Jingqun Gao

Liaoning University, Feng-t’ien, Liaoning, China

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Publications (39)94.59 Total impact

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    ABSTRACT: In this paper, the Thymol Blue derivants including Thymol Blue (thymolsulfonphthalein), Thymol Blue-DA (3,3'-Bis [N,N-bis (carboxymethyl) aminomethyl] thymolsulfonphthalein) and Thymol Blue-DA-Fe(III) (3,3'-Bis [N,N-bis (carboxymethyl) aminomethyl] thymolsulfonphthalein-Ferrous(III)) were adopted as sonosensitizers to study the sonodynamic and sonocatalytic activities under ultrasonic irradiation. At first, the interaction of Thymol Blue derivants with bovine serum albumin (BSA) was studied by fluorescence spectroscopy. On that basis, the sonodynamic and sonocatalytic damages of Thymol Blue derivants to BSA under ultrasonic irradiation were investigated by the combination of UV-vis, circular dichroism (CD) and fluorescence spectroscopy. Meanwhile, some influenced factors (ultrasonic irradiation time, Thymol Blue derivants concentration and ionic strength) on the damaging degree of BSA molecules were also reviewed. In addition, synchronous fluorescence spectra were used to estimate the binding and damage sites of Thymol Blue derivants to BSA. Finally, the generation of ROS during sonodynamic and sonocatalytic processes was confirmed by the method of Oxidation-Extraction Spectrometry (OEP). Perhaps, this paper may offer some important subjects for the study of Thymol Blue derivants in sonodynamic therapy (SDT) and sonocatalytic therapy (SCT) technologies for tumor treatment and the effect of the amino acid and central metal.
    Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy 03/2014; 128C:591-602. DOI:10.1016/j.saa.2014.02.199 · 2.13 Impact Factor
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    ABSTRACT: Two rare-earth metal coordination compounds, (NH4)4[SmIII2(Httha)2]·16H2O (1) (H6ttha = triethylenetetramine-N,N,N′,N′′,N′′′,N′′′-hexaacetic acid) and (NH4)4[SmIII2(dtpa)2]·10H2O (2) (H5dtpa = diethylenetriamine-N,N,N′,N′′,N′′-pentaacetic acid), have been synthesized through reflux and characterized by FT-IR spectroscopy, thermal analysis, and single-crystal X-ray diffraction techniques. SmIII of (NH4)4[SmIII2(Httha)2]·16H2O (1) is nine-coordinate, forming tricapped trigonal prismatic coordination with three amine nitrogens and six oxygens, in which four oxygens are from one ttha and two from the other ttha. (NH4)4[SmIII2(Httha)2]·16H2O (1) crystallizes in the monoclinic crystal system with P2(1)/c space group. The crystal data are: a = 13.9340(13) Å, b = 22.890(3) Å, c = 20.708(2) (14) Å, β = 99.521(2)°, and V = 6513.7(13) Å3. There are two –NH+– groups in the [SmIII2(Httha)2]4−. The polymeric (NH4)4[SmIII2(dtpa)2]·10H2O (2) also is nine-coordinate with tricapped trigonal prismatic conformation and crystallizes in the triclinic crystal system with P–1 space group. The cell dimensions are: a = 9.8240(8) Å, b = 10.0329(9) Å, c = 13.0941(11) Å, β = 77.1640(10)°, and V = 1227.30(18) Å3. In (NH4)4[SmIII2(dtpa)2]·10H2O, there are two types of ammonium cations, which connect [SmIII2(dtpa)2]4− and lattice water through hydrogen bonds, leading to a 2-D ladder-like layer structure.
