Henry Völzke

University of Greifswald, Griefswald, Mecklenburg-Vorpommern, Germany

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Publications (489)3124.15 Total impact

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    ABSTRACT: Breast density is a risk factor associated with the development of breast cancer. Usually, breast density is assessed on two dimensional (2D) mammograms using the American College of Radiology (ACR) classification. Magnetic resonance imaging (MRI) is a non-radiation based examination method, which offers a three dimensional (3D) alternative to classical 2D mammograms. We propose a new framework for automated breast density calculation on MRI data. Our framework consists of three steps. First, a recently developed method for simultaneous intensity inhomogeneity correction and breast tissue and parenchyma segmentation is applied. Second, the obtained breast component is extracted, and the breast-air and breast-body boundaries are refined. Finally, the fibroglandular/ parenchymal tissue volume is extracted from the breast volume. The framework was tested on 37 randomly selected MR mammographies. All images were acquired on a 1.5T MR scanner using an axial, T1-weighted time-resolved angiography with stochastic trajectories sequence. The results were compared to manually obtained groundtruth. Dice's Similarity Coefficient (DSC) as well as Bland-Altman plots were used as the main tools for evaluation of similarity between automatic and manual segmentations. The average Dice's Similarity Coefficient values were 0:96+0:0172 and 0:83+0:0636 for breast and parenchymal volumes, respectively. Bland-Altman plots showed the mean bias (%) + standard deviation equal 5:36+3:9 for breast volumes and {6:9+13:14 for parenchyma volumes. The automated framework produced sufficient results and has the potential to be applied for the analysis of breast volume and breast density of numerous data in clinical and research settings.
    PLoS ONE 11/2014; 9(11). · 3.53 Impact Factor
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    ABSTRACT: The efficacy of statins, which are used commonly in primary and secondary prevention of cardiovascular diseases, shows a wide range of interindividual variability. Genetic variants of OATP1B1, a hepatic uptake transporter, can modify access of statins to its therapeutic target, thereby potentially altering drug efficacy. We studied the impact of genetic variants of OATP1B1 on the lipid-lowering efficacy of statins in a population-based setting.
    Pharmacogenetics and Genomics 11/2014; · 3.61 Impact Factor
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    IEEE Transactions on Visualization and Computer Graphics 11/2014; · 1.90 Impact Factor
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    ABSTRACT: Hypertension and obesity are highly prevalent in Western societies. We show in our study the associations of changes in body weight with changes in blood pressure, without the influence of antihypertensive medication, with a 5-year follow-up.•A loss of 5% of the baseline weight, when compared with the maintenance of the initial weight, resulted in a reduced relative risk of incident hypertension of 0.84 and incident cardiovascular events of 0.81 as well a 15% chance of incident blood pressure normalization in patients who were hypertensive at baseline.•Our findings support previous evidence that lifestyle modifications have an impact on blood pressure and reinforce that weight reduction is an important objective for primary prevention of cardiovascular events in the general population.
    Nutrition, Metabolism and Cardiovascular Diseases. 10/2014;
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    ABSTRACT: Context During the last two decades it became obvious that 3,5-diiodothyronine (3,5-T2), a well-known endogenous metabolite of the thyroid hormones thyroxine (T4) or triiodothyronine (T3), not only represents a simple degradation intermediate of the former but also exhibits specific metabolic activities. Administration of 3,5-T2 to hypothyroid rodents rapidly stimulated their basal metabolic rate, prevented high fat diet-induced obesity as well as steatosis and increased oxidation of long-chain fatty acids. Objective The aim of the present study was to analyze associations between circulating 3,5-T2 in human serum and different epidemiological parameters including age, sex or smoking as well as measures of anthropometry, glucose and lipid metabolism. Study Design and Methods 3,5-T2 concentrations were measured by a recently developed immunoassay in sera of 761 euthyroid participants of the population-based Study of Health in Pomerania (SHIP-TREND). Subsequently, analysis of variance and multivariate linear regression analysis were performed. Results Serum 3,5-T2 concentrations exhibited a right-skewed distribution, resulting in a median serum concentration of 0.24 nM (1st quartile: 0.20 nM; 3rd quartile: 0.37 nM). Significant associations between 3,5-T2 and serum fasting glucose, thyrotropin (TSH) as well as leptin concentrations were detected (p<0.05). Interestingly, the association to leptin concentrations seemed to be mediated by TSH. Age, sex, smoking and blood lipid profile parameters did not show significant associations with circulating 3,5-T2. Conclusion Our findings from a healthy euthyroid population may point towards a physiological link between circulating 3,5-T2 and glucose metabolism.
