M S Roopakala

M. S. Ramaiah Medical College, Bengalūru, Karnātaka, India

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Publications (9)0.45 Total impact

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    ABSTRACT: The Ankle-Brachial Index (ABI) objectively assesses the lower extremity arterial perfusion. A low ABI suggests atherosclerosis and Peripheral Arterial Disease (PAD). PAD is more common in individuals with type2 Diabetes mellitus (Type2 DM). Inflammatory markers are found to be associated with Type2 DM. But the association of the inflammatory markers with the atherosclerotic burden remains poorly defined. To compare the ABI and the hsCRP in the Type 2 DM patients with those in the normal subjects and to study the association of serum hsCRP with ABI in the Type 2 DM patients and in normal subjects. The subjects were 40 Type2 DM and 40 age, sex and BMI matched normal subjects who were aged between 45-60 yrs. The subjects were assigned to two different groups, Group1- the Type2 DM patients and Group2- the healthy controls. The serum hsCRP levels were determined by the turbidimetry method (BIOSYSTEMS) and the ABI values were determined by using the traditional continuous wave (CW) Doppler of NICOLET VERSALAB. The data was analyzed by using the Student's t test (two tailed; independent) to find the significance of the study parameters between the two groups. Pearson's Correlation was used to find the correlation of serum hsCRP with the ABI in the two groups. The ABI showed a significantly low value (P=0.035*) and the serum hsCRP showed a trend towards a significant increase (p = 0.069+) in the type2diabetics as compared to those in the normals. There was a significant negative correlation between ABI and hsCRP in the Type 2 DM patients (r=-0.560, p<0.001**). However, such correlation was not observed in the normal subjects. As serum hsCRP is associated with ABI in the type2 DM patients, inflammation may play a role in the pathogenesis of atherosclerosis.
    Journal of clinical and diagnostic research : JCDR. 01/2013; 7(1):46-50.
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    ABSTRACT: Diabetic nephropathy (DN) is one of the major long-term complications of diabetes mellitus (DM). Type 2 DM is frequently associated with an inflammatory status, but limited information is available on the relationship between low-grade inflammation and DN. The aim of the study is to determine the serum level of high sensitivity C-reactive protein (hsCRP) in DN patients and to compare with that of normal subjects and to study the association between serum hsCRP levels and glycated hemoglobin (HbA1c) levels. Fifty DN patients in the age group of 50- 60 years with more than ten years of duration of diabetes were recruited for this study and 25 age-and sex-matched healthy subjects were included in this study as controls. Serum hsCRP levels were measured by turbidometry method. There was a statistically significant increase in serum hsCRP levels in DN cases as compared to normal controls. The hsCRP levels showed a positive correlation with HbA1c in DN. These results suggest that estimation of serum hsCRP levels and aiming at good glycemic control help in early intervention and prevention of further com-plications in diabetic patients.
    Saudi journal of kidney diseases and transplantation: an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia 03/2012; 23(2):286-9.
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    Lung India 01/2011; Vol 28 I(21).
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    ABSTRACT: Preterm infants can have many neurological problems. An enormous amount of fetal brain development occurs during the last trimester of pregnancy. They include myelination, glial cell migration and the development of a complex gyral pattern. The brain doesn't show the normal growth after birth in preterm infants. Brainstem auditory evoked potentials (BAEPs) are a noninvasive neurophysiologic assessment of brainstem maturation in babies. BAEPs in 25 preterm and 25 full-term infants were considered for the study. Infants having history of birth trauma, metabolic disorders or intracranial infection were excluded. BAEP waveforms (absolute and interpeak latencies) were recorded and analyzed. Student t test was used to analyze the data thus acquired. Analysis of data revealed a significant increase in latency of BAEP waveform V (P<0.05). Other latencies and interpeak latencies of BAEP waveforms were comparable. The preterm infants have a prolonged latency of BAEP waveform V suggestive of a retarded myelination of the central auditory pathway. Thus BAEP could be a useful electrophysiological test to assess neuronal myelination and maturation in preterm infants.
    Indian journal of physiology and pharmacology 01/2011; 55(1):44-52.