    Journal of Coordination Chemistry 01/2014; 67(4). DOI:10.1080/00958972.2014.892074 · 2.22 Impact Factor
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    ABSTRACT: In this study, several up-conversion luminescence agents (Er(3+):Y3Al5O12, Er(3+):Yb0.2Y2.79Al5O12, Er(3+):Yb0.2Y2.79Al5N0.01O11.99, Er(3+):Yb0.2Y2.79Al5F0.01O11.99 and Er(3+):Yb0.2Y2.79Al5N0.01F0.01O11.98) were synthesized using sol-gel method. And then, the corresponding sonocatalyst (Er(3+):Y3Al5O12/TiO2, Er(3+):Yb0.2Y2.79Al5O12/TiO2, Er(3+):Yb0.2Y2.79Al5N0.01O11.99/TiO2, Er(3+):Yb0.2Y2.79Al5F0.01O11.99/TiO2 and Er(3+):Yb0.2Y2.79Al5N0.01F0.01O11.98/TiO2 coated composites) were prepared by sol-gel coating process. The synthesized up-conversion luminescence agents and their coated composites were characterized by X-ray diffraction (XRD) and scanning electron microscope (SEM). And that, the sonocatalytic activities were detected through the degradation of Azo Fuchsine (AF) dye in aqueous solution by UV-vis spectroscopy. Some key influences such as heat-treated temperature and heat-treated time on the sonocatalytic activity of Er(3+):YbaY2.99-aNxFyAl5O12-x-y/TiO2 coated composite, as well as ultrasonic irradiation time and initial dye concentration on the sonocatalytic degradation were studied. The results showed that the doping of Yb, N and F into Er(3+):Y3Al5O12/TiO2 significantly enhanced the sonocatalytic activity of Er(3+):Y3Al5O12/TiO2 coated composite in the degradation of organic dyes. Particularly, Er(3+):Yb0.2Y2.79Al5N0.01F0.01O11.98/TiO2 coated composites with 3:7M ratio heat-treated at 550°C for 60min showed the highest sonocatalytic activity. At last, the experiments also indicated that the Er(3+):Yb0.2Y2.79Al5N0.01F0.01O11.98/TiO2 coated composites has a good sonocatalytic activity to degrade other organic dyes under ultrasonic irradiation.
    Ultrasonics Sonochemistry 05/2013; 21(1). DOI:10.1016/j.ultsonch.2013.05.003 · 3.82 Impact Factor
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    ABSTRACT: The interaction between bovine serum albumin (BSA) and FeIII complexes with three binary organic acid (biorga) ligands, [FeIII(oxa)(H2O)4]+ (oxa = oxalic acid), [FeIII(pra)(H2O)4]+ (pra = propanedioic acid) and [FeIII(sua)(H2O)4]+ (sua = succinic acid), as well as the sonocatalytic damage of BSA in the presence of these three FeIII–biorga complexes under ultrasonic irradiation, were studied by UV–vis and fluorescence spectra. The experimental results show that the fluorescence quenching process of BSA caused by three FeIII–biorga complexes are all static quenching and the corresponding quenching rate constants (K q), equilibrium constants (K A) and the binding site numbers (n) were calculated. The results reveal that, under ultrasonic irradiation, the BSA molecules were obviously damaged by these FeIII–biorga complexes. In addition, the effects of several factors on the damage of BSA molecules were examined. The experimental results demonstrate that the damage degree of BSA increased with an increase of ultrasonic irradiation time, FeIII–biorga complex concentration, and ionic strength. In comparison, [FeIII(pra)(H2O)4]+ exhibited higher sonocatalytic activity than [FeIII(oxa)(H2O)4]+ and [FeIII(sua)(H2O)4]+. Finally, the extent of generation of $ \cdot {\text{O}}_{2}^{ - } $ · O 2 − and ·OH during sonocatalytic processes was estimated. Perhaps, the results will be significant for promoting sonodynamic treatment (SDT) of tumors at the molecular level.
