Haiyan Wang

Chongqing Medical University, Ch’ung-ch’ing-shih, Chongqing Shi, China

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Publications (164)705.98 Total impact

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    ABSTRACT: NiO effectively promotes the sintering of highly refractory Y-doped BaZrO3 (BZY) through the formation of BaY2NiO5, providing a simple and cost-effective method for the fabrication of dense BZY electrolyte and Ni–BZY hydrogen separation membrane at ∼1400 oC. Unfortunately, insulating BaCO3 and Y2O3 phases formed on the surface of BZY and Ni–BZY prepared by solid state reaction method with NiO after annealing in wet CO2. Ni–BZY membranes prepared from different methods suffered different degree of performance loss in wet H2 at 900 °C. The chemical instability of Ni–BZY is attributed to the formation of a secondary phase (BaY2O4) generated from the reduction of BaY2NiO5 in H2 during the sintering process. Both BaY2O4 and BaY2NiO5 react with H2O, and CO2 at elevated temperatures, generating insulating Ba(OH)2 and BaCO3 phases, respectively. The less BaY2O4 is formed in the fabrication process, the better chemical stability the Ni–BZY membranes possess. Therefore, a new Ni–BZY membrane is prepared through a judicial combination of BZY powders prepared from combined EDTA-citric and solid state reaction methods, and demonstrates exceptional chemical stability in H2O and CO2, enabling stable and even improved hydrogen flux in wet 50% CO2 at 900 °C.
    Journal of Power Sources 03/2015; 278. DOI:10.1016/j.jpowsour.2014.12.108 · 5.21 Impact Factor
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    ABSTRACT: High energy particles can introduce severe radiation damage in metallic materials especially those with low stacking fault energy. Twin boundary (TB) has recently been shown to enable the reduction of defect density in heavy ion irradiated nanotwinned Ag. However, the defect-twin boundary interaction mechanisms in nanotwinned metals remain poorly understood. Here we report on the study of TB affected zone wherein time accumulative defect density and defect diffusivity are substantially different from those in twin interior. In situ studies also reveal surprising resilience of TBs in response to radiation: TBs continue to change their geometry to facilitate the capture, transportation and removal of defect clusters and can recover by absorbing opposite type of defects. This study provides further support for the implementation of TBs as effective defect sinks for the design of radiation tolerant nanostructured metallic materials.
  • Applied Physics Letters 01/2015; 106(2):022902. DOI:10.1063/1.4905596 · 3.52 Impact Factor
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    ABSTRACT: Li2MnO3 is an attractive cathode material due to its low cost, non-toxicity and potentially high capacity. However, its electrochemical inactivity, poor electronic conductivity and uncertainty about underlying mechanism have limited its development. In this work, an in-situ technique for extraction of Li and O during deposition of the thin film cathode is developed to investigate structural and electrochemical effects in a controlled fashion. MnO2 has been observed in samples with severe O and Li deficiency (capacity of 115 mAh g-1), while Li2MnO3 cathodes with slightly excess O and Li (capacity of 225 mAh g-1) can be synthesized by tuning growth conditions appropriately. Formation of MnO2 phase, especially in Li and O deficient structures, could be a possible reason for irreversible capacity loss in Li2MnO3 related materials. Further investigation into stoichiometric and microstructure variations enabled by this technique allows rapid investigation of Li2MnO3 as well as other Li-rich composites.