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    ABSTRACT: Immunoglobulin E and associated cellular responses are responsible for allergic airway diseases. A hypersensitivity reaction initiated by immunologic mechanisms, mediated by IgE antibodies occurs in allergic asthma To estimate and compare serum IgE levels in mild, moderate, and severe asthmatics and in normal subjects and to obtain a mathematical model describing the relationship between serum IgE levels and severity of asthma. A stratified sample of 60 patients within age group of 18-60 years and 31 male and 29 female asthmatic patients and 13 healthy controls within 18-60 years were included in this study and classified according to GINA classification. Serum IgE levels were estimated by using ELISA kit. Mean IgE levels ranged from 151.95 IU/ml in normal subjects to 1045.32 IU/ml in severe asthmatics. The model developed was 27% efficient. Serum Immunoglobulin E levels were high in asthmatics as compared to normal subjects. On an average, the levels increased as the severity of asthma increased. However, there was no statistically significant correlation since the variability in each level of asthma was very large.
    Lung India 07/2010; 27(3):138-40.
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    ABSTRACT: Central obesity is known to be an important risk factor in the development of metabolic syndrome and intraabdominal fat thickness has been found to be a reliable indicator of central obesity. Many anthropometric indicators have been suggested for measuring intraabdominal fat. The aim of this study was to relate various anthropometric measurements to intraabdominal fat thickness and to determine which among these is a better predictor of intra abdominal fat in normal subjects. This cross sectional study was carried out. in 60 healthy subjects (32 males and 28 females) in the age group of 25-55 years. Anthropometric measurements such as BMI, waist circumference and waist-hip ratio were assessed by using standard methods. Subcutaneous and visceral fat were measured 1 cm above umbilicus by ultrasonography. Intraabdominal fat thickness was correlated with the anthropometric measures by Pearson's test. Multivariate linear regression test was used to find the best anthropometric measurement as a predictor of abdominal fat. Waist circumference showed a significant positive correlation with subcutaneous fat and visceral fat. Waist circumference was found to be the best predictor of intraabdominal fat thickness in normal subjects and therefore of central obesity.
    Indian journal of physiology and pharmacology 01/2009; 53(3):259-64.
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    ABSTRACT: The totally blind individuals are often considered to be compensated for their visual loss by augmentation in the auditory and tactile perceptions as against the normal sighted individuals. The objective of the present work was to study the somatosensory evoked potentials (SEPs) after median nerve stimulation in the wrist of totally blind and normal sighted individuals. SEPs were recorded after median nerve stimulation in the wrist of 15 Braille reading totally blind females and compared with 15 age matched normal sighted females. Latency and amplitudes of SEPs (N9, N13, and N20) were measured and analyzed statistically. Amplitude of N20 SEP was significantly larger in the totally blind than in normal sighted individuals (P < 0.05). The amplitudes of N9 and N13 SEPs and the latencies of all SEPs showed no significant differences. The congenitally blind individuals have larger N20 amplitude, suggestive of greater somatosensory cortical representation than normal sighted individuals.
    Indian journal of physiology and pharmacology 01/2008; 52(2):183-8.
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    ABSTRACT: Compound muscle action potentials were recorded bilaterally from alae nasi muscles following stimulation of facial nerve in 45 normal subjects in the age group of 20-30 years. Latency, amplitude and total duration of the compound muscle action potential were compared on both sides. A significant positive correlation between the three parameters with the highest for the amplitude was observed. Therefore it is suggested that amplitude is a better parameter for comparison while testing for side to side facial nerve integrity.
    Indian journal of physiology and pharmacology 05/2003; 47(2):217-20.
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    ABSTRACT: The aim of this study was to determine whether the dyslipidemia was associated with glycated hemoglobin (HbA1c) and to study the relationship of dyslipidemia and glycated hemoglobin with atherosclerosis as well as the gender difference in dyslipidemia. Twenty five clinically diagnosed type 1 diabetic children and adolescents in the age group of 7-18years and 25 age and sex matched healthy children and adolescents constituted the study population. HbA1c was positively associated with total triglycerides, LDL, VLDL and HDL in diabetic cases as compared with controls. The gender differences were studied using chi-square test which showed that females were more prone to changes in lipid profiles as related to HbA1c levels. It was concluded that type 1 diabetes mellitus patients were at increased risk of premature atherosclerosis due to associated dyslipidemia that could be due to higher levels of glycated hemoglobin. Lower HDL levels, a possible risk of atherosclerosis showed inverse association with HbA1c levels, implying that elevated glycated hemoglobin was associated with multi-fold risk of atherosclerosis. Females were at increased risk of atherosclerosis than males because of higher prevalence of dyslipidemia among them. KeywordsGlycated hemoglobin–Atherosclerosis–Diabetes mellitus–Dyslipidemia
    International Journal of Diabetes in Developing Countries 31(1):18-21. · 0.45 Impact Factor