Nikolaos Papaioannou

Publications (2)6.29 Total impact

• Article: An improved method for determining enantiomeric excess by 13C‐NMR in chiral liquid crystal media

  Vasilios M. Marathias, Peter A. Tate, Nikolaos Papaioannou, Walter Massefski
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  ABSTRACT: By using a combination of inverse gated 1H decoupled 13C-NMR experiments1 with short acquisition times and NMR Cryo-probe technology, the sample requirements and experimental times necessary to accurately measure enantiomeric excess of small chiral molecules has been reduced 16-fold. Quality 13C-NMR spectra can now be obtained from a 1 to 5 mg sample in 12 minutes. The enantiomeric excess determination achieved from the average integration of all the 13C-resonances in the spectrum is comparable to enantiomeric excess measured by chiral SFC. The advantage of the NMR method is that enantiomeric excess can rapidly be measured in situ on practical amounts of enantioselective reaction products without the need for chromatographic separation or chemical modification and with substantially less solvent waste. Chirality, 2010. © 2010 Wiley-Liss, Inc.
  Chirality 09/2010; 22(9):838 - 843. · 2.35 Impact Factor
• Article: Product-regulation mechanisms for fatty acid biosynthesis catalyzed by Mycobacterium smegmatis FAS I.

  Nikolaos Papaioannou, Hwan-Sung Cheon, Yiqian Lian, Yoshito Kishi
  ChemBioChem 11/2007; 8(15):1775-80. · 3.94 Impact Factor