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ABSTRACT: Malignant peripheral nerve-sheath tumors (MPNSTs) are rare, poorly defined spindle cell sarcomas, and they are accompanied by heterologous elements in some cases. Among them, a fibroblastic element is one of the rarest and has been mentioned in some organs in several publications, but not in the orbit. The authors report a case of fibroblastic low-grade MPNSTs in the orbit. The mass was removed surgically, and the patient has been under close observation without evidence of disease recurrence for 2 years.
Ophthalmic plastic and reconstructive surgery 12/2011; 28(4):e97-8. · 0.69 Impact Factor
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ABSTRACT: A 12-year-old boy who had severe burns in the right eye from a firecracker injury 2 years previously was referred to our hospital with severe and recurrent symblepharon. The patient had received conjunctival sac reconstruction with amniotic membrane grafts twice at another hospital. A symblepharon lysis and conjunctival sac reconstruction with a mouth mucosal graft was performed. Eight months after surgery, he could not wear a prosthesis due to the recurrence of symblepharon. A prepuce mucosal graft obtained from circumcision was applied for forniceal and conjunctival sac reconstruction. One year postoperatively, the patient showed no recurrence of symblepharon and could comfortably wear a prosthesis. The prepuce is a useful alternative donor tissue in a male patient with no other available donor sites for conjunctival sac reconstruction.
Ophthalmic plastic and reconstructive surgery 10/2010; 27(4):e103-6. · 0.69 Impact Factor
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ABSTRACT: Periodontitis is an inflammatory process that ultimately results in tooth loss. Although the primary etiologic agent for periodontitis is bacteria, the majority of periodontal tissue destruction is thought to be caused by an inappropriate host response. Reactive oxygen species (ROS) have been known to be involved in periodontal tissue destruction. We treated human gingival fibroblasts with lipopolysaccharide (LPS) obtained fromE. coli and the periodontopathogensActinobacillus actinomycetemcomitans andPorphyromonas gingivalis, and examined their inflammatory responses in the presence and absence of the antioxidant N-acetylcysteine (NAC). LPS enhanced ROS production, as well as, expression of pro-inflammatory cytokines such as interleukin-1beta, interleukin-6, interleukin-8 and tumor necrosis factor-alpha, and the production and activation of MMP2. NAC suppressed all LPS-induced inflammatory responses examined, suggesting that LPS-induced ROS may play a major regulatory role in these responses in gingival fibroblasts. In addition, NAC prevented LPS-induced activation of p38 MAPK and JNK but not phosphorylation and subsequent degradation of IkB. These results indicate that NAC exerts anti-inflammatory effects in LPS-stimulated gingival fibroblasts, functioning at least in part via down-regulation of JNK and p38 MAPK activation. Furthermore, this work suggests that antioxidants may be useful in adjunctive therapies that complement conventional periodontal treatments.
Archives of Pharmacal Research 11/2007; 30(10):1283-1292. · 1.59 Impact Factor
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ABSTRACT: This research represents the first effort to apply vertical cavity surface emitting lasers (VCSELs) to the monitoring of interferometric fiber optic sensors. Modulation of the drive current causes thermal tuning of the laser light frequency. Reflection of this frequency-modulated light from a fiber Fabry-Perot interferometer (FFPI) sensor produces fringe patterns which can be used to measure the optical path difference of the sensor. Spectral characteristics were measured for 850nm VCSELs to determine the combination of dc bias current, modulation current amplitude and modulation frequency for which single mode VCSEL operation and regular fringe patterns are achieved. The response characteristics of FFPI sensors were determined experimentally for square, triangular, saw-tooth waveforms at frequencies from 10kHz to 100kHz. The dependence of VCSEL frequency on the dc bias current was determined from spectral measurements to be ~165GHz/mA. An independent measurement of this quantity based on counting fringes from the FFPI sensor as the laser modulated was in good agreement with this value. The effect of optical feedback into the laser was also studied. By observing the fringe shift as the FFPI sensor was heated, a fractional change in optical length with temperature of 6.95 X 10⁻⁶/°C was determined in good agreement with previous measurements on a 1300nm single mode fiber. The performance of 850nm VCSEL/FFPI systems was compared with their counterparts using 1300nm distributed feedback (DFB) lasers. The results of these experiments show that the 850nm VCSEL/FFPI combination gives regular fringe patterns at much lower bias current and modulating current amplitudes than their 1300nm DFB/FFPI counterparts. "Major Subject: Electrical Engineering" Title from author supplied metadata (automated record created on Feb. 23, 2007.) Vita. Abstract. Thesis (Ph. D.)--Texas A&M University, 2005. Includes bibliographical references. Text (Dissertation). Mode of access: World Wide Web. System requirements: World Wide Web access and Adobe Acrobat Reader.
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ABSTRACT: A 47-year-old woman presented with a growing mass on the lateral rim of orbit. Orbital CT revealed a well-circumscribed soft tissue mass in the right lateral orbit, with focal hyperostosis of the adjacent zygomatic bone. MRI showed a lesion of mixed T1-signal intensity, which became hypointense after fat suppression. The lesion was excised, and the diagnosis of orbital fibrolipoma was made by histopathologic examination. There was no evidence of tumor after 12 months of follow-up. Orbital fibrolipoma is a rare variant of lipoma, with only 1 case described previously. It should be considered in the differential diagnosis of orbital mass.
Ophthalmic plastic and reconstructive surgery 27(1):e16-8. · 0.69 Impact Factor
