Marta Smycz

Publications of Marta Smycz

• [Systemic lupus erythematosus--still current clinical and diagnostic problem].

  Authors: Karina Gesikowska, Zdzisława Kondera-Anasz, Aleksandra Mielczarek-Palacz, Justyna Sikora, Iwona Machaj, Marta Smycz

  Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego. 02/2012; 32(188):111-5.

  Systemic lupus erythematosus (SLE) is a common autoimmune disease of unknown etiology that frequently affects women of childbearing age. SLE is associated with impairments in immune system, which isSystemic lupus erythematosus (SLE) is a common autoimmune disease of unknown etiology that frequently affects women of childbearing age. SLE is associated with impairments in immune system, which is a consequence of increased production of various autoantibodies. This disease is still a major diagnostic and therapeutic problem. Some hope to explain the complex etiopathogenesis of the disease creates a monitoring function of the immune system. A chance for patients are biologically targeted therapies that affect the critical stages of the disease and autoimmune inflammatory processes.

• [Changes in concentrations of tumor necrosis factor TNF and its soluble receptors type 1 (sTNF-r1) and type 2 (sTNF-R2) in serum of patients with ST-segment elevation myocardial infarction].

  Authors: Aleksandra Mielczarek-Palacz, Justyna Sikora, Zdzisława Kondera-Anasz, Marta Smycz

  Wiadomości lekarskie (Warsaw, Poland : 1960). 01/2011; 64(2):71-4.

  Impairments of apoptosis process, called programmed cell death, are the basis of pathogenesis of cardiovascular disease, including myocardial infarction. The aim of our study was to estimationImpairments of apoptosis process, called programmed cell death, are the basis of pathogenesis of cardiovascular disease, including myocardial infarction. The aim of our study was to estimation dynamic changes of Tumor Necrosis Factor (TNF) and soluble receptors for TNF: type 1 (sTNF-R1) and type 2 (sTNF-R2) levels in serum of patients with ST-segment elevation myocardial infarction. The study group consisted of 70 patients aged 42 to 75 (mean 58.3 +/- 7.6 years) with the confirmed first episode of the ST-segment elevation myocardial infarction. The analyzed material was blood obtained from patients at fourth time: I. - the time of admission, II. - after 12 hour, III. - after 24 hour and IV. - on 5th day. Serum TNF, sTNF-R1 and sTNF-R2 levels were performed with the use of the immunoenzymatic method ELISA. The highest concentrations of TNF, sTNF-R1 and sTNF-R2 at a time of admission were observed. In the next examination dates level of studied parameters decreased: after 12 hours, after 24 hours and on 5th day. In patients with myocardial infarction were observed intensify of apoptosis process, which associated with increased concentration of TNF, sTNF-R1 and sTNF-R2. The measurement of studied parameters might be usefulin monitoring of course myocardial infarction, which need more examinations.

• [Concentration of soluble Fas receptor (sFas) in serum of patients with ST-segment elevation myocardial infarction].

  Authors: Aleksandra Mielczarek-Palacz, Zdzisława Kondera-Anasz, Justyna Sikora, Marta Smycz, Karina Gesikowska, Joanna Podsiadło

  Wiadomości lekarskie (Warsaw, Poland : 1960). 01/2009; 62(4):219-25.

  Impairments ofapoptosis process, called programmed cell death, are the basis of pathogenesis of cardiovascular disease, including myocardial infarction. The aim of our study was to evaluatedImpairments ofapoptosis process, called programmed cell death, are the basis of pathogenesis of cardiovascular disease, including myocardial infarction. The aim of our study was to evaluated concentration of soluble receptor Fas (sFas)--marker ofapoptosis--in serum of patients with ST-segment elevation myocardial infarction. The study group consisted of 70 patients aged 42 to 75 (mean 58.3 +/- 7.6 years) with the confirmed first episode of the ST-segment elevation myocardial infarction. The analyzed material was blood obtained from patients at fourth time: I. the time of admission, II. after 12 hour, III. after 24 hour and IV. on 5th day. The concentrations of the serum sFas was performed with the use of the immunoenzymatic method ELISA using commercial kits Human sAPO-1/Fas ELISA, Bender MedSystems Diagnostics GmbH, Austria. The sensitivity of the kit was 13.2 pg/ml. Concentration of sFas at a time of admission was the highest, among 50.30 and 68.70 pg/ml (mean: 58.73 +/- 5.63 pg/ml). After 12 h, the studied parameter level was significantly lower in comparison with sFas level in admission (p < 0.001), after 24 h (p < 0.0001) and on discharge from hospital (p < 0.001). In patients with myocardial infarction were observed intensify of apoptosis process, which associated with increased concentration of soluble Fas receptor. The measurement of sFas might be useful in monitoring of course myocardial infarction, which need more examinations.