Henry Völzke

University of Greifswald, Griefswald, Mecklenburg-Vorpommern, Germany

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Publications (540)3177.42 Total impact

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    ABSTRACT: Some experts suggest that serum thyrotropin levels in the upper part of the current reference range should be considered abnormal, an approach that would reclassify many individuals as having mild hypothyroidism. Health hazards associated with such thyrotropin levels are poorly documented, but conflicting evidence suggests that thyrotropin levels in the upper part of the reference range may be associated with an increased risk of coronary heart disease (CHD). To assess the association between differences in thyroid function within the reference range and CHD risk. Individual participant data analysis of 14 cohorts with baseline examinations between July 1972 and April 2002 and with median follow-up ranging from 3.3 to 20.0 years. Participants included 55 412 individuals with serum thyrotropin levels of 0.45 to 4.49 mIU/L and no previously known thyroid or cardiovascular disease at baseline. Thyroid function as expressed by serum thyrotropin levels at baseline. Hazard ratios (HRs) of CHD mortality and CHD events according to thyrotropin levels after adjustment for age, sex, and smoking status. Among 55 412 individuals, 1813 people (3.3%) died of CHD during 643 183 person-years of follow-up. In 10 cohorts with information on both nonfatal and fatal CHD events, 4666 of 48 875 individuals (9.5%) experienced a first-time CHD event during 533 408 person-years of follow-up. For each 1-mIU/L higher thyrotropin level, the HR was 0.97 (95% CI, 0.90-1.04) for CHD mortality and 1.00 (95% CI, 0.97-1.03) for a first-time CHD event. Similarly, in analyses by categories of thyrotropin, the HRs of CHD mortality (0.94 [95% CI, 0.74-1.20]) and CHD events (0.97 [95% CI, 0.83-1.13]) were similar among participants with the highest (3.50-4.49 mIU/L) compared with the lowest (0.45-1.49 mIU/L) thyrotropin levels. Subgroup analyses by sex and age group yielded similar results. Thyrotropin levels within the reference range are not associated with risk of CHD events or CHD mortality. This finding suggests that differences in thyroid function within the population reference range do not influence the risk of CHD. Increased CHD risk does not appear to be a reason for lowering the upper thyrotropin reference limit.
    JAMA Internal Medicine 04/2015; DOI:10.1001/jamainternmed.2015.0930 · 13.25 Impact Factor
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    ABSTRACT: To determine the risk of stroke associated with subclinical hypothyroidism. Data Sources and Study Selection Published prospective cohort studies were identified through a systematic search through November 2013 without restrictions in several databases. Unpublished studies were identified through the Thyroid Studies Collaboration. We collected individual participant data (IPD) on thyroid function and stroke outcome. Euthyroidism was defined as thyrotropin (TSH) levels 0.45-4.49 mIU/L, subclinical hypothyroidism as TSH levels 4.5-19.9 mIU/L with normal thyroxin levels. Data Extraction and Synthesis We collected IPD on 47,573 adults (3451 subclinical hypothyroidism) from 17 cohorts, followed-up 1972-2014 (489,192 person-years). Age- and sex-adjusted pooled hazard ratio (HR) for participants with subclinical hypothyroidism compared to euthyroidism was 1.05 (95% CI, 0.91-1.21) for stroke events (combined fatal and non-fatal stroke) and 1.07 (95% CI, 0.80-1.42) for fatal stroke. Stratified by age, the HR for stroke events was 3.32 (95% CI, 1.25-8.80) for individuals aged 18-49 years. There was an increased risk of fatal stroke in the age groups 18-49 and 50-64 years with a HR of 4.22 (95% CI, 1.08-16.55) and 2.86 (95% CI, 1.31-6.26), respectively (p trend 0.04). We found no increased risk for those 65-79 years (HR 1.00, 95% CI, 0.86-1.18) or ≥80 years (HR 1.31, 95% CI, 0.79-2.18). There was a pattern of increased risk of fatal stroke with higher TSH concentrations. Although no overall effect of subclinical hypothyroidism on stroke could be demonstrated, an increased risk in subjects younger than 65 years and those with higher TSH concentrations was observed.
