I V Sorokina

Publications (36)7.33 Total impact

• Article: Correction of Drug-Induced Hepatotoxicity with New Triterpene Derivatives in Transplanted RLS Lymphoma.

  N A Zhukova, D E Semenov, E P Bessergeneva, I V Sorokina, T G Tolstikova
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  ABSTRACT: The hepatoprotective effects of new triterpene derivatives, betulin 3β,28-di-O-nicotinate (of3) and 3,20-dioximino-29-norlup-28-ic acid methyl ester (of15), were studied in CBA/Lac mice with transplanted RLS lymphoma receiving polychemotherapy and without it. Injection of of3 and of15 agents to animals with tumors receiving polychemotherapy reduced the severity of toxic involvement of the liver, reduced mitotic activity of tumor cells in the primary node in animals receiving and not polychemotherapy, and produced a moderate antitumor effect. These effects were more pronounced for of15 agent. In addition, injection of agents of3 and of5 to animals with transplanted RLS lymphoma reduced the intensity of alterations associated with the total systems and local effects of the neoplastic process.
  Bulletin of Experimental Biology and Medicine 12/2012; 154(3):370-374. · 0.27 Impact Factor
• Article: Effect of triterpene derivatives on the total hepatocyte count in the liver of rats with toxic hepatitis.

  D E Semenov, N A Zhukova, E P Bessergeneva, I V Sorokina, D S Baev, B M Glukhov, G I Nepomnyaschikh, T G Tolstikova
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  ABSTRACT: We studied hepatoprotective activity of betulonic acid and its alaninamide on the model of combined CCl(4)- and ethanol-induced toxic liver damage in rats. The test substances, especially betulonic acid alaninamide, considerably reduced the elevated biochemical parameters in animals with toxic liver damage. Betulonic acid alaninamide also stimulated reparative processes in the liver (activated hepatocyte proliferation). Heptral (reference drug) produced no appreciable effects on the reparative processes. Our findings suggest that betulin derivatives exhibit pronounced protective properties.
  Bulletin of Experimental Biology and Medicine 10/2012; 153(6):858-61. · 0.27 Impact Factor
• Article: Structure of the liver in mice with transplanted Lewis carcinoma during polychemotherapy and correction with betulonic acid and its derivatives.

  N A Zhukova, I V Sorokina, T G Tolstikova, E L Lushnikova, L M Nepomnyashih, D E Semenov
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  ABSTRACT: Morphological and morphometric studies of the liver with transplanted Lewis carcinoma were performed after polychemotherapy and correction with betulonic and [3-oxo-20(29)-lupene-28-oil]-3-aminopropionic acids and their methyl esters. It was demonstrated than betulonic and [3-oxo-20(29)-lupene-28-oil]-3-aminopropionic acids reduced the degree of degenerative changes and volume density of necrotic changes in hepatocytes after polychemotherapy. Methyl esters of these acids little changed the severity and spreading of destructive and necrotic changes in the liver caused by complex cytostatic therapy. It was also shown that all studied triterpenoids exhibited more pronounced antimetastatic effect (evaluated by the decrease in volume density of liver metastases) compared to polychemotherapy.
  Bulletin of Experimental Biology and Medicine 07/2010; 150(1):96-9. · 0.27 Impact Factor
• Article: Solification with Hydrobromic Acid as a Factor Defining the Antiarrhythmic Effect of Lappaconitine Derivatives

  T. G. Tolstikova, A. O. Bryzgalov, I. V. Sorokina, S. A. Osadchii, E. E. Shults, M. P. Dolgikh, M. V. Khvostov
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  ABSTRACT: Alkaloid lappaconitine (I) and its derivatives - N(20)-deethyllappaconitine (II) and 5'-bromolappaconitine (III) in the base form and as salts - hydrochloride (I•HCl), hydrobromide (preparation allapinine) (I•HBr), hydrobromide (II•HBr), hydrobromide (III•HBr), succinate (I•Suc) were taken for research of pharmacology activity. Moreover, pharmacology activity was investigated for a clathrates of lappaconitine - the bases, hydrochloride and hydrobromide with glycyrrhizic acid (IV) (I-IV; I•HCl-IV; I•HBr-IV). It is shown that, neither the base nor the salts, with the exception for hydrobromide, possess antiarrhythmic action on any of the models. Among glycyrrhizic acid clathrates, only the clathrate with hydrobromide of lappaconitine (I•HBr-IV) has a high activity on the two models of arrhythmia.
  Letters in Drug Design &amp Discovery 09/2009; 6(7):475-477. · 0.87 Impact Factor
• Article: Antiulcer activity of preparations containing ultralow doses of antibodies in modeled chronic ulcer in rats.

