J. Borrás

Hospital Universitari Sant Joan de Reus, Reus, Catalonia, Spain

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Publications (118)243.4 Total impact

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    ABSTRACT: To predict the burden of cancer in Catalonia by 2020 assessing changes in demography and cancer risk during 2010-2020. Data were obtained from Tarragona and Girona cancer registries and Catalan mortality registry. Population age distribution was obtained from the Catalan Institute of Statistics. Predicted cases in Catalonia were estimated through autoregressive Bayesian age-period-cohort models. There will be diagnosed 26,455 incident cases among men and 18,345 among women during 2020, which means an increase of 22.5 and 24.5 % comparing with the cancer incidence figures of 2010. In men, the increase of cases (22.5 %) can be partitioned in three components: 12 % due to ageing, 8 % due to increase in population size and 2 % due to cancer risk. In women, the role of each component was 9, 8 and 8 %, respectively. The increased risk is mainly expected to be observed in tobacco-related tumours among women and in colorectal and liver cancers among men. During 2010-2020 a mortality decline is expected in both sexes. The expected increase of cancer incidence, mainly due to tobacco-related tumours in women and colorectal in men, reinforces the need to strengthen smoking prevention and the expansion of early detection of colorectal cancer in Catalonia.
    Clinical and Translational Oncology 12/2013; · 1.28 Impact Factor
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    ABSTRACT: The complexes {[Cu(HGLYO)(NO3)(bpy)]·H2O}4 (1), {[Cu(HGLYO)(NO3)(phen)]·H2O}4 (2), and [Cu(HLACO)(ClO4)(phen)]4 (3) (bpy is 2,2′-bipyridine, phen is 1,10-phenanthroline, HGLYO is monoanionic glycolate, and HLACO is monoanionic lactate) have been synthesized and their crystal structures were determined by X-ray diffraction analysis. The thermal behavior and IR, electronic and electron paramagnetic resonance (EPR) spectra are also reported. The structures of compounds 1–3 consist of cyclic tetrameric units in which the copper(II) ions are connected by carboxylate groups in an anti-syn conformation. The hydroxycarboxylates, diimine ancillary ligands, and crystallization water molecules, when present, have a significant influence on the crystal structures through weak interactions such as hydrogen bonding and π–π stacking. These interactions mainly contribute to the stabilization of the overall supramolecular structures, which contain rectangular voids of different dimensionality. Magnetic measurements in the temperature range 1.8–300 K showed that compounds 1 and 2 are ferromagnetic. The J values obtained were 3.2 cm–1 for 1 and 3.3 cm–1 for 2. An electrochemical study for complexes 1 and 2 by cyclic voltammetry in dimethylformamide solutions showed the irreversible nature of the electrode process.
    Crystal Growth & Design 09/2011; 11(10):4344–4352. · 4.56 Impact Factor
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    ABSTRACT: Biallelic inactivation of ATM gene causes the rare autosomal recessive disorder Ataxia-telangiectasia (A-T). Female relatives of A-T patients have a two-fold higher risk of developing breast cancer (BC) compared with the general population. ATM mutation carrier identification is laborious and expensive, therefore, a more rapid and directed strategy for ATM mutation profiling is needed. We designed a case-control study to determine the prevalence of 32 known ATM mutations causing A-T in Spanish population in 323 BRCA1/BRCA2 negative hereditary breast cancer (HBC) cases and 625 matched Spanish controls. For the detection of the 32 ATM mutations we used the matrix-assisted laser desorption/ionization time-of-flight mass spectrometry technique. We identified one patient carrier of the c.8264_8268delATAAG ATM mutation. This mutation was not found in the 625 controls. These results suggest a low frequency of these 32 A-T causing mutations in the HBC cases in our population. Further case-control studies analyzing the entire coding and flanking sequences of the ATM gene are warranted in Spanish BC patients to know its implication in BC predisposition.