    Thyroid: official journal of the American Thyroid Association 10/2014; · 2.60 Impact Factor
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    ABSTRACT: Higher circulating Angiopoietin-2 (Ang-2) levels predict cardiovascular events and mortality in clinical samples and in the general population. To better understand the underlying mechanisms, we investigated the association of circulating Ang-2 and sTie-2 (the soluble form of the Ang-2 receptor) levels with various measures of subclinical cardiovascular disease.
    Heart (British Cardiac Society) 10/2014; · 5.01 Impact Factor
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    ABSTRACT: Depressive disorders are influenced by a complex interplay between genetic and environmental factors. Multiple studies support a role of serotonergic pathways in the pathophysiology of depressive disorders. As a rate-limiting enzyme of serotonin synthesis in the brain, tryptophan hydroxylase 2 (TPH2) represents a plausible candidate gene. This also applies to the serotonin reuptake transporter (5-HTTLPR) regulating the availability of serotonin in the synaptic gap. We hypothesize that functional polymorphisms (TPH2: rs7305115, 5-HTTLPR and rs25531) within both genes contribute to the risk of depressive disorders after childhood abuse in adult life. To confirm our results, we investigated two independent samples of Caucasian subjects from the study of health in Pomerania (SHIP-LEGEND: n = 2,029 and SHIP-TREND-0: n = 2,475). Depression severity was assessed by the Beck depression inventory (BDI-II) for LEGEND and the patient health questionnaire (PHQ-9) for TREND-0. Childhood abuse was assessed by the childhood trauma questionnaire. Rs7305115 (TPH2) revealed significant effects in SNP × abuse and SNP × SNP as well as in the three-way interaction. This three-way interaction among abuse, TPH2 and 5-HTTLPR showed a significant effect on depression score (p = 0.023). The SS genotype of 5-HTTLPR was associated with increased depression scores after childhood abuse only in carriers of the low-expression TPH2 GG genotype, whereas the TPH2 AA genotype reversed this effect. Our results support the role of interaction effects of genetic variants within serotonergic pathways. Genetic variants that may decrease the presynaptic serotonin concentration were associated with increased adult depressive symptoms in subjects with childhood abuse.
    European Archives of Psychiatry and Clinical Neuroscience 09/2014; · 3.36 Impact Factor
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    ABSTRACT: Thyroid dysfunction has been described to be linked to a variety of cardiovascular morbidities. Through this pathway thyroid function might also be associated with cardiorespiratory function and exercise capacity. So far only few patient-studies with small study populations investigated the association between thyroid dysfunction and exercise capacity. Thus, the aim of our study was to investigate the association of serum thyroid-stimulating hormone (TSH) levels with lung function and cardiopulmonary exercise testing (CPET) in the general population.
    BMC Pulmonary Medicine 09/2014; 14(1):145. · 2.76 Impact Factor
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    ABSTRACT: Personalized medicine requires the analysis of epidemiological data for the identification of subgroups sharing some risk factors and exhibiting dedicated outcome risks. We investigate the potential of data mining methods for the analysis of subgroups of cohort participants on hepatic steatosis. We propose a workflow for data preparation and mining on epidemiological data and we present InteractiveRuleMiner, an interactive tool for the inspection of rules in each subpopulation, including functionalities for the juxtaposition of labeled individuals and unlabeled ones. We report on our insights on specific subpopulations that have been discovered in a data-driven rather than hypothesis-driven way.