    ACS Applied Materials & Interfaces 01/2015; 7(4). DOI:10.1021/am5071305 · 5.90 Impact Factor
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    ABSTRACT: Bone morphogenetic proteins (BMPs) are members of the TGF-β superfamily signaling factors. Expression of several BMPs (BMP2, BMP4 and BMP7) is correlated to poor prognosis in gastric cancer patients. The function of BMP9, the latest discovered and most powerful osteogenetic factor, in gastric cancer is relatively unclear. In this report, we investigated the expression, function and underlying molecular mechanisms of BMP9 in gastric cancer. The results show that BMP9 expression was markedly decreased in gastric cancer tissues and cell lines. Enforced BMP9 expression in the gastric cancer cell lines SGC-7901 and MNK-45 increased apoptosis and reduced viability and migration. The in vivo function of BMP9 was evaluated in a xenograft mouse model. Tumors derived from SGC-7901 cells with enforced BMP9 expression (SGC-7901/BMP9) showed significantly reduced size and weight compared to that from control cells. Enforced BMP9 expression resulted in decreased Akt activity shown as lower levels of phosphorylation at Ser473 and Thr308 in Akt. The PI3K/Akt inhibitor LY294002 potentiated BMP9's viability and migration suppression, and apoptosis induction, which was associated with reduced expression of snail and VEGF and increased expression of E-cadherin. In addition, tumors derived from SGC-7901/BMP9 showed reduced Akt activity and VEGF expression, and increased E-cadherin expression. Therefore, our studies reveal for the first time that inhibition of the PI3K-Akt pathway is involved in the tumor suppressor effects of BMP9 in gastric cancer. This article is protected by copyright. All rights reserved
    Journal of Cellular Biochemistry 01/2015; DOI:10.1002/jcb.25063 · 3.37 Impact Factor
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    ABSTRACT: Recent studies have shown that chemical immiscibility is important to achieve enhanced radiation tolerance in metallic multilayers as immiscible layer interfaces are more stable against radiation induced mixing than miscible interfaces. However, as most of these immiscible systems have incoherent interfaces, the influence of coherency on radiation resistance of immiscible systems remains poorly understood. Here, we report on radiation response of immiscible Cu/Fe multilayers, with individual layer thickness h varying from 0.75 to 100 nm, subjected to He ion irradiation. When interface is incoherent, the peak bubble density decreases with decreasing h and reaches a minimum when h is 5 nm. At even smaller h when interface is increasingly coherent, the peak bubble density increases again. However, void swelling in coherent multilayers with smaller h remains less than those in incoherent multilayers. Our study suggests that the coherent immiscible interface is also effective to alleviate radiation induced damage.
    Journal of Materials Research 01/2015; DOI:10.1557/jmr.2015.24 · 1.82 Impact Factor
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    ABSTRACT: Addition of second-phase nanosize defects to YBa2Cu3O7-δ (YBCO) superconductor thin films is known to enhance flux pinning and increase current densities (Jc). The addition of Y2BaCuO5 (Y211) was previously studied in (Y211/ YBCO)N multilayer structures and in Y211 + YBCO films deposited from pie-shaped targets. This research systematically studies the effect of Y211 addition in thin films deposited by pulsed laser deposition from YBCO1-xY211x(x = 0-15 vol.%) single targets, at temperatures of 785°C-840°C. Interestingly, the resulting size of Y211 particles is 20-40 nm, in contrast to 10-15 nm in previous studies of Y211 and 5-10 nm for other second-phase defect additions, and the number density is reduced. A slight increase of Jc(H, T) was achieved, compared with previous optimization studies. Results and comparisons of flux pinning, intrinsic stresses imaged by TEM, current densities, critical temperatures, and microstructures will be presented. The overall low intrinsic stress on YBCO from Y211 lattice mismatch is smaller than previously studied second-phase defect additions known, which is hypothesized to be the driving force in achieving the unusually large second-phase nanoparticle size and volume fraction thus far in YBCO thin films.
    IEEE Transactions on Applied Superconductivity 01/2015; 25(3):1-5. DOI:10.1109/TASC.2014.2368072 · 1.32 Impact Factor
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    ABSTRACT: Functional ferromagnetic (Fe2O3)x:(CeO2)1-x vertically aligned nanocomposite (VAN) layers were deposited as either buffer or cap layers for YBa2Cu3O7-δ (YBCO) thin films. The composition of Fe2O3 dopants in the VAN nanolayers is controlled at 10%, 30% and 50% in order to create different arrangements of Fe2O3 and CeO2 nanopillars and therefore to tune the flux pining landscapes. The composition variation provides tunable and ordered arrangements of magnetic nanodopants and interfacial defects as pinning centers in the YBCO thin films. The superconducting property measurements show that most doped samples obtain a Tc above 90 K and the Jcsf measured at 75K and 65K maximized at 3.07MA/cm2 and 9.2 MA/cm2 for 30% Fe2O3 VAN doped sample. As the temperature decreased to 5 K, the sample with 50% Fe2O3 VAN doped sample show the best pinning effect due to pronounced magnetic pinning effects. This work demonstrates the tunable density of magnetic pinning centers can be achieved by VAN to meet the specific pinning requirement.