    Breast Cancer Research and Treatment 03/2011; 128(2):573-9. · 4.47 Impact Factor
  • Radiotherapy and Oncology 02/2011; 98. · 4.86 Impact Factor
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    ABSTRACT: Three dinuclear and one mononuclear copper(II)-1,10-phenanthroline ternary complexes, [Cu(L1)(phen)(OH)]2 (1), [Cu(L2)(phen)(OH)]2·3H2O (2), [Cu(L3)(phen)(OH)]2 (3) and [Cu(L4)2(phen)(H2O)] (4), with thiadiazole sulfonamide derivative ligands: HL1 (N-(5-ethyl-1,3,4-thiadiazol-2-yl)naphthalene-1-sulfonamide), HL2 (N-(5-ethylthio)-1,3,4-thiadiazol-2-yl)-4-methylbenzenesulfonamide), HL3 (N-(5-ethyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide) and HL4 (N-(5-ethyl-1,3,4-thiadiazol-2-yl)-4-methylbenzenesulfonamide) have been synthesized and characterized. In the four complexes each copper atom is five-coordinated. The structure of complexes 1, 2 and 3 consists of a dimeric unit with a C2 symmetry axis, where both coppers are bridged by two hydroxo anions. Magnetic measurements show that the dimer complexes are ferromagnetic according to the Cu–O–Cu angles. Cleavage experiments using pUC18 plasmid DNA in the presence of H2O2/ascorbic acid as an activating agent show that the title complexes are potent artificial chemical nucleases, the order of efficiency being 3 > 2 ∼ 1 > 4. Control cleavage experiments indicated that the dimer complexes are stronger artificial nucleases than the [Cu(phen)2]2+ complex under the same experimental conditions, while the monomer 4 has a lower nuclease activity than the [Cu(phen)2]2+ complex. The inhibition of the cleavage process in the presence of reactive oxygen intermediate scavengers suggests that the hydroxyl radical and the superoxide anion are reactive species for the breakage of the DNA strands.
    Polyhedron 03/2010; 29(4):1305-1313. · 2.05 Impact Factor
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    ABSTRACT: ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
    ChemInform 01/2010; 27(45).
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    ABSTRACT: To describe the secular trend of cancer incidence in Catalonia and to compare it with that observed in European regions. Using data from the Tarragona and Gerona cancer registries, the number of cases, adjusted rates, and the annual percentages of change in cancer incidence in Catalonia for the period 1985-2002 were estimated. Cancer incidence trends in Catalonia, Spain, and four European regions were compared using variations in the adjusted rates between the periods 1993-1997 and 1998-2002. The number of invasive cancers increased from 15,773 in 1985 to 30,755 in 2002. The adjusted incidence rate showed an annual increase of 2.64% in males and of 1.81% in females. Almost all tumoral types showed an increasing trend. The most frequent malignant tumors in males were prostate, lung, colon and rectum, and urinary bladder tumors, showing increases of 8.74%, 1.67%, 3.47% and 4.32% respectively. The most frequent tumors in females were breast, colon and rectum and corpus uterine tumors, showing increases of 2.45%, 1.67% and 0.78%, respectively. In males, Catalonia showed lower annual incidence rates than the remaining European regions in 1985 and higher rates in 2002. In females, rates remained lower than in other European regions. In Catalonia, the number of incident cancers increased because of population growth and aging, greater exposure to risk factors and, for some cancer types, higher detection rates. Overall cancer incidence trends followed a similar pattern to those of southern Europe, with higher increases than in the remaining European regions, especially in males.
    Medicina Clínica 11/2008; 131 Suppl 1:11-8. · 1.25 Impact Factor
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    ABSTRACT: The objectives of this study were to calculate the incidence of cancer in Catalonia for the period 1998-2002 using incidence data from the areas covered by population-based cancer registries in Catalonia (Tarragona and Gerona), to analyze the similarities and differences in the geographic patterns of cancer incidence between the two areas, and to analyze the cancer incidence calculated for Catalonia in the European context. The average annual number of new cancer cases (except for non-melanoma or in situ skin cancer) estimated for Catalonia as whole during the period 1998-2002 was 29,062 (16,984 in males and 12,078 in females). The most frequent tumor in males was prostate cancer (18.0% of the total in males) followed by lung cancer (16.1%) and colorectal cancer (13.9%). In females, the most frequent type of cancer was breast cancer (28.1% of the total in women) followed by colorectal (15.2%) and uterine corpus cancers (6.1%). The incidence of cancer in males was slightly higher in Gerona, mainly due to a higher incidence of prostate and lung cancers. Similar rates were observed for females in both geographic areas. These differences could be attributed to a distinct prevalence in the risk factors and/or differences in access to and utilization of preventive diagnostic services. In the European context, the incidence of cancer in Catalan males is in fourth place, whereas the incidence of cancer in Catalan females is one of the lowest.
