[Show abstract][Hide abstract] ABSTRACT: With the increasing demand in agriculture it has become important for us to increase theproductivity by using various fertilizers insecticides Pesticides .But with the tremendous use of theseproducts the soil has been affected badly because of the depletion in the essential minerals of the soil. So toovercome this problem it has become important for all of us touse a different remedy for the production ofvarious biofertilizers. The production if such biofertilizers from various microorganisms was studied from thiswork.
International Journal of Microbiology 12/2009; DOI:10.9735/0975-52220.127.116.11-31 · 4.53 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: Laccases are multi copper oxidases having wide substrate specificity mainly found in white-rotfungi, which are the only microorganisms able to degrade the whole wood components. In contrast to mostenzymes, which are generally very substrate specific, laccases act on a surprisingly broad range ofsubstrates, including diphenols, polyphenols, different substituted phenols, diamines, aromatic amines,benzenethiols and even some inorganic compounds such as iodine. As they are capable of degrading awide variety of compounds they are commercially very significant. This project aims at studying theproduction optimization of laccase using different carbon sources.
International Journal of Microbiology 12/2009; DOI:10.9735/0975-5218.104.22.168-12 · 4.53 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: Standardization of a Bioreactor for Industrial purpose is of prime importance. The construction ofthe Bioreactor needs a proper understanding of the different parts of the bioreactor and how they could beused. Hence the basic focus of this work was the Construction and the Standardization of the Bioreactor.The Production of Protease was done by altering the pH and checking the KL a level in the fermentationProcess.
International Journal of Microbiology 12/2009; DOI:10.9735/0975-5222.214.171.124-44 · 4.53 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: Toxicogenomics is emerging field give idea of the application of large-scale differential geneexpression data to toxicology, starting to influence drug discovery and development in the pharmaceuticalindustry. Its future potential in cancer pathogenesis, study of poisons and poisoning and has an ancient andvenerable history. Toxicogenomics is the merging of toxicology with technologies that have been developed,together with bioinformatics, to identify and quantify global gene expression changes for gene therapy.Immunotoxic processes and the development of in vitro screening assays is therefore expected to be ofvalue for mechanistic insight into immunotoxicity and hazard identification of existing and novel compounds.Successful application of toxicogenomic approaches, such as DNA microarrays, inextricably relies onappropriate data management, the ability to extract knowledge from massive amounts of data and theavailability of functional information for data interpretation. Toxicogenomics is considered a valuable tool forreducing pharmaceutical candidate attrition by facilitating earlier identification, prediction and understandingof toxicities. Pharmaco-epidemiological (toxicogenomics) data is now available for both antiepileptic drugs,evidence for human carcinogenicity. Therapeutic researches converge triad of rejuvenation, regeneration orreplacement strategies that rely on self-healing processes, stem cell regeneration organ transplantation.Metastases studies usually display more genetic changes than the primary tumour. Helix-loop-helixapplication in translational and functional toxicogenomics transcription factors has been implicated indiverse cellular processes such as proliferation, apoptosis, differentiation, and migration.
[Show abstract][Hide abstract] ABSTRACT: Oncogenomics is new research sub-field of genomics, which applies high throughputtechnologies to characterize genes associated with cancer and synonymous with cancer genomics. Thegoal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide newinsights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies.Oncoproteomics is the term used to describe the application of proteomic technologies in oncology andparallels the related field of oncogenomics. It is now contributing to the development of personalizedmanagement of cancer. Genomics has generated a wealth of data that is now being used to identifyadditional molecular alterations associated with cancer development. Mapping these alterations in thecancer genome is a critical first step in dissecting oncological pathways.
[Show abstract][Hide abstract] ABSTRACT: The prevalence of HIV /AIDS in Indian population has been carried out. However analysis ofsecondary infection after HIV is carried out by the present studies. A total of 58 patients suffering from HIVAIDSwere analyzed with reference to the age, gender, BMI and Mode of infection. Data analysis showedthat patients suffering from HIV / AIDS have greater risks of Tuberculosis disorders. A distinct correlationbetween Tuberculosis and HIV/ AIDS was observed during the present studies.
[Show abstract][Hide abstract] ABSTRACT: New drug target discovery is currently very popular with a great potential for advancingbiomedical research and chemical genomics. Drug discovery is the process of discovering and designingdrugs that includes target identification, target validation, lead identification, lead optimization andintroduction of the new drugs to the public. G protein-coupled receptors are one of the most important drugtargets. In the current scenario of drug research, approximately 60% of drug target molecules are located atthe cell surface, and half of them are GPCRs. Fragment-based drug discovery is established as analternative approach to high-throughput screening for generating novel small molecule drug candidates.Nanotechnology-based drug delivery systems have seen recent popularity due to their favorable physical,chemical, and biological properties, and great efforts have been made to target nanoDDSs to specificcellular receptors. Protein-protein interactions regulate a wide variety of important cellular pathways, andtherefore represent a highly populated class of targets for drug discovery. An analysis of individual proteinproteininteraction systems has recently yielded success in the discovery of drug-like inhibitors.