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Publications (26)10.14 Total impact

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    ABSTRACT: The postoperative course after cataract surgery can be complicated by the formation of severe fibrinous membranes, especially in cases with previous goniotrepanation, after syn echiolysis, iridotomy or iris suturing, and in patients with diabetes or uveitis. This study retrospectively analyzes the efficacy of intraocular tissue plasminogen activator (tPA) for fibrinolysis in these conditions commonly considered as contraindications to tPA therapy. When antiinflammatory therapy was unsuccessful in lysing fibrinous membranes, 10 micrograms of tPA (Actilyse) was injected into the anterior chamber following the first postoperative day (n = 15). In addition, topical corticosteroids and cycloplegics were given postoperatively. Lysis of the fibrinous membranes was achieved in all patients. However, in three cases lysis was incomplete or recurred. Complications of intraocular tPA therapy consisted of mild hyphema (n = 1) and transient dysfunction of the corneal endothelial cells (n = 2). In conclusion, the results suggest intraocular low-dose tPA as an effective approach for the treatment of severe fibrinous membranes after cataract surgery even in high-risk patients.
    Der Ophthalmologe 03/1996; 93(1):49-53. · 0.53 Impact Factor
  • K B Mellin, A Heiligenhaus, M Schrenk
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    ABSTRACT: It has been recently demonstrated that the intraocular pressure (IOP) after argon laser trabeculoplasty (ALT) in primary open-angle glaucoma rises in the long term. The present study analysed the effect of the postoperative rise in IOP in 36 patients (group A) with glaucomatous optic nerve damage or visual field defects. The results were compared with those in 37 patients without such glaucomatous damage (group B). The IOP, the cup-disk ratios and the visual fields (Goldmann) were retrospectively studied. All patients were under topical glaucoma medication. At the end of the follow-up (group A 20.2 +/- 3.39 months, group B 17.4 +/- 3.59 months), the IOP was uncontrolled in both study groups, and visual fields and disc cupping had worsened in both groups. The results indicate that ALT should not be considered in patients with optic disc damage or glaucomatous visual field defects.
    Der Ophthalmologe 11/1994; 91(5):585-8. · 0.53 Impact Factor
  • K B Mellin, J Koch
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    ABSTRACT: In a retrospective study the effects of goniotrephination following antiglaucoma medication and argon laser trabeculoplasty (ALT) were examined. The study addressed the first treated eye in each of 61 patients. In all patients tropial antiglaucoma medication was continued after ALT. In the period between ALT and goniotrepanation the cup-disc ratio (CDR) progressed significantly (P < 0.01), with worsening of visual field defects. The long-term antiglaucoma medication and the ALT had no effect on the wound healing following the filtering procedure. ALT is contraindicated in preexisting pathologic CDR and visual field defects. In such cases intraocular pressure must be reduced to below 20 mmHg: filtration surgery is effective in lowering the intraocular pressure sufficiently.
    Der Ophthalmologe 12/1993; 90(6):574-7. · 0.53 Impact Factor
  • J M Koch, K B Mellin, T N Waubke
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    ABSTRACT: Based on a new concept of the limbus as a junctional zone for separating the vascularized conjunctiva from the avascular cornea, this study presents conjunctival/limbal autograft transplantation for 22 cases of pterygium. The pterygia were primary in 17 eyes, cicatricial in 1 and recurrent in 4. In all cases a free transplant of the superotemperal limbus with an adjacent piece of thin conjunctiva was placed in the excision area. Postoperative follow-up ranged from 1 1/2 to 17 months, with a mean of 8.7 months. Only two pterygia recurred. In all other cases ideal anatomic reconstruction was achieved without any side effects. The authors believe that conjunctival/limbal transplantation is an encouraging technique for treating a pterygium surgically.
    Der Ophthalmologe 05/1992; 89(2):143-6. · 0.53 Impact Factor
  • H Schilling, K B Mellin, T N Waubke
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    ABSTRACT: We report the clinical and Doppler sonographic findings on the internal carotid artery in 230 patients with various purely ocular vascular symptoms. For evaluation, the patients were subdivided into four groups: group I (107): central retinal artery obstruction (CRAO) (13), branch retinal artery obstruction (BRAO) (31), amaurosis fugax (AF) (13), anterior ischemic optic neuropathy (AION) (50); group II: retinal vein occlusion (25); group III: "low-tension glaucoma" (55); group IV: chronic open-angle glaucoma with a possible vascular co-factor (43). In group I with signs of arterial ocular mal-perfusion; 29.5% of cases with CRAO and BRAO revealed significant stenosis or complete obstruction of the ipsilateral internal carotid artery. Only 4 of 50 cases (8.0%) with AION showed positive findings. A remarkable result of this evaluation is the coincidence that nearly all high-grade obliterations and obstructions of the internal carotid arteries diagnosed in this study were exclusively confined to eyes with very severe ischemic changes in both anterior and posterior segments. In no other case was localization or extent of the obstructive process in the internal carotid artery predictive. Venous retinal obstructions with only 16% positive findings did not show any correlation with arterial occlusive disease of extracranial vessels based on demographic aspects and clinicopathological studies. Also no etiological correlation could be detected in either of the glaucoma groups (III and IV).
    Fortschritte der Ophthalmologie: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft 02/1991; 88(6):694-7.
