Henry Völzke

University of Greifswald, Griefswald, Mecklenburg-Vorpommern, Germany

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Publications (502)3036.52 Total impact

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    ABSTRACT: Epidemiology aims to provide insight into disease causations. Hence, subject groups (cohorts) are analyzed to correlate the subjects' varying lifestyles, their medical properties and diseases. Recently, these cohort studies comprise medical image data. We assess potential relations between image-derived variables of the lumbar spine with lower back pain in a cross-sectional study. Therefore, an Interactive Visual Analysis (IVA) framework was created and tested with 2,540 segmented lumbar spine data sets. The segmentation results are evaluated and quantified by employing shape-describing variables, such as spine canal curvature and torsion. We analyze mutual dependencies among shape-describing variables and non-image variables, e.g., pain indi-cators. Therefore, we automatically train a decision tree classifier for each non-image variable. We provide an IVA technique to compare classifiers with a decision tree quality plot. As a first result, we conclude that image-based variables are only sufficient to describe lifestyle factors within the data. A correlation between lumbar spine shape and lower back pain could not be found with the automatically trained classifiers. How-ever, the presented approach is a valuable extension for the IVA of epidemiological data. Hence, relations between non-image variables were successfully detected and described.
    Proc. of IVAPP; 03/2015
  • K Lau, S E Baumeister, W Lieb, P J Meffert, M M Lerch, J Mayerle, H Völzke
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    ABSTRACT: Research on the association between alcohol consumption and hepatic steatosis revealed conflictive results. To investigate the associations between average daily alcohol consumption and binge drinking with hepatic steatosis, and to analyse combined effects of average daily alcohol consumption and binge drinking with body mass index (BMI) on hepatic steatosis. Data from the population-based Study of Health in Pomerania (SHIP) conducted in north-east Germany comprising 4009 adults were used. Alcohol consumption was assessed by self-report. Serum carbohydrate-deficient transferrin (CDT) was analysed as biomarker for alcohol consumption. Hepatic steatosis was diagnosed by ultrasonography. Analyses revealed a dose-response relationship between average daily alcohol consumption and hepatic steatosis in men starting with a consumption of 20 g of alcohol per day [adjusted odds ratio (OR) compared to abstainers 1.53; 95% confidence interval (CI) 1.15-2.05]. Using CDT as alternative exposure variable confirmed these results. Binge drinking was associated with hepatic steatosis in men (adjusted OR of binge drinkers compared to nonbinge drinkers 1.36, 95% CI 1.06-1.74). The likelihood of having hepatic steatosis increased in men and women with increasing levels of average daily alcohol consumption in combination with overweight or obesity. Similarly, binge drinking in combination with overweight or obesity enhanced the likelihood of having hepatic steatosis. Overweight or obesity substantially enhanced the effect of high levels of average daily alcohol consumption and binge drinking on hepatic steatosis in the present study population. This finding underlines the necessity to screen for multiple risk factors in the prevention of hepatic steatosis. © 2015 John Wiley & Sons Ltd.
    Alimentary Pharmacology & Therapeutics 01/2015; · 4.55 Impact Factor
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    ABSTRACT: The neuropeptide neurokinin 3 (NK3) and its receptor modulate cholinergic activity of the basal forebrain (BF) and are implicated in learning and memory. In Alzheimer’s disease the rs2765 single-nucleotide polymorphism (SNP) of the NK3 receptor-coding gene TACR3 was correlated with right hippocampus volume. Here, we studied the association of the rs2765 SNP with MRI based volumes of the BF and hippocampus in a population-based sample of 1,967 participants between 21 and 90 years of age. The rs2765 SNP was significantly associated with the most anterior BF volume corresponding to the medial septum/diagonal band, and with a significantly steeper age-related volume decline. The rs2765 SNP was not associated with other BF subvolumes or hippocampus volumes. ApoE ε4 showed no correlation with any brain volume or global cognition. Our findings in a large population based sample suggest an association of an NK3 receptor SNP with age-related decline of rostral cholinergic basal forebrain volume.
