Hai-Xia Jiang

Northeast Institute of Geography and Agroecology, Beijing, Beijing Shi, China

Are you Hai-Xia Jiang?

Claim your profile

Publications (6)14.75 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: A novel series of trifluoromethyl indole derivatives have been designed, synthesized and evaluated for anti-HIV-1 activities in MT-2 cells. The hydrophobic constant, acute toxicity, carcinogenicity and mutagenicity were predicted. Trifluoromethyl indoles and showed extremely promising activities against WT HIV-1 with IC50 values at the low nanomolar level, similar to efavirenz, better than nevirapine, and also possessed higher potency towards the drug-resistant mutant strain Y181C than nevirapine. Preliminary SAR and docking studies of detailed binding mode provided some insights for discovery of more potent NNRTIs.
    Organic & Biomolecular Chemistry 04/2014; · 3.57 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Compound 1 ((-)-gossypol) has been long known as a chemical anticancer agent. With its low water solubility and toxicity, it is not widely used as a commercial drug. To overcome these disadvantages, several novel derivatives of gossypol were designed, synthesized, and analyzed. One of the derivatives, compound 7 (6-aminopenicillanic acid sodium-gossypolone), was identified with great water solubility and anticancer property, suggested by inducing a dramatically decrease in Bcl-2 and Bcl-xL protein expression level found in vitro and growth inhibition of murine colon tumor in vivo. Furthermore, it was also recognized with less toxicity than compound 1 in vivo and significantly increased chemotherapeutic sensitivity against colon cancer in combination with traditional chemotherapeutic agent 5-fluorouracil. Therefore, it is concluded that compound 7 is superior to parent compound 1, and further preclinical studies of compound 7 is necessary for colon cancer therapy.
    Journal of Medicinal Chemistry 08/2010; 53(15):5502-10. · 5.61 Impact Factor
  • Hai-Xia Jiang, Xing-Xin Cao, Hao Huang, Biao Jiang
    [Show abstract] [Hide abstract]
    ABSTRACT: A simple and practical procedure has been developed for the resolution of racemic gossypol. The commercially available l-amino acid esters have been employed as the resolving agents with the l-tryptophan methyl ester (l-Trp-OMe) as the best reagent of choice. The individual diastereoisomeric gossypol adducts derived from l-Trp-OMe are readily separated by a simple filtration step to give the (−)-diastereoisomeric adduct, and its (+)-diastereoisomeric adduct can be easily obtained by simple evaporation of the mother liquor. Acid hydrolysis of the separated adduct gave (−)-gossypol and (+)-gossypol, respectively, in high chemical yields (quantitatively) and in high enantiomeric excesses (>95%).
    Tetrahedron Asymmetry 01/2007; 18(20):2437-2441. · 2.12 Impact Factor
  • Hai-Xia Jiang, Ya Li, Jing Pan, Kun Gao
    [Show abstract] [Hide abstract]
    ABSTRACT: Four new terpenoids, namely, rel-(1R,2S,3R,4R,6S)-p-menthane-1,2,3,6-tetrol (1), rel-(1R,2R,3R,4S,6S)-p-menthane-1,2,3,6-tetrol (2), 9-hydroxythymol 3-O-angelate (3), and (3β,20R)-20-hydroxylanost-25-en-3-yl palmitate (4), together with fourteen known compounds, were isolated from the AcOEt part of the MeOH extracts of Eupatorium fortunei. In addition, two other monoterpenoids, ‘acetone thymol-8,9-diyl ketal’ (19) and 8-methoxy-9-hydroxythymol 3-O-angelate (20) were also obtained which were probably artifacts but have never been reported in the literature. The structures of the new compounds, including their relative configurations, were established by an extensive study of their spectral data, especially 1D- and 2D-NMR. The cytotoxic activity of the new compounds against human hepatoma (SMMC-7721), human leukemia (HL-60), and human hepatocyte (LO2) cells was investigated.
    Helvetica Chimica Acta 03/2006; 89(3):558 - 566. · 1.38 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: A new bidihydroflavonoid, thuidinin 1, together with 5 known compounds including one known biflavonoid 3′,3′′′-binaringenin (2) and four other known natural products pentadecane (3), methyl β-orcinolarboxylate (4), β-sitosterol (5) and daucostenol (6), were isolated from leaves of Thuidium kanedae Sak. Their structures were established on the basis of 1D and 2D spectroscopic analysis. The absolute stereochemistry of compounds 1 and 2 was determined by CD spectra.
    Chinese Journal of Chemistry 03/2006; 24(3):393 - 395. · 0.92 Impact Factor
  • Yan-Jun Chen, Hai-Xia Jiang, Kun Gao
    [Show abstract] [Hide abstract]
    ABSTRACT: Phytochemical investigation of Eupatorium fortunei Turcz. afforded one novel 30-nor-ursane triterpene, 3β-hydroxy-30-nor-urs-21-en-20-one, and seven known compounds including two sesquiterpenes and five monoterpenes. These eight compounds were isolated from the genus Eupatorium for the first time. These finds may be chemotaxonomically significant to distinguish E. fortunei from other Eupatorium species.
    Biochemical Systematics and Ecology 47:1–4. · 1.15 Impact Factor

Publication Stats

10 Citations
14.75 Total Impact Points

Institutions

  • 2010
    • Northeast Institute of Geography and Agroecology
      • Key Laboratory of Synthetic Chemistry of Natural Substances
      Beijing, Beijing Shi, China
  • 2006–2007
    • Shanghai Research Institute of Chemical Industry
      Shanghai, Shanghai Shi, China
    • Lanzhou University
      • State Key Laboratory of Applied and Organic Chemistry
      Lanzhou, Gansu Sheng, China