J I Roodnat

Publications (2)1.68 Total impact

• Article: [Acute kidney insufficiency in patients treated with fumaric acid esters for psoriasis].

  J I Roodnat, M H Christiaans, W M Nugteren-Huying, J G van der Schroeff, P C Chang
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  ABSTRACT: We describe four female patients with psoriasis treated with fumaric acid esters. In two patients acute renal failure developed during this therapy. Histological investigation of renal biopsy in one patient was compatible with the diagnosis of acute tubular necrosis; her renal function was reversible after cessation of the medication. The histological diagnosis of the other patient was tubulo-interstitial nephritis, possibly as a reaction to acute tubular necrosis. The recovery of her renal function was incomplete after 9 months.
  Nederlands tijdschrift voor geneeskunde 01/1990; 133(52):2623-6.
• Article: [Acute kidney insufficiency in the treatment of psoriasis using fumaric esters].

  J I Roodnat, M H Christiaans, W M Nugteren-Huying, J G van der Schroeff, P van der Zouwen, B H Stricker, J J Weening, P C Chang
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  ABSTRACT: We describe two patients who developed acute renal failure during therapy with fumaric acid-esters. Histologic findings after renal biopsy in one patient were compatible with the diagnosis of acute tubular necrosis (ATN), and renal function was restored after cessation of the medication. The histologic diagnosis in the other patient was tubulo-interstitial nephritis (TIN), possibly reactive to ATN. The recovery of renal function was incomplete after 9 months. Two other patients had deterioration of renal function and proteinuria during therapy with fumaric acid-esters. The symptoms were completely reversible in one patient after discontinuation of the medication, and incompletely reversible in the other. The literature is reviewed and a comparison is drawn with the maleic acid model in the rat.
  Schweizerische medizinische Wochenschrift 07/1989; 119(23):826-30. · 1.68 Impact Factor