    Neurobiology of Aging. 01/2015;
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    ABSTRACT: -Endothelial growth factors including angiopoietin-2 (Ang-2), its soluble receptor Tie-2 (sTie-2) and hepatocyte growth factor (HGF) play important roles in angiogenesis, vascular remodeling, local tumor growth and metastatic potential of various cancers. Circulating levels of these biomarkers have a heritable component (between 13% and 56%), but the underlying genetic variation influencing these biomarker levels is largely unknown. -We performed a genome-wide association study for circulating Ang-2, sTie-2, and HGF in 3571 Framingham Heart Study (FHS) participants and assessed replication of the top hits for Ang-2 and sTie-2 in 3184 participants of the Study of Health in Pomerania (SHIP). In multivariable-adjusted models, sTie-2 and HGF concentrations were associated with single nucleotide polymorphisms (SNPs) in the genes encoding the respective biomarkers (top p=2.40×10(-65) [rs2273720] and 3.64×10(-19) [rs5745687], respectively). Likewise, rs2442517 in the MCPH1 gene (in which the Ang-2 gene is embedded) was associated with Ang-2 levels (p=5.05×10(-8) in FHS and 8.39×10(-5) in SHIP). Furthermore, SNPs in the AB0 gene were associated with sTie-2 (top SNP rs8176693 with p=1.84×10(-33) in FHS; p=2.53×10(-30) in SHIP) and Ang-2 (rs8176746 with p=2.07×10(-8) in FHS; p=0.001 in SHIP) levels on a genome-wide significant level. The top genetic loci explained between 1.7% (Ang-2) and 11.2% (sTie-2) of the inter-individual variation in biomarker levels. -Genetic variation contributes to the inter-individual variation in growth factor levels and explains a modest proportion of circulating HGF, Ang-2, and Tie-2. This may potentially contribute to the familial susceptibility to cancer, a premise that warrants further studies.
    Circulation Cardiovascular Genetics 12/2014; · 6.73 Impact Factor
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    ABSTRACT: Objectives Little is known about changes in depression and quality of life in East Germany. We examined changes in the prevalence of lifetime and current depressive symptoms and mental health-related quality of life among adults in northeast Germany between 1997–2001 and 2008–2012. Methods Population-based data were drawn from two repeated cross-sectional surveys conducted 11 years apart within the Study of Health of Pomerania project (Ns of 4,228 and 4,251). Assessments included screening items for lifetime depressive symptoms from the Munich Composite International Diagnostic Interview (M-CIDI), the Depression and Exhaustion Scale (DEEX), and the Short Form Health Survey (SF-12). Results Lifetime depressive symptoms rose from 13.2 to 27.8 %. The increase was stronger in men than in women and in individuals aged 35–64 years. No substantial changes occurred in the overall prevalence of current depressive symptoms (DEEX) and mental health-related quality of life (SF-12). A small decrease in current depressive symptoms was observed in middle-aged men and older women and small improvements in mental health-related quality of life in young adults. Conclusions Higher reporting of lifetime depressive symptoms might reflect methodological influences as well as lower stigmatization and higher awareness, while the current burden seems similar.