    The Journal of Clinical Endocrinology and Metabolism 04/2015; DOI:10.1210/jc.2015-1438 · 6.31 Impact Factor
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    ABSTRACT: Cutoff values for increased exercise blood pressure (BP) are not established in hypertension guidelines. The aim of the study was to assess optimal cutoff values for increased exercise BP to predict incident hypertension. Data of 661 normotensive participants (386 women) aged 25-77 years from the Study of Health in Pomerania (SHIP-1) with a 5-year follow-up were used. Exercise BP was measured at a submaximal level of 100 W and at maximum level of a symptom-limited cycle ergometry test. Cutoff values for increased exercise BP were defined at the maximum sum of sensitivity and specificity for the prediction of incident hypertension. The area under the receiver-operating characteristic curve (AUC) and net reclassification index (NRI) were calculated to investigate whether increased exercise BP adds predictive value for incident hypertension beyond established cardiovascular risk factors. In men, values of 160 mmHg (100 W level; AUC = 0.7837; NRI = 0.534, P < 0.001) and 210 mmHg (maximum level; AUC = 0.7677; NRI = 0.340, P = 0.003) were detected as optimal cutoff values for the definition of increased exercise SBP. A value of 190 mmHg (AUC = 0.8347; NRI = 0.519, P < 0.001) showed relevance for the definition of increased exercise SBP in women at the maximum level. According to our analyses, 190 and 210 mmHg are clinically relevant cutoff values for increased exercise SBP at the maximum exercise level of cycle ergometry test for women and men, respectively. In addition, for men, our analyses provided a cutoff value of 160 mmHg for increased exercise SBP at the 100 W level.
    Journal of Hypertension 03/2015; DOI:10.1097/HJH.0000000000000568 · 4.22 Impact Factor
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    ABSTRACT: Associations between thyroid diseases and depression have been described since the 1960s but there is a lack of population-based studies investigating associations of thyroid diseases with depression and anxiety defined by gold-standard methods. Thus, the aim was to investigate the association of diagnosed thyroid disorders, serum thyroid-stimulating hormone (TSH) levels, and anti-thyroid-peroxidase antibodies (TPO-abs) with depression and anxiety. We used data from 2142 individuals, who participated in the first follow-up of the Study of Health in Pomerania (SHIP-1) and in the Life-Events and Gene-Environment Interaction in Depression (LEGEND). DSM-VI diagnoses of major depression disorder and anxiety were defined using the Munich-Composite International Diagnostic Interview; the Beck depression inventory (BDI-II) was used for the assessment of current depressive symptoms. Thyroid diseases were assessed by interviews and by biomarkers and were associated with depression and anxiety using Poisson regression adjusted for age, sex, marital status, educational level, smoking status, BMI, and the log-transformed time between SHIP-1 and LEGEND. Untreated diagnosed hypothyroidism was positively associated with the BDI-II-score and with anxiety, while untreated diagnosed hyperthyroidism was significantly related to MDD during the last 12 months. Serum TSH levels and TPO-Abs were not significantly associated with depression and anxiety. In sub-analyses, distinct interactions were found between childhood maltreatment and thyroid disorders in modifying the association on depression and anxiety disorders. Our results substantiate evidence that diagnosed untreated hypothyroidism is associated with depression and anxiety, and that diagnosed untreated hyperthyroidism is associated with depression.
    Social Psychiatry and Psychiatric Epidemiology 03/2015; DOI:10.1007/s00127-015-1043-0 · 2.58 Impact Factor
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    ABSTRACT: No studies have examined the association between TSH and lipid profiles in healthy children and adolescents of the general population. To investigate the association between thyroid-stimulating hormone (TSH) and lipid profiles. We used a population-based cross-sectional study design and analyzed our results using multivariable regression models. Germany. We analyzed data from 6,622 children (ages 3-10 years) and 6,134 adolescents (ages 11-17 years) drawn from the German Health Interview and Examination Survey for Children and Adolescents (KiGGS). Not applicable. Blood samples were collected and serum TSH levels were measured using the electrochemoluminescence method. High and low serum TSH levels were defined according to age-specific reference limits for the assay. Total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglyceride levels were determined with enzymatic color analyses. We found a significant positive association between TSH and all non-HDL parameters (total cholesterol, LDL-C, and triglycerides) in children (β=0.90 [confidence interval (CI) 0.53-1.27], β=0.78 [CI 0.44-1.13], and β=0.90 [CI 0.52-1.27]), and adolescents (β=0.90 [CI 0.47-1.32], β=0.67 [CI 0.29-1.05], and β=0.92 [CI 0.49-1.35]) (p<0.05). Using stratified models, we found that this relationship was particularly present in overweight/obese children. Furthermore, high TSH levels in children were significantly associated with non-HDL parameters. Higher TSH levels are associated with less favorable lipid levels in children. Longitudinal studies are needed to clarify whether the association between TSH and lipid parameters in children and adolescents is a temporary phenomenon or is sustained into adulthood.
