Andrew R. Battle

Publications (4)0 Total impact

• Article: Gramicidin ion channel-based biosensors: Construction, stochastic dynamical models, and statistical detection algorithms

  Vikram Krishnamurthy, Kai Yiu Luk, Bruce Cornell, Jog Prashar, Isabelle L. Di Maio, Hedayetul Islam, Andrew R. Battle, Stella M Valenzuela, Donald K. Martin
• Article: Structural properties of liposomes from digital holographic microscopy

  Isabelle L. Di Maio, Daniel Carl, Patrik Langehanenberg, Stella M Valenzuela, Andrew R. Battle, Sabah Al Khazaaly, Murray Killingsworth, Bjorn Kemper, Gert von Bally, Donald K. Martin
• Article: 1-Undecyl-4,7-diaza-1-azoniatricyclo[5.2.1.0(4,10)]-decane iodide

  Andrew R. Battle, Lisandra L Martin
• Article: Novel Engineered Ion Channel Provides Controllable Ion Permeability for Polyelectrolyte Microcapsules Coated with a Lipid Membrane

  Andrew R. Battle, Stella M Valenzuela, Adam Mechler, Ryan J Nichols, Slavica Praporski, Isabelle L. Di Maio, Hedayetul Islam, Agnes P Cirard-Egrot, Bruce A Cornell, Jog Prashar, Frank Caruso, Lisandra L Martin, Donald K. Martin
  [show abstract] [hide abstract]
  ABSTRACT: The development of nanostructured microcapsules based on a biomimetic lipid bilayer membrane (BLM) coating of poly(sodium styrenesulfonate) (PSS)/poly(allylamine hydrochloride) (PAH) polyelectrolyte hollow microcapsules Is reported. A novel engineered ion channel, gramicidin (bis-gA), incorporated Into the lipid membrane coating provides a functional capability to control transport across the microcapsule wall. The microcapsules provide transport and permeation for drug-analog neutral species, as well as positively and negatively charged ionic species. This controlled transport can be tuned for selective release biomimetically by controlling the gating of incorporated bis-gA ion channels. This system provides a platform for the creation of "smart" biomimetic delivery vessels for the effective and selective therapeutic delivery and targeting of drugs.