Publications (4)0.7 Total impact
- Arzneimittel-Forschung 02/1979; 29(1):71-81. · 0.70 Impact Factor
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ABSTRACT: Age-dependent changes in the replication- and performance-metabolism of the liver under physiological and pathological conditions are presented in connection with previous works, on human material and in particular on the basis of experimental TAA-intoxication, -fibrosis and -cirrhosis in the rat. Alteration in the cell-content and -metabolism are presented in general terms and for the most part in relation to changes in the structure-macromolecules, particularly collagen. That is because collagen-synthesis and -increase are most important for development, progress and clinical results of liver fibrosis and cirrhosis. Therefore only some findings are given for age-dependent differences in the structure-macromolecules proteoglycan and glycosaminoglycans under physiological and pathological conditions. The various metabolic parameters of collagen and its fractions as well as the resulting total contents make changes in the connective tissue metabolism of the liver visible before they can be demonstrated by morphological methods. Age-dependent changes could be shown not only under physiological conditions but also at the beginning and during the course of human and experimental fibrosis and cirrhosis of the liver, finally also under therapeutic influences. These are demonstrated on the example of penicillamin which increase the collagen solubility. The conclusion that some of the methods demonstrated can also be applied in the dimension of liver biopsies is of particular clinical significance. That is particularly true for the protocollagen-proline-hydroxylase-activity of liver tissue, not however in serum and urine. The CLP (collagen-like-protein) and the hydroxyproline content of serum and the free and bound hydroxyproline-content of urine are not adequate for estimating the activity of connective tissue processes in the liver.
- Verhandlungen der Deutschen Gesellschaft für Innere Medizin 02/1974; 80:503-6.
- Zeitschrift für Gerontologie 12(1):27-39.
University of HamburgHamburg, Hamburg, Germany