6462 controls from previous GWA study investigated the single and combined (GA + GG) genotypic distribution of rs9468925 in subsets of vitiligo patients having different clinical features. We performed a QTL analysis (quantitative trait locus) for age of onset with genotype of rs9468925.
The GA + GG genotypic distribution of SNP rs9468925 tested with an additive model was found to be significantly different in subgroups of patients of >20 vs. <20 years old (genotypic P = 2.57 × 10(-4), combined P = 3.0 × 10(-3), OR = 0.77, 95% CI: 0.64-0.92), and in patients with different clinical subtypes of vitiligo (genotypic P = 0.03, combined P = 5.0 × 10(-3)). However, there was no statistical significance for familial history, halo nevi involvement and autoimmune disease involvement.
Allele G of rs9468925 on HLA-C-HLA-B may be associated with a higher risk of vitiligo. Our study showed a significant genotypic variation between patients with age of onset ≤ 20 years and age of onset >20 years. Obvious clinical differences of generalized vitiligo related to genotypic variation found in the Chinese Han population were confirmed in this study.
Journal of the European Academy of Dermatology and Venereology 09/2011; 26(9):1137-41. · 2.98 Impact Factor
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Wenlong Hu,
Liangdan Sun,
Jinping Gao,
Yun Li, Peiguang Wang,
Yilin Cheng,
Tingmeng Pan,
Jianwen Han,
Yangsheng Liu,
Wensheng Lu,
Xianbo Zuo,
Yujun Sheng,
Sha Yao,
Caifeng He,
Zeying Yu,
Xianyong Yin,
Yong Cui,
Sen Yang,
Xuejun Zhang
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ABSTRACT: Systemic lupus erythematosus (SLE) is a multi-system autoimmune disease with complex genetic inheritance. IKZF1 was established as a new susceptibility gene for SLE in a recent genome-wide association study (GWAS) in Chinese Han population. In order to examine whether expression levels of IKZF1 contribute to the pathogenesis of SLE, we estimated IKZF1 mRNA expression levels in peripheral blood mononuclear cells (PBMCs) via fluorescent quantitative reverse transcription polymerase chain reaction (RT-PCR) in 60 patients with SLE and 60 controls. We also explored whether the IKZF1 mRNA expression levels are associated with the variant of the SNP rs4917014 and the SLE Disease Activity Index (SLEDAI). The expression levels of IKZF1 mRNA in patients with SLE were significantly decreased compared with those in healthy controls (P<0.001). No significant differences were found between IKZF1 mRNA expression levels and SLEDAI scores, SNP rs4917014. Our results suggest that decreased expression of IKZF1 mRNA may be correlated with the pathogenesis of SLE.
Rheumatology International 06/2011; 31(6):819-22. · 1.88 Impact Factor
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ABSTRACT: This paper investigates a class of second-order functional differential equations with damping, and derives two new oscillatory criteria of solution.
Journal of Computational and Applied Mathematics.
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ABSTRACT: In this paper, for a second-order boundary value problem on time scales, a method of generalized quasilinearization, under coupled upper and lower solutions, is discussed. An attempt for the method is to establish sufficient conditions for generating monotone iterative schemes whose elements converge rapidly to the unique solution of the given problem. Furthermore, the convergence is of order , which is even. Finally, two examples are provided to illustrate our results.
Computers & Mathematics with Applications.
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ABSTRACT: A class of even-order nonlinear neutral differential equations with distributed deviating arguments is studied, and oscillatory criteria for solutions of such equations are established.
Applied Mathematics Letters.
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ABSTRACT: This paper establishes several results on oscillation of a class of second neutral differential equations with distributed deviating arguments.
Journal of Computational and Applied Mathematics.