    Journal of Solution Chemistry 05/2013; 42(4). DOI:10.1007/s10953-013-9996-7 · 1.08 Impact Factor
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    ABSTRACT: The interaction between 1,2-dihydroxy-9, 10-anthraquinone-3-aminomethyl-N, N-diacetate-Ferrous(III) (Alizarin-DA-Fe(III)) and bovine serum albumin (BSA) was studied by using UV-vis and fluorescence spectra. And then, the H2O2 damage of BSA induced by Alizarin-DA-Fe(III) was examined. The results show that due to the interaction the fluorescence of BSA solution can be obviously quenched by Alizarin-DA-Fe(III) and that the quenching process belongs to the static quenching. In addition, in the presence of Alizarin-DA-Fe(III) the BSA molecules were markedly damaged by H2O2. Meanwhile, the effects of the standing time, Alizarin-DA-Fe(III) concentration and H2O2 concentration on the damage of BSA molecules were also researched. The experimental results demonstrate that the damage degree increase with the increase of standing time, Alizarin-DA-Fe(III) concentration and H2O2 concentration. Finally, the generation of reactive oxygen species (ROS) from H2O2 induced by Alizarin-DA-Fe(III) as Fenton-like reagent was estimated by some quenchers. Because the Iminodiacetic-Ferrous(III) (IDA-Fe(III)) and Nitrilotriacetic-Ferrous(III) (NTA-Fe(III)) can be thought of as the active part of Alizarin-DA-Fe(III), they were used to compare the catalytic activity with Alizarin-DA-Fe(III). Owing to the special plane structure, the experiment results showed that the Alizarin-DA-Fe(III) exhibited higher damage ability than IDA-Fe(III) and NTA-Fe(III). Perhaps, the Alizarin-DA-Fe(III) may be used as a new antitumor compound to induce peroxides in body to kill cancer cells.
    Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy 04/2013; 112C:206-213. DOI:10.1016/j.saa.2013.04.005 · 2.13 Impact Factor
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    ABSTRACT: The fluorescein derivants (Fluorescein: (2-(6-Hydroxy-3-oxo-(3H)-xanthen-9-yl) benzoic acid), Fluorescein-DA: (Bis [N,N-bis (carboxymethyl) aminomethyl] fluorescein) and Fluorescein-DAFe(III): (Bis [N,N-bis (carboxymethyl) aminomethyl] fluoresceinFerrous(III)) with a tricyclic plane structure were used to study the interaction and sonodynamic damage to bovine serum albumin (BSA) under ultrasonic irradiation through fluorospectrometry and UV-vis spectrophotometry. Besides, because of the existence of Fe(III) ion in Fluorescein-DAFe(III), under ultrasonic irradiation the sonocatalytic activity in the damage of BSA molecules was also found. Three-dimensional fluorescence spectra and three-dimensional fluorescence contour profile spectra were mentioned to determine the fluorescence quenching and the conformation change of BSA in the absence and presence of these fluorescein derivants. As judged from the experimental results, the fluorescence quenching of BSA in aqueous solution caused by these fluorescein derivants were all attributed to static quenching process. The damage degree and mode were related to some factors such as ultrasonic irradiation time, fluorescein derivant concentration and ionic strength. Finally, several quenchers were used to determine the amount and kind of generated reactive oxygen species (ROS) during sonodynamic and sonocatalytic reaction processes. It suggests that these fluorescein derivants induce protein damage via various ROS, at least, including singlet oxygen ((1)O2) and hydroxyl radicals (OH). Perhaps, this paper may offer some important subjects for broadening the application of these fluorescein derivants in sonodynamic therapy (SDT) and sonocatalytic therapy (SCT) technologies for tumor treatment.
    Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy 03/2013; 110C:364-376. DOI:10.1016/j.saa.2013.03.073 · 2.13 Impact Factor
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    ABSTRACT: Two dysprosium coordination compounds, (mnH)2[DyIII(Httha)]·3H2O (1) (H6ttha = triethylenetetramine-N,N,N′,N″,N′′′,N′′′-hexaacetic acid and mn = methylamine) and (enH2)3[DyIII(ttha)]2·9H2O (2) (en = ethylenediamine), were synthesized through direct heating and characterized by elemental analysis, FT-IR, thermal analysis, and single-crystal X-ray diffraction. X-ray diffraction analysis displays that 1 is a mononuclear nine-coordinate complex with a pseudo-monocapped square antiprismatic conformation (MCSAP) crystallizing in the monoclinic crystal system with P2(1)/c space group. The crystal data are as follows: a = 16.1363(19) Å, b = 13.9336(11) Å, c = 13.6619(14) Å, β = 102.2490(10)°, and V = 3001.8(5) Å3. There are two kinds of methylamine cation in 1. They connect [DyIII(Httha)]2−and crystal waters through hydrogen bonds, leading to formation of a 2-D ladder-like layer structure. The polymeric 2 also is a nine-coordinate structure with a pseudo-MCSAP crystallizing in the monoclinic crystal system with P2/c space group. The cell dimensions are: a = 17.7801(16) Å, b = 9.7035(10) Å, c = 22.096(2) Å, β = 118.874(2)°, and V = 3338.3(6) Å3. In 2 there are also two types of ethylenediamine cations. One connects three adjacent [DyIII(ttha)]3− complex anions through hydrogen bonds and the other is symmetrical forming hydrogen bonds with two neighboring [DyIII(ttha)]3− complex anions. These hydrogen bonds result in formation of a 2-D ladder-like layer structure as well.
    Journal of Coordination Chemistry 02/2013; 66(3). DOI:10.1080/00958972.2012.757600 · 2.22 Impact Factor
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    ABSTRACT: Two lanthanide complexes, (mnH)2[EuIII(egta)]2·6H2O (1) (H4egta = ethyleneglycol-bis-(2aminoethylether)-N,N,N′,N′-tetraacetic acid) and (mnH)4[EuIII2(dtpa)2]·6H2O (2) (H5dtpa = diethylenetriamine-N,N,N′,N″,N″-pentaacetic acid), have been synthesized and characterized by FT-IR spectroscopy, thermal analysis, and single-crystal X-ray diffraction. X-ray diffraction reveals that 1 is multinuclear nine-coordinate and crystallizes in the monoclinic crystal system with space group C2/c. The obtained cell dimensions are a = 38.513(3) Å, b = 13.5877(8) Å, c = 8.7051(5) Å, β = 99.6780(10)°, and 4490.6(5) Å3. Each methylamine (mnH+) cation in 1, through hydrogen bonds, connects three adjacent [EuIII(egta)]− anions. The [EuIII(egta)]− anions connect one another forming a 1-D multinuclear zigzag chain structure along the c-axis. Complex 2 is nine-coordinate binuclear structure with tricapped trigonal prismatic conformation and crystallizing in the monoclinic crystal system, but with space group P2 1/n. The obtained cell dimensions are a = 9.9132(8) Å, b = 24.1027(18) Å, c = 10.7120(10) Å, β = 109.1220(10)°, and 2418.2(3) Å3. For 2, there are two kinds of methylamine cations (mnH+) connecting [EuIII2(dtpa)2]4− complex anions and lattice waters through hydrogen bonds, leading to formation of a 2-D ladder-like layer structure.
    Journal of Coordination Chemistry 01/2013; 66(20). DOI:10.1080/00958972.2013.850677 · 2.22 Impact Factor
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    ABSTRACT: Ag/TiO(2) coated composite was prepared via sol-gel method in order to elucidate its application in magnetic field assisted photocatalytic degradation of dyes. Through the degradation of organic dyes, the key influences such as Ag amount, heat-treated temperature and time on the photocatalytic activity of Ag/TiO(2), as well as UV irradiation time, rotational speed, dye concentration and magnetic sheet number on the photocatalytic degradation were studied. Results showed that the Ag/TiO(2) with 25 wt% Ag content heat-treated at 550 °C for 60 min has the best photocatalytic activity. With the increase of UV light irradiation time, rotational speed and magnetic sheet number, the degradation rate is improved. Different dye degradation proved that the method could universally be used.
