Young Kee Shong

Seoul National University Hospital, Sŏul, Seoul, South Korea

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Publications (129)347.21 Total impact

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    ABSTRACT: Major problems of fine-needle aspiration (FNA) of thyroid nodules arise due to the non-diagnostic results caused by inadequately obtained FNA specimens. The purpose of this study is to evaluate the value of visual assessment of liquid-based cytology specimens during FNA of thyroid nodules for predicting the sampling adequacy. For three months, visual assessment of FNA specimens was used for 534, consecutive nodules in 534 patients. The FNA specimens were visually graded immediately following aspiration for each nodule, and the visual grades were classified into two categories, i.e. inadequate (less than six cell groups) and adequate (more than six cell groups). The cytology results were classified as diagnostic and non-diagnostic result based on the Bethesda System. We compared the US features and FNA characteristics between the diagnostic and non-diagnostic results. Multiple logistic regression analysis was used to determine factors independently predictive of non-diagnostic results. We also evaluated the inter-observer agreement regarding the visual assessment. Visual assessment was feasible in all patients, and the non-diagnostic rate was 11.6% (62/534). Non-diagnostic results were more frequent in the inadequate visual assessment group (38.1%) than in the adequate group (10.5%) (P = 0.001). Independent predictive factors for non-diagnostic results were inadequate visual assessment (odds ratio = 5.18), >50% vascularity (odds ratio = 3.98), and macrocalcification (odds ratio = 3.60). Interobserver agreement for the prediction of visual assessment was good (kappa value = 0.767, p < 0.001). Immediate visual assessment of a specimen during FNA of a thyroid nodule is a feasible method for predicting the sampling adequacy.
    Endocrine Practice 07/2015; DOI:10.4158/EP14529.OR · 2.59 Impact Factor
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    ABSTRACT: The accurate diagnosis of thyroid nodules is important for making management decisions. The purpose of this study is to evaluate the feasibility of core-needle biopsy with BRAF(V600E) mutation analysis (CNB+BRAF(V600E) ) and to compare the clinical usefulness of CNB+BRAF(V600E) and fine-needle aspiration with BRAF(V600E) mutation analysis (FNA+BRAF(V600E) ) in the diagnosis of thyroid malignancy. The results of BRAF(V600E) mutation analyses of 820 nodules from 820 patients (153 men, 667 women; mean age, 51.1 years), who underwent CNB+BRAF(V600E) (n=256) or FNA+BRAF(V600E) (n=564) between January 2011 and March 2012 were retrospectively evaluated. The feasibility of CNB+BRAF(V600E) was assessed by comparing its rate of detection of BRAF(V600E) mutations and positive predictive value with those of FNA+BRAF(V600E) . The clinical usefulness of CNB+BRAF(V600E) was determined by comparing rates of inconclusive results, the additional value of BRAF(V600E) mutation analysis, diagnostic surgery, and diagnostic performance with those of FNA+BRAF(V600E) . CNB+BRAF(V600E) and FNA+BRAF(V600E) had similar rates of BRAF(V600E) mutation detection (66.3% versus 64.4%, P = 0.883) and positive predictive value (100.0% versus 96.6%, P = 0.135). CNB+BRAF(V600E) had a significantly higher diagnostic accuracy rate (95.7% versus 85.9%, P < 0.001), and significantly lower rates of inconclusive results (8.2% versus 51.8%, P < 0.001), and diagnostic surgery (8.9% versus 22.3%, P = 0.006), than FNA+BRAF(V600E) . The greater diagnostic performance of CNB+BRAF(V600E) and its lower rate of inconclusive results than FNA+BRAF(V600E) suggest that CNB+BRAF(V600E) can reduce rates of preventable diagnostic surgery. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.
