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ABSTRACT: Manufacturing of steel involves thermal energy intensive processes with coal as the major input. Energy generated is a direct
function of ash content of coal and as such it weighs very high as regards the choice of coal. In this paper, we study a multiobjective
transportation problem to introduce a new type of coal in a steel manufacturing unit in India. The use of new type of coal
serves three non-prioritized objectives, viz. minimization of the total freight cost, the transportation time and the ratio
of ash content to the production of hot metal. It has been observed from the past data that the supply and demand points have
shown fluctuations around their estimated values because of changing economic conditions. To deal with uncertainties of supply
and demand parameters, we transform the past data pertaining to the amount of supply of the ith supply point and the amount of demand of the jth demand point using level (λ,ρ) interval-valued fuzzy numbers. We use a linear ranking function to defuzzify the fuzzy transportation problem. A transportation
algorithm is developed to find the non-dominated solutions for the defuzzified problem. The application of the algorithm is
illustrated by numerical examples constructed from the data provided by the manufacturing unit.
Top 04/2012; 15(1):114-137. · 0.87 Impact Factor
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ABSTRACT: Patients with sickle cell disease (SCD) are often treated with opioids for severe pain. Although opioids are known to have renal-specific effects, their role in nephropathy in SCD remains unknown. Because a subset of patients receives opioids for long periods of time, we examined the influence of chronic morphine treatment on mice with pre-existing renal disease expressing varying amounts of sickle hemoglobin. Morphine treatment for 3-6 weeks resulted in a variety of defects in renal morphology observed using light and electron microscopy. Notably, morphine induced glomerular pathology, resulting in increased glomerular volume, mesangial expansion, mesangial cell proliferation, parietal cell metaplasia, podocyte effacement, and microvillus transformation. Cystic tubulopathy and hemeoxygenase-1 expression and activity were also increased in morphine-treated mice. Naloxone, a non-selective opioid receptor (OR) antagonist, ameliorated these effects. Functionally, the urine albumin to creatinine ratio was increased following acute as well as chronic morphine treatment. These results suggest that clinically relevant doses of morphine induce renal pathology and that OR antagonists may be effective for ameliorating morphine-induced renal disease.
International Journal of Nephrology and Renovascular Disease 01/2012; 5:109-18.
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Optimization Letters. 01/2012; 6:273-289.
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ABSTRACT: We present an application of the “modified subgradient method” to solve a fuzzy linear fractional programming problem. We
concentrate on a linear fractional programming problem in which both the right-hand side and the technological coefficients
are fuzzy numbers. We compare efficiency of the proposed solution method with the well-known “fuzzy decisive set method” in
terms of the number of iterations taken to reach the optimal solution. A numerical illustration is provided for the purpose.
05/2011: pages 115-131;
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Computational Science and Its Applications - ICCSA 2011 - International Conference, Santander, Spain, June 20-23, 2011. Proceedings, Part III; 01/2011
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Expert Syst. Appl. 01/2011; 38:5620-5632.
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Divyanshoo R Kohli,
Yunfang Li,
Sergey G Khasabov, Pankaj Gupta,
Lois J Kehl,
Marna E Ericson,
Julia Nguyen,
Vinita Gupta,
Robert P Hebbel,
Donald A Simone,
Kalpna Gupta
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ABSTRACT: Sickle cell disease causes severe pain. We examined pain-related behaviors, correlative neurochemical changes, and analgesic effects of morphine and cannabinoids in transgenic mice expressing human sickle hemoglobin (HbS). Paw withdrawal threshold and withdrawal latency (to mechanical and thermal stimuli, respectively) and grip force were lower in homozygous and hemizygous Berkley mice (BERK and hBERK1, respectively) compared with control mice expressing human hemoglobin A (HbA-BERK), indicating deep/musculoskeletal and cutaneous hyperalgesia. Peripheral nerves and blood vessels were structurally altered in BERK and hBERK1 skin, with decreased expression of mu opioid receptor and increased calcitonin gene-related peptide and substance P immunoreactivity. Activators of neuropathic and inflammatory pain (p38 mitogen-activated protein kinase, STAT3, and mitogen-activated protein kinase/extracellular signal-regulated kinase) showed increased phosphorylation, with accompanying increase in COX-2, interleukin-6, and Toll-like receptor 4 in the spinal cord of hBERK1 compared with HbA-BERK. These neurochemical changes in the periphery and spinal cord may contribute to hyperalgesia in mice expressing HbS. In BERK and hBERK1, hyperalgesia was markedly attenuated by morphine and cannabinoid receptor agonist CP 55940. We show that mice expressing HbS exhibit characteristics of pain observed in sickle cell disease patients, and neurochemical changes suggestive of nociceptor and glial activation. Importantly, cannabinoids attenuate pain in mice expressing HbS.
