Luis Salleras

Publications (10)35.47 Total impact

• Article: Results of the rubella elimination program in Catalonia (Spain), 2002-2011.

  Irene Barrabeig, Nuria Torner, Ana Martínez, Gloria Carmona, Pilar Ciruela, Joan Batalla, Josep Costa, Sergi Hernández, Luis Salleras, Angela Domínguez, The Rubella Surveillance Group Of Catalonia
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  ABSTRACT: Rubella is usually a mild disease with nonspecific symptoms, but can cause congenital rubella syndrome (CRS) when infection occurs during pregnancy. The objective of this study was to evaluate the sensitivity and positive predictive value of different data sources used for surveillance purposes in the Rubella Elimination Program of Catalonia between 2002 and 2011. The Urgent Notification to the Statutory Disease Reporting System, the Individualized Disease Reporting System, screening for other viruses included in the Measles Elimination Program, the Microbiological Reporting System and the Minimum Hospital Discharge Data were evaluated. 100 suspected cases of postnatal rubella and 6 suspected cases of CRS were detected. For postnatal rubella, Urgent Notification had the highest sensitivity (32.5%; 95%CI 18.6-49.1), followed by the Microbiological Reporting System (22.5%; 95%CI 10.8-38.5). Virus screening in the Measles Elimination Program had the highest PPV (76.9%; 95%CI 46.1-94.9), followed by the Individualized Statutory Disease Reporting System (57.1%; 95%CI 28.9-82.3). For CRS cases, the Individualized Statutory Reporting System had the highest sensitivity (100%, 95%CI 29.2-100) and the highest PPV (60%; 95%CI 14.7-100). Most confirmed postnatal cases (25 cases, 48.1%) were in the 25-44 y age group followed by the 15-24 y age group (11 cases, 21.2%). The highest values of sensitivity and PPV for the detection of confirmed cases corresponded to activities that were specifically introduced in the measles and rubella elimination programs.
  Human vaccines & immunotherapeutics. 01/2013; 9(3).
• Article: Risk factors for invasive pneumococcal disease in a community with a high proportion of non-vaccine serotypes.

  Pilar Ciruela, Núria Soldevila, Laura Selva, Sergi Hernández, Juan Jose Garcia-Garcia, Fernando Moraga, Mariona F de Sevilla, Gemma Codina, Ana Maria Planes, Cristina Esteva, Francis Coll, Neus Cardeñosa, Iolanda Jordan, Joan Batalla, Luis Salleras, Carmen Muñoz-Almagro, Angela Domínguez
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  ABSTRACT: The aim of this study was to investigate risk factors for the most common serotypes of invasive pneumococcal disease (IPD). A total of 293 IPD cases were analyzed in children aged 3-59 mo in a community with intermediate vaccination coverage with the 7-valent pneumococcal vaccine (PCV7). IPD cases were reviewed during 2007-2009 in two pediatric hospitals in Catalonia (Spain). A multivariate analysis using unconditional logistic regression was performed to estimate the adjusted odds ratio. PCV7 coverage was 45.4%. Pneumonia with empyema (64.5%) was the most frequent clinical manifestation. The most common serotypes were: serotype 1 (21.2%), 19A (16.0%), 3 (12.6%) and 7F/A (6.8%). 70.0% of serotypes found were included in the 13-valent conjugate vaccine (PCV13), 39.2% in the 10-valent conjugate vaccine and 8.1% in the PCV7. PCV7 was protective in IPD cases due to PCV7-serotypes (aOR: 0.15, 95% CI:0.04-0.55). Serotype 1 was positively associated with attending day care or school (aOR: 3.55, 95% CI: 1.21-10.38) and age 24-59 mo (aOR: 7.70, 95% CI:2.70-21.98). Serotype 19A was positively associated with respiratory infection in the previous month (aOR: 2.26, 95% CI: 1.03-4.94), non-penicillin susceptible IPD (aOR: 1.89, 95% CI:1.13-3.16) and negatively associated with age 24-59 mo (aOR: 0.19, 95% CI:0.09-0.41). Serotype 3 was positively associated with vaccination (aOR: 4.87, 95% CI:2.05-11.59). No factors were associated with serotype 7F/A. Vaccination with pneumococcal vaccines including more serotypes may reduce the risk of disease in our setting.
  Human vaccines & immunotherapeutics. 01/2013; 9(3).
• Article: Economic benefits of inactivated influenza vaccines in the prevention of seasonal influenza in children.

  Luis Salleras, Encarna Navas, Nuria Torner, Andreu A Prat, Patricio Garrido, Núria Soldevila, Angela Domínguez
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  ABSTRACT: The aim of this study was to systematically review published studies that evaluated the efficiency of inactivated influenza vaccination in preventing seasonal influenza in children. The vaccine evaluated was the influenza-inactivated vaccine in 10 studies and the virosomal inactivated vaccine in three studies. The results show that yearly vaccination of children with the inactivated influenza vaccine saves money from the societal and family perspectives but not from the public or private provider perspective. When vaccination does not save money, the cost-effectiveness ratios were very acceptable. It can be concluded, that inactivated influenza vaccination of children is a very efficient intervention.
  Human vaccines & immunotherapeutics. 01/2013; 9(3).
• Article: Clinical presentation of invasive pneumococcal disease in Spain in the era of heptavalent conjugate vaccine.

