K U Schentke

Carl Gustav Carus-Institut, Pforzheim, Baden-Württemberg, Germany

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Publications (48)21.12 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: Teile von Leberbiopsieproben des Menschen von etwa 0,4 mg Masse werden auf ihren Gehalt an Mangan, Kupfer und Zink untersucht. Die Proben werden gefriergetrocknet und in Quarzröhrchen im Rossendorfer Forschungsreaktor bei einem Fluβ thermischer Neutronen von 2 · 1013 n cm−2 s−1 aktiviert. Nach chemischer Auftrennung an einem Anionenaustauscher werden die Aktivitäten von 56Mn, 64Cu und 69mZn im NaJ(Tl)-Szintillationsdetektor gemessen. In jeder Probe wird gesondert der Leber-Triglyzeridgehalt bestimmt. 20 Proben von Normalpersonen mit kontrolliertem Kohlenhydrat- und Fettstoffwechsel wiesen 6,3 ppm Mn, 30 ppm Cu und 164ppm Zn, bezogen auf Trockenmasse, auf. Diese Konzentrationen stimmen mit Literaturangaben etwa überein. Bei Fettleber und Hypertriglyzeridamie waren die Metallkonzentrationen verringert. Es wurden zwischen den Metallkonzentrationen untereinander positive Korrelationen und zwischen Metall- und Triglyzerid-konzentrationen negative Korrelationen festgestellt.
    Isotopes in Environmental and Health Studies - ISOT ENVIRON HEALTH STUD. 08/2008; 11(4):130-133.
  • K U Schentke, S Subat
    DMW - Deutsche Medizinische Wochenschrift 07/1995; 120(25-26):923-5. · 0.65 Impact Factor
  • K. U. Schentke, S. Subat
    Deutsche Medizinische Wochenschrift - DEUT MED WOCHENSCHR. 01/1995; 120:923-925.
  • J Krappweis, G Petereit, K U Schentke, W Kirch
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    ABSTRACT: A 65-year-old woman, known to have peptic ulcers, developed nausea and retching. Clinical examination demonstrated pain on pressure in the epigastrium with otherwise normative findings for age. Two gastric ulcers and gastritis with erosions were seen at endoscopy. The patient, who was being treated with digitoxin for heart failure, reported having taken up to four digitoxin tablets (0.07 mg each) daily because she had insomnia. The plasma digitoxin level was between 150 and 160 nmol/l (therapeutic range 17-33 nmol/l), while the ECG showed no signs of digitalis intoxication. Initially the platelet count was 40,000/microliter: there had been no history of thrombocytopenia or symptoms of abnormal haemostasis. Other laboratory tests were within normal limits. After digitoxin had been discontinued, the platelet count rose without further treatment to 373,000/microliter 3 weeks after hospital admission by which time the digitoxin level had fallen to 48.9 nmol/l. The gastrointestinal symptoms regressed completely on treatment with omeprazole (40 mg three times daily for 8 days) and ranitidine (150 mg twice daily).
    DMW - Deutsche Medizinische Wochenschrift 01/1995; 119(50):1734-6. · 0.65 Impact Factor
  • J. Krappweis, G. Petereit, K. U. Schentke, W. Kirch
    Deutsche Medizinische Wochenschrift - DEUT MED WOCHENSCHR. 01/1994; 119(50):1734-1736.
  • D Kürktschiev, S Subat, D Adler, K U Schentke
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    ABSTRACT: Peripheral blood lymphocytes of 22 patients with primary biliary cirrhosis under ursodeoxycholic acid therapy were examined for selected lymphocyte activation markers. The percentage of dipeptidyl peptidase IV positive Peripheral blood lymphocytes of primary biliary cirrhosis patients by using immune- and enzyme-histochemical staining was found to be low (5-12%), with healthy controls exhibiting a normal range of 18-27%. After pokeweed mitogen stimulation in vitro the interleukin-2 production by peripheral blood lymphocytes in primary biliary cirrhosis patients was significantly decreased (3.135 pg/ml mean value), compared to healthy subjects (61.167 pg/ml mean value). After 4-20 weeks ursodeoxycholic acid treatment the dipeptidyl peptidase IV expression and IL-2 production were normalised. These results provide evidence for the immunomodulating effect of ursodeoxycholic acid.
    Journal of Hepatology 08/1993; 18(3):373-7. · 9.86 Impact Factor
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    ABSTRACT: Investigations concerning changes of dipeptidyl-peptidase IV-positive (DP IV+) lymphocytes in the peripheral blood (PBL) were undertaken in 22 patients with primary biliary cirrhosis (PBC) under therapy with ursodeoxycholic acid (750 mg/day). We found that 4-8 weeks after therapy beginning the number of DP IV+ PBL was raised from a low initial suppressed level of 5-12% into a range of 18-33% corresponding to that of a healthy. Concurrently liver function parameters of the patients were improved significantly. The identity of DP IV+ and CDw26+ of peripheral T-cells could be shown by combination of the cytochemical DP IV-staining with the indirect immunofluorescence of the lymphocyte marker CDw26. These results show that the UDCA-therapy in patients with PBC has a direct effect on the immune system and a positive influence on the immuno-regulative capacity.
