Mikhail D Antoun

Publications (3)1.12 Total impact

• Source

  Available from: Valerie E Wojna

  Article: Linguistic adaptation of the clinical dementia rating scale for a Spanish-speaking population: a focus group approach.

  Ilia Oquendo-Jiménez, Rafaela Mena, Mikhail D Antoun, Valerie Wojna
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  ABSTRACT: Alzheimer's disease (AD) is the most common form of dementia worldwide. In Hispanic populations there are few validated tests for the accurate identification and diagnosis of AD. The Clinical Dementia Rating (CDR) scale is an internationally recognized questionnaire used to stage dementia. This study's objective was to develop a linguistic adaptation of the CDR for the Puerto Rican population. The linguistic adaptation consisted of the evaluation of each CDR question (item) and the questionnaire's instructions, for similarities in meaning (semantic equivalence), relevance of content (content equivalence), and appropriateness of the questionnaire's format and measuring technique (technical equivalence). A focus group methodology was used to assess cultural relevance, clarity, and suitability of the measuring technique in the Argentinean version of the CDR for use in a Puerto Rican population. A total of 27 semantic equivalence changes were recommended in four categories: higher than 6th grade level of reading, meaning, common use, and word preference. Four content equivalence changes were identified, all focused on improving the applicability of the test questions to the general population's concept of street addresses and common dietary choices. There were no recommendations for changes in the assessment of technical equivalence. We developed a linguistically adapted CDR instrument for the Puerto Rican population, preserving the semantic, content, and technical equivalences of the original version. Further studies are needed to validate the usefulness of the adapted CDR instrument with the staging of Alzheimer's disease in the Puerto Rican population.
  Puerto Rico health sciences journal 06/2010; 29(2):102-8. · 0.56 Impact Factor
• Article: The University of Puerto Rico, School of Pharmacy at the turn of the new millenium.

  Ilia Oquendo, Ana Velez, Mikhail D Antoun
  Puerto Rico health sciences journal 07/2002; 21(2):83-4. · 0.56 Impact Factor
• Source

  Available from: benthamscience.com

  Article: Genotoxicity of Alkaloid-Rich Extract from Lupinus termis Seeds

  Marie R Santiago Quiles, Ilia Oquendo-Jiménez, Diógenes Herreño-Saénz, Mikhail D Antoun
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  ABSTRACT: The seeds of Lupinus termis are used in the Middle East and Africa as food and in folklore medicine. In tradi-tional medicine, the seeds are reputed to be effective for diabetes. Topically, the powdered seeds are used to treat acne, and in clinical studies performed outside the U.S.A., the ethanolic extract demonstrated efficacy in the treatment of chronic hand and foot eczema. In order to evaluate these traditional uses in controlled clinical trials in the U.S.A., the Food and Drug Administration requires proof of safety of the product under investigation. Three required genotoxicity studies are described in this paper: the Reverse Mutation Assay; the Mouse Lymphoma Assay; and the Mouse Micronu-cleus Assay. In all three assays, the ethanolic extract of L. termis was found to be not genotoxic. Further toxicity studies required by the FDA will be reported in due course.