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    ABSTRACT: The regional prevalence of risk factors can vary over time. The Study of Health in Pomerania (SHIP) addresses prevalence trends for common risk factors in a region in northeast Germany. A longitudinal study was carried out from 1997 to 2001 (SHIP-0, with 4308 subjects), and a second, independent random sample of the population in the same region was studied from 2008 to 2012 (SHIP-Trend, with 4420 subjects). All data were standardized with post-stratification weighting derived from the adult population of the state of Mecklenburg-West Pomerania. SHIP reveals a marked decline of mean alcohol consumption in the adult population, from 5.57 g/day (95% confidence interval, 5.51-5.63) to 3.12 g/day (95% CI 3.09-3.15). The percentage of active smokers among men declined from 38.6% (95% CI 36.0-41.2) to 34.3% (95% CI 32.1-36.6). Simultaneously, however, there was a rightward shift of the BMI distribution, with a marked increase in the prevalence of obesity, from 24.7% to 32.0%. There was a corresponding increase in the prevalence of diabetes, from 9.1% to 13.8%. Compared to eleven years ago, the amount of exercise taken during free time has risen among the elderly, but fallen among young women. Tobacco and alcohol consumption have declined over the past decade, although this study may have overestimated these trends through a combination of selection bias and reporting bias. Meanwhile, the northeast German population now has a worse metabolic risk profile, as indicated by the increased prevalence of obesity and diabetes. Society as a whole must take measures to combat this trend.
    Deutsches Ärzteblatt International 03/2015; 112(11):185-92. DOI:10.3238/arztebl.2015.0185 · 3.61 Impact Factor
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    ABSTRACT: In developed countries, sclerotic and calcific degeneration of the aortic valve is a common disorder showing pathophysiologic similarities with atherothrombotic coronary disease. Light to moderate alcohol consumption has been associated with a lower risk for atherothrombotic coronary disease and mortality. Whether alcohol consumption affects the development of aortic valve sclerosis (AVS) is not well known. In the present study, we aim to analyze the cross-sectional association between average daily alcohol consumption and AVS in the general population. We analyzed cross-sectional data from 2022 men and women, aged 45 to 81 years, from the population-based Study of Health in Pomerania. We used a computer-assisted interview that included beverage-specific questions about quantity and frequency of alcohol over the last 30 days to calculate the average quantity of alcohol consumption (in grams of ethanol per day). AVS was ascertained by echocardiography. The prevalence of AVS was 32.3%. Average daily alcohol intake displayed a J-type relation with AVS (fully adjusted P value: 0.005). Compared with individuals with an average consumption of 10 g of alcohol per day, multivariable-adjusted odds ratios were 1.60 (95% confidence interval, 1.19-2.14) among current abstainers and 1.56 (95% confidence interval, 1.01-2.41) among individuals with an average consumption of 60 g per day. Our findings indicate that light to moderate alcohol consumption was associated with a lower odd of having AVS. Prospective data need to address whether alcohol consumption and related changes over time in several biological markers affect the progression of AVS. © 2015 American Heart Association, Inc.
    Arteriosclerosis Thrombosis and Vascular Biology 03/2015; DOI:10.1161/ATVBAHA.114.304831 · 5.53 Impact Factor
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    ABSTRACT: Cardiopulmonary exercise testing allows for assessment of cardiac and respiratory limitation, but is often affected by patient effort. Indices of oxygen kinetics, including the Oxygen Uptake Efficiency Slope (OUES), oxygen uptake-work-rate slope (VO2-WR slope) and the heart rate-oxygen uptake slope (HR-VO2 slope) are relatively effort independent but may be affected by patient characteristics.
