Muthiah N. Inbasekaran

Concordia University–Ann Arbor, Ann Arbor, Michigan, United States

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Publications (2)5.48 Total impact

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    ABSTRACT: Fourteen 125I-labeled aralkylguanidines were synthesized and evaluated as potential imaging agents for the adrenal medullae and tumors of adrenomedullary origin. These guanidines are radiotracer analogues of guanethidine, an antihypertensive agent thought to mediate neuron blockade by uptake into adrenergic nerves. Dog adrenal medullae were used as a model to test radiotracer affinity for catecholamine storage tissue. Tissue distribution studies revealed that a number of radioiodinated guanidines showed pronounced localization in the adrenal medullae following intravenous injection, in certain cases exceeding that of either (-)-[3H]norepinephrine or [14C]guanethidine. (m-[125I]Iodobenzyl)guanidine (m-IBG, 2b) gave the best combination of high concentration and selectivity. The low adrenomedullary affinity observed with [14C]guanidine and m-[125I]iodobenzylamine demonstrates the uniqueness of the aralkylguanidine structure. Preliminary evidence suggests that 2b is a storage analogue of norepinephrine. [125I]2a is now being used clinically in imaging and radiotherapy of catecholamine tumors, such as pheochromocytoma.
    Journal of Medicinal Chemistry 03/1984; 27(2):149-55. DOI:10.1021/jm00368a008 · 5.48 Impact Factor
  • Muthiah N. Inbasekaran, Thomas J. Mangner, Donald M. Wieland
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    ABSTRACT: [α-14C]-benzylguanidine (1) having a specific activity of 14 mCi/mmol was synthesized in 55% yield (isolated) by reacting [α-14C]-benzylamine hydrochloride and cyanamide in 1-butanol.
    Journal of Labelled Compounds 10/1983; 20(10):1201-1205. DOI:10.1002/jlcr.2580201010