    International Journal of Public Health 12/2014; · 1.97 Impact Factor
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    ABSTRACT: -The renin-angiotensin-aldosterone-system (RAAS) is critical for regulation of blood pressure and fluid balance and influences cardiovascular remodeling. Dysregulation of the RAAS contributes to cardiovascular and renal morbidity. The genetic architecture of circulating RAAS components is incompletely understood. -We meta-analyzed genome-wide association data for plasma renin activity (n=5,275), plasma renin concentrations (n=8,014) and circulating aldosterone (n=13,289) from up to four population-based cohorts of European and European-American ancestry, and assessed replication of the top results in an independent sample (n=6,487). Single nucleotide polymorphisms (SNPs) in two independent loci displayed associations with plasma renin activity at genome-wide significance (p<5x10(-8)). A third locus was close to this threshold (rs4253311 in kallikrein B [KLKB1], p=5.5x10(-8)). Two of these loci replicated in an independent sample for both plasma renin and aldosterone concentrations (SNP rs5030062 in kininogen 1 [KNG1]: p=0.001 for plasma renin, p=0.024 for plasma aldosterone concentration; rs4253311 with p<0.001 for both plasma renin and aldosterone concentration). SNPs in the NEBL gene reached genome-wide significance for plasma renin concentration in the discovery sample (top SNP rs3915911, p=8.81x10(-9)), but did not replicate (p=0.81). No locus reached genome-wide significance for aldosterone. SNPs rs5030062 and rs4253311 were not related to blood pressure or renal traits; in a companion study, variants in the kallikrein B locus were associated with B-type natriuretic peptide concentrations in African-Americans. -We identified two genetic loci (kininogen 1 and kallikrein B) influencing key components of the RAAS, consistent with the close interrelation between the kallikrein-kinin system and the RAAS.
    Circulation Cardiovascular Genetics 12/2014; · 6.73 Impact Factor
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    ABSTRACT: Usual sleep duration is a heritable trait correlated with psychiatric morbidity, cardiometabolic disease and mortality, although little is known about the genetic variants influencing this trait. A genome-wide association study (GWAS) of usual sleep duration was conducted using 18 population-based cohorts totaling 47 180 individuals of European ancestry. Genome-wide significant association was identified at two loci. The strongest is located on chromosome 2, in an intergenic region 35- to 80-kb upstream from the thyroid-specific transcription factor PAX8 (lowest P=1.1 × 10(-9)). This finding was replicated in an African-American sample of 4771 individuals (lowest P=9.3 × 10(-4)). The strongest combined association was at rs1823125 (P=1.5 × 10(-10), minor allele frequency 0.26 in the discovery sample, 0.12 in the replication sample), with each copy of the minor allele associated with a sleep duration 3.1 min longer per night. The alleles associated with longer sleep duration were associated in previous GWAS with a more favorable metabolic profile and a lower risk of attention deficit hyperactivity disorder. Understanding the mechanisms underlying these associations may help elucidate biological mechanisms influencing sleep duration and its association with psychiatric, metabolic and cardiovascular disease.Molecular Psychiatry advance online publication, 2 December 2014; doi:10.1038/mp.2014.133.
    Molecular Psychiatry 12/2014; · 15.15 Impact Factor
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    ABSTRACT: Breast density is a risk factor associated with the development of breast cancer. Usually, breast density is assessed on two dimensional (2D) mammograms using the American College of Radiology (ACR) classification. Magnetic resonance imaging (MRI) is a non-radiation based examination method, which offers a three dimensional (3D) alternative to classical 2D mammograms. We propose a new framework for automated breast density calculation on MRI data. Our framework consists of three steps. First, a recently developed method for simultaneous intensity inhomogeneity correction and breast tissue and parenchyma segmentation is applied. Second, the obtained breast component is extracted, and the breast-air and breast-body boundaries are refined. Finally, the fibroglandular/ parenchymal tissue volume is extracted from the breast volume. The framework was tested on 37 randomly selected MR mammographies. All images were acquired on a 1.5T MR scanner using an axial, T1-weighted time-resolved angiography with stochastic trajectories sequence. The results were compared to manually obtained groundtruth. Dice's Similarity Coefficient (DSC) as well as Bland-Altman plots were used as the main tools for evaluation of similarity between automatic and manual segmentations. The average Dice's Similarity Coefficient values were 0:96+0:0172 and 0:83+0:0636 for breast and parenchymal volumes, respectively. Bland-Altman plots showed the mean bias (%) + standard deviation equal 5:36+3:9 for breast volumes and {6:9+13:14 for parenchyma volumes. The automated framework produced sufficient results and has the potential to be applied for the analysis of breast volume and breast density of numerous data in clinical and research settings.