  T G Tolstikova, N A Zhukova, I V Sorokina, M P Dolgikh, T V Ogorodnikova, M V Borodavkina, Yu L Dugina, S A Sergeeva
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  ABSTRACT: Screening of three potential antiulcer preparations containing ultralow doses of antibodies to endogenous regulators of ulcer formation (gastrin, histamine, and H2 histamine receptors) on the model of acetic acid-induced gastric ulcer in rats revealed pronounced antiulcer effect of ultralow doses of antibodies to histamine. The dynamics of regeneration of the ulcer focus by morphological and histological characteristics was similar during treatment with ultralow doses of antibodies to histamine and with famotidine.
  Bulletin of Experimental Biology and Medicine 09/2009; 148(3):540-2. · 0.27 Impact Factor
• Article: Cardiomyocyte count in rat myocardium under the effect of antitumor agents cyclophosphamide and triterpenoids.

  E L Lushnikova, T G Tolstikova, L M Nepomnyashchikh, M G Klinnikova, O P Molodykh, E A Sviridov, I V Sorokina, N A Zhukova
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  ABSTRACT: Structural reorganization of the myocardium in response to antitumor agents (cyclophosphamide, betulonic acid and its amide) was studied. Cardiotoxic effects of these chemicals manifested in cardiomyocyte contracture and lytic injuries and by significant hemodynamic disorders. The most pronounced lytic and necrobiotic changes in cardiomyocytes were detected after injection of cyclophosphamide followed by betulonic amide; this led to a more pronounced decrease in heart weight as a result of a decrease in total cardiomyocyte count. Antitumor drugs differently changed the ratio of mono- to binuclear cardiomyocytes, which differ by their regeneratory and compensatory adaptive potential.
  Bulletin of Experimental Biology and Medicine 10/2007; 144(3):355-61. · 0.27 Impact Factor
• Article: Antiarrhythmic activity of n-tyrosol during acute myocardial ischemia and reperfusion.

  G A Chernyshova, M B Plotnikov, V I Smol'yakova, I V Golubeva, O I Aliev, T G Tolstikova, A P Krysin, I V Sorokina
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  ABSTRACT: Antiarrhythmic activity of n-tyrosol was demonstrated on the model of early occlusion and reperfusion arrhythmia. The preparation reduces the incidence of ventricular tachycardia and fibrillation, increases the percent of animals without ventricular arrhythmia, and moderates the severity of developing ventricular arrhythmias.
  Bulletin of Experimental Biology and Medicine 07/2007; 143(6):689-91. · 0.27 Impact Factor
• Article: Increase in Pharmacological Activity of Drugs in their Clathrates with Plant Glycosides

  T. G. Tolstikova, A. O. Bryzgalov, I. V. Sorokina, M. V. Hvostov, A. S. Ratushnyak, T. A. Zapara, O. G. Simonova
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  ABSTRACT: The effect of pharmacones clathration with glycosides results in significant decrease of drug agent dosage. We investigated the clathrates of hypotensive agent Nifedipine with glycyrrhizic acid, which was prepared in molecular proportion 1:4 respectively. Present study was carried out on the calcium channels on neurons of Lymnaea stagnalis mollusc.
  Letters in Drug Design &amp Discovery 03/2007; 4(3):168-170. · 0.87 Impact Factor
• Article: Effect of n-tyrosol on blood viscosity and platelet aggregation.

  M B Plotnikov, G A Chernysheva, V I Smol'yakova, M Yu Maslov, I V Cherkashina, A P Krysin, I V Sorokina, T G Tolstikova
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  ABSTRACT: Experiments on rats showed that n-tyrosol limited the increase in blood viscosity during thermal exposure at a shear rate of 5-300 sec(-1) and inhibited ADP-induced platelet aggregation. The effects of n-tyrosol are comparable to that of pentoxyphylline.
  Bulletin of Experimental Biology and Medicine 02/2007; 143(1):61-3. · 0.27 Impact Factor
• Article: Formation of salts with hydrobromic acid determines the antiarrhythmic effect of lappaconitine derivatives

  T. G. Tolstikova, A. O. Bryzgalov, I. V. Sorokina, M. P. Dolgikh, E. E. Shul’ts, S. A. Osadchii, G. A. Tolstikov
  Doklady Biological Sciences 01/2007; 415(1):265-266.
• Article: Antitumor and antimetastatic effects of betulonic acid amides in mice with transplantable lewis carcinoma.

