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T Sumikama,
K Yoshinaga, H Watanabe,
S Nishimura,
Y Miyashita,
K Yamaguchi,
K Sugimoto,
J Chiba,
Z Li,
H Baba, [......],
K Steiger,
D Steppenbeck,
S Takano,
A Takashima,
K Tajiri,
T Teranishi,
Y Wakabayashi,
P M Walker,
O Wieland,
H Yamaguchi
05/2011;
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T Kodani,
T Osada,
T Terai,
T Ohkusa,
T Shibuya,
N Sakamoto,
K Beppu,
J Kato,
A Nagahara, H Watanabe,
S Watanabe
Endoscopy 01/2011; 43 Suppl 2 UCTN:E298-9. · 5.21 Impact Factor
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T Sumikama,
K Yoshinaga, H Watanabe,
S Nishimura,
Y Miyashita,
K Yamaguchi,
K Sugimoto,
J Chiba,
Z Li,
H Baba, [......],
K Steiger,
D Steppenbeck,
S Takano,
A Takashima,
K Tajiri,
T Teranishi,
Y Wakabayashi,
P M Walker,
O Wieland,
H Yamaguchi
Physical Review Letters 01/2011; 106:202501. · 7.37 Impact Factor
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[show abstract]
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ABSTRACT: The influence of hot B implantation into diamond and postimplantation high-temperature annealing at 1600 °C on doping properties has been investigated. B multiple ion implantation was performed at 30– 360 keV into high-pressure, high-temperature synthetic type-IIa diamond or high-quality homoepitaxially grown diamond films at 400 °C, followed by 1450 °C and higher temperature (1600 °C) annealing. Optical transmission spectra indicated that radiation damage was almost removed with an increase in annealing temperatures up to 1600 °C. In the sample of 5 × 10 18 cm − 3 using a type-IIa substrate, the hole concentration and the Hall mobility were 2 × 10 13 cm − 3 and 55 cm 2 /Vs after 1450 °C annealing, respectively. After 1600 °C annealing, their values increased to 6.5 × 10 13 cm − 3 and 82 cm 2 /Vs, respectively. The doping efficiency of the sample after 1600 °C annealing ~ 50% is the highest ever reported for B implanted diamond. By contrast, in the sample of 5 × 10 19 cm − 3 using a type-IIa substrate, high-temperature annealing at 1600 °C resulted in the appearance of hopping conduction in the low-temperature region below 400 K. In the case of a homoepitaxial film B doped at 5 × 10 19 cm − 3 , band conduction is still dominant even after such 1600 °C annealing, giving an increase in the hole concentration in the valence band. The resultant resistivity of the film became much lower than that of annealing at 1450 °C.
10/2008;
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Physical review A. 01/2008; 77(6):062709.
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Physical Review A. 01/2007; 75(1):012702.
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H Watanabe,
AP Kavanagh,
H Kuramoto,
YM Li,
N Nakamura,
S Ohtani,
BE O’Rourke,
A Sato,
H Tawara,
XM Tong,
others
Nuclear Instruments and Methods in Physics Research Section B Beam Interactions with Materials and Atoms 01/2005; 235(1):261-264. · 1.21 Impact Factor
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Journal of Physics B: Atomic, Molecular and Optical Physics. 01/2004; 37:2343.
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G.J.A. Offerhaus,
P. Correa,
S. Eeden,
K. Geboes,
P. Drillenburg,
M. Vieth,
M.L. Velthuysen, H. Watanabe,
P. Sipponen,
F.J.W. Kate,
F.T. Bosman,
A. Bosma,
A. Ristimaki,
H. Dekken,
R. Riddell,
G.N.J. Tytgat
Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin 01/2003; 443(5):602-608. · 2.49 Impact Factor
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Nuclear Instruments and Methods in Physics Research Section B Beam Interactions with Materials and Atoms 01/2003; 205:378-381. · 1.21 Impact Factor
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ABSTRACT: The aim of this study was to determine the most appropriate line of resection for extrahepatic bile duct carcinoma.
A retrospective review was carried out of 253 resected specimens of extrahepatic bile duct carcinoma. Carcinomas were classified histologically as invasive or non-invasive in addition to assessment of the resection margin.