    Water Science & Technology 01/2013; 67(4):722-8. DOI:10.2166/wst.2012.588 · 1.21 Impact Factor
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    ABSTRACT: In this progress report, seven kinds of novel carefully designed and fabricated up-conversion luminescence agents, Er3+:Y3Al5O12, Er3+:YbnY3−nAl5O12, Er3+:Y3BaAl5−aO12, Er3+:Y3GabAl5−bO12, Er3+:Y3Al5NxO12−x, Er3+:Y3Al5FyO12−y and Er3+:YbnY3−nBaGabAl5−a−bNxFyO12−x−y, are successfully synthesized using sol–gel methods. After that, their corresponding photocatalysts, Er3+:Y3Al5O12/TiO2, Er3+:YbnY3−nAl5O12/TiO2, Er3+:Y3BaAl5−aO12/TiO2, Er3+:Y3GabAl5−bO12/TiO2, Er3+:Y3Al5NxO12−x/TiO2, Er3+:Y3Al5FyO12−y/TiO2 and Er3+:YbnY3−nBaGabAl5−a−bNxFyO12−x−y/TiO2, are also prepared by sol–gel coating process. The obtained up-conversion luminescence agents and photocatalysts were characterized by using XRD, XPS, SEM, UV–vis and fluorescence spectrophotometer. Synchronously, several kinds of organic dyes are used to test their photocatalytic degradation using prepared photocatalysts. It indicates that the up-conversion luminescence ability of Er3+:Y3Al5O12 can be improved obviously through doping of some elements. And then, the photocatalytic activity of TiO2 is markedly enhanced by modified up-conversion luminescence agents which can transform much visible light into ultraviolet light.
    Journal of Luminescence 11/2012; 132(11):3010–3018. DOI:10.1016/j.jlumin.2012.06.017 · 2.37 Impact Factor
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    ABSTRACT: The interaction of Cresol Red derivatives (Cresol Red (o-Cresolsulfonphthalein), Cresol Red-DA (3,3'-Bis [N,N-di (carboxymethyl) aminomethyl]-o-cresolsulfonphthalein) and Cresol Red-DA-Fe(III) (3,3'-Bis [N,N-di (carboxymethyl) aminomethyl]-o-cresolsulfonphthalein-Ferrous(III)) with bovine serum albumin (BSA) were studied by the combination of ultraviolet spectroscopy, circular dichroism (CD) spectroscopy, fluorescence spectroscopy and synchronous fluorescence spectroscopy. On that basis, the sonodynamic and sonocatalytic damages of Cresol Red derivatives to BSA under ultrasonic irradiation were also investigated by means of corresponding spectrum technology. Meanwhile, some influenced factors such as ultrasonic irradiation time, Cresol Red derivatives concentration and ionic strength on the damage degree of BSA molecules were also reviewed. In addition, the binding site and damage site of BSA molecules were estimated by synchronous fluorescence spectra. Finally, the results of oxidation-extraction photometry (OEP) using several reactive oxygen species (ROS) scavengers indicated that the damage of BSA molecules is mainly due to the generation of ROS. Perhaps, this paper may offer some important subjects for broadening the application of Cresol Red derivatives in sonodynamic therapy (SDT) and sonocatalytic therapy (SCT) technologies for tumor treatment.
    Ultrasonics Sonochemistry 10/2012; 20(2). DOI:10.1016/j.ultsonch.2012.10.008 · 3.82 Impact Factor
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    ABSTRACT: ZnO/hydroxylapatite (ZnO/HA) composite with HA molar content of 6.0% was prepared by the method of precipitation and heat-treated at 500°C for 40min and was characterized by powder X-ray diffraction (XRD). The sonocatalytic activities of ZnO/HA composite was carried out through the damage of bovine serum albumin (BSA) in aqueous solution. Furthermore, the effects of several factors on the damage of BSA molecules were evaluated by means of UV-vis and fluorescence spectra. Experimental results indicated that the damage degree of BSA aggravated with the increase of ultrasonic irradiation time, irradiation power and ZnO/HA addition amount, but weakened with the increase of solution acidity and ionic strength. In addition, the damage site to BSA was also studied by synchronous fluorescence technology and the damage site was mainly at tryptophan (Trp) residue. This paper provides a valuable reference for driving sonocatalytic method to treat tumor in clinic application.
    Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy 04/2012; 94:228-34. DOI:10.1016/j.saa.2012.03.076 · 2.13 Impact Factor
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    ABSTRACT: BACKGROUND: In order to effectively degrade bovine serum albumin (BSA) under ultrasonic irradiation, biological mineral material (tooth powder) was adopted to mix with nano-sized TiO2 powder. A TiO2/tooth composite with high sonocatalytic activity and remarkable selectivity was prepared.RESULTS: TiO2/tooth composite with tooth content of 30% (w/w) heat-treated at 500 °C for 40 min was used as sonocatalyst and the catalytic degradation of BSA under ultrasonic irradiation was examined. Some influencing factors, such as ultrasonic irradiation time, TiO2/tooth catalyst amount, solution acidity and NaCl concentration, were studied by UV-vis and fluorescence spectroscopic analysis. Furthermore, the BSA attack site for the TiO2/tooth composite was identifies by synchronous fluorescence spectra.CONCLUSION: The results indicated that, under ultrasonic irradiation, the TiO2/tooth composite can promote the degradation of BSA more effectively than pure nano-sized TiO2 powder. The attack site is identified as tyrosine (Tyr) residue. These results are of great significance for the use of a sonocatalytic method to treat tumours in clinical applications. Copyright © 2011 Society of Chemical Industry
    Journal of Chemical Technology & Biotechnology 04/2012; 87(4). DOI:10.1002/jctb.2741 · 2.49 Impact Factor
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    ABSTRACT: In this work, three anthraquinone derivants (Alizarin: 1,2-dihydroxy-9, 10-anthraquinone, Alizarin–DA: 1,2-dihydroxy-9, 10-anthraquinone-3-aminomethyl-N, N-diacetic acid and Alizarin–DA–Fe: 1,2-dihydroxy-9, 10-anthraquinone-3-aminomethyl-N, N-diacetate-Ferrous(III)) were used to study the sonodynamic and sonocatalytic damage of bovine serum albumin (BSA) molecules according to the hyperchromic effect of UV–vis spectra and quenching effect of intrinsic fluorescence. Meanwhile, some influencing factors such as ultrasonic irradiation time, anthraquinone derivants concentration and ionic strength on the damage of BSA molecules were also considered. The results show that the synergetic effect of anthraquinone derivants and ultrasonic irradiation can efficiently damage the BSA molecules. Finally, some special radical scavengers were used to determine the kind of generated reactive oxygen species (ROS) in the presence of three anthraquinone derivants under ultrasonic irradiation. The results show that the ROS, at least, including singlet oxygen (1O2) and hydroxyl radicals (OH) are generated during the sonodynamic and sonocatalytic processes. It is wished that this paper could offer some valuable references for the application of anthraquinone derivants in sonodynamic therapy (SDT) and sonocatalytic therapy (SCT) for tumor treatment.
    Journal of Luminescence 03/2012; 132(3):818–825. DOI:10.1016/j.jlumin.2011.11.018 · 2.37 Impact Factor
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    ABSTRACT: In this paper, the Safranine T (ST) was used as sonosensitive compound to study the sonodynamic damage to bovine serum albumin (BSA) under ultrasonic irradiation using fluorescence and UV–vis spectroscopy. The experimental results revealed the obvious synergetic effect of Safranine T (ST) and ultrasonic irradiation during the damage of BSA molecules. In addition, some influencing factors such as ultrasonic irradiation time, Safranine T (ST) concentration, pH value and ionic strength on the sonodynamic damage of BSA molecules were also considered. Finally, the generation of reactive oxygen species (ROS) in sonodynamic process was estimated by the method of Oxidation-Extraction Photometry (OEP). Meanwhile, several radical scavengers were used to determine the kind of generated ROS. Experiments showed that under ultrasonic irradiation the Safranine T (ST) can generate several kinds of ROS at the same time, at least including singlet oxygen (1O2) and hydroxyl radicals (OH).