    Clinical Endocrinology 07/2015; DOI:10.1111/cen.12866 · 3.35 Impact Factor
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    ABSTRACT: The prognosis of papillary thyroid cancer (PTC) with cervical lymph node (LN) metastasis has changed with increased detection of subclinical metastatic LNs. The number and size of metastatic LNs were proposed as new prognostic factors in PTC with cervical LN metastasis (N1). To evaluate changes in N1 PTC characteristics and clinical outcome over time and to confirm the prognostic value of the number and size of metastatic LNs. This study included 1,815 N1 PTC patients diagnosed between 1997 and 2011. Patients were classified into three risk groups according to the number and size of metastatic LNs: very low risk, ≤ 5 and < 0.2 cm; low risk, ≤ 5 and ≥ 0.2 cm; and high risk, > 5. Response to initial therapy and disease -free survival (DFS) Results: Metastatic LNs became smaller and the ratio of metastatic LNs, which represents the extent of LN involvement and the completeness of surgery, decreased significantly over time. The proportion of patients with excellent response significantly increased from 33% to 67% over time (P < .001). These improvements were more evident in the low- and high-risk groups than in the very low-risk group. The DFS 5 years after initial surgery was also significantly increased from 73% to 91% over time (P < .001). The new LN classification was strongly associated with outcome. Patients in the very low-risk group had longer DFS than those in the low- and high-risk groups during the study period. The clinical outcome of N1 PTC has significantly changed over time with the earlier detection of thyroid cancers with less extensive LN involvement. More complete surgical neck dissection also might be responsible for these changes. The number and size of metastatic LNs are important prognostic factors of recurrence in N1 PTC.
    The Journal of Clinical Endocrinology and Metabolism 06/2015; DOI:10.1210/JC.2015-2084 · 6.31 Impact Factor
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    ABSTRACT: The definitive diagnosis of minimal extrathyroid extension (ETE) is subjective because a well-defined true capsule is absent in the thyroid gland. We subclassified the extent of minimal ETE and investigated the clinicopathological significance of the presence of minimal ETE in patients with solitary papillary thyroid carcinomas (PTCs) and solitary papillary thyroid microcarcinomas (PTMCs). A series of 546 patients with solitary PTCs, including 144 patients with solitary PTMCs, were retrospectively analyzed. Whether the presence of minimal ETE had an effect on recurrence-free survival (RFS) along with other clinicopathological parameters was investigated. The only independent prognostic factor found to be associated with recurrence was the presence of LN metastasis in solitary PTC (p = 0.002) but not in solitary PTMC groups (p = 0.073). The presence of minimal ETE had no effect on RFS in both solitary PTC (p = 0.053) and solitary PTMC (p = 0.816). The presence of minimal ETE has no significant influence on RFS in solitary PTC and PTMC. There is a risk of overrepresenting the T3 category in solitary PTC and PTMC patients with minimal ETE.
    Annals of Surgical Oncology 06/2015; DOI:10.1245/s10434-015-4659-0 · 3.94 Impact Factor
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    ABSTRACT: A diffuse hepatic uptake (DHU) on radioiodine whole-body scans (WBS) after (131)I therapy is caused by (131)I-labeled iodoproteins, particularly (131)I-labeled thyroglobulin (Tg). We hypothesized that the DHU intensity after (131)I therapy might correlate with subsequent serum Tg reduction, suggesting that DHU reflects destruction of functioning thyroid tissue as measured by serum Tg. We retrospectively reviewed the medical records and (131)I WBSs of 47 patients treated with (131)I therapy for distant metastasis from differentiated thyroid cancer (M:F = 15:32, median age 45 years, range 11-74 years). All patients received post-ablative (131)I scans (PAWBS) at first (131)I ablation after total thyroidectomy and post-therapy (131)I scan (PTWBS) at second (131)I therapy. The DHU intensities of the PAWBS and PTWBS were classified into 3 grades: 1, faint; 2, modest; and 3, intense. Serum thyroid-stimulating hormone-stimulated Tg (sTg) levels were measured at the time of each therapy and 1 year after the second (131)I therapy. One year after the second (131)I therapy, 10 patients (21.3 %) were in remission and 37 (78.7 %) had persistent disease. The DHU intensity on PAWBS correlated with the percentage sTg reduction at the next follow-up point (σ = 0.466, p = 0.0016). The patients with intense DHU on PTWBS tended to have a higher percentage sTg reduction than the other patients, although statistical significances were marginal (Spearman's rank correlation: σ = 0.304, p = 0.054; Kruskal-Wallis test: p = 0.067). In univariate analysis, the DHU grades on PAWBS and the initial sTg levels were significantly different between patients in remission and those with persistent disease (PAWBS: p = 0.022; initial sTg: p = 0.0059). In multivariate logistic regression analysis, after adjusting for initial sTg levels, a DHU grade of 3 on PAWBS was an independent predictor of remission (PAWBS: p = 0.028; initial sTg <100 ng/ml: p = 0.043). In patients with iodine-avid distant metastases, intensity of DHU on (131)I post-therapy scan correlated with subsequent percentage serum sTg reduction. Also, intense DHU could be one of the predictors of remission in these patients.