    Zeitschrift für Gastroenterologie 03/1993; 31 Suppl 2:104-5. · 1.41 Impact Factor
  • K U Schentke, E Kobe, M Taha, W Schimming
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    ABSTRACT: The spectrum of causes of cholestasis ranges from microscopically recognizable damage to the parenchymal cells of the liver to obstruction of the ductus choledochus und papilla Vateri. Liver biopsy on the one hand and ERCP on the other therefore constitute the morphological methods that come closest to the pathological substrate. Obligatory sonography serves the restriction of diagnosis to a large extent. Laparoscopy is nearly always dispensable. Even in case of liver biopsy the therapeutic consequences should have an influence. Consequently, for transpapillary endoscopic methods in obstructive jaundice it is essential to remove the obstruction (papillotomy and extraction of the calculus or nasobiliary probe or intraluminal tube) if possible in one and the same session. The purely diagnostic ERC possibly causes dangerous cholangitis in mechanical icterus. Transpapillary and percutaneous transhepatic endoscopic methods are becoming more and more sophisticated and new indications are being discovered. However, the results of sonography and endoscopy in obstructive jaundice depend very much on the equipment available and experience of the investigator. He should realistically estimate what he is able to do as well as the patients' chances of recovery. In addition he should maintain contact to large departments of surgery and endoscopy.
    Zeitschrift für Gastroenterologie 03/1993; 31 Suppl 2:44-6. · 1.41 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Investigations concerning changes of dipeptidyl-peptidase IV-positive (DP IV+) lymphocytes in the peripheral blood (PBL) were undertaken in 22 patients with primary biliary cirrhosis (PBC) under therapy with ursodeoxycholic acid (750 mg/day). We found that after 4-8 weeks of therapy the number of DP IV+ PBL was raised from an initially low, suppressed level of 5-12% to 18-33% corresponding to the range observed in healthy subjects. Concurrently liver function parameters of the patients were significantly improved. The identity of DP IV+ CD 26+ peripheral T-cells could be shown by the combination of cytochemical DP IV-staining with the indirect immuno-fluorescence of the lymphocyte marker CD 26. These results show that the UDCA-therapy in patients with PBC has a direct effect on the immune system and a positive influence on the immuno-regulative capacity.
    Zeitschrift für Gastroenterologie 03/1993; 31(2):135-9. · 1.41 Impact Factor
  • Zeitschrift für ärztliche Fortbildung 11/1992; 86(19):981-6.
  • A Schramm, M Weise, K U Schentke
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    ABSTRACT: The development and establishment of intensive care units for adult patients requires a far-reaching subdivision into surgical and conservatively oriented intensive care for qualitative and quantitative reasons. Insufficiently substantiated claims to monopolization of intensive care techniques that are polemically asserted have to be strongly contradicted. The present paper is concerned with approved structural concepts of intensive care developed by Deutsche Krankenhausgesellschaft and various medical societies. They are supplemented by personal experience in the field of internal intensive care.
    Zeitschrift für die gesamte innere Medizin und ihre Grenzgebiete 04/1991; 46(3):72-5.
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    ABSTRACT: 40 women, average age 52.5 years, with varying stages of primary biliary cirrhosis, were observed. One third of them suffered from a mild anaemia, mean plasma concentrations of ALAT were increased four times and those of AP six times. Despite the hepatocellular damage products of the liver synthesis such as transport proteins or coagulation factors were found to be normal or enhanced. 60% of the patients had a hypercholesterolaemia. The risk factors low density lipoprotein (LDL)- and very low density lipoprotein (VLDL)-cholesterol showed normal levels, but the protective factor high density lipoprotein (HDL)-cholesterol was clearly increased. Apart from the low blood pressure in most of the patients and the absence of other risk factors these observations explain, why patients with PBC and hypercholesterolaemia don't usually develop arteriosclerotic complications. Only in case of severe cholestasis a lipid constellation comes into being accompanied by high risk for the blood vessels, but in these cases the terminal stage of PBC limits the survival. Positive correlations between markers of cholestasis and lipid parameters let an enhanced production and simultaneous impaired excretion of cholesterol be assumed.
    Gastroenterologisches Journal: Organ der Gesellschaft für Gastroenterologie der DDR 02/1991; 51(1):18-21.