  Maria F de Sevilla, Juan-José García-García, Cristina Esteva, Fernando Moraga, Sergi Hernández, Laura Selva, Francisco Coll, Pilar Ciruela, Ana Maria Planes, Gemma Codina, Luis Salleras, Iolanda Jordan, Angela Domínguez, Carmen Muñoz-Almagro
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  ABSTRACT: The aim of this study was to analyze the rate of incidence, clinical presentation, serotype, and clonal distribution of invasive pneumococcal disease (IPD) in the era of heptavalent pneumococcal conjugate vaccine (PCV7) in Barcelona, Spain. This was a prospective study comprising all children <5 years with IPD who were managed in 2 tertiary-care, pediatric hospitals between January 2007 and December 2009. IPD was defined as the presence of clinical findings of infection together with isolation or detection of DNA of Streptococcus pneumoniae in a sterile fluid sample. In this study, 319 patients (53.3% male), mean age 29.6 months, were included. Comparing rates in 2007 and 2009 (76.2 and 109.9 episodes/100,000 population, respectively), an increase of 44% (95% confidence interval, 10%-89%) was observed. The main clinical presentation was pneumonia (254 episodes, 79.6%), followed by meningitis (29, 9.1%), and bacteremia (25, 7.8%).The diagnosis was made by positive culture in 123 (38.6%) patients and in 196 (61.4%) by real-time polymerase chain reaction. Serotype study was performed in 300 episodes, and 273 (91%) were non-PCV7 serotypes. The most frequent serotypes were 1 (20.7%), 19A (15.7%), and 3 (12.3%). A minimal inhibitory concentration ≥0.12 μg/mL to penicillin was detected in 34.4% of isolates. Sequence type 306 expressing serotype 1 was the most frequent clonal type detected (20.3% of studied strains). IPD continues to increase in Barcelona, and the rate is higher than previously reported as a result of low sensitivity of bacterial culture. Non-PCV7 serotypes were responsible for 91% of episodes and pneumonia was the main clinical presentation.
  The Pediatric Infectious Disease Journal 12/2011; 31(2):124-8. · 3.58 Impact Factor
• Source

  Available from: Pilar Ciruela

  Article: Effectiveness of 7-valent pneumococcal conjugate vaccine in the prevention of invasive pneumococcal disease in children aged 7-59 months. A matched case-control study.

  Angela Domínguez, Pilar Ciruela, Juan José García-García, Fernando Moraga, Mariona F de Sevilla, Laura Selva, Francis Coll, Carmen Muñoz-Almagro, Ana María Planes, Gemma Codina, Iolanda Jordán, Cristina Esteva, Sergi Hernández, Núria Soldevila, Neus Cardeñosa, Joan Batalla, Luis Salleras
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  ABSTRACT: The aim of this study was to evaluate the effectiveness of the administration of the 7-valent pneumococcal conjugate vaccine in a region with an intermediate vaccination coverage. A matched case-control study was carried out in children aged 7-59 months with invasive pneumococcal disease (IPD) admitted to two university hospitals in Catalonia. Three controls matched for hospital, age, sex, date of hospitalization and underlying disease were selected for each case. Information on the vaccination status of cases and controls was obtained from the vaccination card, the child's health card, the hospital medical record or the vaccination register of the primary healthcare center where the child was attended for non-severe conditions. A conditional logistic regression analysis was made to control for the effect of possible confounding variables. The adjusted vaccination effectiveness of the complete vaccination schedule (3 doses at 2, 4 and 6 months and a fourth dose at 15 months, 2 doses at least two months apart in children aged 12-23 months or a single dose in children aged >24 months) in preventing IPD caused by vaccine serotypes was 93.7% (95% CI 51.8-99.2). It was not effective in preventing cases caused by non-vaccine serotypes. The results of this study carried out in a population with intermediate vaccination coverage confirm those of other observational studies showing high levels of effectiveness of routine 7-valent pneumococcal conjugate vaccination.
  Vaccine 09/2011; 29(48):9020-5. · 3.77 Impact Factor
• Article: Infrequent detection of hepatitis E virus RNA in pregnant women with hepatitis E virus antibodies in Spain.

  Maria Buti, Angela Dominguez, Pere Plans, Rossend Jardí, Francisco Rodriguez-Frias, Rosa Gironés, Rafael Esteban, Luis Salleras, Antoni Plasencia
  Liver international: official journal of the International Association for the Study of the Liver 11/2010; 30(10):1549-51. · 3.82 Impact Factor
• Source

  Available from: PubMed Central

  Article: Influence of socioeconomic status on community-acquired pneumonia outcomes in elderly patients requiring hospitalization: a multicenter observational study.