    03/2015; 27. DOI:10.1016/j.ijcme.2015.02.002
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    ABSTRACT: Epidemiology aims to provide insight into disease causations. Hence, subject groups (cohorts) are analyzed to correlate the subjects' varying lifestyles, their medical properties and diseases. Recently, these cohort studies comprise medical image data. We assess potential relations between image-derived variables of the lumbar spine with lower back pain in a cross-sectional study. Therefore, an Interactive Visual Analysis (IVA) framework was created and tested with 2,540 segmented lumbar spine data sets. The segmentation results are evaluated and quantified by employing shape-describing variables, such as spine canal curvature and torsion. We analyze mutual dependencies among shape-describing variables and non-image variables, e.g., pain indi-cators. Therefore, we automatically train a decision tree classifier for each non-image variable. We provide an IVA technique to compare classifiers with a decision tree quality plot. As a first result, we conclude that image-based variables are only sufficient to describe lifestyle factors within the data. A correlation between lumbar spine shape and lower back pain could not be found with the automatically trained classifiers. How-ever, the presented approach is a valuable extension for the IVA of epidemiological data. Hence, relations between non-image variables were successfully detected and described.
    Proc. of IVAPP; 03/2015
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    ABSTRACT: AimTo examine associations of prediabetes and well controlled diabetes with periodontitis.Materials and methodsThe Study of Health in Pomerania (SHIP)-Trend is a cross-sectional survey in North-Eastern Germany including 3,086 participants (49.4% men; age 20–82 years). Clinical attachment loss (CAL) and periodontal probing depth (PPD) were assessed applying a random half-mouth protocol. The number of teeth was determined. Prediabetes comprised impaired fasting glucose and impaired glucose tolerance. Previously known diabetes was defined as well controlled if glycated hemoglobin (HbA1c) was <7.0%. Participants were categorized as follows: normal glucose tolerance (NGT), prediabetes, newly detected type 2 diabetes (T2DM), known T2DM with HbA1c<7.0%, known T2DM with HbA1c≥7.0%.ResultsPrediabetes was neither associated with mean CAL and PPD in multivariable adjusted linear regression models nor with edentulism (OR=1.09 (95%-CI: 0.69-1.71)) and number of teeth (OR=0.96 (95%-CI: 0.75-1.22), lowest quartile versus higher quartiles) in logistic regression models. Associations with mean CAL and edentulism were stronger in poorly controlled previously known diabetes than in well controlled previously known diabetes (for edentulism: OR=2.19 (95%-CI: 1.18-4.05), and OR=1.40 (95%-CI: 0.82-2.38), respectively, for comparison with NGT).Conclusions Periodontitis and edentulism were associated with poorly controlled T2DM, but not with prediabetes and well controlled diabetes.This article is protected by copyright. All rights reserved.
    Journal Of Clinical Periodontology 03/2015; DOI:10.1111/jcpe.12391 · 3.61 Impact Factor
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    ABSTRACT: Context: Antibodies against thyroid peroxidase (TPOAb) are detected in 90% of all patients with Hashimoto's thyroiditis, the most common cause of hypothyroidism. Hypothyroidism is associated with a range of adverse outcomes. The current knowledge of its genetic underpinnings is limited. Objective: To identify novel genetic variants associated with TPOAb concentrations and positivity using genome-wide association data, and to characterize their association with thyroid function and disease. Design, setting and participants: European ancestry participants of three independent prospective population-based studies: Atherosclerosis Risk In Communities study (n= 7524), Study of Health in Pomerania (n=3803) and SHIP-TREND (n=887). Exposure: Single nucleotide polymorphisms (SNPs), individually and combined into a genetic risk score (GRS). Main Outcomes: TPOAb concentrations and positivity, thyroid hormone concentrations (TSH, FT4), clinical thyroid diseases (subclinical and overt hypothyroidism, goiter) Results: Significantly associated SNPs (p<5*10(-8)) mapped into four genomic regions not previously implicated for TPOAb (RERE, extended HLA-region), and into five previously described loci. A higher GRS based on these nine SNPs showed strong and graded associations with higher TPOAb, TSH and lower FT4 concentrations (p<0.001). Compared to individuals in the lowest GRS quartile, those in the highest quartile had 1.80-fold higher odds of subclinical hypothyroidism (95% CI 1.27-2.55) and 1.89-fold higher odds of overt hypothyroidism (95% CI 1.24-2.87). Conclusion: The identification of four novel genetic loci associated with TPOAb concentrations and positivity furthers insight into the genetic underpinnings of hypothyroidism. A genetic risk score showed strong and graded associations with markers of thyroid function and disease in independent population-based studies.
