Mehmet Turgut

Eskisehir Osmangazi University, Dorylaeum, Eskişehir, Turkey

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Publications (8)14.32 Total impact

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    ABSTRACT: Extracorporeal shockwave lithotripsy (SWL) has remained the preferred method of treatment of urinary stones since its introduction in 1980. Although SWL is classified as a potential first-line treatment for renal stones smaller than 2 cm and its overall success rate is higher than 85% for stone clearance, not all renal calculi are successfully fragmented after SWL. Among the urinary stones, calcium oxalate monohydrate (COM) stone is one of the hardest stones to fragment. Several factors interfering with stone fragility are known to exist. In addition to technical properties for SWL to increase the quality and rate of stone disintegration, the composition of stones such as trace element levels may also interfere with the efficacy of SWL. Therefore, in the present study, we aimed to elucidate the correlation, if it exists, between fragmentation of renal stones and their trace element (Cu, Zn, Mg, Fe, Pb, Mn, Cr) concentrations. For this purpose, the patients admitted to our department who were identified with urinary stones (740 patients) and underwent SWL sessions were evaluated prospectively. Patients having 5-20 mm of solitary COM stone in the renal pelvis were included in this study. The trace element concentrations of renal stones that were successfully fragmented with SWL (SWL-S) were compared with those that were unsuccessfully fragmented after three SWL sessions (SWL-US) and removed surgically. Our measurements showed that the concentrations of Cu, Fe, Pb, and Cr were similar in both groups; by contrast, the concentration of Zn, Mg and Mn was significantly lower in SWL-US renal stones. The present results suggest that low concentrations of Zn, Mg and Mn in COM stones appear to make them resistant to SWL fragmentation and may offer a critical distinction for the choice of a treatment program.
    Urological Research 03/2008; 36(1):31-8. DOI:10.1007/s00240-007-0133-1 · 1.39 Impact Factor
  • Mehmet Turgut · Cavit Can · Aydin Yenilmez · Nevbahar Akcar ·
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    ABSTRACT: Perforation of the upper ureter is a rare but serious complication of extracorporeal shock wave lithotripsy (SWL). Ureteral perforation can cause a series of problems including the retroperitoneal urinoma, urosepsis, abscess formation, infection, and subsequent renal function impairment. We reported here a rare case of SWL-induced upper ureteral rupture resulting in an expanding retroperitoneal urinoma that required percutaneous drainage. Ureteral perforation was treated successfully without major surgical intervention by employing temporary percutaneous drainage and antibiotics. The present case indicates that potential ureter rupture may form in rare cases; especially in patients having infected stones and exposed to a high number of shock waves. This complication further emphasizes the importance of adequate pre-and post-operative evaluation and the precise identification of the cause of the persistent pain after SWL.
    Urological Research 09/2007; 35(4):215-8. DOI:10.1007/s00240-007-0101-9 · 1.39 Impact Factor
  • Ayten Bilir · Sacit Gulec · Mehmet Turgut · Dilek Cetinkaya · Ayse Erkan · Imran Kurt ·
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    ABSTRACT: To assess the analgesic efficacy of lornoxicam and compare it with that of tenoxicam in patients undergoing extracorporeal shock-wave lithotripsy (ESWL) for renal stones. The study was carried out in a randomized, double-blind fashion and involved 60 patients (American Society of Anesthesiologists physical status I-II) undergoing ESWL who were divided into three groups. Patients in the placebo group (n = 20) received saline and those in the lornoxicam group (n = 20) received lornoxicam 8 mg intravenously 60 min before the procedure. In the tenoxicam group, patients (n = 20) received tenoxicam 20 mg intravenously at the same time point. All patients were started on patient-controlled i.v. meperidine analgesia during the procedure. The effectiveness was assessed by using a visual analog scale (VAS) and by calculating the total analgesic consumption of meperidine during the procedure. Arterial blood pressure, oxygen saturation, and respiratory rate were recorded throughout the procedure; nausea and vomiting, agitation, and respiratory depression were assessed. Compared with patients in the placebo group, patients in the lornoxicam and tenoxicam groups received smaller doses of meperidine at all time points (p < 0.05). After 30, 45, and 60 min of ESWL, patients in the lornoxicam group required significantly smaller doses of meperidine than those in the tenoxicam group (p < 0.05). Patients in the placebo group showed higher VAS scores than those in the lornoxicam and tenoxicam groups at 15, 30 and 60 min. The VAS score in the lornoxicam group was lower than that in the tenoxicam group at 15, 30, and 45 min, but the difference between the groups was statistically significant only at 45 min (1 and 3, respectively; p < 0.05). In patients undergoing ESWL the i.v. administration of a single dose of 8 mg lornoxicam provides significantly better pain control compared with tenoxicam 20 mg and placebo, without increasing adverse side-effects.
    Scandinavian Journal of Urology and Nephrology 05/2007; 42(2):143-7. DOI:10.1080/00365590701225988 · 1.24 Impact Factor
  • A Yenilmez · M Ozçifçi · Y Aydin · M Turgut · K Uzuner · A Erkul ·