  Conchita Izquierdo, Manuel Oviedo, Laura Ruiz, Xavier Sintes, Isabel Vera, Manel Nebot, Jose-María Bayas, Jordi Carratalà, Wenceslao Varona, Dolores Sousa, Jose-Miguel Celorrio, Luis Salleras, Angela Domínguez
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  ABSTRACT: The associations between socioeconomic status and community-acquired pneumonia outcomes in adults have been studied although studies did not always document a relationship.The aim of this multicenter observational study was to determine the association between socioeconomic status and community-acquired pneumonia outcomes in the elderly, in the context of a public health system providing universal free care to the whole population. A total of 651 patients aged > or =65 years hospitalized due to community-acquired pneumonia through the emergency departments of five Spanish public hospitals were recruited and followed up between May 2005 and January 2007. The primary outcomes studied were: length of stay, intensive care unit admission, overall mortality and readmission. Socioeconomic status was measured using both individual and community data: occupation [categorized in six social groups (I, II, III, IVa, IVb and V)], educational level (< or = primary level or > or = secondary level) and disposable family income of the municipality or district of residence [>12,500 euro (high municipality family income) and < or =12,500 euro (low municipality family income)]. The six social groups were further categorized as upper/middle social class (groups I-IVb) and lower class (group V).Bivariate and multivariate analyses were performed. OR and their 95% confidence intervals were calculated. All statistical tests were two tailed and statistical significance was established as p < 0.05. 17.7% of patients lived in a municipality or district with a high municipality family income and 63.6% were upper/middle social class (I-IVb). Only 15.7% of patients had a secondary education. The adjusted analysis showed no association between pneumonia outcomes and social class, educational level or municipality family income. However, length of stay increased significantly in patients in whom the factors, living alone and being a smoker or ex-smoker coincided (p < 0.001). We measured socioeconomic status using both individual and community data and found no association between social class, educational level or municipality family income and the variables of pneumonia outcomes. The lack of differences between social classes supports the provision of universal, equitable health care by the public health system.
  BMC Public Health 01/2010; 10:421. · 2.00 Impact Factor
• Article: Prevalence of hepatitis E virus infection in children in the northeast of Spain.

  Maria Buti, Pere Plans, Angela Domínguez, Rossend Jardi, Francisco Rodriguez Frias, Rafael Esteban, Luis Salleras, Antoni Plasencia
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  ABSTRACT: The prevalence of immunoglobulin G (IgG) anti-hepatitis E virus (anti-HEV) antibodies was studied with a representative sample of 1,249 healthy children aged between 6 and 15 years. IgG anti-HEV antibodies were detected in 57 (4.6%) of the 1,249 samples analyzed, suggesting that some children are exposed to HEV in early childhood.
  Clinical and vaccine immunology: CVI 05/2008; 15(4):732-4. · 2.37 Impact Factor
• Article: Streptococcus pneumoniae incidence in western Europe.

  Luis Salleras, Angela Domínguez
  The Lancet Infectious Diseases 05/2007; 7(4):242-3; author reply 243-4. · 17.39 Impact Factor
• Article: Community-based seroepidemiological survey of hepatitis E virus infection in Catalonia, Spain.

  Maria Buti, Angela Domínguez, Pere Plans, Rossend Jardí, Mélani Schaper, Jordi Espuñes, Neus Cardeñosa, Francisco Rodríguez-Frías, Rafael Esteban, Antoni Plasència, Luis Salleras
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  ABSTRACT: The objective of the study was to investigate the prevalence of immunoglobulin G (IgG) antibodies to hepatitis E virus (HEV) infection in a population sample from Catalonia and to analyze the demographic and clinical variables associated with the presence of these antibodies. A total of 1,280 subjects between 15 and 74 years of age were selected randomly from urban and rural areas. Data for sociodemographic and clinical variables were collected by using a questionnaire. IgG antibodies to HEV were determined by an immunoenzymatic method. The odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated for studied variables. Multiple logistic regression analysis was used to determine which variables were independently associated with the prevalence of HEV infection. Anti-HEV antibodies were detected in 96 (7.3%) of the 1,280 samples analyzed. The prevalence of antibodies was greater among males (7.8%) than among women (7%) and increased with age for both sexes, from 3% among subjects 15 to 24 years of age to 12% among subjects >/=65 years of age. Bivariate analysis of the sociodemographic and clinical variables showed an association between the prevalence of hepatitis E virus infection and minor surgery (OR, 1.96; 95% CI, 1.24 to 3.11), abdominal surgery (OR, 1.74; 95% CI, 1.12 to 2.73), and, for women, being uniparous or multiparous (OR, 2.84; 95% CI, 1.19 to 6.79). The multivariate analysis showed an association with minor surgery only (OR, 1.68; 95% CI, 1.03 to 2.70). In conclusion, anti-HEV antibodies were detected in 7.3% of the Catalan population. The seroprevalence of anti-HEV antibodies increased with age and was associated with previous minor surgery.
  Clinical and Vaccine Immunology 01/2007; 13(12):1328-32. · 2.55 Impact Factor