  • J M Koch, K B Mellin, T N Waubke
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    ABSTRACT: The present paper reports on the technique and results of conjunctiva/limbus transplantation in 13 eyes with primary or cicatricial pterygium (12 cases and 1 case, respectively). In all cases the pterygia were located nasally. The operation was performed by bare sclera excision, covered with a free graft from the superotemporal conjunctiva and limbus. After a mean follow-up time of 5 months there was only one recurrence. On the basis of a new understanding of limbal diseases the authors believe that conjunctiva/limbus transplantation is an encouraging and appropriate technique for ideal anatomic reconstruction and low recurrence rates in pterygia.
    Klinische Monatsblätter für Augenheilkunde 09/1990; 197(2):106-9. · 0.70 Impact Factor
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    ABSTRACT: In 69 of 107 patients with primary angle-closure glaucoma, it was possible to control intraocular pressure and visual fields by means of peripheral surgical iridectomy; in 17 of these patients topical glaucoma medication was required in addition. In 11 cases a second surgical operation other than iridectomy was necessary: 6 lensectomies for malignant glaucoma in 2 cases and lens subluxation or phacomorphic glaucoma in 4 and 5 filtering procedures. Among the 85 treated fellow eyes 68 were controlled by iridectomy alone and 17 eyes needed additional topical glaucoma medication. One case of persisting wound leakage from the corneo/scleral wound was the only complication observed in this study. The advantages and disadvantages of peripheral surgical iridectomy are compared with those of argon and neodymium: YAG iridotomies. Owing to the low rate of complications the authors apply the surgical approach as the routine technique for primary angleclosure glaucoma.
    Fortschritte der Ophthalmologie: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft 02/1990; 87(5):449-52.
  • K B Mellin
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    ABSTRACT: In this retrospective study, the functional results of a total of 14 children with congenital cataract have been analyzed. Four had unilateral and 10 cases bilateral cataract. All children were operated on before the age of 4 months and received a silicone permanent-wear contact lens a few days after the operation. At the time of surgery in all children with unilateral cataract we found additional pathology of the eye, such as microcornea or strabismus. The children with bilateral cataract had secondary eye disorders such as nystagmus and strabismus. After an average follow-up time of 4.5 years, the children with unilateral aphakia reached a visual acuity of 10/200 in the cases with bilateral aphakias an average visual acuity of 60/200 was obtained. In the future, improvement of the functional results can only be achieved when the diagnosis and therapy take place before secondary eye disorders develop such as nystagmus and strabismus.
    Fortschritte der Ophthalmologie: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft 02/1990; 87(5):497-9.
  • K B Mellin, T N Waubke
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    ABSTRACT: The incidence of acute keratoconus has increased in recent years. A defect of the endothelium and Descemet's membrane allows the aqueous to flow into the stroma. The therapy of choice is penetrating keratoplasty. The discussion concerning the best time for the operation is still going on. The present authors have performed penetrating keratoplasties on 9 patients at the acute stage during the last 2 years. The results show that early surgery can prevent progression of the symptoms, with corneal edema and pannus, and subsequent complications.
    Klinische Monatsblätter für Augenheilkunde 05/1986; 188(4):266-8. · 0.70 Impact Factor
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    ABSTRACT: Experimental keratomileusis operations were performed on 13 rabbit eyes. The corneas of the rabbits, in particular the stroma, were investigated up to 24 months after the operation by light and electron microscopy. The most striking features of the corneal ultrastructure following experimental keratomileusis were the presence of abnormal collagen fibrils and electron-translucent vacuoles in the interface.
    Archives of Ophthalmology 03/1986; 104(2):253-8. · 3.83 Impact Factor
  • K B Mellin, T N Waubke
    Fortschritte der Ophthalmologie: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft 02/1986; 83(2):206-7.
  • K.-B. Mellin, Th. Waubke
    Klinische Monatsblatter Fur Augenheilkunde - KLIN MONATSBL AUGENHEILK. 01/1986; 188(04):266-268.
  • K B Mellin, T N Waubke
    Fortschritte der Ophthalmologie: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft 02/1985; 82(1):37-8.
  • T N Waubke, K B Mellin
    Fortschritte der Ophthalmologie: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft 02/1984; 81(4):331.
  • Fortschritte der Ophthalmologie: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft 02/1984; 81(5):426-8.
  • K B Mellin, T N Waubke
    Fortschritte der Ophthalmologie: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft 02/1983; 80(3):265-6.
  • F Härting, K B Mellin, L Essers
    Fortschritte der Ophthalmologie: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft 02/1983; 80(2):152-4.
  • K B Mellin, T N Waubke
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    ABSTRACT: Corneal endothelial cell loss may result from endogenic causes, such as acute angle-closure glaucoma, or exogenic causes, such as corneal contusion, corneal perforation or surgery involving the anterior chamber. The extent of endothelial cell loss varies with the severity of trauma. Despite the different causes the response of the corneal endothelium is always an endothelial cell loss. Corneal endothelial decomposition may result from an acute endothelial cell loss.
    Klinische Monatsblätter für Augenheilkunde 02/1983; 182(1):10-4. · 0.70 Impact Factor
  • K.-B. Mellin, Th. Waubke
    Klinische Monatsblatter Fur Augenheilkunde - KLIN MONATSBL AUGENHEILK. 01/1983; 182(01):10-14.
  • F Härting, K B Mellin
    Fortschritte der Ophthalmologie: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft 02/1982; 79(4):370-3.