Publications (16)41.43 Total impact
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Article: Nephrotic syndrome as paraneoplastic manifestation of a primary pulmonary lymphoepithelioma-like carcinoma.
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ABSTRACT: We present a case of nephrotic syndrome secondary to a membranous glomerulonephritis (MG), in a nonsmoking female with a solitary pulmonary nodule, which did not show growth during 2 years of followup. A biopsy by videothoracoscopy showed a granulomatous non-neoplastic process with giant multinucleated cells. The appearance of a nephrotic syndrome and its interpretation as paraneoplastic revealed the existence of a primary pulmonary lymphoepithelioma-like carcinoma (LELC), a very rare pulmonary tumor. After resection of tumor there was a complete recovery from the nephrotic syndrome. This case highlights how the investigation of paraneoplastic syndromes can help in the early diagnosis of some malignancies.Clinical nephrology 09/2009; 72(3):206-10. · 1.17 Impact Factor -
Article: Ectopic growth hormone-releasing hormone secretion by thymic carcinoid tumour.
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ABSTRACT: The case of a 33-year-old-woman with Multiple Endocrine Neoplasia Type 1 (MEN1) syndrome and acromegaly due to ectopic growth hormone-releasing hormone (GHRH) secretion by a thymic carcinoid tumour is reported. Immunohistochemistry revealed positive immunoreactivity for GHRH, vasoactive intestinal polypeptide, somatostatin and alpha-subunit in the tumour cells. A previously undescribed new germ line mutation of the MEN1 protein gene was revealed.Clinical Endocrinology 08/2002; 57(1):131-4. · 3.17 Impact Factor -
Article: [Diffuse lymphoproliferative disease after renal transplantation and its relation with Epstein-Barr virus. Experience at one center].
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ABSTRACT: Post-transplant lymphoproliferative disorders (PTLD) are a group of heterogeneous lymphoid proliferations in chronic immunosuppressed recipients which appear to be related to Epstein Barr Virus (EBV). Receptor EBV seronegativity, use of antilymphocyte antibodies and CMV disease have been identified as risk factors that may tigger development of PTLD. We have studied the incidence of PTLD and its relationship with EBV in 588 adult renal transplant recipients who were transplanted in our hospital from 1988 to 2001. We have also evaluated the diagnostic and therapeutic methods used, the risk factors and outcome of the patients who developed PTLD. We identified 8 recipients (4 males and 4 females), range from 18 to 67 years (mean age 45.6 years) with a median time between grafting and PTLD of 4.1 years (0.1-7 years), who developed PTLD (1.3%). Only 1 patient received OKT3 and had CMV disease, two of them (25%) had been treated with hight doses of prednisolone, another was EBV seronegative, but the rest of them (50%) had no risk factors. Two patients were diagnosed at autopsy, the diagnosis of 5 was based on the histology of biopsy and the last one by CT scans of chest-abdomen and cytology. The presence of EBV in the lymphoproliferative cells was assessed in 5 out of the 7 studied patients (71.4%). The outcome of our recipients was poor. Five out of 8 patients died shortly after diagnosis as a direct consecuence of PTLD and another of an infectious complication of the treatment (75%). The 2 patients alive started dialysis and 1 of them died 2 years later of a non-related cause. In conclusion, PTLD is a relatively frequent disease with a poor prognosis in renal transplant patients. It seems to have a close relationship with EBV and can develop in the absence of the classical risk factors.Nefrologia: publicacion oficial de la Sociedad Espanola Nefrologia 02/2002; 22(5):463-9. · 1.00 Impact Factor -
Article: Malignant transient pleural transudate: a sign of early lymphatic tumoral obstruction.
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ABSTRACT: In the absence of a responsible comorbid condition, the transudative character of a pleural effusion in patients with malignancy does not imply a favorable outcome. We report a case of colon carcinoma metastatic to lung and pleura presenting as a bilateral transudative pleural effusion. Tumoral diffuse lymphatic permeation was identified as the cause of lymphatic obstruction on pleural and transbronchial biopsies. The transudative character of the pleural effusion was transient denoting its obstructive origin.Respiration 02/2000; 67(3):333-6. · 2.26 Impact Factor -
Article: [Twenty years of retrospective study of malignant paranasal sinus tumors].