    Annals of Nuclear Medicine 05/2015; DOI:10.1007/s12149-015-0983-5 · 1.51 Impact Factor
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    ABSTRACT: The diagnostic accuracy of thyroid dysfunctions is primarily affected by the validity of the reference interval for serum thyroid-stimulating hormone (TSH). Thus, the present study aimed to establish a reference interval for TSH using a normal Korean population. This study included 19,465 subjects who were recruited after undergoing routine health check-ups. Subjects with overt thyroid disease, a prior history of thyroid disease, or a family history of thyroid cancer were excluded from the present analyses. The reference range for serum TSH was evaluated in a normal Korean reference population which was defined according to criteria based on the guidelines of the National Academy of Clinical Biochemistry, ultrasound (US) findings, and smoking status. Sex and age were also taken into consideration when evaluating the distribution of serum TSH levels in different groups. In the presence of positive anti-thyroid peroxidase antibodies or abnormal US findings, the central 95 percentile interval of the serum TSH levels was widened. Additionally, the distribution of serum TSH levels shifted toward lower values in the current smokers group. The reference interval for TSH obtained using a normal Korean reference population was 0.73 to 7.06 mIU/L. The serum TSH levels were higher in females than in males in all groups, and there were no age-dependent shifts. The present findings demonstrate that the serum TSH reference interval in a normal Korean reference population was higher than that in other countries. This result suggests that the upper and lower limits of the TSH reference interval, which was previously defined by studies from Western countries, should be raised for Korean populations.
    The Korean Journal of Internal Medicine 05/2015; 30(3):335. DOI:10.3904/kjim.2015.30.3.335
  • E J Ha · J H Baek · D G Na · J-H Kim · J K Kim · H S Min · D E Song · K E Lee · Y K Shong
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    ABSTRACT: Medullary thyroid carcinoma is an uncommon malignancy that is challenging to diagnose. Our aim was to present our experience using core needle biopsy for the diagnosis of medullary thyroid carcinoma compared with fine-needle aspiration. Between January 2000 and March 2012, 202 thyroid nodules in 191 patients were diagnosed as medullary thyroid cancer by using sonography-guided fine-needle aspiration, core needle biopsy, or surgery. One hundred eighty-three thyroid nodules in 172 patients were included on the basis of the final diagnosis. We evaluated the sensitivity and positive predictive value of fine-needle aspiration and core needle biopsy for the diagnosis of medullary thyroid cancer. We compared the rate of a delayed diagnosis, a diagnostic surgery, and surgery with an incorrect diagnosis for fine-needle aspiration and core needle biopsy and investigated the factors related to the fine-needle aspiration misdiagnosis of medullary thyroid cancer. Fine-needle aspiration showed 43.8% sensitivity and 85.1% positive predictive value for the diagnosis of medullary thyroid cancer; 25.7% (44/171) of patients had a delayed diagnosis, while 18.7% (32/171) underwent an operation for accurate diagnosis, and 20.5% (35/171) underwent an operation with an incorrect diagnosis. Core needle biopsy achieved 100% sensitivity and positive predictive value without a delay in diagnosis (0/22), the need for a diagnostic operation (0/22), or an operation for an incorrect diagnosis (0/22). A calcitonin level of <100 pg/mL was the only significant factor for predicting the fine-needle aspiration misdiagnosis of medullary thyroid cancer (P = .034). Core needle biopsy showed a superior sensitivity and positive predictive value to fine-needle aspiration and could optimize the surgical management in patients with medullary thyroid cancer. Because the ability of fine-needle aspiration to diagnose medullary thyroid cancer significantly decreases in patients with serum calcitonin levels of <100 pg/mL, core needle biopsy could be indicated for these patients to optimize their surgical management. © 2015 American Society of Neuroradiology.