  • C Strohbach, T Grammatté, K U Schentke
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    ABSTRACT: The effects of 4 non-ulcer drugs and the M1-antagonist pirenzepine on the nocturnal intragastric pH were investigated in 12 healthy volunteers. We tested single doses of pirenzepine (100 mg), Chlorprothixene (30 mg), clonidine (75 micrograms), ketotifen (3 mg) and nifedipine (30 mg) in an randomized, single-blind, cross-over study. The nocturnal intraluminal pH is significantly elevated not only by pirenzepine but also by the other substances. As expected pirenzepine (mean nocturnal pH = 2.49 +/- 0.22) shows the most distinct effect, nifedipine (mean nocturnal pH = 1.72 +/- 0.20) the most sparsely effect. The other drugs are nearly half as effective as pirenzepine. The acid suppressive side effect of the non-ulcer remedies is considered to be important for the treatment of ulcer patients with concomitant diseases.
    Gastroenterologisches Journal: Organ der Gesellschaft für Gastroenterologie der DDR 02/1991; 51(2):62-5.
  • M Zillmann, K U Schentke
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    ABSTRACT: The intra- and interindividual variations of gallbladder motility were sonographically studied in 10 healthy subjects. We investigated the following criteria: a) the gallbladder volumes after overnight fasting on 5 consecutive days, b) the spontaneous motility under fasting over 12 or 24h at hourly intervals, c) the emptying rate and time of maximal contraction after stimulation with sorbitol, and d) the emptying rate and time (like c) after premedication with "cholagogic" drugs (Cholecysmon, Divalol), nifedipine, indomethacin or N-butylscopolaminiumbromide. We found a great intrapersonal and interpersonal variability in gallbladder volumes after overnight fasting in consecutive days. In subjects fasting over 24h phases of dilatation with maxima at 12 AM and 4 PM alternated with phases of contraction with maxima at 8 AM and 4 PM. After premedication with nifedipine, indomethacin and N-butylscopolaminiumbromide a significant decrease of the emptying rate was observed. The time of maximal contraction did not differ however. After premedication we found a distinct intra- and interindividual variability too. Cautious interpretation of gallbladder motility studies is necessary.
    Gastroenterologisches Journal: Organ der Gesellschaft für Gastroenterologie der DDR 02/1991; 51(2):66-72.
  • E Kobe, B Zipprich, K U Schentke, R Nilius
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    ABSTRACT: Sixty-three patients with degree III or IV esophageal varices and the so-called red color sign, but without previous bleeding were randomly assigned to either prophylactic sclerotherapy (PST) (n = 30) or to a control group (n = 33). In 58 cases the portal hypertension was caused by liver cirrhosis (40% alcoholics). The two groups were comparable with respect to demographic data and endoscopic appearance, causes and severity of liver damage. Sclerotherapy was performed as combined intra-and paravariceal injections of 2 or 3% polidocanol. All patients, both in the treatment and in the control groups, who bled from varices after randomization, received sclerotherapy until the varices were eradicated, and remained in their groups. After a mean follow-up of 44.5 months, the bleeding rate in the PST group was significantly lower (30% vs 75%, p less than 0.01). The difference became significant from the second year onward. Fourteen patients of the PST group and 19 of the controls died (4 and 14, respectively, p less than 0.05 as a result of the bleeding). Life table analysis (Kaplan-Meier) revealed no differences in survival between the two groups. At the present time PST cannot yet be recommended as a method for clinical routine use.
    Endoscopy 12/1990; 22(6):245-8. · 5.74 Impact Factor
  • Zeitschrift für ärztliche Fortbildung 02/1990; 84(13):631-5.
  • H J Wünschmann, K U Schentke, B Dökert, E Kobe
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    ABSTRACT: A case of multiple abdominal haemangiomas (mesentery, intestine, liver) in a 19 year-old patient is described. The anomalies, at first incidentally found during appendectomy, were confirmed by angiographies and vascular surgery. Ascites and bleeding esophageal varices developed in further course. A short review of literature and classifications is given.
    Deutsche Zeitschrift für Verdauungs- und Stoffwechselkrankheiten 02/1987; 47(6):294-300.
  • K U Schentke
    Zeitschrift für ärztliche Fortbildung 02/1987; 81(14):687-92.
  • E Kobe, K U Schentke
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    ABSTRACT: Several prospective studies on the efficiency and technique of endoscopic sclerotherapy (EST) were performed among 300 patients with bleeding esophageal varices, 173 of which had been treated by EST. Contrasted with a comparable control group (n = 80), EST (n = 100) reduced the incidence of rebleedings (40% vs 13.3%; p less than 0.0005) and the lethality (46.7% vs 30.6%; p less than 0.05) during the observation period of 21 months. The paravariceal and the intravariceal injection techniques were compared in 20 patients each. A higher number of initial and repeated treatment sessions argued against the paravaricel technique (mean follow up: 4 years). In a randomized study on prophylactic EST we found a lower bleeding frequency (13% vs 39%) in 16 patients treated by EST compared to 18 controls.
    Deutsche Zeitschrift für Verdauungs- und Stoffwechselkrankheiten 02/1987; 47(4):151-7.
  • N Grosche, S Geissler, K Köhler, K U Schentke
    Zeitschrift für ärztliche Fortbildung 02/1987; 81(14):695-704.