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Publications (2)3.85 Total impact

  • Pedro Oliveira · Mafalda Nogueira · António Pinto · M.Odette Almeida ·
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    ABSTRACT: The objective of this study was to determine whether p53 expression correlated with clinicopathological and DNA ploidy in osteosarcoma of the jaw, a particular subtype of osteosarcoma associated with an older age at presentation, longer median survival, rare metastasis, and death due to uncontrolled local recurrence. Seventeen cases of osteosarcoma of the jaw were stained for p53 using CM1 antibody (Novocastra). Eight cases (47.5%) showed nuclear staining in more than 10% of the neoplastic nuclei. Ploidy analysis showed 13 aneuploid (eight p53+) and three diploid (none p53+) tumors. No significant relationship was found between p53 positivity and clinicomorphological features, DNA ploidy or survival. p53-positive cases were, however, more commonly associated with aneuploidy and chondroblastic differentiation. These results indicate that p53 immunostaining does not seem to provide prognostic information in osteosarcoma of the jaw.
    Human Pathlogy 01/1998; 28(12):1361-5. DOI:10.1016/S0046-8177(97)90224-0 · 2.77 Impact Factor
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    ABSTRACT: Mitochondria-rough endoplasmic reticulum complexes identical to the ones usually found in chordoma were frequently observed in tumors cells of a malignant fibrous histiocytoma arising in the left thigh of a 48-year-old woman. Although the significance of these structures is unknown, this finding is consistent with the known transformation of chordoma into malignant fibrous histiocytoma.
    Ultrastructural Pathology 01/1994; 18(4):433-6. DOI:10.3109/01913129409023214 · 1.08 Impact Factor