J M Guerra Vales

Publications (38)74.89 Total impact

• Source

  Available from: Mario Fernández-Ruiz

  Article: Enoxaparin-induced retroperitoneal haematoma in patients with renal insufficiency.

  Mario Fernández-Ruiz, Juan Manuel Guerra-Vales
  Schweizerische medizinische Wochenschrift 02/2010; 140(7-8):122-3; author reply 123. · 1.68 Impact Factor
• Article: [Incidence of second non-hematologic malignancies in patients with multiple myeloma].

  M Fernández-Ruiz, J M Guerra-Vales, J Llenas-García, F Colina-Ruiz Delgado
  Revista Clínica Española 01/2010; 210(1):50-1. · 2.01 Impact Factor
• Article: [Bronchiolitis obliterans with organized pneumonia secondary to amiodarone: presentation of two cases with different therapeutic approach].

  M Fernández-Ruiz, J M Guerra-Vales, V Villena-Garrido
  Revista Clínica Española 12/2009; 209(11):568-9. · 2.01 Impact Factor
• Article: [Therapeutic management of cancer of unknown primary site by pathological types].

  M J Fernández Cotarelo, J M Guerra Vales
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  ABSTRACT: The term cancer of unknown primary site includes metastatic tumours with different histology and behaviour. Although most of them have a poor short-term prognosis, some patients can benefit from a treatment and will achieve a longer survival. The treatable cases are: metastases of squamous carcinoma in cervical or inguinal adenopathies, metastases of adenocarcinoma in axilar adenopathies in women, malignant ascites due to adenocarcinoma in women, osteoblastic bone metastases in men with elevated serum prostatic specific antigen levels, poorly differentiated tumours with features of a germinal extragonadal tumour, poorly differentiated neuroendocrine carcinomas and patients with a single metastasis. Chemotherapy must be considered in the rest of patients, although the optimum regimen is not well established yet.
  Revista Clínica Española 10/2009; 209(9):439-43. · 2.01 Impact Factor
• Article: [Hepatocellular carcinoma in the elderly: clinical characteristics, survival analysis, and prognostic indicators in a cohort of Spanish patients older than 75 years].

  M Fernández-Ruiz, J M Guerra-Vales, J Llenas-García, F Colina-Ruizdelgado
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  ABSTRACT: Hepatocellular carcinoma (HCC) remains poorly characterized in elderly patients with comorbid conditions, a fact that limits the clinical management of the disease. This study analyzes the natural history of HCC in patients older than 75, and determines factors that condition their survival. A retrospective analysis of 235 patients with HCC divided into 2 groups by age at diagnosis: < or = 75 (n = 186) and > 75 (n = 49). After comparing their clinical variables (chi2 and t test), a logistic regression analysis was performed to determine factors associated with receiving locoregional treatment (versus symptomatic treatment). Survival in the 2 groups was compared using a log rank test with subsequent multivariate analysis (Cox proportional hazards model). There were no differences between groups for sex, presence of cirrhosis, etiology, Child-Pugh score, BCLCancer stage, presence of ascites or portal thrombosis, or bilirubin, AST, ALT, gammaGT, LDH or hematocrit values. Patients of advanced age were more frequently diagnosed in the presence of clinical manifestations, and had multifocal, non-localized disease and alpha-fetoprotein levels > 400 ng/mL (all p < 0.05). This group received exclusively symptomatic treatment in 78% of cases (compared to 33% in younger patients), and only 3 of them underwent surgical resection (p < 0.0001). Age older than 75 was a predictive factor for not receiving locoregional therapy (p < 0.0001). Survival in the elderly group (9.8 +/- 1 months) differed substantially from that of younger patients (25.6 +/- 2 months) (p < .00001). Advanced age continued to be a prognostic factor of poor survival in the multivariate analysis (p = 0.025), but lost significance when the analysis was stratified by treatment subgroups (p = 0.344). The lower survival seen in elderly patients with HCC, beyond differences in tumor extension or liver failure, seems conditioned by the use of suboptimal treatment in this population.
  Revista espanola de enfermedades digestivas: organo oficial de la Sociedad Espanola de Patologia Digestiva 11/2008; 100(10):625-31. · 1.55 Impact Factor
• Article: [Spontaneous idiopathic thrombosis of the internal jugular vein].

