[Show abstract][Hide abstract] ABSTRACT: The yeast hydrolysate from Saccharomyces cerevisiae wasevaluated for acute/subacute toxicity on female and maleSprague-Dawley (SD) rats. The single oral dose of thehydrolysate at 5,000 mg/kg did not produce mortality orsignificant changes in the general behavior and grossappearance of the internal organs of rats. In subacute toxicitystudy, the hydrolysate was administered orally at a dose of1,000 mg/kg/day for a period of 14 days. The satellite groupwas treated with the hydrolysate at the same dose and thesame period and kept for another 14 days after treatment.There were no significant differences in organ weightsbetween control and treated group of both sexes.Hematological analysis and blood chemistry revealed notoxicity effects of S.cerevisiae hydrolysate. Pathologically,neither gross abnormalities nor histopathological changeswere observed. These results show that the hydrolysatepossesses very low toxicity as indicated in SD rat model.