    Medicina Clínica 11/2008; 131 Suppl 1:4-10. · 1.25 Impact Factor
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    ABSTRACT: Heterozygous carriers of ATM (ataxia telangiectasia mutated gene) mutations have increased risk of breast cancer (BC). We have estimated the prevalence of mutations in the ATM gene among Spanish patients with early-onset BC. Forty-three patients diagnosed with BC before the age of 46 years, and negative for BRCA1 and BRCA2 mutations, were analysed for the presence of ATM mutations. A total of 34 ATM sequence variants were detected: 1 deleterious mutation, 10 unclassified variants and 23 polymorphisms. One patient (2.3%) carried the ATM deleterious mutation (3802delG that causes ataxia telangiectasia in the homozygous state) and 13 patients carried the 10 ATM unclassified variants. The truncating mutation 3802delG and eight of the rare variants were not detected in a control group of 150 individuals. Different bioinformatic sequence analysis tools were used to evaluate the effects of the unclassified ATM changes on RNA splicing and function protein. This in silico analysis predicted that the missense variants 7653 T>C and 8156 G>A could alter the splicing by disrupting an exonic splicing enhancer motif and the 3763 T>G, 6314 G>C, and 8156 G>A variants would affect the ATM protein function. These are the initial results concerning the prevalence of germline mutations in the ATM gene among BC cases in a Spanish population, and they suggest that ATM mutations can confer increased susceptibility to early-onset BC.
    Clinical Genetics 06/2008; 73(5):465-73. · 3.65 Impact Factor
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    ABSTRACT: The reaction of 2,4,6-tris(pyridyl)-1,3,5-triazine (ptz) and copper(II) salts in DMF–water (4:1) resulted in the hydrolysis of ptz, giving rise to the bis(2-pyridylcarbonyl)amide anion (ptO2-) and affording the complexes [Cu(ptO2)(2-Clbenz)(H2O)] (1), [Cu(ptO2)(3-Clbenz)] (2), and [Cu(ptO2)(4-Clbenz)(DMF)] (3). This report includes the chemical and spectroscopic characterization of all these compounds along with the crystal structures of the Cu(II) complexes thus formed. The coordination spheres of Cu(II) in 1 and 3 are best described as distorted square based pyramidal, while for 2 the coordination sphere is distorted square planar.
    Polyhedron 10/2007; 26(17):5009-5015. · 2.05 Impact Factor
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    ABSTRACT: A new dinuclear copper(II) complex has been synthesized and structurally characterized: [Cu(mu-ade)(tolSO3)(phen)]2.2H2O (Hade = adenine, tolSO3- = toluenesulfonate anion). Its magnetic properties and electronic paramagnetic resonance (EPR) spectra have been studied in detail. The compound has two metal centers bridged by two adeninate NCN groups. The coordination geometry of the copper(II) ions in the dinuclear entity is distorted square pyramidal, with the four equatorial positions occupied by two phenanthroline N atoms and two N atoms from different adenine molecules. The axial position is occupied by one sulfonate O atom. Magnetic susceptibility data show antiferromagnetic behavior with an estimated exchange constant of -2J = 65 cm-1. The EPR spectrum has been obtained at both X- and Q-band frequencies; a study at different temperatures has been carried out at the latter. Above 20 K, the Q-band spectra are characteristic of S = 1 species with a small zero-field splitting parameter (D = 0.0970 cm-1). A detailed study of the DNA-complex interaction has been performed. The title complex efficiently cleaves the pUC18 plasmid in the presence of reducing agents. Both the kinetics and the mechanism of the cleavage reaction are examined and described herein.
    Inorganic Chemistry 09/2007; 46(17):7178-88. · 4.79 Impact Factor
  • L. Soto, A. Sancho, J. Borrás
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    ABSTRACT: The complexes formed between Cu(II) ions and Cimetidine (CM) in solution have been investigated by means of potentiometric titration, spectrophotometry and electron spin resonance spectroscopy. The stability constants of Cu(CM)2+ and Cu(CM)22+ are 1g β1 = 4.05±0.03 and 1g β2 = 8.47 ± 0.02 respectively. Based on the σ(S) → Cu(II), πN(ImH) → Cu(II) LMCT frequencies and values of the stability constants we propose a bidentate behaviour of the CM through the N(ImH) and S(thioether) donor atoms.
    Synthesis and Reactivity in Inorganic and Metal-Organic Chemistry 12/2006; 16(5):595-606.
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    ABSTRACT: NaCuL2(OH).1,5H2O, KCuP2(OH).1H2O, Na2CuL4 and K2CuP4-8H2O (HL=Phenobarbitone and HP=Methyl Phenobarbitone) were prepared and characterized by elemental analysis, IR and electronic spectral data and magnetic susceptibility measurements. The ESR spectra show and octahedral environment for the Cu(II) ion.
    Synthesis and Reactivity in Inorganic and Metal-Organic Chemistry 12/2006; 14(8):1099-1109.
