Keiji Takemura

Kansai Medical University, Moriguchi, Ōsaka, Japan

Are you Keiji Takemura?

Claim your profile

Publications (2)5.94 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: The protective effect of dexamethasone (DEX) against noise-induced trauma, as reflected in hair cell destruction and elevation in auditory brainstem response (ABR) sensitivity, was assessed in guinea pigs. The animals were administered DEX (1, 10, 100, and 1000 ng/ml) or artificial perilymph (AP) via a mini-osmotic pump directly into scala tympani and, on the fourth day after pump implantation, exposed to 120 dB SPL octave band noise, centered at 4 kHz, for 24 h. Animals receiving DEX demonstrated a dose-dependent reduction in noise-induced outer hair cell loss (significant at 1, 10 and 100 ng/ml DEX animals compared to AP control animals) and a similar attenuation of the noise-induced ABR threshold shifts, observed 7 days following exposure (significant at 100 ng/ml DEX animals compared to AP control animals). These physiological and morphological results indicate that direct infusion of DEX into the perilymphatic space has protective effects against noise-induced trauma in the guinea pig cochlea.
    Hearing Research 11/2004; 196(1-2):58-68. DOI:10.1016/j.heares.2004.06.003 · 2.97 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: This study demonstrates the attenuation of aminoglycoside ototoxicity by cochlear infusion of dexamethasone (Dex) using a microcannulation-osmotic pump delivery system. The results indicate that treating the cochlea with Dex both before and after kanamycin administration was more effective in preventing ototoxicity than Dex treatment only after kanamycin administration. A concentration of 1 ng/ml Dex showed the greatest protective effect on both kanamycin-induced threshold shift of the auditory brainstem response and outer hair cell survival. These results show that the Dex treatment attenuates both functional and structural damage of the inner ear from aminoglycoside toxicity.
    Hearing Research 06/2002; 167(1-2):61-70. DOI:10.1016/S0378-5955(02)00345-3 · 2.97 Impact Factor

Publication Stats

163 Citations
5.94 Total Impact Points

Top Journals


  • 2002–2004
    • Kansai Medical University
      • Department of Otolaryngology
      Moriguchi, Ōsaka, Japan