Publications (10)0.81 Total impact
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Article: [Collagenofibrotic glomerulopathy--rare glomerulonephritis].
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ABSTRACT: Glomerulopathies with fibrillary deposits form a heterogeneous group of renal diseases that can be identified only by means of electron microscopy. A case of a rare type of such a nephropathy, the collagenofibrotic glomerulopathy with focus on differential diagnostics is presented and current knowledge relating to this renal disease is reviewed.Vnitr̆ní lékar̆ství 01/2007; 52(12):1200-4. -
Article: [Atherosclerotic nephropathy in renal artery stenosis--from randomized studies to individualized therapy].
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ABSTRACT: Randomized trials in hypertensive patients with atherosclerotic renal artery stenosis (ARAS) mostly did not reveal any significant difference between antihypertensive treatment and revascularization (by angioplasty or bypass surgery) in their effects on blood pressure or glomerular filtration rate. This unexpected conclusion reflects a fact that in addition to potentially reversible ischemia, some other factors which are not eliminated by technically successful revascularization take part in the decrease of renal function in ARAS, including cholesterol microemboli from atherosclerotic plaques, secondary focal segmental glomerulosclerosis and hypertensive nephroangiosclerosis. Moreover, these changes have been also found in the contralateral kidney without any stenosis. Scintigraphic studies confirmed that the individual kidney function was not related to the presence of ARAS, i.e., the glomerular filtration rate in the stenotic kidney was often equal to, or paradoxically even better than that in the kidney with normal renal artery. This has obviously important consequences for the indication of revascularization which should be based on measurement of the individual kidney function rather than overall renal function. A conservative treatment of ARAS should comprise ACE inhibitors or angiotensin II receptor antagonists, statins and acetylsalicylic acid. The long-term effect of such treatment on the progression of atherosclerotic nephropathy is now being evaluated in randomized trials.Vnitr̆ní lékar̆ství 04/2003; 49(3):217-21. -
Article: [Treatment of ascites with reinfusion of ascitic fluid concentrate].
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ABSTRACT: Ascites which is refractory to common therapeutical measures is a great problem. It deteriorates patient's life and is a sign of poor prognosis. Different methods of peritoneal fluid reinfusion belong to effective non-pharmaceutical therapeutic approaches. Main target of this study was to analyse the effectiveness and safety of peritoneal fluid reinfusion and to compare two methods of its administration (i.v. reinfusion and intraperitoneal reinfusion). During three years we have performed 97 reinfusions in 4 patients (2 women and 2 men; mean age 56 years). I.v. reinfusion was administered 68 times and intraperitoneal ewinfusion was performed 28 times. Usually we evacuated 8000 ml of ultrafiltrate. The most common complications were haemoperitoneum (6x) and short-term chills (2x). We didn't have any complications such as coagulopathy, peritonitis or circulation collapse. Intraperitoneal administration seems to be more advantageous when compared with i.v. application, because of less frequent detection of fibrin degradation products and D-dimers after the procedure and higher diuresis during the following days. (Tab. 2, Fig. 5, Ref. 13.).Bratislavske lekarske listy 02/2000; 101(5):306-9. · 0.40 Impact Factor -
Article: [Fibrillary glomerulopathy].
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ABSTRACT: The authors present an account on contemporary knowledge of the diagnosis and differential diagnosis of fibrillar glomerulopathies. The latter are characterized by extracellular localized microfibrils and microtubules resp. in the glomeruli of the kidneys, their diameter being 8-60 nm. They are divided into amyloid and non-amyloid types. The others are classified according to the immunofluorescent finding into immunoglobulin positive and negative ones. The differential diagnosis is important in particular in immunoglobulin positive ones as they are present in serious diseases such as cryoglobulinaemia, monoclonal gammapathy, systemic lupus erythematosus and immunotactoid glomerulopathy.Vnitr̆ní lékar̆ství 11/1997; 43(10):691-5. -
Article: [Chronic renal insufficiency].
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ABSTRACT: The authors submit a review on the etiopathogenesis, clinical picture and treatment of chronic renal insufficiency. They emphasize the fact that based on pathogenetic ideas it proved possible to influence the majority of pathological processes: retention and deficiency of substances as well as impaired regulation. After introduction of treatment, using erythropoietin, calcitriol as well as due to advances in the technique and quality of dialysis treatment, the patients' quality of life improved substantially. The authors draw attention also to the danger of accumulation of some drugs in renal insufficiency and its development.Vnitr̆ní lékar̆ství 08/1996; 42(7):503-6. -
Article: [Chronic renal insufficiency. Present views on pathogenesis, clinical aspects and treatment].