  • J. A. Real, J. Borras
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    ABSTRACT: Complexes of types MBx(ClO4)2nH2O (where x=2, M=Mn(II), Co(II) Ni(II), Cu(II) and Zn(II); x=3, M=Fe(II)) and MBxSO4nH2O (where x=2, M=Mn(II), Co(II), Ni(II) and Zn(II);x=1, M=Cu(II) and x=3, M=Fe(II)) (B is 7-Bromo-1,3-dihydro-5-(2-pyridil)-2H-1,4-benzodiazepine-2-one) have been synthesized and characterized on the basis of elemental analysis, IR, electronic and NMR spectra and magnetic measurements.These studies suggest for all derivatives a pseudo-octahedral structure.However, the very strong distortion to square-planar environment takes place in the Co(II) and Ni(II) derivatives. The Sulphate group shows Td, C3v and C2v behaviour in these complexes.
    Synthesis and Reactivity in Inorganic and Metal-Organic Chemistry 12/2006; 14(6):857-868.
  • M. C. Mollá, J. Garcia, J. Borras
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    ABSTRACT: Compounds of Co(II); Ni(II); Cu(II) and Zn(II) perchlorates chlorides and sulphates with 4-methoxy-2-(5-methoxy-3-methyl-pyrazol-1-yl)-6-methyl-pyrimidine are reported. The compounds are: M(L)3 (C104)2 (M=Co, Ni), Zn(L)2(C104)2.H2O, M(L)Cl2 (M=Co, Cu, Zn) and M(L)SO4.x H2O (M=Co, Cu, Zn).
    Synthesis and Reactivity in Inorganic and Metal-Organic Chemistry. 12/2006; 15(5):553-561.
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    ABSTRACT: To evaluate the cosmetic outcome of breast conservative therapy and to examine the degree of agreement between the patients' and oncologists' ratings. We also analyze the influence of several factors on cosmesis. We retrospectively evaluated 145 patients with primary breast cancer treated by local excision and radiotherapy between January 2000 and May 2001. Cosmetic outcome was evaluated by doctors and patients and was scored as excellent, good, fair or poor. 73% of patients rated cosmesis as excellent or good while the percentage was 71% when rated by radiation oncologists. The degree of cosmesis concordance evaluated by oncologists and patients was low (kappa = 0.3). In our study the variables which significantly influence on the cosmetic outcome were concomitant adjuvant chemotherapy (p = 0.04) and radiation therapy boost, either by electron beam or brachytherapy (p = 0.013). The cosmetic outcome of breast conserving therapy was good. There was a similar rating by the patient and radiation oncologist, but the level of concordance between patients and doctors was low. Factors that significantly influence the cosmesis appear to be concomitant adjuvant chemotherapy and radiation therapy boost.
    Clinical and Translational Oncology 06/2006; 8(5):334-8. · 1.60 Impact Factor
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    ABSTRACT: A new dinuclear copper(II) complex has been synthesised and structurally characterised: [Cu2(tz-ben)4] (Htz-ben = N-thiazol-2-yl-benzenesulfonamide). Its crystal structure, magnetic properties and electronic paramagnetic resonance (EPR) spectra were studied in detail. In the compound the metal centres are bridged by four non-linear triatomic NCN groups. The coordination geometry of the copper ions in the dinuclear entity is distorted square pyramidal (4+1). Two thiazole N and two sulfonamido N atoms occupy the equatorial positions and one sulfonamido O atom is in the axial position. Magnetic susceptibility data show a strong antiferromagnetic coupling, -2J = 114.1 cm(-1). The EPR spectra of a polycrystalline sample of compound has been obtained at the X- and Q-band frequencies at different temperatures. Above 20K the spectra are characteristic of S = 1 species with a zero field splitting parameter D = 0.4 cm(-1). The EPR parameters are discussed in terms of the known binuclear structures. The chemical nuclease ability of the title complex and that of the related [Cu2(tz-tol)4] compound (Htz-tol = N-thiazol-2-yl-toluenesulfonamide) is reported. The participation of hydroxyl radicals and a singlet oxygen-like entity in the DNA cleavage reaction has been deduced from the assays with radical oxygen scavengers.