    Journal of Luminescence 02/2012; 132(2):282-288. DOI:10.1016/j.jlumin.2011.09.014 · 2.37 Impact Factor
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    ABSTRACT: Sonodynamic therapy (SDT) is an innovative cancer treatment involving a tumor-localizing sonosensitizer. The synthesis, modification and activity of novel sonosensitizers have attracted more and more researchers’ attention. In the present study, chlorophyll-magnesium (Chl-Mg) and metronidazole (MTZ) were used as reactants and the chlorophyll-magnesium linked metronidazole complex (chlorophyll-magnesium-metronidazole, Chl-Mg-MTZ) was synthesized and characterized. Bovine serum albumin (BSA) was selected as the target protein; the biomolecule affinity and sonodynamic activity of Chl-Mg-MTZ were assessed by their UV–vis and fluorescence spectra. The results indicate that the interaction of Chl-Mg-MTZ to BSA is comparable with that of chlorophyll-magnesium (Chl-Mg). However, during damage of BSA, Chl-Mg-MTZ shows a higher sonodynamic activity than chlorophyll-magnesium (Chl-Mg). Moreover, synchronous fluorescence spectroscopy indicates that Chl-Mg-MTZ has similar binding ability with the tyrosine (Tyr) and tryptophan (Trp) residues of BSA molecules. However, the damage is mainly focused on the Trp residues. In addition, the production of reactive oxygen species (ROS) in the sonodynamic process was detected through the oxidation-extraction of 1,5-diphenylcarbazide (DPCI). The results promote the potential of Chl-Mg-MTZ as a new sonosensitive drug for use in SDT, encouraging further study on tumor treatment.
    Journal of Solution Chemistry 01/2012; 41(1). DOI:10.1007/s10953-011-9787-y · 1.08 Impact Factor
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    ABSTRACT: A novel two-dimensional (2D) mononuclear complex, namely, (enH(2))[Tb(III)(egta)(H(2)O)](2)·6H(2)O (H(4)egta=ethyleneglycol-bis-(2-aminoethylether)-N,N,N',N'-tetraacetic acid and en=ethylenediamine), was successfully synthesized and characterized by infrared spectrum, UV-vis spectrum, fluorescence spectrum, thermal analysis and single-crystal X-ray diffraction techniques. Single-crystal X-ray diffraction analysis reveals that the central Tb(III) ion is nine-coordinate in geometry of pseudo-monocapped square antiprismatic polyhedron. Furthermore, the hydrogen bonds play an important role in the fabrication of layer structure of the complex. Through hydrogen bonds between ethylenediamine cation (enH(2)(2+)) and [Tb(III)(egta)(H(2)O)](-) complex anion, the title complex forms a 2D layer network along [111] crystallographic direction. Particularly, the fluorescent property is also fully investigated, which indicates that the title complex would be a potential candidate as fluorescent materials.
    Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy 10/2011; 86:1-7. DOI:10.1016/j.saa.2011.10.036 · 2.13 Impact Factor
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    ABSTRACT: The sonodynamic damage of bovine serum albumin (BSA) under ultrasonic irradiation in the presence of amsacrine (AMSA) was studied by hyperchromic effect of UV–vis spectra and quenching effect of intrinsic fluorescence. In addition, several influencing factors such as ultrasonic irradiation time, AMSA concentration, system acidity and ionic strength about the damage of BSA molecules were reviewed. The results showed that the damage degree was obviously enhanced with the increase of ultrasonic irradiation time and AMSA concentration, but it was only slightly increased with the increase of solution pH value and ionic strength. Furthermore, the binding and damaging sites to BSA molecules were estimated by synchronous fluorescence spectra. The different chances to damage tryptophan (Trp) and tyrosine (Tyr) residues were found through the ratios of synchronous fluorescence quenching (RSFQ). At last, the generation of reactive oxygen species (ROS) in sonodynamic process was estimated by the method of oxidation-extraction Spectrometry (OES). And then, several radical scavengers were used to determine the kind of ROS, which includes singlet oxygen (1O2) and hydroxyl radicals (·OH). Perhaps, the result would bring a certain guiding significance to use sonosensitive drugs in the fields of tumor treatment.