    Physica C Superconductivity 12/2014; 510. DOI:10.1016/j.physc.2014.12.004 · 1.11 Impact Factor
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    ABSTRACT: Human astroviruses (HAstVs) are one of the leading viral agents of acute gastroenteritis. However, there is limited information on HAstVs in China. Here, we describe the molecular characterization of HAstVs in Shandong, China via sewage surveillance. A total of 23 sewage samples were collected from sewage treatment plants in the cities of Jinan and Linyi in 2013. After concentration via adsorption-elution method, 9 samples (39.1%) were positive by reverse transcription PCR (RT-PCR) for the presence of the 719-nt HAstV nucleotide sequence. Genetic cloning and sequencing were performed on positive PCR products, and 26 HAstV sequences were obtained. Phylogenetic analysis on these sequences revealed 4 genotypes (HAstV-1, -2, -4 and -5), with HAstV-1 and -5 as the most common genotypes in Jinan and Linyi, respectively. Homologous comparison revealed Shandong sequences had relatively less genetic divergence among themselves than with foreign sequences. This study represents the first effort to investigate the genotypes and molecular epidemiology of HAstVs via sewage surveillance in China. The high detection rate in this study reflects that HAstVs circulated at a relatively high frequency in the local population, and demonstrates that environmental surveillance is an effective method in investigating circulating HAstVs.
    Scientific Reports 12/2014; 4:7539. DOI:10.1038/srep07539 · 5.08 Impact Factor
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    ABSTRACT: Making silicon an efficient light-emitting material is an important goal of silicon photonics. Here we report the observation of broadband sub-bandgap photoluminescence in silicon nanowires with a high density of stacking faults. The photoluminescence becomes stronger and exhibits a blue shift under higher laser powers. The super-linear dependence on excitation intensity indicates a strong competition between radiative and defect-related non-radiative channels, and the spectral blue shift is ascribed to the band filling effect in the heterostructures of wurtzite silicon and cubic silicon created by stacking faults.
    Nanoscale 12/2014; 7(5). DOI:10.1039/C4NR05410E · 6.74 Impact Factor
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    ABSTRACT: To gain fundamental insight into the relationship between length scales and mechanical behaviour, Ni-Fe multilayered materials with a 5-μm-layer thickness and a modulated grain size distribution have been synthesized by pulsed electrodeposition. Microstructural studies by SEM and TEM reveal the alternating growth of well-defined layers with either nano (d = 16 nm) or coarse grains (d ≥ 500 nm). Room temperature tensile tests have been performed to investigate the mechanical response and understand the underlying deformation mechanisms. Tensile test results and fractographic studies demonstrate that the overall room temperature mechanical behaviour of the multilayered material, i.e. strength and ductility, is governed primarily by the layers containing nanocrystalline grains. The measured properties have been discussed in the context of modulated grain structure of the multilayered sample and contribution of each grain size regime to the overall strength and ductility.
    Philosophical Magazine 11/2014; 94(31). DOI:10.1080/14786435.2014.964346 · 1.43 Impact Factor
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    ABSTRACT: Highly strained films of BiFe0.5Mn0.5O3 (BFMO) grown at very low rates by pulsed laser deposition were demonstrated to exhibit both ferrimagnetism and ferroelectricity at room temperature and above. Magnetisation measurements demonstrated ferrimagnetism (TC ∼ 600K), with a room temperature saturation moment (MS) of up to 90 emu/cc (∼ 0.58 μB/f.u) on high quality (001) SrTiO3. X-ray magnetic circular dichroism showed that the ferrimagnetism arose from antiferromagnetically coupled Fe3+ and Mn3+. While scanning transmission electron microscope studies showed there was no long range ordering of Fe and Mn, the magnetic properties were found to be strongly dependent on the strain state in the films. The magnetism is explained to arise from one of three possible mechanisms with Bi polarization playing a key role. A signature of room temperature ferroelectricity in the films was measured by piezoresponse force microscopy and was confirmed using angular dark field scanning transmission electron microscopy. The demonstration of strain induced, high temperature multiferroism is a promising development for future spintronic and memory applications at room temperature and above.