    PLoS ONE 11/2014; 9(11). · 3.53 Impact Factor
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    ABSTRACT: This study compares health-related quality of life (HRQL) in patients with type 2 diabetes (T2DM) across treatment groups and explores gender differences. Four regional surveys (KORA, CARLA, SHIP, DHS) and a national survey (GNHIES98) were pooled at individual level. HRQL was assessed with the SF-12/-36v1. Linear regression models were used to assess the effect of T2DM by treatment type (no medication; oral; oral/insulin combination; insulin) on the physical (PCS-12) and mental summary score (MCS-12) and the SF-6D, controlling for age, sex, study and covariates. We also performed an explanatory analysis of single items. PCS-12 scores and treatment type were associated (P-value 0.006), with lowest values for insulin treatment (-4.44 vs. oral; -4.41 vs. combination). MCS-12 scores were associated with treatment type and gender (P-value <0.012), with lower scores for women undergoing oral (-4.25 vs. men) and combination treatment (-6.99 vs. men). Similar results were observed for SF-6D utilities and single items, related to mental health, social functioning, vitality and role limitation (emotional). Comorbidities were predictors of lower PCS-12 and SF-6D scores. T2DM treatment impacts differently on physical and mental HRQL and on women and men. Further studies of gender-specific perceptions of T2DM treatment regimens are needed. Copyright © 2014 Elsevier Inc. All rights reserved.
    Journal of Diabetes and its Complications 11/2014; · 1.93 Impact Factor
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    ABSTRACT: Large-scale epidemiological evidence on the role of inflammation in early atherosclerosis, assessed by carotid ultrasound, is lacking. We aimed to quantify cross-sectional and longitudinal associations of inflammatory markers with common-carotid-artery intima-media thickness (CCA-IMT) in the general population. Information on high-sensitivity C-reactive protein, fibrinogen, leucocyte count and CCA-IMT was available in 20 prospective cohort studies of the PROG-IMT collaboration involving 49,097 participants free of pre-existing cardiovascular disease. Estimates of associations were calculated within each study and then combined using random-effects meta-analyses. Mean baseline CCA-IMT amounted to 0.74 mm (SD = 0.18) and mean CCA-IMT progression over a mean of 3.9 years to 0.011 mm/year (SD = 0.039). Cross-sectional analyses showed positive linear associations between inflammatory markers and baseline CCA-IMT. After adjustment for traditional cardiovascular risk factors, mean differences in baseline CCA-IMT per one-SD higher inflammatory marker were: 0.0082 mm for high-sensitivity C-reactive protein (p < 0.001); 0.0072 mm for fibrinogen (p < 0.001); and 0.0025 mm for leucocyte count (p = 0.033). 'Inflammatory load', defined as the number of elevated inflammatory markers (i.e. in upper two quintiles), showed a positive linear association with baseline CCA-IMT (p < 0.001). Longitudinal associations of baseline inflammatory markers and changes therein with CCA-IMT progression were null or at most weak. Participants with the highest 'inflammatory load' had a greater CCA-IMT progression (p = 0.015). Inflammation was independently associated with CCA-IMT cross-sectionally. The lack of clear associations with CCA-IMT progression may be explained by imprecision in its assessment within a limited time period. Our findings for 'inflammatory load' suggest important combined effects of the three inflammatory markers on early atherosclerosis. © The European Society of Cardiology 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.
    European Journal of Preventive Cardiology 11/2014; · 2.68 Impact Factor
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    ABSTRACT: We have previously found regional differences in the prevalence of known type 2 diabetes between northeastern and southern Germany. We aim to also provide prevalence estimates for prediabetes (isolated impaired fasting glucose (i-IFG), isolated glucose intolerance (i-IGT), combined IFG and IGT) and unknown type 2 diabetes for both regions.
    PLoS ONE 11/2014; 9(11):e113154. · 3.53 Impact Factor
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    ABSTRACT: The efficacy of statins, which are used commonly in primary and secondary prevention of cardiovascular diseases, shows a wide range of interindividual variability. Genetic variants of OATP1B1, a hepatic uptake transporter, can modify access of statins to its therapeutic target, thereby potentially altering drug efficacy. We studied the impact of genetic variants of OATP1B1 on the lipid-lowering efficacy of statins in a population-based setting.