    Journal of Luminescence 10/2011; 131(10):2046-2052. DOI:10.1016/j.jlumin.2011.05.025 · 2.37 Impact Factor
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    ABSTRACT: In this work, three Tricyclo [3.3.1.1(3,7)] decane-1-amine (Amantadine) Schiff-Bases, Amantadine-Salicylaldehyde (AS), Amantadine-5-Chloro-Salicylaldehyde (AS-5-C) and Amantadine-o-Vanillin (AS-o-V), were synthesized by direct heating reflux method in ethanol solution and characterized by infrared spectrum and elementary analysis. Fluorescence quenching was used to study the interaction of these Amantadine Schiff-Bases (AS, AS-5-C and AS-o-V) with bovine serum albumin (BSA). According to fluorescence quenching calculations the bimolecular quenching constant (K(q)), apparent quenching constant (K(SV)), effective binding constant (K(A)) and corresponding dissociation constant (K(D)), binding site number (n) and binding distance (r) were obtained. The results show that these Amantadine Schiff-Bases can obviously bind to BSA molecules and the binding strength order is AS<AS-5-C=AS-o-V. Synchronous fluorescence spectroscopy reveals that these Amantadine Schiff-Bases adopt different way to bind with BSA molecules. That is, the AS and AS-5-C are accessibility to tryptophan (Trp) residues more than the tyrosine (Tyr) residues, while the AS-o-V is equally close to the Tyr and Trp residues.
    Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy 09/2011; 83(1):511-7. DOI:10.1016/j.saa.2011.08.076 · 2.13 Impact Factor
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    ABSTRACT: In this work, the Er3+:YAlO3 as an up-conversion luminescence agent was prepared by sol–gel and auto-combustion method. And then the Er3+:YAlO3/TiO2 composite, a novel sonocatalyst, was successfully synthesized by sol–gel method. The key influences such as amount of coating Er3+:YAlO3, heat treatment temperature and heat treatment time on the sonocatalytic activity of Er3+:YAlO3/TiO2 composites, as well as the amount of Er3+:YAlO3/TiO2 on the sonocatalytic degradation of organic dye was studied. The results indicated that the sonocatalytic activity of TiO2 could be enhanced obviously by coating Er3+:YAlO3. When 1.0 g/L Er3+:YAlO3/TiO2 composite with 50 wt.% amount of coated Er3+:YAlO3 and mixed crystal of TiO2 film was adopted, the highest degradation efficiency was obtained. In addition, the effect of 1-butanol as OH scavenger on the degradation was studied. It showed that the degradation of Acid red B was mainly caused by hydroxyl radical oxidation. Finally, the sonocatalytic degradation of some other organic dyes revealed that the Er3+:YAlO3/TiO2 composite was a widely useable sonocatalyst in treating various dye wastewaters.Highlights► The Er3+:YAlO3 was combined with TiO2 for effectively utilizing sonoluminescence. ► A novel sonocatalyst Er3+:YAlO3/TiO2 was synthesized successfully. ► The Er3+:YAlO3/TiO2 irradiated by ultrasound was used to degrade organic dyes. ► The activity of TiO2 is effectively enhanced by coating Er3+:YAlO3.
    Separation and Purification Technology 09/2011; 81(1):94-100. DOI:10.1016/j.seppur.2011.07.014 · 3.07 Impact Factor