[Show abstract][Hide abstract] ABSTRACT: Interleukin 6 (IL-6) is a pleiotropic cytokine with many physiological functions. The present study was designed to determine the expression of IL-6 and its receptor (IL-6R) in human gastric and colorectal cancers. Nine gastric- and nine colorectal cancer cell lines were analysed. The IL-6 gene was expressed in two gastric cancer cell lines and one colorectal cancer cell line; however, most of the cancer cell lines studied expressed the IL-6R gene. The level of IL-6 secretion in the gastric cancer cell lines correlated with the level of soluble IL-6R secretion, and was significantly higher (< approximately 100 pg/ml) than the level of IL-6 secretion in the colorectal cancer cell lines (< approximately 50 pg/ml). These results suggest that IL-6 may act in a paracrine fashion rather than an autocrine fashion in these cell lines.
The Journal of international medical research 04/2003; 31(2):69-75. DOI:10.1177/147323000303100202 · 1.44 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: Leukocytapheresis (LCAP) was performed in seven patients with moderate or severe active ulcerative colitis (UC) at the Koga Hospital. LCAP was considered as having been effective in all seven patients (excellent clinical response in five and moderate clinical response in two patients). The excellent or moderate clinical response continued throughout maintenance LCAP in three of seven patients. None of the patients required discontinuation of LCAP, despite the appearance of some side effects, including facial redness, low-grade fever, discomfort, headache and hypotension during the therapy. The results of this study indicate that LCAP may be a safe and effective intensive and maintenance therapy for UC