Publications (2)5.72 Total impact
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Article: Higher risk of hospitalization among females with cystic fibrosis.
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ABSTRACT: Persons with cystic fibrosis (CF) who tend to be hospitalized have poorer overall survival and quality of life. Whether differences exist in hospitalization rates between males and females with CF is unknown. The objective was to assess sex-specific differences in hospitalization rates after adjusting for clinically important factors within a universal health care system. A provincial-based longitudinal study using national CF registry data linked to health administrative databases examined differences in annual hospitalization rates estimated by Poisson regression using generalized estimating equations with adjustment for markers of CF disease severity. Among those aged 7 to 19 years, the RR of respiratory-related annual hospitalizations among females vs. males was 1.38 (95% CI 1.11-1.73). Among those over 19 years, the corresponding RR was 1.30 (95% CI 1.06-1.59). Females affected by CF are at a higher risk of respiratory-related hospitalization, which may extend beyond classic clinical measures of disease severity.Journal of cystic fibrosis: official journal of the European Cystic Fibrosis Society 12/2010; 10(2):93-9. · 3.19 Impact Factor -
Article: Socioeconomic status and risk of hospitalization among individuals with cystic fibrosis in Ontario, Canada.
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ABSTRACT: Socioeconomic status (SES) is a strong predictor of outcomes in cystic fibrosis (CF); however, there are no published studies evaluating this relationship in Canadians with CF. The objective of this study was to assess the effect of SES on annual hospitalization rates in a large cohort of pediatric and adult CF subjects under a universal health care system. A population-based longitudinal study was completed in Ontario from 1993 to 2002 using a comprehensive CF registry containing patient-level data, linked to provincial health care administrative databases. Income quintiles were derived at the neighborhood level using postal code information and Statistics Canada census data. The effect of income quintile on the annual hospitalization rate for respiratory-related illness was estimated by Poisson regression using generalized estimating equations, and was expressed as a rate ratio (RR) and 95% confidence interval (CI). The analysis was adjusted for age, sex, lung function, nutritional status, the presence of diabetes, area of residence, and distance between the subject's residence and the reporting CF centre. A total of 1,174 participants over the age of 6 years contributed 8,444 patient-years of data. No statistically significant differences in annual hospitalization rates for respiratory-related causes were found between the lowest and highest income quintiles (adjusted RR 1.17 [95% CI 0.96-1.43]). The effect of income quintile remained non-significant across a majority of markers of CF disease severity and across a range of subgroups. After adjusting for important covariates, no SES-disparities in hospitalization rates were found in a large Canadian pediatric and adult CF cohort. It may be the distinctive combination of universal health care, a national network of specialty CF clinics, and drug and travel coverage available in Ontario that results in similar hospitalization rates regardless of SES.Pediatric Pulmonology 10/2010; 46(4):376-84. · 2.53 Impact Factor