    Expert Systems with Applications 09/2014; 41(11):5405–5415. · 1.85 Impact Factor
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    ABSTRACT: Background: Recent studies have shown associations of hypothyroidism with arterial blood pressure, atherosclerosis, and inflammation. Based on these pathways there might also be an association between hypothyroidism and retinal arteriolar narrowing (RAN), a marker of micro-vascular damage from hypertension, atherosclerosis, and inflammation. Against this background the aim of this study was to investigate the putative association between serum thyrotropin (TSH) levels and RAN defined by arterio-venous ratio (AVR) from static vessel analysis. Methods: We used data from 3189 individuals from the second population-based cohort of the Study of Health in Pomerania (SHIP-TREND-0). Thyroid function was defined according to serum TSH and serum diiodothyronine (3,5-T2) levels. Low and high serum TSH levels were defined by the cut-offs 0.3 mIU/L and 3.0 mIU/L. Fundus photography of the central retina was recorded with a non-mydriatic camera and images were evaluated by one experienced reader. An AVR < 0.8 was defined as decreased. Serum TSH levels, low and high TSH, and serum 3,5-T2 levels were associated with AVR by linear regression and with AVR < 0.8 by Poisson regression, both adjusted for age, sex, cigarette smoking, alcohol consumption, and intake of beta blockers. Results: Serum TSH levels were significantly associated with AVR (β = -0.028; 95% confidence interval (CI) = -0.049; -0.007; p=0.009) and with a decreased AVR < 0.8 (relative risk = 2.05; 95% CI = 1.13; 3.73; p = 0.019). Individuals with high TSH had a 1.43 higher risk for a decreased AVR (95%-CI = 1.04; 1.96; p = 0.027) than individuals with serum TSH levels within the reference range. Serum 3,5-T2 levels were also associated with a decreased AVR (Relative risk for an increase of 1 nM =0.45; 95% CI=0.23 - 0.87; p=0.017). Conclusions: Our results substantiate evidence for an association between hypothyroidism and RAN. Potential mechanisms explaining this association are long-term hypertension, atherosclerotic processes, and inflammation.
    Thyroid: official journal of the American Thyroid Association 08/2014; · 2.60 Impact Factor
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    ABSTRACT: To investigate the frequency of pancreatic duct (PD) variants and their effect on pancreatic exocrine function in a population-based study using non-invasive secretin-stimulated magnetic resonance cholangiopancreatography (sMRCP).
    European Radiology 08/2014; · 4.34 Impact Factor
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    ABSTRACT: Purpose: To analyze device-dependent variability of two non-mydriatic fundus cameras to obtain arterio-venous ratio (AVR), central retinal arteriolar equivalent (CRAE), and central retinal venular equivalent (CRVE) in static vessel analysis (SVA). Methods: We examined 53 participants (29 men, 24 women; median age 46 years) of the Study of Health in Pomerania (SHIP). We took 45° optic-disc-centered fundus images of the right eye with two different non-mydriatic fundus cameras. The first photograph was obtained from the TRC-NW 200, the second from the OCT 2000 (both Topcon Corporation, Tokyo, Japan). One experienced grader graded image quality from 1 “ideal quality” to 5 “not analyzable” and determined AVR, CRAE, and CRVE with the software Vesselmap3 (Imedos, Jena, Germany). Results: Average image quality was 1.8 for the TRC-NW 200 and 1.6 for the OCT 2000. AVR could not be determined in 5 images of the TRC-NW 200 due to low image quality, while six images of the OCT 2000 were not analyzable. The difference between AVR taken from two different non-mydriatic cameras was 0.01 ± 0.03 in Bland-Altman plots. The difference between CRAE was 0.17 ± 10.15 and between CRVE was −2.32 ± 11.76. Conclusions: The two different non-mydriatic cameras showed good agreement with respect to image quality. When using the same reading software, AVR, CRAE, and CRVE agreed well. Thus, funduscopy and SVA seem to be robust against inter-device variability. As a result, device dependency can remain unconsidered in follow-up examinations with different technical equipment. However, variability might impact more with devices from different manufacturers.