    Pharmacogenetics and Genomics 11/2014; · 3.45 Impact Factor
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    IEEE Transactions on Visualization and Computer Graphics 11/2014; · 1.92 Impact Factor
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    ABSTRACT: AimTo analyse the association of neighbourhood unemployment with incident self-reported physician-diagnosed Type 2 diabetes in a population aged 45–74 years from five German regions.Methods Study participants were linked via their addresses at baseline to particular neighbourhoods. Individual-level data from five population-based studies were pooled and combined with contextual data on neighbourhood unemployment. Type 2 diabetes was assessed according to a self-reported physician diagnosis of diabetes. We estimated proportional hazard models (Weibull distribution) in order to obtain hazard ratios and 95% CIs of Type 2 diabetes mellitus, taking into account interval-censoring and clustering.ResultsWe included 7250 participants residing in 228 inner city neighbourhoods in five German regions in our analysis. The incidence rate was 12.6 per 1000 person-years (95% CI 11.4–13.8). The risk of Type 2 diabetes mellitus was higher in men [hazard ratio 1.77 (95% CI 1.45–2.15)] than in women and higher in people with a low education level [hazard ratio 1.41 (95% CI 1.14–1.73)] than in those with a high education level. Independently of individual-level characteristics, we found a higher risk of Type 2 diabetes mellitus in neighbourhoods with high levels of unemployment [quintile 5; hazard ratio 1.77 (95% CI 1.26–2.49)] than in neighbourhoods with low unemployment (quintile 1).Conclusions Low education level and high neighbourhood unemployment were independently associated with an elevated risk of Type 2 diabetes mellitus. Studies examining the impact of the residential environment on Type 2 diabetes mellitus will provide knowledge that is essential for the identification of high-risk populations.This article is protected by copyright. All rights reserved.
    Diabetic Medicine 11/2014; · 3.24 Impact Factor
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    ABSTRACT: Hypertension and obesity are highly prevalent in Western societies. We show in our study the associations of changes in body weight with changes in blood pressure, without the influence of antihypertensive medication, with a 5-year follow-up.•A loss of 5% of the baseline weight, when compared with the maintenance of the initial weight, resulted in a reduced relative risk of incident hypertension of 0.84 and incident cardiovascular events of 0.81 as well a 15% chance of incident blood pressure normalization in patients who were hypertensive at baseline.•Our findings support previous evidence that lifestyle modifications have an impact on blood pressure and reinforce that weight reduction is an important objective for primary prevention of cardiovascular events in the general population.
    Nutrition Metabolism and Cardiovascular Diseases 10/2014; · 3.88 Impact Factor
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    ABSTRACT: Context During the last two decades it became obvious that 3,5-diiodothyronine (3,5-T2), a well-known endogenous metabolite of the thyroid hormones thyroxine (T4) or triiodothyronine (T3), not only represents a simple degradation intermediate of the former but also exhibits specific metabolic activities. Administration of 3,5-T2 to hypothyroid rodents rapidly stimulated their basal metabolic rate, prevented high fat diet-induced obesity as well as steatosis and increased oxidation of long-chain fatty acids. Objective The aim of the present study was to analyze associations between circulating 3,5-T2 in human serum and different epidemiological parameters including age, sex or smoking as well as measures of anthropometry, glucose and lipid metabolism. Study Design and Methods 3,5-T2 concentrations were measured by a recently developed immunoassay in sera of 761 euthyroid participants of the population-based Study of Health in Pomerania (SHIP-TREND). Subsequently, analysis of variance and multivariate linear regression analysis were performed. Results Serum 3,5-T2 concentrations exhibited a right-skewed distribution, resulting in a median serum concentration of 0.24 nM (1st quartile: 0.20 nM; 3rd quartile: 0.37 nM). Significant associations between 3,5-T2 and serum fasting glucose, thyrotropin (TSH) as well as leptin concentrations were detected (p<0.05). Interestingly, the association to leptin concentrations seemed to be mediated by TSH. Age, sex, smoking and blood lipid profile parameters did not show significant associations with circulating 3,5-T2. Conclusion Our findings from a healthy euthyroid population may point towards a physiological link between circulating 3,5-T2 and glucose metabolism.