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ABSTRACT: Carcinomas of the nasal cavity and paranasal sinuses represent 3% of tumors of the head and neck. Their histology and location vary widely. We reviewed the case histories of patients with malignant tumors of the nasal sinuses seen by us between 1975 and 1996, a total of 37 suitable cases. The site of origin of the tumor was the maxillary sinus in 16 cases, ethmoid sinus in 15, nasal septum in 3, nasal roof in 2, and nasal floor in 1 case. Fifty percent of the tumors were squamous cell carcinomas, 11% undifferentiated carcinomas, 13% non-squamous carcinomas, 5% melanomas, 5% olfactory neuroblastomas, 3% chondrosarcomas and 8% non-Hodgkin lymphomas. When diagnosed, one patient had carcinoma in situ, 3 stage I, 5 stage II, 12 stage III and 16 stage i.v. The cumulative survival was 63% after 3 years and 47% after 5 years.Acta Otorrinolaringológica Española 06/1998; 49(4):289-92. -
Article: Organizing pneumonia in textile printing workers: a clinical description.
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ABSTRACT: In April 1992 an outbreak of severe respiratory illness occurred among aerographic textile workers in the area of Alcoi, Autonomous Community of Valencia, Spain. An epidemiological study linked this outbreak to the use of a reformulated aerosolized product, Acramin-FWN. We analyzed clinical, laboratory, and pathological data of the first 14 patients with confirmed organizing pneumonia (OP) secondary to this newly recognized occupational toxicant. The mean age of the patients was 30 yrs. The most common clinical findings were cough (86%), epistaxis (71%), dyspnoea (64%), oppressive chest pain (57%), and crackles (50%). A restrictive functional pattern was evident in 64%. Radiographic findings consisted predominantly of patchy infiltrates in 65% and a micronodular pattern in 35%. Treatment with corticosteroids did not prevent initial progression in 11 of the 14 patients and development of irreversible respiratory failure in five patients. At necropsy, besides features of OP, interstitial fibrosis and diffuse alveolar damage were evident. A low total lung capacity, the presence of crackles at admission, and increases in the alveolar-arterial oxygen difference were predictive of death. The organizing pneumonia caused by the inhalation of Acramin-FWN is characterized by a tendency to evolve into progressive interstitial fibrosis despite the use of corticosteroids. The illness is restricted to the respiratory system and once respiratory failure has developed the prognosis is poor.European Respiratory Journal 02/1998; 11(2):265-71. · 5.89 Impact Factor -
Article: Follow-up on a transplant recipient with chromomycosis.
Nephrology Dialysis Transplantation 05/1997; 12(4):852-3. · 3.40 Impact Factor -
Article: Hepatitis C virus infection complicating lupus nephritis.
Nephrology Dialysis Transplantation 08/1996; 11(7):1342-5. · 3.40 Impact Factor -
Article: Chromomycosis in a European renal transplant recipient.
Nephrology Dialysis Transplantation 05/1996; 11(4):715-6. · 3.40 Impact Factor -
Article: [Cushing syndrome secondary to suprarenal metastasis of bronchial carcinoid tumor].
Medicina Clínica 07/1995; 105(3):118-9. · 1.38 Impact Factor -
Article: Malignant lymphoma in a patient with relapsing bronchiolitis obliterans organizing pneumonia.
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ABSTRACT: A case of relapsing bronchiolitis obliterans organizing pneumonia complicated by malignant lymphoma (four years after the diagnosis) is reported in a 58-year-old woman. To our knowledge, such an association has not been described previously in detail in the literature.Chest 01/1993; 102(6):1895-7. · 5.25 Impact Factor -
Article: Pleural effusion as manifestation of temporal arteritis.
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ABSTRACT: Two patients with temporal arteritis who presented with pleural effusion are reported. Both had an exudate that responded to prednisolone treatment.Thorax 06/1992; 47(5):398-9. · 6.84 Impact Factor -
Article: Autoantibodies against P53 protein in patients with transitional cell carcinoma of the bladder.
