H.L. Nijman

Publications (2)0 Total impact

• Article: Seclusion of admitted psychotic patients: later in the case of antipsychotic

  J.J. Stolker, G.W.K. Hugenholtz, E.R. Heerdink, H.L. Nijman, H.G.M. Leufkens, W.A. Nolen
• Article: Trials Assessing Pharmacotherapeutical Management of Aggression in Psychiatric Patients: Comparability with Clinical Practice

  L.E. Goedhard, J.J. Stolker, H.L. Nijman, T.C. Egberts, E.R. Heerdink
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  ABSTRACT: Introduction: In a previous review of randomized controlled trials (RCTs) on the pharmacotherapeutic management of aggression, it was shown that there is only weak evidence of eff ectiveness. In the present study we aim to determine comparability of patients included in these RCTs and patients of psychiatric long-stay wards. Methods: Exclusion criteria that were used in at least 20 % of the RCTs were applied to a sample of aggressive inpatients from clinical practice, in order to fi nd what proportion of these patients would be eligible to participate in the reviewed, high quality RCTs. Results: Only 30 % of aggressive psychiatric patients as seen in clinical practice would be eligible to participate in a typical randomized controlled trial based on the most frequently applied exclusion criteria. Discussion: The low comparability of patients included in RCTs with those seen in clinical practice may decrease the generalizability of the fi ndings form RCTs to clinical practice.