    Thyroid: official journal of the American Thyroid Association 10/2014; · 2.60 Impact Factor
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    ABSTRACT: The hippocampus-crucial for memory formation, recall and mood regulation-is involved in the pathophysiology of dementia and depressive disorders. Recent genome-wide association studies (GWAS) have identified five genetic loci associated with hippocampal volume (HV). Previous studies have described psychosocial and clinical factors (for example, smoking, type 2 diabetes and hypertension) to have an impact on HV. However, the interplay between genetic, psychosocial and clinical factors on the HV remains unclear. Still, it is likely that genetic variants and clinical or psychosocial factors jointly act in modifying HV; it might be possible they even interact. Knowledge of these factors might help to quantify ones individual risk of or rather resilience against HV loss. We investigated subjects (N=2463; 55.7% women; mean age 53 years) from the Study of Health in Pomerania (SHIP-2; SHIP-TREND-0) who underwent whole-body magnetic resonance imaging (MRI) and genotyping. HVs were estimated with FreeSurfer. For optimal nonlinear model fitting, we used regression analyses with restricted cubic splines. Genetic variants and associated psychosocial or clinical factors were jointly assessed for potential two-way interactions. We observed associations between HV and gender (P<0.0001), age (P<0.0001), body height (P<0.0001), education (P=0.0053), smoking (P=0.0058), diastolic blood pressure (P=0.0211), rs7294919 (P=0.0065), rs17178006 (P=0.0002), rs6581612 (P=0.0036), rs6741949 (P=0.0112) and rs7852872 (P=0.0451). In addition, we found three significant interactions: between rs7294919 and smoking (P=0.0473), rs7294919 and diastolic blood pressure (P=0.0447) and between rs7852872 and rs6581612 (P=0.0114). We suggest that these factors might have a role in the individual susceptibility to hippocampus-associated disorders.
    Translational psychiatry. 10/2014; 4:e465.
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    ABSTRACT: Higher circulating Angiopoietin-2 (Ang-2) levels predict cardiovascular events and mortality in clinical samples and in the general population. To better understand the underlying mechanisms, we investigated the association of circulating Ang-2 and sTie-2 (the soluble form of the Ang-2 receptor) levels with various measures of subclinical cardiovascular disease.
    Heart (British Cardiac Society) 10/2014; · 6.02 Impact Factor
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    ABSTRACT: Depressive disorders are influenced by a complex interplay between genetic and environmental factors. Multiple studies support a role of serotonergic pathways in the pathophysiology of depressive disorders. As a rate-limiting enzyme of serotonin synthesis in the brain, tryptophan hydroxylase 2 (TPH2) represents a plausible candidate gene. This also applies to the serotonin reuptake transporter (5-HTTLPR) regulating the availability of serotonin in the synaptic gap. We hypothesize that functional polymorphisms (TPH2: rs7305115, 5-HTTLPR and rs25531) within both genes contribute to the risk of depressive disorders after childhood abuse in adult life. To confirm our results, we investigated two independent samples of Caucasian subjects from the study of health in Pomerania (SHIP-LEGEND: n = 2,029 and SHIP-TREND-0: n = 2,475). Depression severity was assessed by the Beck depression inventory (BDI-II) for LEGEND and the patient health questionnaire (PHQ-9) for TREND-0. Childhood abuse was assessed by the childhood trauma questionnaire. Rs7305115 (TPH2) revealed significant effects in SNP × abuse and SNP × SNP as well as in the three-way interaction. This three-way interaction among abuse, TPH2 and 5-HTTLPR showed a significant effect on depression score (p = 0.023). The SS genotype of 5-HTTLPR was associated with increased depression scores after childhood abuse only in carriers of the low-expression TPH2 GG genotype, whereas the TPH2 AA genotype reversed this effect. Our results support the role of interaction effects of genetic variants within serotonergic pathways. Genetic variants that may decrease the presynaptic serotonin concentration were associated with increased adult depressive symptoms in subjects with childhood abuse.