    American Journal of Neuroradiology 04/2015; DOI:10.3174/ajnr.A4317 · 3.68 Impact Factor
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    ABSTRACT: Pulmonary function test (PFT) is a useful tool for an objective assessment of respiratory function. Impaired pulmonary function is critical for the survival and quality of life in patients with pulmonary metastases of solid cancers including thyroid cancer. This study aimed to evaluate clinical factors associated with severely impaired pulmonary function by serial assessment with PFT in patients with pulmonary metastasis of differentiated thyroid cancer (DTC) who received radioactive iodine treatment (RAIT). This retrospective study enrolled 31 patients who underwent serial PFTs before and after RAIT for pulmonary metastasis of DTC. We evaluated the risk factors for severe impairment of pulmonary function. The median age of the patients was 44.1 years and 18 of them were female patients. Severe impairment of pulmonary function was observed in five patients (16%) after a median of three RAITs (cumulative I-131 activity = 20.4 GBq). These patients were older and more frequently had mild impairment of baseline pulmonary function, respiratory symptoms, or progressive disease compared with patients with stable pulmonary function. Neither cumulative dose nor number of RAIT was associated with decreased pulmonary function. Coexisting pulmonary diseases, presence of respiratory symptoms, and metastatic disease progression were significantly associated with severe decrease in forced vital capacity during follow-up (p =.047, p =.011, and p =.021, respectively). Pulmonary function was severely impaired during follow-up in some patients with pulmonary metastasis of DTC after a high-dose RAITs. Neither the number of RAIT nor the cumulative I-131 activity was associated with decreased pulmonary function. Serial PFT might be considered for some high-risk patients during follow-up.
    PLoS ONE 04/2015; 10(4):e0125114. DOI:10.1371/journal.pone.0125114 · 3.23 Impact Factor
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    03/2015; 30(1):116. DOI:10.3803/EnM.2015.30.1.116
  • Experimental and Clinical Endocrinology & Diabetes 03/2015; 122(03). DOI:10.1055/s-0035-1547604 · 1.76 Impact Factor
  • Experimental and Clinical Endocrinology & Diabetes 03/2015; 122(03). DOI:10.1055/s-0035-1547632 · 1.76 Impact Factor
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    ABSTRACT: Acute short-term hypothyroidism induced by thyroid hormone withdrawal (THW) for follow-up surveillance or therapeutic radioiodine causes patients with differentiated thyroid cancer to suffer from a myriad of deleterious symptoms. To know how patient recognition of hypothyroid symptoms compares to physician perception of patient symptoms. The survey was performed in 10 referral hospitals throughout Korea from December 2010 to May 2011 and targeted patients with total thyroidectomy and remnant ablation. The survey consisted of questions regarding the effect of THW on patient symptoms, the duration of symptoms, impact on social life, and patient complaints. The physicians treating thyroid cancer patients also responded to the survey and provided their perceptions of patient symptoms and treatment decisions. About 70% of the patients responded that they experienced a negative physical or psychological impact on their life and work due to hypothyroid symptoms. However, 76% of doctors thought hypothyroidism could negatively impact a patient's daily life but would be endurable. Two thirds of physicians do not routinely recommend recombinant human TSH (rhTSH) to their patients. Multivariate analysis showed patients with female sex, stronger educational background, emotionally negative experiences of hypothyroidism, and younger age were more willing to pay for therapy that could prevent hypothyroidism symptoms. There was a substantial gap in the perception of hypothyroid symptoms during THW between physicians and patients. Physicians who are aware of the seriousness of hypothyroidism in their patients were more likely to recommend the use of rhTSH for their patients.