  M Fernández-Ruiz, J M Guerra-Vales, V Guillén-Camargo
  Revista Clínica Española 08/2008; 208(7):374-5. · 2.01 Impact Factor
• Article: [Advanced hepatocellular carcinoma presenting with bone metastases].

  M Fernández Ruiz, J M Guerra Vales, J L Aranda Arcas, A L Coto López
  Revista espanola de enfermedades digestivas: organo oficial de la Sociedad Espanola de Patologia Digestiva 06/2008; 100(5):309-11. · 1.55 Impact Factor
• Article: [Solitary gastric carcinoid tumor and pernicious anaemia: treatment by endoscopic polypectomy].

  M Fernández-Ruiz, Y Rodríguez-Gil, S Sáenz-López, J M Guerra-Vales, V Guillén-Camargo
  Revista espanola de enfermedades digestivas: organo oficial de la Sociedad Espanola de Patologia Digestiva 04/2008; 100(3):186-7. · 1.55 Impact Factor
• Article: [Hemoperitoenum as presentation of hepatocellular carcinoma: experience in three cases with spontaneous tumoral rupture and review of the literature].

  M Fernández-Ruiz, J M Guerra-Vales, J Llenas-García, J M Delgado-García, C Gómez-Pellico, A González-Barber
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  ABSTRACT: Hemoperitoneum due to spontaneous rupture of hepatocellular carcinoma (HCC) constitutes a life-threatening situation if no appropriate therapy is provided. This complication is a well-known form of HCC presentation in countries with high incidence of liver tumours, but is an unusual event in Western countries, where it has been described in 5% or less of cases with HCC. We report three patients admitted to our centre with acute hemoperitoneum secondary to non-traumatic rupture as a first manifestation of not previously diagnosed HCC. A review of the related literature is also performed.
  Anales de medicina interna (Madrid, Spain: 1984) 03/2008; 25(2):81-4.
• Article: [A 33-year old man with upper digestive tract bleeding and epigastric pain].

  M Fernández-Ruiz, J L Aranda-Arcas, J Llenas-García, J M Guerra-Vales, A B Enguita-Valls, F Alonso-Navas
  Revista Clínica Española 02/2008; 208(1):52-5. · 2.01 Impact Factor
• Article: [Cardiac tamponade as initial clinical manifestation of a non-small cell lung cancer].

  M Fernández-Ruiz, J L Aranda-Arcas, F Alonso-Navas, J M Guerra-Vales
  Revista Clínica Española 01/2008; 207(11):587-9. · 2.01 Impact Factor
• Article: [Tuberculosis in the autopsy. Clinical and pathological study: an analysis of 92 cases of active tuberculosis found in 2,180 autopsies].

  M Morales Conejo, J M Guerra Vales, V J Moreno Cuerda, J F Varona Arche, S Hernando Polo, E Palenque Mataix, C Pérez de Oteyza, F J Martínez Tello
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  ABSTRACT: Tuberculosis is an infectious disease currently having great importance in the daily clinical practice in Spain. Some cases of active tuberculosis are not identified until after the patient had died and an autopsy has been performed. This study has analyzed the clinical and pathological characteristics of patients diagnosed with active tuberculosis in the autopsy. We reviewed all the autopsies performed in the University Hospital 12 de Octubre of Madrid between 1974 and 2002. The autopsy reports and clinical records were examined in those cases in which active tuberculosis was found. RESUTS: We found 92 cases of active tuberculosis, 57% corresponding to men. Mean age of this group was 64 years. A total of 20% of the patients died within 48 hours after admission. Predisposing factors were identified in 90% of the cases. Dyspnea (24% of cases) and wasting syndrome (23%) were the main symptoms that motivated patients to request medical attention. Up to 30% of cases had normal chest X-ray. Tuberculosis was suspected in only 46% of patients before death. Principal cause of death was tuberculosis in 61% of patients, 52% of patients had pulmonary tuberculosis, 28% suffered from miliary tuberculosis and 20% from extra-pulmonary tuberculosis. The lungs were the most frequently affected organ. Epithelioid granulomas were found in all patients. Tuberculosis is an uncommon finding in the autopsy as the cause of death. The presence of unspecific symptomatology, insufficient cost-effectiveness of the diagnostic tests and precocious death, are identified as the most frequent causes of undiagnosed tuberculosis.
  Revista Clínica Española 07/2007; 207(6):278-83. · 2.01 Impact Factor
• Source

  Available from: Mario Fernández-Ruiz

  Article: [Pyogenic liver abscess as presenting manifestation of silent colon adenocarcinoma].