  I V Sorokina, T G Tolstikova, N A Zhukova, N I Petrenko, N V Uzenkova, E E Shul'ts, N A Popova
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  ABSTRACT: We studied the effects of four synthetic amides of betulonic acid containing amino acid fragments (d,l-alpha-alanine, beta-alanine, and their methyl esters) on the rate of growth and metastatic dissemination of transplantable Lewis lung carcinoma in C57Bl/6 mice. The test compounds were administered intragastrically in a single dose of 500 mg/kg. 3-[-oxo-20(29)-lupen-28-oilamino]-propionic acid suppressed primary tumor growth (by 26%) and decreased the number of lung metastases (by more than 2 times). Antitumor and antimetastatic activity of triterpenoids decreased after methylation of the amino acid fragment in betulonic acid.
  Bulletin of Experimental Biology and Medicine 08/2006; 142(1):69-72. · 0.27 Impact Factor
• Article: Antitumor and antimetastatic effects of betulonic acid amides in mice with transplantable Lewis carcinoma

  I. V. Sorokina, T. G. Tolstikova, N. A. Zhukova, N. I. Petrenko, N. V. Uzenkova, E. E. Shul’ts, N. A. Popova
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  ABSTRACT: We studied the effects of four synthetic amides of betulonic acid containing amino acid fragments (d,l-α-alanine, β-alanine, and their methyl esters) on the rate of growth and metastatic dissemination of transplantable Lewis lung carcinoma in C57Bl/6 mice. The test compounds were administered intragastrically in a single dose of 500 mg/kg. 3-[-oxo-20(29)-lupen-28-oilamino]-propionic acid suppressed primary tumor growth (by 26%) and decreased the number of lung metastases (by more than 2 times). Antitumor and antimetastatic activity of triterpenoids decreased after methylation of the amino acid fragment in betulonic acid.
  Bulletin of Experimental Biology and Medicine 06/2006; 142(1):69-72. · 0.27 Impact Factor
• Article: The effects of fluoxetine and its complexes with glycerrhizic acid on behavior in rats and brain monoamine levels.

  G T Shishkina, N N Dygalo, A M Yudina, T S Kalinina, T G Tolstikova, I V Sorokina, I L Kovalenko, L V Anikina
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  ABSTRACT: The effects of the serotonin reuptake inhibitor fluoxetine (FL) and its complexes with glycyrrhizic acid (GA) in molar ratios of 1:1 (FLG-1) and 4:1 (FLG-4) on the behavior of adult rats were studied in an elevated cross maze, with measurement of brain monoamine and monamine metabolite levels. Agents were given via the intragastric route using a cannula at a dose of 25 mg/kg 1 h before testing. FL increased anxiety in the rats and decreased their movement activity; FLG-1 and FLG-4 had no effect on behavior. None of the agents affected brain serotonin content, though all decreased the levels of its metabolite 5-hydroxyindoleacetic acid in the hypothalamus, FLG-4 also decreasing this in the cortex. Noradrenaline levels in the hypothalamus were increased after FLG-1 and FLG-4. In the striatum, FL increased the levels of dopamine and its metabolite dihydroxyphenylacetic acid but had no effect on the level of transmitter catabolism. Unlike FL, FLG-1 activated dopamine metabolism in the striatum. Overall, use of FL complexed with GA significantly modified its behavioral effects, which appears to be associated with the effects of FL and its complexes on the function of the monoaminergic systems involved in controlling behavior.
  Neuroscience and Behavioral Physiology 06/2006; 36(4):329-33.
• Article: Effect of betulonic acid and its derivative [3-oxo-20(29)-lupene-28-oyl]-3-aminopropionic acid on liver structure in mice with RLS lymphoma.

  N A Zhukova, D E Semenov, I V Sorokina, T G Tolstikova, S V Pozdnyakova, O R Grek
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  ABSTRACT: Morphological study of the effects of semisynthetic derivatives of betulin (betulonic acid and [3-oxo-20(29)-lupene-28-oyl]-3-aminopropionic acid) on the liver of CBA/Lac mice with transplanted RLS lymphoma was studied in the control and after cytostatic polychemotherapy. The number of small focal necroses decreased, while the counts of hepatocytes in a state of slight hyaline droplet degeneration increased. Morphometry of the main elements of liver parenchyma showed that alanine amide derivative of betulonic acid decreases the severity of necrotic and degenerative changes in the liver parenchyma, induced by cytostatic polychemotherapy. Betulonic acid exhibited no appreciable hepatoprotective effect under these conditions.
  Bulletin of Experimental Biology and Medicine 10/2005; 140(3):361-4. · 0.27 Impact Factor
• Article: Synthesis and Pharmacological Activity of the Oxidized Fractions of Arabinogalactan from Siberian Larch (Larix sibirica L.)

