J Bazin

Publications (5)0 Total impact

• Article: Pressure support ventilation attenuates ventilator-induced protein modifications in the diaphragm

  E Futier, J Constantin, L Combaret, L Mosoni, L Roszyk, V Sapin, D Attaix, B Jung, S Jaber, J Bazin
  [show abstract] [hide abstract]
  ABSTRACT: INTRODUCTION: Controlled mechanical ventilation (CMV) induces profound modifications of diaphragm protein metabolism, including muscle atrophy and severe ventilator-induced diaphragmatic dysfunction. Diaphragmatic modifications could be decreased by spontaneous breathing. We hypothesized that mechanical ventilation in pressure support ventilation (PSV), which preserves diaphragm muscle activity, would limit diaphragmatic protein catabolism. METHODS: Forty-two adult Sprague-Dawley rats were included in this prospective randomized animal study. After intraperitoneal anesthesia, animals were randomly assigned to the control group or to receive 6 or 18 hours of CMV or PSV. After sacrifice and incubation with 14C-phenylalanine, in vitro proteolysis and protein synthesis were measured on the costal region of the diaphragm. We also measured myofibrillar protein carbonyl levels and the activity of 20S proteasome and tripeptidylpeptidase II. RESULTS: Compared with control animals, diaphragmatic protein cataboli
  Critical care (London, England). 01/2008; 12:R116.
• Article: [Immunotherapy of contact dermatitis].

  E Henocq, G Fanet, J Bazin
  Archives des maladies professionnelles de médecine du travail et de sécurité sociale 04/1970; 31(3):147-9.
• Article: [Electroshock apparatus for bioassay of antiepileptic drugs].

  A QUEVAUVILLER, J BAZIN
  Annales Pharmaceutiques Françaises 07/1950; 8(6):500-2.
• Article: ScvO2 and Pcv-aCO2 as complementary tools for goal-directed therapy during high-risk surgery

  E Futier, B Vallet, E Robin, J Constantin, J Bazin
• Article: Use of near-infrared spectroscopy during a vascular occlusion test to assess the microcirculatory response during fluid responsiveness

  E Futier, B Vallet, E Robin, M Vignaud, J Constantin, J Bazin