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    ABSTRACT: To evaluate the association of cardiovascular risk factors with wall thickness of the ascending and descending thoracic aorta in the general population. The study included 1,176 individuals (523 women) 21-83 years old from the Study of Health in Pomerania without history of stroke or myocardial infarction. Aortic wall thickness (AWT) was determined by cine magnetic resonance imaging. The associations of AWT with the cardiovascular risk factors male sex, age, smoking, body mass index (BMI), systolic and diastolic blood pressure, hemoglobin A1c, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides were assessed by multivariable linear regression models, and interaction effects were tested. Male sex (β = .086, P < .001), age (β = .006, P < .001), and BMI (β = .013, P < .001) were positively associated with the AWT of the ascending aorta. Male sex (β = .105, P < .001), age (β = .006, P < .001), current smoker (β = .044, P = .010), BMI (β = .013, P < .001), and HDL-C (β = .057, P = .008) revealed a positive association with AWT of the descending aorta. LDL-C (β = -.024, P = .009; β = -.018, P = .010) was inversely associated with the AWT of the ascending and descending aorta, respectively. Triglyceride levels (β = .024, P = .027; β = .018, P = .024) showed a positive association with the AWT of the ascending and descending aorta, respectively, in men, but not in women. Established cardiovascular risk factors, including male sex, older age, smoking, high BMI, and high triglyceride levels, were associated with increasing thoracic AWT of the ascending and descending aorta. High HDL-C and low LDL-C levels were correlated with AWT. Copyright © 2015 SIR. Published by Elsevier Inc. All rights reserved.
    Journal of Vascular and Interventional Radiology 02/2015; 26(5). DOI:10.1016/j.jvir.2014.12.022 · 2.15 Impact Factor
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    ABSTRACT: Accumulating evidence demonstrates an important interaction between bone and energy metabolism. We aimed to study the associations of three bone turnover markers (BTM: osteocalcin, beta-crosslaps, procollagen type 1 N-terminal propeptide) as well as of 25-hydroxyvitamin D and parathyroid hormone with metabolic syndrome (MetS) or type 2 diabetes mellitus (T2DM) in a large population-based cohort. This cross-sectional study comprised 2671 adult men and women participating in the first follow-up of the population-based Study of Health in Pomerania (SHIP-1). Multivariable logistic regression analyses were performed to assess sex-specific associations between the BTMs, 25-hydroxyvitamin D or parathyroid hormone and metabolic disease. All models were adjusted for age, body mass index, smoking status, physical activity, estimated glomerular filtration rate and month of blood sampling. The models for women were further adjusted for menopausal status. Higher BTM or 25-hydroxyvitamin D concentrations were associated with significantly lower odds for metabolic disease, while there was no association between parathyroid hormone and MetS or T2DM. Our results contribute to the accumulating evidence of a cross-sectional association between high BTM or 25-hydroxyvitamin D concentrations and a lower prevalence of MetS or T2DM. Further research is necessary to evaluate the mechanisms underlying these results. Copyright © 2015 Elsevier B.V. All rights reserved.
    Nutrition, metabolism, and cardiovascular diseases: NMCD 02/2015; 25(5). DOI:10.1016/j.numecd.2015.02.002 · 3.88 Impact Factor
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    ABSTRACT: Purpose To determine the relationship between pancreatic fat content and type 2 diabetes and prediabetes. Materials and Methods From the prospective population-based Study of Health in Pomerania (SHIP), 1367 volunteers (563 men, 678 women; median age, 50 years) underwent whole-body magnetic resonance (MR) imaging at 1.5 T, which included multiecho chemical shift-encoded acquisition of the abdomen. SHIP was approved by the institutional review board, and written informed consent was obtained from all participants. The proton density fat fraction (PDFF) was calculated after correction for T1 bias, T2* bias, multipeak spectral complexity of fat, and noise bias. On the basis of oral glucose tolerance test results, participants were grouped into those with normal glucose tolerance (n = 740), those with prediabetes (n = 431), and those with confirmed type 2 diabetes but without medication (n = 70). PDFF was assessed in the pancreatic head, body, and tail. Multivariable regression analysis was conducted to investigate possible relationships of PDFF with demographic factors, behavioral factors, and laboratory data associated with the metabolic syndrome. Results In all subjects, the mean unadjusted pancreatic fat content was 4.4% (head, 4.6%; body, 4.9%; tail, 3.9%; being unequally distributed, P < .001). There was no significant difference in pancreatic PDFF among subjects with normal glucose tolerance, prediabetes, and type 2 diabetes (P = .980). Pancreatic PDFF showed a positive association with age and body mass index and a negative association with serum lipase activity (P < .001). Conclusion The presence of pancreatic fat is not related to prediabetes or diabetes, which suggests that it has little clinical relevance for an individual's glycemic status. (©) RSNA, 2015 Online supplemental material is available for this article.