    Journal of Inorganic Biochemistry 02/2006; 100(1):70-9. · 3.27 Impact Factor
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    ABSTRACT: Reactions between different copper(II) salts and 2-pyridineformamide thiosemicarbazone (HAm4DH) in neutral ethanolic media led to the formation of complexes with the formulae [Cu(HAm4DH)X2] (X = Cl or Br) (1, 2) and [Cu(HAm4DH)2]X2 (X = NO3 or ClO4) (3, 4). The same reactions carried out in the presence of triethylamine gave rise to new complexes with the general formulae [Cu(Am4DH)X] (X = Cl, Br, AcO, or NO3) (5–8), [Cu(H2O)(Am4DH)](ClO4) (9), and [Cu(Am4DH)2] (10), many of which were isolated with different molecules of crystallization and contain a deprotonated thiosemicarbazone (Am4DH). These complexes were characterized by elemental analysis, and different spectroscopic and magnetic techniques. The thermal and redox behavior of the complexes was also evaluated. Complexes 1, 2, 5, and 6 show better nuclease activity than [Cu(phen)2]2+. Inaddition, crystals were isolated in the cases of [Cu(HAm4DH)Cl2]2 (5a), 1∞[Cu(Am4DH)Cl] (5b), 1∞[Cu(Am4DH)Br] (6a), and [Cu(HAm4DH)(H2O)(ClO4)2]·MeOH·H2O (9a) and these structures were analyzed by X-ray diffraction. Compound 5a has a dimeric structure with chlorine bridges and shows weak antiferromagnetism (J = –12.2 cm–1). Complexes 5b and 6a are one-dimensional polymers formed through halogen bridges and the deprotonated thiosemicarbazone in the thiolate form. In compound 9a the copper(II) is in a distorted octahedral environment with two ClO4 units coordinated to the metal center. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)
    Berichte der deutschen chemischen Gesellschaft 01/2006; 2006(6):1231 - 1244. · 2.97 Impact Factor
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    ABSTRACT: Four new dinuclear copper(II) complexes have been synthesized and have the general formula [Cu2(L)(H2O)2], where L = GLYDTO [N,N′-bis(carboxymethyl)dithiooxamide], ALADTO [N,N′-bis(carboxyethyl)dithiooxamide], VALDTO [N,N′-bis(1-carboxy-2-methylpropyl)dithiooxamide] and LEUDTO [N,N′-bis(1-carboxy-3-methylbutyl)dithiooxamide]. The complexes were characterized by elemental analysis as well as by IR, electronic and EPR spectroscopy. These techniques provided evidence for the presence of the CuNO2S chromophore. Magnetic susceptibility measurements on all the complexes in the range 4–300 K show the existence of a dominant antiferromagnetic interaction with −J values greater than 300 cm−1. Thermal decomposition behaviour of the complexes was studied by thermogravimetry.
    Zeitschrift für anorganische Chemie 08/2005; 631(11):2221 - 2226. · 1.25 Impact Factor
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    ABSTRACT: Reaction between benzoguanamine (2,4-diamino-6-phenyl-1,3,5-triazine) and 2-mesitylenesulfonyl chloride leads to formation of a sulfonamide able to form two mononuclear Cu(II) complexes with a CuL(2) stoichiometry. The local environment of the metal cation is a distorted octahedron, with two ligands and two solvent molecules; both complexes crystallize in the monoclinic structure, space group P2(1), with Z=2. In the presence of ascorbate/H(2)O(2,) the two complexes significantly cleavage double-strand pUC18 DNA plasmid. Both complexes exhibit more nuclease efficiency that the copper phenantroline complex. From scavenging reactive oxygen studies we conclude that the hydroxyl radical and a singlet oxygen-like entity, such a peroxide copper complex, are the radical species involved in the DNA damage.
    Journal of Inorganic Biochemistry 08/2005; 99(7):1441-8. · 3.27 Impact Factor

Publication Stats

2k Citations
243.40 Total Impact Points

Institutions

  • 1987–2011
    • Hospital Universitari Sant Joan de Reus
      Reus, Catalonia, Spain
  • 1983–2010
    • University of Valencia
      • • Departamento de Química Inorgánica
      • • Facultad de Farmacia
      Burjassot, Valencia, Spain
  • 2008
    • IDIBGI Girona Biomedical Research Institute
      Girona, Catalonia, Spain
    • Hospital Universitari de Girona Dr. Josep Trueta
      Girona, Catalonia, Spain
  • 2002
    • University of Santiago de Compostela
      • Department of Inorganic Chemistry
      Santiago, Galicia, Spain
  • 2001–2002
    • Universidad de Salamanca
      • Departamento de Química Inorgánica
      Salamanca, Castile and Leon, Spain
  • 2000
    • Hospital Clínic de Barcelona
      Barcino, Catalonia, Spain
    • Hospital Sant Joan de Déu
      • Servicio de Oncología
      Barcelona, Catalonia, Spain
  • 1999
    • Institut Català d'Oncologia
      Barcino, Catalonia, Spain
  • 1989
    • Universidad de Valladolid
      Valladolid, Castille and León, Spain