Hisako Endo

Publications (4)9.91 Total impact

• Article: A case of malignant insulinoma: successful control of glycemic fluctuation by replacing octreotide injections with octreotide LAR injections.

  Masahide Okamoto, Miyako Kishimoto, Yoshihiko Takahashi, Keiichiro Osame, Hiroshi Noto, Ritsuko Yamamoto-Honda, Hiroshi Kajio, Makoto Tokuhara, Yoshihiro Edamoto, Hisako Endo, Toru Igari, Kazuo Kubota, Mitsuhiko Noda
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  ABSTRACT: A 73-year-old woman with malignant insulinoma was treated with 100 μg/day octreotide for unresected insulinoma and liver metastases. The daily administration of the drug induced hyperglycemia after dinner in addition to existing fasting hypoglycemia possibly because this drug suppressed both insulin and glucagon secretion and its blood concentration was unstable. After replacing a daily injection of octreotide with a monthly injection of octreotide long-acting repeatable (LAR), blood glucose levels stabilized within the normal range. The findings of the present study showed that octreotide LAR could be useful for the long-term treatment of unresectable insulinomas.
  Endocrine Journal 05/2013; · 2.03 Impact Factor
• Article: Severely Fluctuating Blood Glucose Levels Associated with a Somatostatin-Producing Ovarian Neuroendocrine Tumor.

  Takehiro Sugiyama, Misao Nakanishi, Kazufusa Hoshimoto, Takashi Uebanso, Kaori Inoue, Hisako Endo, Shigeki Minoura, Kazuki Yasuda, Mitsuhiko Noda
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  ABSTRACT: Context:Somatostatin-producing tumors are a rare type of neuroendocrine tumor. Their effects on blood glucose levels have been variously reported, and detailed reports have been scarce.Objective:The aim of this study was to identify the reasons for the extraordinary blood glucose fluctuations in a case with no previous history of diabetes.Patients and Methods:A 68-yr-old nondiabetic woman with an ovarian tumor was suffering from hyper- and hypoglycemia. Based on the results of an oral glucose tolerance test and continuous glucose monitoring, we speculated that the fluctuating blood glucose level was accompanied not only by a low insulin level but also by low counter-regulatory hormones levels, and that those broad hormonal suppressions were caused by a high somatostatin level produced in the ovarian tumor. We performed an oophorectomy and assessed the pathology of the tumor and changes in the blood glucose profile as well as hormonal levels postoperatively.Results:The blood glucose level was completely normalized after the oophorectomy. Insulin secretion was also normalized. Histological examination showed that the tumor comprised a mature cystic teratoma and a stromal carcinoid. Immunohistochemically, the stromal carcinoid component was positive for somatostatin. The somatostatin level was 8505 pmol/liter preoperatively, which dropped down to 71.5 pmol/liter postoperatively. We found two previous reports of somatostatin-producing ovarian neuroendocrine tumors. Somatostatin levels among cases of ovarian origin were much higher than those among cases of gastrointestinal origins, and cases of ovarian origin all experienced blood glucose fluctuations.Conclusion:Extremely high somatostatin levels and blood glucose fluctuations may be characteristics of somatostatin-producing ovarian neuroendocrine tumors.
  The Journal of clinical endocrinology and metabolism 09/2012; · 6.50 Impact Factor
• Article: A patient with diabetes and breast cancer in whom virilization was caused by a testosterone-producing mature cystic teratoma containing a Brenner tumor.

  Tetsuro Tsujimoto, Maki Takaichi, Hisako Endo, Kazuki Yasuda, Miyako Kishimoto, Hiroshi Noto, Hideto Gomibuchi, Hidemitsu Yasuda, Ritsuko Yamamoto-Honda, Yoshihiko Takahashi, Hiroshi Kajio, Hironobu Sasano, Mitsuhiko Noda
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  ABSTRACT: A 74-year-old woman with impaired glucose tolerance exhibited virilization. An examination of various hormone levels showed normal pituitary hormone and adrenal hormone levels. However, the patient's blood testosterone level was remarkably high and was suspected of having caused the virilization. An abdominal computed tomography revealed a multilocular cystoma in the left ovary with the features of a mature cystic teratoma. In addition, a chest computed tomography revealed the presence of a mass in the left breast that was subsequently diagnosed as breast cancer based on the results of a biopsy. After the simultaneous surgical resection of the ovarian and breast tumors, her blood testosterone level decreased. The mature cystic teratoma containing a Brenner tumor was considered to be responsible for the high testosterone level because of the presence of androgenic enzymes. This case is extremely rare, but the case was accurately diagnosed through a comprehensive analysis.
  The American Journal of the Medical Sciences 10/2010; 341(1):74-7. · 1.39 Impact Factor
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  Available from: tokushima-u.ac.jp

  Article: Immunohistochemical findings in the pancreatic islets of a patient with transfusional iron overload and diabetes: case report.

  Miyako Kishimoto, Hisako Endo, Shotaro Hagiwara, Akiyoshi Miwa, Mitsuhiko Noda
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  ABSTRACT: Excessive iron storage sometimes causes diabetes in patients with hemochromatosis, a disease caused by iron overloading. We performed an immunohistochemical analysis to study an autopsy case of aplastic anemia and diabetic hemochromatosis caused by frequent blood transfusions, and extensive hemosiderin deposition was observed in the liver and pancreas. The pancreatic islets of the patient and a control subject were stained to detect glucagon, insulin, and proinsulin. Significantly lower levels of immunoreactivity with both insulin antibodies and proinsulin antibodies, but not with glucagon antibodies, was observed in the islet cells in the patient's tissue than in the islet cells of the control. Hemosiderin deposition in the islets is known to be exclusively distributed in the β-cells, thus, selective iron-induced damage to the β-cells may have affected insulin synthesis and secretion and led to glucose intolerance in the patient.
  The Journal of Medical Investigation 08/2010; 57(3-4):345-9.