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ABSTRACT: Five new (1-3, 5, and 7) and two known (4, 6) furanosesterterpene tetronic acids were isolated from the marine sponge Sarcotragus sp. by bioactivity-guided fractionation. These compounds showed cytotoxicity against a panel of five human tumor cell lines. The gross structures were established on the basis of NMR and MS analyses. The compounds showed interesting variations of geometry and absolute configuration.
Journal of Natural Products 11/2001; 64(10):1301-4. · 3.13 Impact Factor
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ABSTRACT: Ten new (1, 4-6, 9-14) and four known (2, 3, 7, 8) diacetylenes have been isolated from a brine shrimp active fraction of the methanolic extract of the stony coral Montipora sp. The structures were determined by combined spectroscopic methods. The compounds exhibited significant cytotoxicity against a small panel of human solid tumor cell lines. Montiporyne A (15), a previously reported congener, was also found to induce apoptosis in human colon tumor cell.
Journal of Natural Products 09/2001; 64(8):1059-63. · 3.13 Impact Factor
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ABSTRACT: A new pyridinium alkaloid, montipyridine (1), has been isolated from the stony coral Montipora sp. The structure was established from spectroscopic data.
Journal of Natural Products 08/2001; 64(7):956-7. · 3.13 Impact Factor
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ABSTRACT: A known (1) and four new (2--5) lyso-PAF (platelet activating factor) derivatives were isolated from the sponge Spirastrella abata. Two of them are unprecedented in having a methoxy group at C-2'. The structures have been determined by combined spectroscopic methods. Their inhibitory effect on the biosynthesis of cholesterol and cytotoxicity against human solid tumor cell lines are reported.
Journal of Natural Products 05/2001; 64(4):533-5. · 3.13 Impact Factor
