K Kluge

Publications (4)1.79 Total impact

• Article: A contribution to safety assessment of veterinary drug residues: in vitro/ex vivo studies on the intestinal toxicity and transport of covalently bound residues.

  S Klee, I Baumung, K Kluge, F R Ungemach, E Horne, M O'Keeffe, I De Angelis, A L Vignoli, F Zucco, A Stammati
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  ABSTRACT: 1. The gastrointestinal fate of protein-bound residues of the model compound furazolidone (FZD) was investigated in vitro and ex vivo. Protein-bound residues were generated in rat liver microsomes, isolated by solvent extraction and digested with 0.5% hydrochloric acid and Pronase E. 2. During digestion, 3-amino-2-oxazolidinone (AOZ), the side chain of furazolidone, was partly released from bound residues. 3. The absorption of free AOZ and digested protein-bound residues was tested in isolated perfused rat gut segments (IPGS) and in the intestinal cell line Caco-2. Free AOZ was transfered both in the IPGS model and in Caco-2 monolayer cultures, while no indications for passage of bound residues were obtained. 4. No acute toxicity of AOZ or digested food residues respectively was observed in gut segments and Caco-2 cells at concentrations that were substantially above maximum residue levels to be expected in food of animal origin after administration of therapeutic doses. 5. The results demonstrate that digestive processes can alter the chemical nature of drug residues and yield degradation products that may be bioavailable for the consumer. Thus, the covalent binding of xenobiotics to macromolecular tissue constituents cannot necessarily be regarded as an irreversible endpoint of residue bioavailability and toxicity.
  Xenobiotica 07/1999; 29(6):641-54. · 1.79 Impact Factor
• Article: [New drugs for horses and agriculturally useful animals and changes in the pharmaceutical market since 1996].

  K Kluge, F R Ungemach
  Tierärztliche Praxis. Ausgabe G, Grosstiere/Nutztiere 12/1998; 26(6):301-6.
• Article: [Legal determinations concerning narcotics which are important for the veterinarian].

  F R Ungemach, K Kluge
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  ABSTRACT: In January 1998 the German legislation of narcotic drugs was subject of important changes also concerning the use of narcotic drugs in veterinary practice. The annexes I-III of the law of narcotic drugs (BtMG) containing all substances classified as narcotics were reorganized. Furthermore, the directive on the prescription of narcotic drugs (BtMVV) was changed with the aim to facilitate the prescription as well as the supply of narcotic drugs by veterinarians in their home dispensary. The directive on inland trade of narcotics (BtMBinHV) regulating the distribution of narcotic drugs from wholesalers to veterinarians remained unchanged. The following regulations of prescription or distribution of narcotic drugs by veterinarians for treated animals are described in detail: notification of participation on supply of narcotic drugs, general principles of the use of narcotic drugs, safety measurements, inactivation of narcotics, prescription for patients or for use in veterinary practice/clinics, details of prescription, supply to animal owners by the veterinarian home-dispensary, book-keeping, purchase of narcotic drugs.
  Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere 08/1998; 26(4):224-9.
• Article: [Changes in pharmaceutical market 1996/1997].

  K Kluge, F R Ungemach
  Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere 06/1998; 26(3):150-3.