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    ABSTRACT: We investigated the effect of thiamine (B1) treatment on bladder dysfunction in streptozotocin (STZ)-induced diabetic rats. A total of 40 rats were randomly divided into four groups: a control group, a group given thiamine only, a diabetic group and a diabetic group given thiamine therapy. Diabetes was induced in the rats by 65 mg/kg STZ via an intraperitoneal injection. Thiamine was given 50 mg/kg/day. Diabetic cystopathy was confirmed on cystometry 8 weeks later in diabetic groups. Rats' body and bladder weights were measured. Contractile response to carbachol and potassium chloride (KCl) of detrusor strips in all groups was studied in vitro. The body weights were significantly decreased (p<0.01), the bladder weights were significantly increased (p<0.01), and the cystometric bladder capacity and the residual urine volumes were significantly increased (p<0.001, p<0.01 respectively) in STZ-induced diabetic groups compared to the control group and the group given thiamine only. Contractile responses increased in the diabetic group in high carbachol and KCl concentrations (p<0.01, p<0.01, respectively). On the other hand, there were no differences in the other groups. These data suggest that high-dose thiamine (B(1)) treatment may be beneficial in delaying the progression of diabetic cystopathy in this experimental animal model.
    Acta Diabetologica 12/2006; 43(4):103-8. DOI:10.1007/s00592-006-0223-5 · 2.40 Impact Factor
  • H Hassa · A Yildirim · C Can · M Turgut · H M Tanir · T Senses · F Sahin-Mutlu ·
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    ABSTRACT: To assess the effects of smoking on total sperm count, progressive sperm motility and sperm morphology among couples attending an infertility clinic. A total of 223 sperm samples (126 smokers and 97 nonsmokers) from men attending an infertility clinic for routine infertility workup were compared on the basis of standard semen analysis. Cigarette smoking is negatively correlated with progressive motile sperm count (r = -0.1464, p = 0.042), but not with sperm concentration (p = 0.961), total motile sperm count (p = 0.890) and sperm morphology (p = 0.838). Furthermore, packages/ year (cumulative dose of cigarettes) did not correlate with any of the sperm parameters including sperm density (p = 0.976), total (p = 0.559) and progressive (p = 0.406) motile sperm count and sperm morphology (p = 0.449). Although the effect of smoking on male infertility remains inconclusive, smoking had an adverse effect on the progressive sperm motility, irrespective of total amount of cigarettes smoked per day.
    Clinical and experimental obstetrics & gynecology 02/2006; 33(1):19-22. · 0.42 Impact Factor
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    ABSTRACT: To determine the prevalence of Y-chromosome microdeletions among infertile men and to correlate the clinical presentation of the men with specific deletions, microdeletion analysis in 53 infertile men (30 nonobstructive azoospermic, 23 severely oligozoospermic patients), and 100 age-matched, fathered normospermic men who had fathered children was performed by the multiplex PCR with 18 different Y-chromosome-specific STS primer sets, spanning the AZFa, AZFb, AZFd, and AZFc regions. Detection of the same locus deletion of the AZFd region in three cases indicated the possible importance of the genes located in this region in spermatogenesis.
    Fertility and sterility 09/2005; 84(2):519-22. DOI:10.1016/j.fertnstert.2005.02.024 · 4.59 Impact Factor
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    ABSTRACT: A case of fibroepithelial polyp of the penis in a 59-year-old man is presented. The physical examination showed that the lesion affected the ventral surface of the glans, near the urethral meatus. No communication was found with the urethra. The patient had a history of long-term condom catheter use. He was successfully treated by wide local excision. The histopathologic diagnosis was a fibroepithelial polyp. Postoperatively, the follow-up examinations at 3, 6, 12, and 24 months showed normal findings and no recurrence.
    Urology 04/2005; 65(3):593. DOI:10.1016/j.urology.2004.09.071 · 2.19 Impact Factor
  • Nevbahar Akcar · Mehmet Turgut · Baki Adapinar · I Ragip Ozkan ·
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    ABSTRACT: The aim of this study was to evaluate whether intratesticular arterial resistance and testicular volume differed between infertile men with subclinical varicoceles and infertile men without varicoceles. Fifty-eight infertile men were examined by gray-scale and color Doppler sonography for presence of varicocele, testicular volume, and arterial resistance. For men in the study group, mean testicular volume and resistance index (RI) in testes with varicoceles were compared with those in the contralateral testis by the paired t-test; statistical analyses between the study and control groups were performed by independent t-tests. Twenty-seven men had left-sided varicoceles (96% of which were subclinical), and 31 infertile men without varicoceles served as controls. Mean volumes of the right and left testes of study subjects were 14.8 ml and 14.6 ml, respectively, and in controls were 14.2 ml and 13.6 ml, respectively. Mean RI values for the right and left testes of study subjects were 0.61 and 0.58, respectively, and in controls were 0.61 and 0.58, respectively. There were no statistically significant differences in volume or RI, either between the right and left testes within patient groups or between the control and study groups' combined mean values. While the mean intertesticular volume differences for the study and control groups were 2.2 ml and 3.4 ml, respectively, the mean intertesticular RI differences were 0.04 and 0.07, respectively. These values also did not differ significantly between the 2 groups. Subclinical varicocele is not associated with ipsilateral testicular atrophy, and does not affect the intratesticular arterial RI.
    Journal of Clinical Ultrasound 11/2004; 32(8):389-93. DOI:10.1002/jcu.20059 · 0.69 Impact Factor