Publications (2)2.12 Total impact
-
Article: Study on acute toxicity and structure-activity relationship of zebrafish (Danio rerio) exposed to naphthoquinones.
[show abstract] [hide abstract]
ABSTRACT: In this paper, we evaluated the acute toxicity of five naphthoquinone compounds, expressed as median lethal concentration at 96 h (LC(50)) using zebrafish as a model. The five compounds were classified as harmful or very toxic. The Gaussian method was used to calculate the quantitative-chemical parameters of each compound. Based on the structure-activity relationship analysis, the interaction between the naphthoquinones and the target is likely mediated by 1-carbonyl and the hydrophobic fraction substituted in alpha -position of naphthoquinone via hydrogen bonding and hydrophobic interactions. Our results provide a foundation for evaluating the aquatic ecological risk and the mode of action of naphthoquinones in the environment.Journal of Environmental Science and Health Part B Pesticides Food Contaminants and Agricultural Wastes 10/2010; 45(7):601-5. · 1.10 Impact Factor -
Article: Evaluation and structure-activity relationship study of acute toxicity of naphthoquinones to Photobacterium phosphoreum, Photobacterium T3B.
[show abstract] [hide abstract]
ABSTRACT: The acute toxicities of five naphthoquinone compounds to Photobacterium phosphoreum were determined. We evaluated the mechanism of toxicity using the structure-activity relationship technique. The results showed that some factors, including the species of substituents, shape/size of molecule and oil-water partition coefficient (log P) played the important roles in the interaction between the naphthoquinones and the target. Among of these, the toxicities of Atovaquone and Buparvaquone were lower than the other naphthoquinones we tested because of the alkyl-substitution with the bigger volume and strong hydrophobicity. Conversely, Menadione had the highest toxicity because of the appropriate log P and shape/size of molecule resulting in the easier interaction with the target.Bulletin of Environmental Contamination and Toxicology 08/2010; 85(2):116-20. · 1.02 Impact Factor