Blood 03/2010; 116(3):456-65. · 9.90 Impact Factor
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SIGMETRICS 2010, Proceedings of the 2010 ACM SIGMETRICS International Conference on Measurement and Modeling of Computer Systems, New York, New York, USA, 14-18 June 2010; 01/2010
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Proceedings of the ACM SIGMOD International Conference on Management of Data, SIGMOD 2010, Indianapolis, Indiana, USA, June 6-10, 2010; 01/2010
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ABSTRACT: Monocytes, their progeny such as dendritic cells and osteoclasts and products including tumor necrosis factor (TNF)-alpha, interleukin (IL)-1alpha and IL-1beta play important roles in cancer, inflammation, immune response and atherosclerosis. We previously showed that mactinin, a degradative fragment of the cytoskeletal protein alpha-actinin, is present at sites of monocytic activation in vivo, has chemotactic activity for monocytes and promotes monocyte/macrophage maturation. We therefore sought to determine the mechanism by which mactinin stimulates monocytes.
Radiolabeled mactinin bound to a heterocomplex on monocytes comprised of at least 3 proteins of molecular weight 88 kD, 79 kD and 68 kD. Affinity purification, mass spectroscopy and Western immunoblotting identified heat shock protein (Hsp)-90 as the 88 kD component of this complex. Hsp90 was responsible for mediating the functional effects of mactinin on monocytes, since Hsp90 inhibitors (geldanamycin and its analogues 17-allylamino-17-demethoxygeldanamycin [17-AAG] and 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin [17-DMAG]) almost completely abrogated the stimulatory activity of mactinin on monocytes (production of the pro-inflammatory cytokines IL-1alpha, IL-1beta and TNF-alpha, as well as monocyte chemotaxis).
Mactinin is a novel inducer of Hsp90 activity on monocytes and may serve to perpetuate and augment monocytic activation, thereby functioning as a "matrikine." Blockage of this function of mactinin may be useful in diseases where monocyte/macrophage activation and/or Hsp90 activity are detrimental.
BMC Cell Biology 09/2009; 10:60. · 2.59 Impact Factor
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ABSTRACT: Abstract
Background
Monocytes, their progeny such as dendritic cells and osteoclasts and products including tumor necrosis factor (TNF)-α, interleukin (IL)-1α and IL-1β play important roles in cancer, inflammation, immune response and atherosclerosis. We previously showed that mactinin, a degradative fragment of the cytoskeletal protein α-actinin, is present at sites of monocytic activation in vivo, has chemotactic activity for monocytes and promotes monocyte/macrophage maturation. We therefore sought to determine the mechanism by which mactinin stimulates monocytes.
Results
Radiolabeled mactinin bound to a heterocomplex on monocytes comprised of at least 3 proteins of molecular weight 88 kD, 79 kD and 68 kD. Affinity purification, mass spectroscopy and Western immunoblotting identified heat shock protein (Hsp)-90 as the 88 kD component of this complex. Hsp90 was responsible for mediating the functional effects of mactinin on monocytes, since Hsp90 inhibitors (geldanamycin and its analogues 17-allylamino-17-demethoxygeldanamycin [17-AAG] and 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin [17-DMAG]) almost completely abrogated the stimulatory activity of mactinin on monocytes (production of the pro-inflammatory cytokines IL-1α, IL-1β and TNF-α, as well as monocyte chemotaxis).
Conclusion
Mactinin is a novel inducer of Hsp90 activity on monocytes and may serve to perpetuate and augment monocytic activation, thereby functioning as a "matrikine." Blockage of this function of mactinin may be useful in diseases where monocyte/macrophage activation and/or Hsp90 activity are detrimental.
BMC Cell Biology. 01/2009;
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Fuzzy Sets and Systems. 01/2009; 160:3290-3308.
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Computational Science and Its Applications - ICCSA 2009, International Conference, Seoul, Korea, June 29-July 2, 2009, Proceedings, Part I; 01/2009
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First International Conference on Networks and Communications, NetCoM 2009, Chennai, India, December 27-29, 2009; 01/2009
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Applied Mathematics and Computation. 01/2006; 179:662-671.
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Applied Mathematics and Computation. 01/2005; 170:1243-1260.
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Computational Science and Its Applications - ICCSA 2005, International Conference, Singapore, May 9-12, 2005, Proceedings, Part IV; 01/2005
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Proceedings of the 2nd Indian International Conference on Artificial Intelligence, Pune, India, December 20-22, 2005; 01/2005
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Fuzzy Sets and Systems. 01/2004; 146:221-233.
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IEEE Transactions on Information Theory. 01/2004; 50:3294-3298.