    03/2015; 4(1):48-54. DOI:10.1159/000371512
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    ABSTRACT: The prevalence of thyroid cancer has increased very rapidly in Korea. However, there is no published report focusing on thyroid cancer mortality in Korea. In this study, we aimed to evaluate standardized thyroid cancer mortality using data from Statistics Korea (the Statistical Office of Korea). Population and mortality data from 1985 to 2010 were obtained from Statistics Korea. Age-standardized rates of thyroid cancer mortality were calculated according to the standard population of Korea, as well as World Health Organization (WHO) standard population and International Cancer Survival Standard (ICSS) population weights. The crude thyroid cancer mortality rate increased from 0.1 to 0.7 per 100,000 between 1985 and 2010. The pattern was the same for both sexes. The age-standardized mortality rate (ASMR) for thyroid cancer for Korean resident registration population increased from 0.19 to 0.67 between 1985 and 2000. However, it decreased slightly, from 0.67 to 0.55, between 2000 and 2010. When mortality was adjusted using the WHO standard population and ICSS population weights, the ASMR similarly increased until 2000, and then decreased between 2000 and 2010. Thyroid cancer mortality increased until 2000 in Korea. It started to decrease from 2000.
    12/2014; 29(4):530-5. DOI:10.3803/EnM.2014.29.4.530
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    ABSTRACT: Obesity is associated with aggressive pathological features and poor clinical outcomes in breast and prostate cancers. In papillary thyroid carcinoma (PTC), these relationships remain still controversial. This study aimed to evaluate the associations between body mass index (BMI) and the clinical outcomes of patients with PTC. This retrospective study included 1,189 patients who underwent total thyroidectomy for PTCs equal to or larger than 1 cm in size. Clinical outcomes were evaluated and compared based on the BMI quartiles. There were no significant associations between BMI quartiles and primary tumor size, extrathyroidal invasion, cervical lymph node metastasis, or distant metastasis. However, an increase in mean age was associated with an increased BMI (P for trend <0.001). Multifocality and advanced tumor node metastasis (TNM) stage (stage III or IV) were significantly associated with increases of BMI (P for trend 0.02 and <0.001, respectively). However, these associations of multifocality and advanced TNM stage with BMI were not significant in multivariate analyses adjusted for age and gender. Moreover, there were no differences in recurrence-free survivals according to BMI quartiles (P=0.26). In the present study, BMI was not associated with the aggressive clinicopathological features or recurrence-free survivals in patients with PTC.
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    ABSTRACT: Objective The follicular variant of papillary thyroid carcinoma (FVPTC) has multiple histological subtypes. Clinical outcomes of FVPTC are variable depending on the subtypes. This study evaluated the association of preoperative ultrasonographic (US) findings and clinico-pathological features of FVPTC.PatientsThis retrospective study enrolled patients with FVPTC (n=70), size-matched classical variant of papillary thyroid carcinoma (CPTC, n=328), follicular carcinoma (n=85), and follicular adenoma (FA, n=120). We defined the histological subtypes of FVPTC as infiltrative (I-FVPTC; n=19) or encapsulated (E-FVPTC; n=51) according to the presence of a fibrous capsule. Preoperative US was reviewed using a US scoring system and classified into low-US score (n=42) and high-US score (n=28).ResultsThe median US score for FVPTC was lower than CPTC (2 vs. 7, p<0.001), but higher than FA (2 vs. 0, p<0.001). The median US score for I-FVPTC was significantly higher than E-FVPTC (4 vs. 2, p=0.009). I-FVPTC was more likely to be diagnosed as a malignancy or suspicious for malignancy on cytology than E-FVPTC (p=0.002). The cumulative risks of cervical lymph node (LN) or distant metastasis according to tumour size were significantly higher in I-FVPTC than E-FVPTC (all p<0.001). The cumulative risks for cervical LN metastasis or capsular invasion according to tumour size were significantly higher in FVPTC with high-US score than FVPTC with low-US score (p=0.005, p<0.001, respectively).Conclusions Preoperative US findings of thyroid nodules were associated with not only histological subtypes, but also the clinical behaviour in FVPTC.This article is protected by copyright. All rights reserved.