    Ophthalmic Epidemiology 08/2014; · 2.18 Impact Factor
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    ABSTRACT: Alexithymia is perceived as a personality construct involving deficits in the cognitive processing of emotion. Brain areas that process emotions might be structurally altered in affected people. Subjects from the Study of Health in Pomerania who underwent whole body magnetic resonance imaging were investigated. After quality control procedures 2,589 subjects with Toronto Alexithymia Scale 20 (TAS-20) data and interview-based information on major depressive disorder (MDD) were available. After exclusion of study participants who were older than 65 years or had MDD in their lifetime, 1,685 subjects were included in the voxel-based morphometric (VBM 8) analyses. In whole-brain analyses, the TAS-20 total score was associated with less gray matter (GM) volumes of the bilateral dorsal anterior cingulate cortex (dACC). The TAS-20 factor scale difficulty identifying feelings (DIF) was associated with less GM volume in three clusters: dACC, left middle and inferior temporal gyrus, left fusiform gyrus and cerebellum. The lower GM volume in the left fusiform gyrus was specific for females. Absolute GM volume analyses also revealed associations between the factor scales difficulty describing feelings, external orientated thinking and the dACC. Adjustment for current symptoms of anxiety and depression did not change the effects sizes substantially. In conclusion, lower GM volume in the dACC represents the major structural correlate of alexithymia. Associations with DIF suggest a prominent involvement of left temporal areas. These areas represent language and semantic processing and might be involved in the cognitive processing of emotions and the conscious identification of feelings. Hum Brain Mapp, 2014. © 2014 Wiley Periodicals, Inc.
    Human Brain Mapping 08/2014; · 6.88 Impact Factor
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    ABSTRACT: The genetic determinants of cerebral asymmetries are unknown. Sex differences in asymmetry of the planum temporale, that overlaps Wernicke’s classical language area, have been inconsistently reported. Meta-analysis of previous studies has suggested that publication bias established this sex difference in the literature. Using probabilistic definitions of cortical regions we screened over the cerebral cortex for sexual dimorphisms of asymmetry in 2337 healthy subjects, and found the planum temporale to show the strongest sex-linked asymmetry of all regions, which was supported by two further datasets, and also by analysis with the Freesurfer package that performs automated parcellation of cerebral cortical regions. We performed a genome-wide association scan meta-analysis of planum temporale asymmetry in a pooled sample of 3095 subjects, followed by a candidate-driven approach which measured a significant enrichment of association in genes of the ´steroid hormone receptor activity´ and 'steroid metabolic process' pathways. Variants in the genes and pathways identified may affect the role of the planum temporale in language cognition.
    Cortex 08/2014; · 6.16 Impact Factor
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    ABSTRACT: Autoimmune hepatitis (AIH) is an uncommon autoimmune liver disease of unknown etiology. We used a genome-wide approach to identify genetic variants that predispose individuals to AIH. We performed a genome-wide association study of 649 adults in the Netherlands with AIH type-1 and 13,436 controls. Initial associations were further analyzed in an independent replication panel comprising 451 patients with AIH type-1 in Germany and 4103 controls. We also performed an association analysis in the discovery cohort using imputed genotypes of the MHC region. We associated AIH with a variant in the MHC region, at rs2187668 (P=1.5x10(-78)). Analysis of this variant in the discovery cohort identified HLA-DRB1*0301 (P = 5.3x10(-49)) as a primary susceptibility genotype and HLA-DRB1*0401 (P=2.8x10(-18)) as a secondary susceptibility genotype. We also associated AIH with variants of SH2B3 (rs3184504, 12q24; P=7.7x10(-8)) and CARD10 (rs6000782, 22q13.1; P=3.0x10(-6)). Furthermore, strong inflation of association signal was found with single-nucleotide polymorphisms (SNPs) associated with other immune-mediated diseases, including primary sclerosing cholangitis and primary biliary cirrhosis, but not with SNPs associated with other genetic traits. In a genome-wide association study, we associated AIH type-1with variants in the MHC region, and identified variants of SH2B3and CARD10 as likely risk factors. These findings support a complex genetic basis for AIH pathogenesis and indicate that part of the genetic susceptibility overlaps with that for other immune-mediated liver diseases.