    European Archives of Psychiatry and Clinical Neuroscience 09/2014; · 3.36 Impact Factor
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    ABSTRACT: Thyroid dysfunction has been described to be linked to a variety of cardiovascular morbidities. Through this pathway thyroid function might also be associated with cardiorespiratory function and exercise capacity. So far only few patient-studies with small study populations investigated the association between thyroid dysfunction and exercise capacity. Thus, the aim of our study was to investigate the association of serum thyroid-stimulating hormone (TSH) levels with lung function and cardiopulmonary exercise testing (CPET) in the general population.
    BMC Pulmonary Medicine 09/2014; 14(1):145. · 2.49 Impact Factor

Publication Stats

10k Citations
3,036.52 Total Impact Points

Institutions

  • 2000–2014
    • University of Greifswald
      • • Institute of Community Medicine
      • • Institute of Clinical Chemistry and Laboratory Medicine
      • • Department of Psychiatry and Psychotherapy
      • • Institute of Epidemiology and Social Medicine
      • • Center for Internal Medicine
      Griefswald, Mecklenburg-Vorpommern, Germany
  • 2013
    • Karolinska University Hospital
      Tukholma, Stockholm, Sweden
    • Semmelweis University
      Budapeŝto, Budapest, Hungary
  • 2012–2013
    • Klinik Dr. Guth Hamburg
      Hamburg, Hamburg, Germany
    • Heinrich-Heine-Universität Düsseldorf
      • Deutsches Diabetes-Zentrum DDZ
      Düsseldorf, North Rhine-Westphalia, Germany
    • University of Münster
      • Institute of Epidemiology and Social Medicine
      Münster, North Rhine-Westphalia, Germany
    • Helios Hanseklinikum Stralsund
      Stralsund, Mecklenburg-Vorpommern, Germany
    • University Medical Center Hamburg - Eppendorf
      Hamburg, Hamburg, Germany
    • Johns Hopkins Bloomberg School of Public Health
      Baltimore, Maryland, United States
  • 2008–2013
    • Helmholtz Zentrum München
      • Institute of Epidemiology II
      München, Bavaria, Germany
    • HELIOS Klinikum Berlin-Buch
      Berlín, Berlin, Germany
  • 2010–2012
    • Columbia University
      • Department of Epidemiology
      New York City, NY, United States
    • Erasmus MC
      • Department of Epidemiology
      Rotterdam, South Holland, Netherlands
    • Brigham and Women's Hospital
      • Department of Medicine
      Boston, MA, United States
  • 2006–2012
    • University Medical Center Schleswig-Holstein
      Kiel, Schleswig-Holstein, Germany
  • 2011
    • King's College London
      • Department of Twin Research and Genetic Epidemiology
      London, ENG, United Kingdom
    • University of Gothenburg
      • Centre for Bone and Arthritis Research (CBAR) (1)
      Göteborg, Vaestra Goetaland, Sweden
    • Albert Einstein College of Medicine
      New York City, New York, United States
    • Universität Bern
      • Department of Clinical Pharmacology and Visceral Research
      Bern, BE, Switzerland
    • University of Washington Seattle
      • Cardiovascular Health Research Unit (CHRU)
      Seattle, WA, United States
  • 2009–2011
    • University of Hamburg
      • Department of Psychosomatic Medicine and Psychotherapy
      Hamburg, Hamburg, Germany
    • Wellcome Trust Sanger Institute
      Cambridge, England, United Kingdom
  • 2005–2010
    • Charité Universitätsmedizin Berlin
      Berlín, Berlin, Germany
  • 2007
    • Robert Koch Institut
      • Department of Epidemiology and Health Reporting
      Berlin, Land Berlin, Germany