  M Fernández Ruiz, J M Guerra Vales, F J Castelbón Fernández, J Llenas García
  Revista espanola de enfermedades digestivas: organo oficial de la Sociedad Espanola de Patologia Digestiva 06/2007; 99(5):303-5. · 1.55 Impact Factor
• Article: [75 year old man with middle lobe atelectasis].

  M J Fernández Cotarelo, J M Guerra Vales, R Navas Espejo, F López-Ríos, C Holguera Vázquez
  Revista Clínica Española 06/2007; 207(5):253-4. · 2.01 Impact Factor
• Article: [Massive pulmonary thromboembolism associated to peripheral arterial embolism].

  M Morales Conejo, V J Moreno Cuerda, J M Guerra Vales, M Catalán, A Adrados, J C Montejo
  Revista Clínica Española 01/2007; 206(11):587-8. · 2.01 Impact Factor
• Article: [27 year old male with bilateral pulmonary infiltrates and acute bilateral parotitis].

  J F Varona, J M Guerra Vales, M Grande, J L Rodríguez-Peralto, R Pérez-Rojo
  Revista Clínica Española 11/2005; 205(10):507-8. · 2.01 Impact Factor
• Article: Effect of highly active antiretroviral therapy on the incidence and clinical manifestations of visceral leishmaniasis in human immunodeficiency virus-infected patients.

  M J Fernández Cotarelo, J Abellán Martínez, J M Guerra Vales, P Martínez Sánchez, M Rodrigo Gómez De La Bárcena, E Salto Fernández
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  ABSTRACT: This study analyzes the effect of highly active antiretroviral therapy (HAART) on visceral leishmaniasis in human immunodeficiency virus-infected individuals. We describe 66 episodes diagnosed in our hospital from 1994 through 2000 (35 episodes in patients who were not receiving HAART and 31 episodes in patients who were receiving HAART). Since HAART became available, the incidence of visceral leishmaniasis has significantly decreased and the number of first episodes has decreased, although the number of relapses is increasing.
  Clinical Infectious Diseases 11/2003; 37(7):973-7. · 9.15 Impact Factor
• Article: Intestinal pseudo-obstruction and urinary retention: cardinal features of a mitochondrial DNA-related disease.

  A García-Velasco, C Gómez-Escalonilla, J M Guerra-Vales, A Cabello, Y Campos, J Arenas
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  ABSTRACT: The syndrome of mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) is a multisystemic disorder associated in most of the patients with an A to G transition at nucleotide position 3243 in the transfer RNA (tRNA)Leu(UUR) (A3243G) of the mitochondrial DNA. This syndrome is characterized by the preponderant involvement of skeletal muscle and central nervous system, but urinary or gastrointestinal symptoms are seldom documented. Here we report an unusual case of a 52-year-old woman with a clinical phenotype characterized by encephalopathy, left hemiparesis, urinary retention and gastrointestinal pseudo-obstruction. She had the classical A3243G mitochondrial DNA point mutation of MELAS syndrome. We also present a clinically heterogeneous multigenerational pedigree with several affected members in the maternal lineage.
  Journal of Internal Medicine 04/2003; 253(3):381-5. · 5.48 Impact Factor
• Article: [SAPHO syndrome].

  J Abellán Martínez, J M Guerra Vales, P Manjón Luengo
  Medicina Clínica 12/1999; 113(15):599. · 1.38 Impact Factor
• Article: [Localized Castleman's disease associated with high-grade lymphoma].

  R M Sanz García, J M Guerra Vales, I de Prada, M A Martínez, V Guillén Camargo
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  ABSTRACT: Castleman's disease is a rare entity which is characterized by its histologic features: hyperplasia of lymph nodes and capillary proliferation. Two distinct histological patterns has been described: hyaline vascular type and plasma-cell type. Two different clinical course has been identified. While localized type is usually a benign disease in which surgical resection is curative, multicentric type has a poor prognosis regarded to the appearance of severe infection or neoplasm (Kaposi's sarcoma or malignant lymphoma. We present a rare association of localized Castleman's disease that presents synchronously with a diffuse large-cell lymphoma.
  Anales de medicina interna (Madrid, Spain: 1984) 07/1999; 16(6):305-7.