K Ohtani

Publications (3)4.88 Total impact

• Article: A case of systemic lupus erythematosus associated with trigger wrist

  K. Ohtani, K. Fukuda, C. Hamanishi
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  ABSTRACT: A 54-year-old woman complained of a painful, swollen, and clicking left wrist for 1 year. She had an 8-year history of systemic lupus erythematosus (SLE), treated with oral prednisolone. Flexion and extension of all fingers were difficult to initiate on wrist extension, and movement was accompanied by a palpable click at the wrist. Magnetic resonance imaging (MRI) and tenography revealed the expanded sheath of the flexor tendons and well-defined round free bodies known as rice bodies. Synovectomy and excision of rice bodies resulted in complete disappearance of swelling and triggering of the wrist.
  Modern Rheumatology 02/2002; 12(1):69-71. · 1.58 Impact Factor
• Article: Interleukin-1 inhibits keratan sulfate production by rabbit chondrocytes: possible role of prostaglandin E2.

  K Fukuda, K Ohtani, H Dan, S Tanaka
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  ABSTRACT: We investigated the importance of prostaglandin E2 (PGE2) release in interleukin-1 (IL-1)-induced inhibition of aggrecan synthesis by chondrocytes. Keratan sulfate (KS) production was measured in parallel with PGE2 release in chondrocytes. IL-1 inhibited KS production and stimulated PGE2 release. In the presence of PGE2, there was a dose-dependent decrease in baseline KS production. Indomethacin and dexamethasone partially blocked the IL-1-induced PGE2 release while KS production recovered. Our results suggest that IL-1 inhibits KS production, in part, by stimulating the release of PGE2.
  Inflammation Research 05/1995; 44(4):178-81. · 2.11 Impact Factor
• Article: Keratan sulfate inhibits its release in rabbit chondrocyte.

  K Fukuda, K Ohtani, F Matsumura, S Tanaka
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  ABSTRACT: Keratan sulfate (KS) is one of the major glycosaminoglycans in cartilage matrix proteoglycan. We find that exogenously added KS totally blocks keratanase sensitive glycosaminoglycan release measured by radiolabeled ligand. We also find that KS release is potentially inhibited by its own presence as measured by ELISA. When KS is digested with keratanase before its addition to the medium, its inhibitory effect on KS secretion is partially blocked. Exogenously added KS promotes the accumulation of the KS epitope in the cell layer. These data suggest that KS negatively regulates its own secretion.
  Connective Tissue Research 02/1993; 30(1):75-83. · 1.20 Impact Factor