    Gastroenterology 08/2014; 147(2):443-452. · 12.82 Impact Factor
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    ABSTRACT: The phenotypic effect of some single nucleotide polymorphisms (SNPs) depends on their parental origin. We present a novel approach to detect parent-of-origin effects (POEs) in genome-wide genotype data of unrelated individuals. The method exploits increased phenotypic variance in the heterozygous genotype group relative to the homozygous groups. We applied the method to >56,000 unrelated individuals to search for POEs influencing body mass index (BMI). Six lead SNPs were carried forward for replication in five family-based studies (of ∼4,000 trios). Two SNPs replicated: the paternal rs2471083-C allele (located near the imprinted KCNK9 gene) and the paternal rs3091869-T allele (located near the SLC2A10 gene) increased BMI equally (beta = 0.11 (SD), P<0.0027) compared to the respective maternal alleles. Real-time PCR experiments of lymphoblastoid cell lines from the CEPH families showed that expression of both genes was dependent on parental origin of the SNPs alleles (P<0.01). Our scheme opens new opportunities to exploit GWAS data of unrelated individuals to identify POEs and demonstrates that they play an important role in adult obesity.
    PLoS Genetics 07/2014; · 8.52 Impact Factor
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    ABSTRACT: Population-based data are paramount to investigate the long-term course of diabetes, for planning in healthcare and to evaluate the cost-effectiveness of primary prevention. We analysed regional differences in the incidence of self-reported type 2 diabetes mellitus in Germany.
    Journal of epidemiology and community health. 07/2014;
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    ABSTRACT: Maltreatment of children is a major public-health and social-welfare problem but socio-demographic variability has received little attention. This work addresses such variability in a general population cohort and associations with depression. Analyses were based on the cross-sectional SHIP-LEGEND examination among 2265 adults (29-89 years). Childhood maltreatment was multi-dimensionally assessed with the German 28-item Childhood Trauma Questionnaire (CTQ): emotional neglect; emotional abuse; physical neglect; physical abuse; sexual abuse. Non-linear associations between CTQ responses and age were assessed with fractional polynomials and cubic splines. Scale properties were analysed with confirmatory factor analyses and item response models. Associations between childhood maltreatment domains and depression [Beck Depression Inventory-II (BDI-II)] were assessed. The majority (58.9%) reported events indicative of at least mild levels of childhood maltreatment. CTQ subscales showed characteristically different non-linear associations to age across the five studied domains, indicating methodological issues like recall bias and the influence of seminal events. Psychometric scale properties were acceptable to good for all subscales except for physical neglect. Associations to depression measures varied systematically across socio-demographic strata. We conclude that socio-demographic variability is a major issue when studying self-reported childhood maltreatment in a community sample. This needs to be taken into account for the study of associations to psychiatric key outcomes. Copyright © 2014 John Wiley & Sons, Ltd.
    International Journal of Methods in Psychiatric Research 07/2014; · 1.76 Impact Factor
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    ABSTRACT: Chronic kidney disease (CKD) is a frequent, under-recognized condition and a risk factor for renal failure and cardiovascular disease. Increasing evidence connects non-alcoholic fatty liver disease (NAFLD) to CKD. We conducted a meta-analysis to determine whether the presence and severity of NAFLD are associated with the presence and severity of CKD.
    PLoS Medicine 07/2014; 11(7):e1001680. · 15.25 Impact Factor
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    ABSTRACT: OBJECTIVES:We used data from population-based studies to determine the accuracy of the Fatty Liver Index (FLI) and the Hepatic Steatosis Index (HSI) in determining individual risk of hepatic steatosis. We also developed a new risk scoring system and validated all three indices using external data.METHODS:We used data from the Study of Health in Pomerania (SHIP; n=4,222), conducted in North-eastern Germany, to validate the existing scoring systems and to develop our own index. Data from the South German Echinococcus Multilocularis and Internal Diseases in Leutkirch (EMIL) study (n=2,177) were used as an external validation data set. Diagnostic performance was evaluated in terms of discrimination (area under the receiver operating characteristic curve (AUC)) and calibration plots. We applied boosting for generalized linear models to select relevant diagnostic separators.RESULTS:The FLI accurately discriminated patients with fatty liver disease from those without (AUC=0.817) but had poor calibration, in that predicted risks differed considerably from observed risks, based on SHIP data. The FLI performed well in discrimination and calibration in the analysis of EMIL data (AUC=0.890). The HSI performed worse than the FLI in analysis of both data sets (SHIP: AUC=0.782 and EMIL: AUC=0.841), showing an extremely skewed calibration. Our newly developed risk score had a good performance in the development data set (SHIP: AUC=0.860) and also good discrimination ability in the validation data (EMIL: AUC=0.876), but it had low calibration based on the validation data set.CONCLUSIONS:We compared the ability of the FLI, HSI, and our own scoring system to determine the risk of hepatic steatosis using two population-based data sets (one for the development of our own system and one for validation). In the development and independent replication data set, all three indices discriminated well between patients with and without hepatic steatosis, but the predicted risks did not match well with the observed risks, when applied to external data. Scoring systems for fatty liver disease could depend on methodological standardization of ultrasound diagnosis and laboratory measurements.Am J Gastroenterol advance online publication, 24 June 2014; doi:10.1038/ajg.2014.155.