    Clinical Endocrinology 11/2014; DOI:10.1111/cen.12674 · 3.35 Impact Factor
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    ABSTRACT: To investigate the prognostic value of BRAF V600E mutation for the recurrence of papillary thyroid cancer (PTC).
    Journal of Clinical Oncology 10/2014; 33(1). DOI:10.1200/JCO.2014.56.8253 · 18.43 Impact Factor
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    ABSTRACT: AIM: To evaluate recurrence rate and associated risk factors for recurrence after ethanol ablation (EA) in patients with predominantly cystic thyroid nodules. MATERIALS AND METHODS: This observational study was approved by the Ethics Committee of the Institutional Review Board and informed consent for procedures was obtained. From April 2009 to April 2013, 107 consecutive patients with predominantly cystic nodules were treated using EA. Recurrence was defined as nodules showing a residual solid portion with internal vascularity, cosmetic problems remaining, or persistent symptoms, and patients who requested additional therapy to resolve their symptomatic or cosmetic problems. Delayed recurrence was defined as treated nodules that showed no recurrent features at 1 month, but showed newly developed recurrent features during the longer follow-up period. Multivariate analysis was used for variables to demonstrate the independent factors related to volume reduction. RESULTS: One month after EA, 18.7% of patients (20/107) showed recurrence. Among 87 patients with non-recurrence, 24.1% (21/87) showed delayed recurrence. The total recurrence rate was 38.3% (41/107). Patients with recurrence (n = 41) were treated using radiofrequency ablation (n = 28), second EA (n = 4), and refused further treatment (n = 9). These patients responded well to repeat EA and radiofrequency ablation. Multivariate analysis demonstrated that the initial nodule volume (>20 ml; p < 0.036) and vascularity (grade >1; p <0.049) were independent predictors of volume reduction at last follow-up. CONCLUSIONS: The results revealed that although EA seemed to be effective during the initial period, delayed recurrence should be considered during longer-term follow-up. The independent predictors of recurrence were initial volume (>20 ml) and vascularity.
    Clinical Radiology 10/2014; 70(1). DOI:10.1016/j.crad.2014.09.008 · 1.66 Impact Factor
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    ABSTRACT: Objectives To assess the efficacy and safety of ultrasound- (US) guided radiofrequency ablation (RFA) for controlling locoregional recurrent papillary thyroid cancer (PTC) in a large patient population. Methods We included patients who had undergone RFA for locoregional recurrent PTC between September 2008 and April 2012 who fulfilled the following criteria: no metastasis beyond the neck; not more than four tumours; confirmed recurrence by US-guided fine needle aspiration biopsy or thyroglobulin measurement of needle washouts; more than a six-month follow-up period; and surgery not feasible or was refused by the patient. Results Sixty-one recurrent tumours in 39 patients were included. The mean follow-up duration was 26.4 ± 13.7 months. Tumour volume decreased significantly from 0.20 ± 0.35 ml before ablation to 0.02 ± 0.11 ml (P
    European Radiology 09/2014; 25(1). DOI:10.1007/s00330-014-3405-5 · 4.34 Impact Factor
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    Tae Yong Kim · Won Gu Kim · Won Bae Kim · Young Kee Shong
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    ABSTRACT: Thyroid cancer is increasing all over the world. The exact cause of this increase is still debated and there are conflicting reports. Sophisticated molecular studies suggest that environmental chemicals may have effects of thyroid carcinogenesis. The development of powerful molecular biology techniques has enabled targeted next-generation sequencing for detection of mutations in thyroid cancer, and this technique can make a specific diagnosis of thyroid cancer in cytologically indeterminate cases. The initial treatment of well-differentiated thyroid cancer (DTC) is surgery followed by radioiodine remnant ablation. However, further studies are needed to determine the optimal dosage of radioactive iodine for DTC patients with lateral neck metastasis. DTC is an indolent tumor and may cause death even decades later. Thus, long-term follow-up is mandatory. Recently, dynamic risk stratification (DRS) has begun to use stimulated thyroglobulin level at 1 year after the initial treatment and restratified the risk in accordance with the response to the initial treatment. This DRS strategy accurately predicts disease free survival and can be widely used in daily clinical settings. For the iodine refractory metastatic disease, redifferentiation therapy and targeted therapy are two promising alternative treatments. Sorafenib is the first approved agent for the treatment of progressive iodine refractory advanced thyroid cancer in Korea and may be very helpful for radioactive-refractory locally advanced or metastatic DTC. Selumetinib may be an effective redifferentiating agent and could be used within several years.