    Advanced Functional Materials 10/2014; DOI:10.1002/adfm.201401464 · 10.44 Impact Factor
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    ABSTRACT: FeSe0.1Te0.9 thin films were deposited on single crystal SrTiO3 (STO) (100) substrates by a pulse laser deposition (PLD) technique. CeO2 nanolayer was introduced as either cap layer or buffer layer to investigate its pinning effects in FeSe0.1Te0.9 thin films. The results show improved film quality after doping with CeO2 nanolayers, and no impurity phase was identified. All the samples achieve T c of 12.5 K, and in-field J c was greatly enhanced after doping with either cap or buffer CeO2 nanolayer for the field range up to 7 T. The buffered one shows the best self-field J c of 0.89 MA cm−2 at 4 K and a high upper critical field H c 2 of 186 T.
    Superconductor Science and Technology 09/2014; 27(10):105006. DOI:10.1088/0953-2048/27/10/105006 · 2.80 Impact Factor
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    ABSTRACT: Enteroviruses (EVs) are important human pathogens associated with various clinical syndromes. This study represents an overview of non-polio enteroviruses (NPEVs) isolated from acute flaccid paralysis (AFP) surveillance in Shandong Province, China from 1988 to 2013. Altogether 792 and 170 NPEV isolates were isolated from stool specimens of 9263 AFP cases and 1059 contacts, respectively. Complete VP1 sequencing and typing on all 962 isolates revealed 53 NPEV types in which echovirus (E) 6 (7.6%), E14 (7.6%), E11 (7.4%), coxsackievirus (CV) B3 (7.4%), E25 (5.6%), CVB5 (4.9%), E7 (4.5%) and EV-A71 (4.4%) were the eight most commonly reported serotypes. Distinct summer-fall seasonality was observed, with June-October accounting for 79.3% of isolation from AFP cases with known month of specimen collection. Increase of isolation of EV-A71 and CVA-the predominant pathogens for the hand, foot, and mouth disease-was observed in recent years. Sequence analysis on VP1 coding region of EV-A71 and E6 suggested Shandong strains had great genetic divergence with isolates from other countries. The results described in this study provide valuable information on the circulation and emergence of different EV types in the context of limited EV surveillance in China.
    Scientific Reports 08/2014; 4:6167. DOI:10.1038/srep06167 · 5.08 Impact Factor
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    ABSTRACT: A combined chemical pressure and substrate biaxial pressure crystal engineering approach was demonstrated for producing highly epitaxial Sm-doped BiMnO3 (BSMO) films on SrTiO3 single crystal substrates, with enhanced magnetic transition temperatures, TC of ~ 140 K, 40K higher than for standard BiMnO3 (BMO) films. Strong room temperature ferroelectricity with piezoresponse amplitude, d33 = 10pm/V and long term retention of polarisation were also observed. Furthermore, the BSMO films were much easier to grow than pure BMO films, with excellent phase purity over a wide growth window. The work represents a very effective way to independently control strain in-plane and out-of-plane which is important not just for BMO but for controlling properties of many other strongly correlated oxides.
    ACS Applied Materials & Interfaces 08/2014; 6(17). DOI:10.1021/am501351c · 5.90 Impact Factor
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    ABSTRACT: Thin films of TiN and Ti0.35Al0.65N nanocomposite were deposited on polished Zircaloy-4 tubes. After exposure to supercritical water for 48 h, the coated tubes are remarkably intact, while the bare uncoated tube shows severe oxidation and breakaway corrosion. X-ray diffraction patterns, secondary electron images, backscattered electron images, and energy dispersive X-ray spectroscopy data from the tube surfaces and cross-sections show that a protective oxide, formed on the film surface, effectively prevents further oxidation and corrosion to the Zircaloy-4 tubes. This result demonstrates the effectiveness of thin film ceramics as protective coatings under extreme environments.
    Journal of Nuclear Materials 07/2014; 451(1-3). DOI:10.1016/j.jnucmat.2014.04.010 · 2.02 Impact Factor
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    ABSTRACT: We report the observation of a strong 2D band Raman in twisted bilayer graphene (tBLG) with large rotation angles under 638 nm and 532 nm visible laser excitations. The 2D band Raman intensity increased four-fold as opposed to the two-fold increase observed in single-layer graphene. The same tBLG samples also exhibited rotation-dependent G-line resonances and folded phonons under 364 nm UV laser excitation. We attribute this 2D band Raman enhancement to the constructive interference between two double-resonance Raman pathways, which were enabled by a nearly degenerate Dirac band in the tBLG Moiré superlattices.