    The American journal of gastroenterology. 06/2014;

Publication Stats

9k Citations
3,124.15 Total Impact Points

Institutions

  • 2000–2014
    • University of Greifswald
      • • Institute of Community Medicine
      • • Institute of Clinical Chemistry and Laboratory Medicine
      • • Department of Psychiatry and Psychotherapy
      • • Institute of Epidemiology and Social Medicine
      • • Center for Internal Medicine
      Griefswald, Mecklenburg-Vorpommern, Germany
  • 2013
    • Semmelweis University
      Budapeŝto, Budapest, Hungary
    • Karolinska University Hospital
      Tukholma, Stockholm, Sweden
  • 2012–2013
    • Klinik Dr. Guth Hamburg
      Hamburg, Hamburg, Germany
    • Heinrich-Heine-Universität Düsseldorf
      • Deutsches Diabetes-Zentrum DDZ
      Düsseldorf, North Rhine-Westphalia, Germany
    • Helios Hanseklinikum Stralsund
      Stralsund, Mecklenburg-Vorpommern, Germany
    • University Medical Center Hamburg - Eppendorf
      Hamburg, Hamburg, Germany
    • University of Münster
      • Institute of Epidemiology and Social Medicine
      Münster, North Rhine-Westphalia, Germany
    • Johns Hopkins Bloomberg School of Public Health
      Baltimore, Maryland, United States
  • 2008–2013
    • Helmholtz Zentrum München
      • Institute of Epidemiology II
      München, Bavaria, Germany
    • HELIOS Klinikum Berlin-Buch
      Berlín, Berlin, Germany
  • 2010–2012
    • Columbia University
      • Department of Epidemiology
      New York City, NY, United States
    • Brigham and Women's Hospital
      • Department of Medicine
      Boston, MA, United States
    • University Hospital Regensburg
      Ratisbon, Bavaria, Germany
    • Johns Hopkins University
      • Department of Epidemiology
      Baltimore, MD, United States
    • Erasmus MC
      • Department of Epidemiology
      Rotterdam, South Holland, Netherlands
  • 2006–2012
    • University Medical Center Schleswig-Holstein
      Kiel, Schleswig-Holstein, Germany
  • 2011
    • Universität Bern
      • Department of Clinical Pharmacology and Visceral Research
      Bern, BE, Switzerland
    • King's College London
      • Department of Twin Research and Genetic Epidemiology
      London, ENG, United Kingdom
    • Albert Einstein College of Medicine
      New York City, New York, United States
    • University of Gothenburg
      • Centre for Bone and Arthritis Research (CBAR) (1)
      Göteborg, Vaestra Goetaland, Sweden
    • University of Washington Seattle
      • Cardiovascular Health Research Unit (CHRU)
      Seattle, WA, United States
  • 2009–2011
    • University of Hamburg
      • Department of Psychosomatic Medicine and Psychotherapy
      Hamburg, Hamburg, Germany
    • Wellcome Trust Sanger Institute
      Cambridge, England, United Kingdom
  • 2005–2010
    • Charité Universitätsmedizin Berlin
      Berlín, Berlin, Germany
  • 2007
    • Robert Koch Institut
      • Department of Epidemiology and Health Reporting
      Berlin, Land Berlin, Germany