    Radiology 02/2015; DOI:10.1148/radiol.15140446 · 6.21 Impact Factor
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    ABSTRACT: This study describes (i) the procedure of obtaining patients' consent for secondary data usage, (ii) the complexity of integrating data from multiple sources, and (iii) the correspondence among patients' self-reports, physician reports, routine data, hospital discharge diagnosis, and cause-of-death coding regarding stroke. Data from the first follow-up (N=3 186) of the population-based Study of Health in Pomerania (SHIP) were used. These data were combined with secondary data from the Greifswald University Hospital, the association of statutory health insurance physicians Mecklenburg-Western Pomerania, physician reports, and death certificates. Consent for using health-related information from all data sources in question was obtained from more than 90% of the SHIP participants. Follow-up data from at least one source were available for 2 747 (86%) participants. For 92 participants information about the occurrence of stroke was found in at least one data source. In 59 cases the event appeared in only one data source, in 24 cases the event was found in 2 sources, and for 9 participants 3 data sources reported on the event. Participants of a population-based cohort are highly willing to give consent for using their health-related information from secondary data sources. Yet, data integration is challenging due to considerable differences in data type, structure and coverage. © Georg Thieme Verlag KG Stuttgart · New York.
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    ABSTRACT: The highly complex structure of the human brain is strongly shaped by genetic influences1. Subcortical brain regions form circuits with cortical areas to coordinate movement2, learning, memory3 and motivation4, and altered circuits can lead to abnormal behaviour and disease2. To investigate how common genetic variants affect the structure of these brain regions, here we conduct genome-wide association studies of the volumes of seven subcortical regions and the intracranial volume derived from magnetic resonance images of 30,717 individuals from 50 cohorts. We identify five novel genetic variants influencing the volumes of the putamen and caudate nucleus. We also find stronger evidence for three loci with previously established influences on hippocampal volume5 and intracranial volume6. These variants show specific volumetric effects on brain structures rather than global effects across structures. The strongest effects were found for the putamen, where a novel intergenic locus with replicable influence on volume (rs945270; P = 1.08 × 10−33; 0.52% variance explained) showed evidence of altering the expression of the KTN1 gene in both brain and blood tissue. Variants influencing putamen volume clustered near developmental genes that regulate apoptosis, axon guidance and vesicle transport. Identification of these genetic variants provides insight into the causes of variability in human brain development, and may help to determine mechanisms of neuropsychiatric dysfunction.
    Nature 01/2015; DOI:10.1038/nature14101 · 42.35 Impact Factor
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    ABSTRACT: Research on the association between alcohol consumption and hepatic steatosis revealed conflictive results. To investigate the associations between average daily alcohol consumption and binge drinking with hepatic steatosis, and to analyse combined effects of average daily alcohol consumption and binge drinking with body mass index (BMI) on hepatic steatosis. Data from the population-based Study of Health in Pomerania (SHIP) conducted in north-east Germany comprising 4009 adults were used. Alcohol consumption was assessed by self-report. Serum carbohydrate-deficient transferrin (CDT) was analysed as biomarker for alcohol consumption. Hepatic steatosis was diagnosed by ultrasonography. Analyses revealed a dose-response relationship between average daily alcohol consumption and hepatic steatosis in men starting with a consumption of 20 g of alcohol per day [adjusted odds ratio (OR) compared to abstainers 1.53; 95% confidence interval (CI) 1.15-2.05]. Using CDT as alternative exposure variable confirmed these results. Binge drinking was associated with hepatic steatosis in men (adjusted OR of binge drinkers compared to nonbinge drinkers 1.36, 95% CI 1.06-1.74). The likelihood of having hepatic steatosis increased in men and women with increasing levels of average daily alcohol consumption in combination with overweight or obesity. Similarly, binge drinking in combination with overweight or obesity enhanced the likelihood of having hepatic steatosis. Overweight or obesity substantially enhanced the effect of high levels of average daily alcohol consumption and binge drinking on hepatic steatosis in the present study population. This finding underlines the necessity to screen for multiple risk factors in the prevention of hepatic steatosis. © 2015 John Wiley & Sons Ltd.