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ABSTRACT: Cellular accumulation and conformational changes of mutant p53 could act as immunogens for auto-antibodies (auto-Abs) generation when altered p53 from tumoral cells reaches the blood stream. Our main objective was to compare the presence and clinical implications of p53-antibodies in serum with the immunohistochemical (IHC) tissue overexpression of protein p53 in patients with transitional cell carcinoma of the bladder, evaluating their association with bladder cancer parameters and their prognostic value. The study comprised 59 patients with bladder cancer (group 1) and 15 healthy controls (group 2). Serum p53-Abs were measured by ELISA. Mutant p53 protein IHC overexpression was examined from paraffin embedded tissues using monoclonal DO-7 Ab. Serum p53-Abs were detected in 14/59 and IHC P53 was positive in 24/59 patients from group 1. All p53-Abs positive patients had IHC p53 positive tumors, but some patients with IHC positive immunoreactivity showed undetectable p53-Abs. None of the healthy controls had detectable p53-Abs. Titres of p53-Abs were associated with stage and grade. P53 overexpression was dependent on stage, grade, pattern of growth and focality. P53 Abs showed a significant prognostic value for disease free survival (p = 0.0059) and life expectancy (p < 0.0005) and for IHQ p53 for life expectancy (p = 0.0033). Patients with positive P53 Abs showed a higher probability for a shorter survival OR = 6.38 (1.77-22.99) than those who were positive for IHQ p53 OR = 4.00 (1.31-12.8) or those who were negative for p53 Abs and/or IHQ p53. The measurement of p53 Abs in serum appeared to be a simple determination which might reflect the p53 status and might help in the selection of those bladder cancer patients with a worse prognosis.Anticancer research 19(4C):3531-7. · 1.73 Impact Factor -
Article: [Neurological clinical findings as the initial manifestation of a peripheral lymphoma].
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ABSTRACT: Lymphomas of the central nervous system include primary and secondary lymphomas of Hodgkin and non-Hodgkin types. For a long time central nervous system involvement during the course of systemic non-Hodgkin lymphoma has been considered unusual, to occur late on in the disease process and usually to be located in the meninges. We describe the case of a 27 year old man initially diagnosed as having a primary cerebral lymphoma after having had repeated convulsive crises. Two months later he was found to have a retroperitoneal mass. On anatomopathological study of the mass, a peripheral T lymphoma was confirmed. Dissemination of systemic lymphomas to the central nervous system is usually seen in persons with advanced systemic disease. It is atypical to find a peripheral T lymphoma with initial clinical findings that were neurological, and even less frequent that these neurological findings were due to an intraparenchymatous lesion. In this article we describe a patient with these characteristics, and conclude that it is necessary to study patients with a diagnosis of primary cerebral lymphoma very fully to establish where the primary focus is.Revista de neurologia 29(1):42-5. · 0.65 Impact Factor -
Article: Follicular bronchiolitis: clinical and pathologic findings in six patients.
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ABSTRACT: The purpose of this study was to review our experience with patients who had a definitive diagnosis of follicular bronchiolitis (FB), and to describe in detail the clinical and pathological findings, looking for common clinical aspects that may help to identify this entity. Ours is a community 750 bed teaching hospital that acts as a tertiary referral center for several subspecialties, including thoracic surgery. Six patients with a morphological diagnosis of FB, defined by the presence of coalescent germinal centers adjacent to airways, were included. Lung biopsy was obtained by thoracotomy in all patients (2 women and 4 men, mean age 53 years). In one patient FB was associated with advanced AIDS, and in another with prolonged exposure to polyethylene-flock. In 4 patients no condition previously associated with FB was found. Five patients had a history of repeated respiratory infections, 3 patients complained of dyspnea and none had peripheral blood eosinophilia. After a mean follow-up of 25 months, 2 patients responded well to steroid therapy; 3 patients suffered symptomatic exacerbations that required an increase in the steroid dose and 1 patient was not treated with steroids. The most important contribution of this series is the description of a subset of patients with FB who were not associated with other processes. These patients present relatively homogeneous clinical and pathological pictures that do not differ greatly from secondary forms.Beiträge zur Klinik der Tuberkulose 181(6):309-19. · 1.90 Impact Factor -
Article: Hipofisitis linfocitaria: difícil diagnóstico diferencial con adenomas hipofisarios
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Institutions
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1996
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Hospital General Universitario de Alicante
Alicante, Valencia, Spain
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