James E Biggs-Houck

Publications (1)3.7 Total impact

• Article: Synthetic studies on the mycolactone core.

  Kwang-Seuk Ko, Matthew D Alexander, Shaun D Fontaine, James E Biggs-Houck, James J La Clair, Michael D Burkart
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  ABSTRACT: Two approaches are presented for the synthesis of the macrolide core of the mycolactone polyketides. The first intertwines ring closing metathesis (RCM) within a two-step Julia olefination protocol, while the second intercepts the optimized routes of Kishi, thereby providing formal access to the mycolactones.
  Organic & Biomolecular Chemistry 11/2010; 8(22):5159-65. · 3.70 Impact Factor