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ABSTRACT: The authors present contemporary views on the pathogenesis, clinical picture and treatment of chronic renal failure. A comprehensive approach to the pathogenesis of renal failure revealed new therapeutic methods such as treatment with erythropoietin, vitamin D etc. The authors emphasize substantial changes in the quality and range of the clinical picture which developed due to the prolonged survival of patients with dialyzation treatment. New problems developed such as e.g. dialyzation amyloidosis, aluminium intoxication, endocrine changes, increased occurrence of malignities etc. These must be foreseen, diagnosed and treated. While during the first half of this century uraemia was a fatal disease, at the end of the nineties patients survive due to the dialyzation and transplantation programme.Vnitr̆ní lékar̆ství 02/1996; 42(1):49-53. -
Article: [Antibiotic therapy of infections in patients on dialysis].
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ABSTRACT: The results obtained in treating infections in 53 patients involved in a chronic dialysis-transplantation program are reported. Higher susceptibility to infections and reduced immune functions were observed in dialyzed patients. The problem of the occurrence rate of individual infections was analyzed and infections of the respiratory system, particularly bronchopneumonia, were found to be predominant. No patient died of infection; in two patients the prescribed antibiotic of first choice had to be changed; positive clinical and laboratory effect was recorded in 51 of the 53 patients treated, and after change of the antibiotic in all the patients. Particular regimens of individual antibiotics in dialyzed patients are given along with the dialyzability of the drugs. The best results were obtained with ofloxacin and doxycycline of Czecho-Slovak make in monotherapy, in combined treatment gentamycin an amikacin with cefamezin or with cefotaxim proved to be most effective. Of the 45 pathogenic agents isolated, Staphylococcus aureus, Klebsiella spp, and Acinetobacter lwoffi, which have a good sensitivity to antibiotics, had the highest occurrence rates. (Tab. 4, Ref. 6.).Bratislavske lekarske listy 02/1992; 93(1):32-6. · 0.40 Impact Factor -
Article: [Acute renal insufficiency after the administration of tetracycline and gentamycin].
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ABSTRACT: The clinical course of eight case reports of patients with acute renal failure after administration of nephrotoxic antibiotics--specially of tetracycline and gentamycin--is demonstrated. All patients were suffering on preexisting nephropathy, many of them in stage of chronic renal failure according to various etiopathogenesis. As concomitant factor inducing acute renal failure together with antibiotics are: elderly, hepatopathy, surgical interventions, administration of other nephrotoxic drugs. In 6 patients, where acute renal failure induced by nonreducted doses of antibiotics appeared, the treatment was successful, in five cases due to short term haemodialysis, once conservatively with diuretics and volume diuresis. Two patients died before the therapeutic measures and dialysis could be performed. Algorithms in diagnosis and treatment of chronic renal failure--patients where antibiotic treatment is necessary are discussed.Casopís lékar̆ů c̆eských 08/1989; 128(31):981-4. -
Article: [Duplex ultrasonic examination of arteries of the lower extremities--comparison with angiography].
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ABSTRACT: The authors compared the results of duplex ultrasonic examination of 86 sections of the ileo-femoro-popliteal portion of the arterial circulation with angiographic findings. The correlation between angiographically and ultrasonically assessed degrees of stenosis was close and highly significant (r = 0.895, p = 0.001, y = 0.782x + 17.382). The sensitivity of duplex sonography when assessing significant stenoses (60% of the arterial lumen or more) was 100%, the specificity 76.5%, the probable positive value 75%, the probable negative value 100%, the probable positive ratio 3, the reliability of the test 86%. With regard to these results the authors recommend to make a non-invasive duplex ultrasonic examination of the arteries of the lower extremities in all echocardiographic laboratories and to include it in the algorithm of angiological examinations before angiography.Vnitr̆ní lékar̆ství 05/1989; 35(4):358-62. -
Article: Turning dilemmas into opportunities: a UNU/SCN capacity development network in public nutrition in Central and Eastern Europe
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ABSTRACT: Capacity development in nutrition is a process whereby individuals, groups, institutions, organizations and societies enhance their abilities to identify and meet challenges in a sustainable manner. To address these issues, in 2001 the UN System Standing Committee on Nutrition (SCN) established a Working Group on Capacity Development under the joint coordination of the United Nations University (UNU) and the International Union of Nutritional Sciences. Several regional professional networks have developed under this working group, the latest for the Central and Eastern Europe (CEE) countries. Ten CEE countries formed a network in 2006 and identified major nutritional challenges in the region, which included: irregular meal patterns; low consumption of fruits/vegetables, milk products and fish; low intake of some micronutrients; and high intakes of fat, sugar and salt. Public policies in nutrition were either weak or absent. Some countries had recently developed nutrition plans. Higher education in nutrition was seen as very important for public nutrition work by professionals in the region, who considered it a prerequisite for reversing the negative trend of the nutrition transition. The network will continue to work on issues that are still not covered adequately. Its activities to date and prospects for the future are assessed against ten principles for good capacity development suggested by the United Nations Development ProgrammePublic Health Nutrition 12 (2009) 8.