    Nanotechnology 07/2014; 25(33):335201. DOI:10.1088/0957-4484/25/33/335201 · 3.67 Impact Factor
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    ABSTRACT: Environmental surveillance is an effective approach in investigating the circulation of polioviruses (PVs) and other human enteroviruses (EVs) in the population. The present report describes the results of environmental surveillance conducted in Shandong Province, China, from 2008 to 2012. A total of 129 sewage samples were collected, and 168 PVs and 1,007 nonpolio enteroviruses (NPEVs) were isolated. VP1 sequencing and typing were performed on all isolates. All PV strains were Sabin-like, with the numbers of VP1 substitutions ranging from 0 to 7. The NPEVs belonged to 19 serotypes, and echovirus 6 (E6), E11, coxsackievirus B3 (CVB3), E3, E12, and E7 were the six main serotypes, which accounted for 18.3%, 14.8%, 14.5%, 12.9%, 9.0%, and 5.7% of NPEVs isolated, respectively. Typical summer-fall peaks of NPEV were observed in the monthly distribution of isolation, and an epidemic pattern of annual circulation was revealed for the common serotypes. Phylogenetic analysis was performed on environmental CVB3 and E3 strains with global reference strains and local strains from aseptic meningitis patients. Shandong strains formed distinct clusters, and a close relationship was observed between local environmental and clinical strains. As an EV-specific case surveillance system is absent in China and many other countries, continuous environmental surveillance should be encouraged to investigate the temporal circulation and phylogeny of EVs in the population.
    Applied and Environmental Microbiology 07/2014; 80(15):4683-4691. DOI:10.1128/AEM.00851-14 · 3.95 Impact Factor
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    ABSTRACT: We develop a novel device structure using easy-to-grow nanoscaffold films to localize oxygen vacancy at vertical heterointerfaces. Our strategy is to design vertical interfaces using two structurally incompatible oxides, which are likely to generate a high concentration oxygen vacancy. We demonstrate nonlinear electroresistance at room temperature using these nanoscaffold devices. The resistance variations exceed two orders of magnitude with very high uniformity and tunability.
    Advanced Materials 07/2014; 26(36). DOI:10.1002/adma.201401917 · 15.41 Impact Factor

Publication Stats

1k Citations
705.98 Total Impact Points


  • 2013–2015
    • Chongqing Medical University
      Ch’ung-ch’ing-shih, Chongqing Shi, China
    • Soochow University (PRC)
      • School of Physical Science and Technology School of Energy
      Suzhou, Jiangsu Sheng, China
  • 2007–2015
    • Texas A&M University
      • • Materials Science and Engineering Program
      • • Department of Electrical and Computer Engineering
      College Station, Texas, United States
    • Texas A&M University - Kingsville
      Kingsville, Texas, United States
  • 2014
    • University of Houston
      • Center for Advanced Materials
      Houston, Texas, United States
  • 2011–2014
    • Shandong University
      • School of Public Health
      Chi-nan-shih, Shandong Sheng, China
    • Jiangsu Provincial Center for Disease Control and Prevention
      Chiang-tu, Jiangsu Sheng, China
    • Huazhong University of Science and Technology
      • Wuhan National Laboratory for Optoelectronics
      Wu-han-shih, Hubei, China
    • Tsinghua University
      • Centre for Nano and Micro Mechanics
      Peping, Beijing, China
  • 2012
    • Shandong University of Traditional Chinese Medicine
      Shan-tang, Jiangxi Sheng, China
  • 2008–2012
    • University of Cambridge
      • Department of Materials Science and Metallurgy
      Cambridge, ENG, United Kingdom
  • 2007–2012
    • Alabama A & M University
      Huntsville, Alabama, United States
  • 2008–2010
    • Los Alamos National Laboratory
      • Materials Physics and Applications Division
      Los Alamos, California, United States
  • 2001
    • North Carolina State University
      • Department of Materials Science and Engineering
      Raleigh, NC, United States