    Alimentary Pharmacology & Therapeutics 01/2015; 41(5). DOI:10.1111/apt.13067 · 4.55 Impact Factor
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    ABSTRACT: Epidemiology characterizes the influence of causes to disease and health conditions of defined populations. Cohort studies are population-based studies involving usually large numbers of randomly selected individuals and comprising numerous attributes, ranging from self-reported interview data to results from various medical examinations, e.g., blood and urine samples. Since recently, medical imaging has been used as an additional instrument to assess risk factors and potential prognostic information. In this chapter, we discuss such studies and how the evaluation may benefit from visual analytics. Cluster analysis to define groups, reliable image analysis of organs in medical imaging data and shape space exploration to characterize anatomical shapes are among the visual analytics tools that may enable epidemiologists to fully exploit the potential of their huge and complex data. To gain acceptance, visual analytics tools need to complement more classical epidemiologic tools, primarily hypothesis-driven statistical analysis.
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    ABSTRACT: The neuropeptide neurokinin 3 (NK3) and its receptor modulate cholinergic activity of the basal forebrain (BF) and are implicated in learning and memory. In Alzheimer’s disease the rs2765 single-nucleotide polymorphism (SNP) of the NK3 receptor-coding gene TACR3 was correlated with right hippocampus volume. Here, we studied the association of the rs2765 SNP with MRI based volumes of the BF and hippocampus in a population-based sample of 1,967 participants between 21 and 90 years of age. The rs2765 SNP was significantly associated with the most anterior BF volume corresponding to the medial septum/diagonal band, and with a significantly steeper age-related volume decline. The rs2765 SNP was not associated with other BF subvolumes or hippocampus volumes. ApoE ε4 showed no correlation with any brain volume or global cognition. Our findings in a large population based sample suggest an association of an NK3 receptor SNP with age-related decline of rostral cholinergic basal forebrain volume.
    Neurobiology of Aging 01/2015; DOI:10.1016/j.neurobiolaging.2014.12.031 · 4.85 Impact Factor
  • it - Information Technology 01/2015; 57(1):22-29.

Publication Stats

12k Citations
3,177.42 Total Impact Points

Institutions

  • 2000–2015
    • University of Greifswald
      • • Institute of Community Medicine
      • • Institute of Epidemiology and Social Medicine
      • • Center for Internal Medicine
      Griefswald, Mecklenburg-Vorpommern, Germany
  • 2013
    • University of Münster
      • Institute of Epidemiology and Social Medicine
      Muenster, North Rhine-Westphalia, Germany
    • Karolinska University Hospital
      Tukholma, Stockholm, Sweden
    • Klinik Dr. Guth Hamburg
      Hamburg, Hamburg, Germany
  • 2012
    • Helios Hanseklinikum Stralsund
      Stralsund, Mecklenburg-Vorpommern, Germany
    • Helmholtz Zentrum München
      • Institute of Epidemiology II
      München, Bavaria, Germany
    • Johns Hopkins Bloomberg School of Public Health
      Baltimore, Maryland, United States
  • 2011
    • Universität Bern
      • Department of Clinical Pharmacology and Visceral Research
      Bern, BE, Switzerland
    • University of Washington Seattle
      • Cardiovascular Health Research Unit (CHRU)
      Seattle, WA, United States
    • Albert Einstein College of Medicine
      New York City, New York, United States
  • 2010
    • Columbia University
      • Department of Epidemiology
      New York City, NY, United States
    • Johns Hopkins University
      • Welch Center for Prevention, Epidemiology, and Clinical Research
      Baltimore, Maryland, United States
    • Erasmus MC
      • Department of Epidemiology
      Rotterdam, South Holland, Netherlands
  • 2009
    • Wellcome Trust Sanger Institute
      Cambridge, England, United Kingdom
  • 2007
    • University Medical Center Schleswig-Holstein
      Kiel, Schleswig-Holstein, Germany
  • 2006
    • Charité Universitätsmedizin Berlin
      Berlín, Berlin, Germany
  • 2004
    • University of Minnesota Duluth
      Duluth, Minnesota, United States