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ABSTRACT: The authors describe a custom designed mandibular external fixator II system that can be used to treat complex, comminuted fractures. The system is adjustable and lightweight, quick, robust, simple to apply, and allows mouth opening during healing, It is well suited to use in the modern war surgery environment. The authors present a case of successful treatment of a ballistic fracture of the mandible using this device.
International Journal of Oral and Maxillofacial Surgery 01/2011; 40(1):103-5. · 1.51 Impact Factor
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ABSTRACT: This article describes the combined lessons learned from two deployments of a cadre of British Oral and Maxillofacial surgeons to Kandahar between July 2006 to April 2007, and September 2008 to April 2009.
Journal of the Royal Army Medical Corps 06/2010; 156(2):113-6.
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ABSTRACT: Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder. Histologically the lesion has a fragile capillary bed that could result in a catastrophic bleed after a minor injury, as in this case.
British Journal of Oral and Maxillofacial Surgery 06/2010; 48(4):319-21. · 1.95 Impact Factor
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ABSTRACT: Between January 2007 and December 2008, 44 technical notes or related publications (such as letters) were published in the British Journal of Oral and Maxillofacial Surgery (BJOMS). These covered most of the remit of the specialty and ranged from operative surgical techniques to the use of digital photographs to orientate surgical specimens. However, there would seem to be very little feedback on the value of these articles in everyday practice. We reviewed these technical notes and assessed readability, the value and use of illustrations, the possible expense and/or equipment required in their use, and finally the frequency that the techniques could be used. The anonymised publications were read and scored by a minimum of two dentally qualified senior house officers, two doubly qualified specialist registrars, an SAS grade and two consultants in oral and maxillofacial surgery. The six techniques that gained the highest mean average score are briefly discussed. Although we used a relatively small number of assessors who might not be representative of the whole BJOMS readership, this study would suggest that some sort of change in the way that these technical notes are published should be considered. Options might include inviting a commentary from the reviewers who have tried the technique and also encouraging colleagues to report their experiences of these techniques in the 'letters to the editor' section.
British Journal of Oral and Maxillofacial Surgery 04/2009; 47(4):306-9. · 1.95 Impact Factor
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ABSTRACT: We studied the incidence of recurrent nodal metastases in level V (posterior triangle) in patients who had previously had a staging or therapeutic dissection of the neck, with or without postoperative radiotherapy. Of 160 patients studied (177 neck dissections), 41 (26%) developed recurrent metastases in the neck. Four patients (3%) developed ipsilateral recurrent disease in level V. In these four patients, level III or IV lymph nodes were shown histologically to have extracapsular spread at the time of the original dissection. All four metastases were located at or just beyond the anatomical boundaries of the posterior triangle. None of the metastases at level V were from oral or oropharyngeal primary tumours.
British Journal of Oral and Maxillofacial Surgery 05/2006; 44(2):83-6. · 1.95 Impact Factor
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British Journal of Oral and Maxillofacial Surgery 03/2006; 44(1):48. · 1.95 Impact Factor
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British Journal of Oral and Maxillofacial Surgery 11/2005; 43(5):409. · 1.95 Impact Factor
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ABSTRACT: Hypoxia is a common feature of many cancers. It contributes to local and systemic tumour progression as well as potentially compromising radiotherapy and chemotherapy. Hypoxia-inducible factor 1alpha (HIF-1alpha) is an essential component in changing the transcriptional response of tumours under hypoxia. It targets the transcription of over 60 genes involved in many aspects of cancer biology including cell survival, glucose metabolism, cell invasion and angiogenesis.
In this review, we discuss the relevant literature on HIF-1alpha with specific emphasis on oral cancer. We also present some of our preliminary data on HIF-1alpha in oral cancer.
Although there are a few conflicting reports of its prognostic significance, over expression of HIF-1alpha seems to play an adverse role in the malignant progression of head and neck cancer by facilitating the adaptation of cells to hypoxia as well as contributing to the invasive properties and angiogenesis in these tumours.
HIF-1alpha has an important role to play in pathophysiology of oral cancer, both under normal and hypoxic conditions. The pharmacological manipulation of HIF-1alpha has marked effects on tumour growth, and it could prove to be an important target for drug therapy, both in oral cancer and in other hypoxia-dependent disease states.
Journal of Oral Pathology and Medicine 09/2005; 34(7):385-9. · 1.63 Impact Factor
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ABSTRACT: Many clinicians are uncertain about the correct place of letters after their names and are unaware that there is a strict hierarchical order in which they should be placed. The aim of this paper is to give the correct order of such letters.
British Journal of Oral and Maxillofacial Surgery 09/2004; 42(4):337-8. · 1.95 Impact Factor
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ABSTRACT: Hypoxia is a common feature of many cancers. It contributes to local and systemic tumour progression as well as potentially compromising radiotherapy and chemotherapy. Hypoxia-inducible factor 1 (HIF-1) is an essential component in changing the transcriptional response of tumours under hypoxia. It targets the transcription of over 60 genes involved in many aspects of cancer biology including cell survival, glucose metabolism, cell invasion and angiogenesis. Over-expression of HIF-1 has been associated with increased patient mortality in several cancer types including breast, stomach, cervical, endometrial and ovarian cancers. The pharmacological manipulation of HIF-1 has marked effects on tumour growth, and it could prove to be an important target for drug therapy, both in cancer and in other hypoxia-dependent disease states.
European Journal of Surgical Oncology 07/2004; 30(5):465-8. · 2.50 Impact Factor