  R. Kh. Mudarisova, E. N. Shirokova, L. A. Badykova, I. M. Borisov, T. G. Tolstikova, I. V. Sorokina, M. P. Dolgikh, Yu. B. Monakov
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  ABSTRACT: Aqueous solutions of arabinogalactan from Siberian larch (Larix sibirica L.) were subjected to oxidative destruction by a hydrogen peroxide – molecular oxygen system. The obtained high- and low-molecular-weight fractions of oxidation products were characterized by chemical and spectral methods and tested for pharmacological activity. The results of experiments on animals showed evidence for significant antiulcer and antiinflammatory properties of the preparations studied.
  Pharmaceutical Chemistry Journal 07/2005; 39(8):418-421. · 0.37 Impact Factor
• Article: Neurotropic activity of lambertianic acid adducts with N-substituted maleinimides

  T. G. Tolstikova, I. V. Sorokina, M. P. Dolgikh, Yu. V. Kharitonov, S. V. Chernov, É. É. Shul’ts, G. A. Tolstikov
  Pharmaceutical Chemistry Journal 09/2004; 38(10):532-534. · 0.37 Impact Factor
• Source

  Available from: nsc.ru

  Article: Ethological analysis of the effects of fluoglyzine on mice exposed to chronic social stress.

  D F Avgustinovich, I L Kovalenko, I V Sorokina, T G Tolstikova, A G Tolstikov
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  ABSTRACT: Ethological study of a new agent fluoglyzine (fluoxetine analog) was carried out. Porsolt test revealed a positive antidepressant effect of fluoglyzine in mice with pronounced depression-like state. This effect was more pronounced than the effect of fluoxetine. Both drugs effectively improved communicative activity of experimental animals. Anxiety tests showed no anxiolytic effects of fluoglyzine and fluoxetine.
  Bulletin of Experimental Biology and Medicine 02/2004; 137(1):86-9. · 0.27 Impact Factor
• Article: Ethological Analysis of the Effects of Fluoglyzine on Mice Exposed to Chronic Social Stress

  D.F. Avgustinovich, I.L. Kovalenko, I.V. Sorokina, T.G. Tolstikova, A.G. Tolstikov
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  ABSTRACT: Ethological study of a new agent fluoglyzine (fluoxetine analog) was carried out. Porsolt test revealed a positive antidepressant effect of fluoglyzine in mice with pronounced depression-like state. This effect was more pronounced than the effect of fluoxetine. Both drugs effectively improved communicative activity of experimental animals. Anxiety tests showed no anxiolytic effects of fluoglyzine and fluoxetine.
  Bulletin of Experimental Biology and Medicine 12/2003; 137(1):86-89. · 0.27 Impact Factor
• Source

  Available from: nsc.ru

  Article: Changes in blood biochemistry in mice during development of experimental depression.

  D F Avgustinovich, I L Kovalenko, I V Sorokina, T G Tolstikova
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  ABSTRACT: Biochemical parameters of the plasma were studied in mice at different stages of the development of depression-like states in males after social defeats in 10 and 20 intermale confrontations (T10 and T20 victims, respectively). Glucose and cholesterol levels were increased in T10 victims in comparison with intact animals. In T20 victims the increase in glucose level was paralleled by an increase in total protein. T20 victims differed from T10 victims by lower catalase activity.
  Bulletin of Experimental Biology and Medicine 05/2003; 135(4):346-8. · 0.27 Impact Factor
• Article: Pharmacological Activity of Complexes of Nonsteroidal Antiinflammatory Drugs with Glycyrrhizic Acid Obtained by Liquid- and Solid-State Synthesis

  I. V. Sorokina, T. G. Tolstikova, M. P. Dolgikh, É. É. Shul'ts, A. V. Dushkin, L. M. Karnatovskaya, E. N. Chabueva, V. V. Boldyrev
  Pharmaceutical Chemistry Journal 12/2001; 36(1):11-13. · 0.37 Impact Factor