Hong Wang

Are you Hong Wang?

Claim your profile

Publications (2)5.07 Total impact

  • Source
    Article: Regional expression of the ADAMs in developing chicken cochlea.
    Xin Yan, Juntang Lin, Hong Wang, Annett Markus, Andreas Wree, Arndt Rolfs, Jiankai Luo
    [show abstract] [hide abstract]
    ABSTRACT: The expression patterns of five members of the ADAM (a disintegrin and metalloprotease) family including ADAM9, ADAM10, ADAM17, ADAM22, and ADAM23 were analyzed in different anatomical structures of the developing chicken cochlea by in situ hybridization and immunohistochemistry. Results show that ADAM9, ADAM10, and ADAM17 are widely expressed in the sensory epithelium of the basilar papilla, by homogene cells, spindle-shaped cells, and acoustic ganglion cells, and in the tegmentum vasculosum, each with a different pattern. ADAM22 expression is restricted to spindle-shaped cells and acoustic ganglion cells, while ADAM23 is prominently expressed by hair cells and acoustic ganglion cells. Furthermore, ADAM10 protein is coexpressed with several members of the classic cadherins, including cadherin-7, N-cadherin, and R-cadherin in distinct anatomical regions of the cochlea except for acoustic ganglion cells. The expression of the ADAMs in the developing cochlea suggests a contribution of the ADAMs to the development of distinct cochlear structures.
    Developmental Dynamics 08/2010; 239(8):2256-65. · 2.54 Impact Factor
  • Source
    Article: Cadherin expression in the developing chicken cochlea.
    Jiankai Luo, Hong Wang, Juntang Lin, Christoph Redies
    [show abstract] [hide abstract]
    ABSTRACT: In this study, we demonstrate that eight classic cadherins are differentially expressed in distinct anatomical regions of the cochlea during late stages of chicken embryonic development. Cadherin-6B is expressed in hair cells and spindle-shaped cells, while cadherin-8 mRNA is found only in supporting cells. Cadherin-11 is widely expressed not only in mesenchymal cell around the cochlea, but also in supporting cells and homogene cells. N-cadherin is found in the sensory epithelium, the neurons of the acoustic ganglion and on their neurites that target the hair cells. Three closely related cadherins (cadherin-7, cadherin-19, and cadherin-20) are expressed in a partially complementary manner in spindle-shaped cells and acoustic ganglion cells. R-cadherin is observed in homogene cells, acoustic ganglion cells, and their projections to hair cells. The expression of classic cadherins in the developing cochlea suggests a role for cadherins in the development of the cochlea.
    Developmental Dynamics 09/2007; 236(8):2331-7. · 2.54 Impact Factor
Browse more researchers