Publications (4)0 Total impact
-
-
-
-
Andrew R. Battle,
Stella M Valenzuela,
Adam Mechler,
Ryan J Nichols,
Slavica Praporski,
Isabelle L. Di Maio,
Hedayetul Islam,
Agnes P Cirard-Egrot,
Bruce A Cornell,
Jog Prashar,
Frank Caruso,
Lisandra L Martin,
Donald K. Martin
[show abstract]
[hide abstract]
ABSTRACT: The development of nanostructured microcapsules based on a biomimetic lipid bilayer membrane (BLM) coating of poly(sodium styrenesulfonate) (PSS)/poly(allylamine hydrochloride) (PAH) polyelectrolyte hollow microcapsules Is reported. A novel engineered ion channel, gramicidin (bis-gA), incorporated Into the lipid membrane coating provides a functional capability to control transport across the microcapsule wall. The microcapsules provide transport and permeation for drug-analog neutral species, as well as positively and negatively charged ionic species. This controlled transport can be tuned for selective release biomimetically by controlling the gating of incorporated bis-gA ion channels. This system provides a platform for the creation of "smart" biomimetic delivery vessels for the effective and selective therapeutic delivery and targeting of drugs.