    09/2014; 29(3):217-25. DOI:10.3803/EnM.2014.29.3.217
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    ABSTRACT: Objective Serum calcitonin (CT) level is used to detect medullary thyroid carcinoma (MTC), but the cut-off level is unclear. We aimed at identifying optimal cut-off value of basal serum CT levels for detecting MTC.Design and PatientsWe retrospectively enrolled patients with hypercalcitoninemia (≥ 2.9 pmol/L) who had undergone thyroid ultrasonography (US) and subsequent work-up between 2001 and 2013 at Asan Medical Center. We divided patients into four groups: proven MTC (group 1, n=93), pathologically proven non-MTC after surgery (group 2, n=57), benign single nodule by cytology (group 3, n=68) and patients without nodules on US (group 4, n=24).MeasurementBasal serum CT levels were evaluated.ResultsThe median CT level of group 1 (119.5 pmol/L) was significantly higher than those of other groups (4.0, 3.8 and 3.8 pmol/L, P<0.001). When we adopted 19.0 pmol/L of CA level as cut-off value, the sensitivity, specificity, and positive and negative predictive value were 77.4%, 98.7%, 97.3% and 87.8%, respectively. When we compared 29.2 pmol/L (100 pg/mL) and 19.0 pmol/L (65 pg/mL) as cut-off value, 19.0 pmol/L was more sensitive and accurate than 29.2 pmol/L. Factors associated with hypercalcitoninemia in non-MTC groups were autoimmune thyroiditis, chronic kidney disease, proton pump inhibitors, and other malignancies. Serum CT levels tended to decrease spontaneously in non-MTC groups.Conclusion Basal serum CT levels higher than 19.0 pmol/L can be useful cut-off value for detecting macroscopic MTC, even though values below 19.0 pmol/L cannot exclude the presence of MTC like small volume MTC or premalignant C-cell hyperplasia.This article is protected by copyright. All rights reserved.
    Clinical Endocrinology 07/2014; 82(4). DOI:10.1111/cen.12562 · 3.35 Impact Factor

Publication Stats

2k Citations
347.21 Total Impact Points

Institutions

  • 2015
    • Seoul National University Hospital
      • Department of Internal Medicine
      Sŏul, Seoul, South Korea
  • 1990–2015
    • Asan Medical Center
      • • Department of Endocrinology/Metabolism
      • • Asan Institute of Life Sciences
      Sŏul, Seoul, South Korea
    • Seoul National University
      • Department of Internal Medicine
      Seoul, Seoul, South Korea
  • 2005–2014
    • University of Ulsan
      • • Asan Medical Center
      • • Department of Internal Medicine
      Urusan, Ulsan, South Korea
  • 2000–2014
    • Ulsan University Hospital
      Urusan, Ulsan, South Korea
  • 2012
    • Sungkyunkwan University
      • School of Medicine
      Sŏul, Seoul, South Korea