Tumour was present microscopically at the resection margin in 80 (31.6 per cent) of 253 cases, with 46 showing marginal involvement by non-invasive carcinoma, 20 showing invasive carcinoma at a margin, and 14 showing both. Involvement of the resection margin by invasive carcinoma was encountered only when the margin was shorter than 10 mm, whereas non-invasive carcinoma was encountered even when the margin length reached 40 mm. The observed length of microscopic extension of invasive carcinoma beyond the macroscopically evident tumour mass was limited to 10.0 mm. Median microscopic extension of non-invasive carcinoma beyond the mass was 10 mm (75th percentile 19.5 and 14.5 mm in proximal and distal directions respectively; maximum 52 mm). Margins of 20 mm could be assured to be negative proximally in 89.0 per cent of cases and distally in 93.8 per cent.
For eradication of invasive extrahepatic bile duct carcinoma, a 10-mm margin is required. However, additional removal of any non-invasive component requires a 20-mm margin. These guidelines should be followed in any operation performed with curative intent.
British Journal of Surgery 11/2002; 89(10):1260-7. · 4.61 Impact Factor
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ABSTRACT: It has been reported that human CD161 (NKR-P1A)+ T cells are counterparts of murine natural T (NT) cells and predominantly accumulate in the liver. However, NT cells in the human intestine have not been well analysed. The aim of this study was to assess the existence of NT cells in human intestinal epithelium and determine their phenotypical characterization. Intra-epithelial lymphocytes (IEL) were isolated from surgical specimens (jejunum, ileum and colon). The surface phenotype of IEL was analysed using a FACScan and compared with that of mononuclear cells (MNC) from other organs. CD161+ T cells were abundant in human intestinal epithelium as well as the liver. The majority of CD161+ T cells in IEL were CD8+ cells. About 50% of CD161+ T cells in hepatic lymphocytes (HL) expressed CD56, whereas only 14% of CD161+ T cells in IEL expressed CD56. The jejunum showed the greatest abundance of CD161+ T cells among the intestinal regions investigated. These results suggest that CD161+ T (NT) cells predominantly exist in human intestinal epithelium and may play an important role in local immunity.
Clinical & Experimental Immunology 08/2002; 129(1):92-8. · 3.36 Impact Factor
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M Rugge,
P Correa,
M F Dixon,
R Fiocca,
T Hattori,
J Lechago,
G Leandro,
A B Price,
P Sipponen,
E Solcia, H Watanabe,
R M Genta
[show abstract]
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ABSTRACT: Considerable difficulties persist amongst pathologists in agreeing on the presence and severity of gastric atrophy. An international group of pathologists pursued the following aims: (i) to generate an acceptable definition and a simple reproducible classification of gastric atrophy; and (ii) to develop guidelines for the recognition of atrophy useful for increasing agreement among observers.
After redefining atrophy as the 'loss of appropriate glands' and examining histological samples from different gastric compartments, three categories were identified: (i) negative; (ii) indefinite; (iii) atrophy, with and without intestinalization. Atrophy was graded on a three-level scale. Interobserver reproducibility of the classification was tested by kappa statistics (general and weighted) in a series of 48 cases.
The medians of the general agreement and weighted kappa values were 0.78 and 0.73, respectively. The weighted kappa coefficients, obtained by cross-tabulating the evaluation of each pathologist against all others, were, with only one exception, > 0.4 (moderate to excellent agreement).
By using the definition of atrophy as the loss of appropriate glands and distinguishing the two main morphological entities of metaplastic and non-metaplastic types, a high level of agreement was achieved by a group of gastrointestinal pathologists trained in different cultural contexts.
Alimentary Pharmacology & Therapeutics 07/2002; 16(7):1249-59. · 3.77 Impact Factor
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ABSTRACT: We report the successful implantation of a cardioverter defibrillator (ICD) in a 12-month-old infant. A single-lead ICD using an epicardial patch and a cathodal pulse-generator titanium shell electrode was very useful for implantation in this infant.
The Annals of Thoracic Surgery 01/2002; 72(6):2125-7. · 3.74 Impact Factor
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Journal of Physics B: Atomic, Molecular and Optical Physics. 01/2002; 35:5095.
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T Washizuka,
M Chinushi,
M Tagawa,
H Kasai, H Watanabe,
Y Hosaka,
F Yamashita,
H Furushima,
A Abe,
J Hayashi,
Y Aizawa
[show abstract]
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ABSTRACT: The study prospectively investigated the incidence, cause and efficient management of inappropriate discharge by the fourth generation implantable cardioverter-defibrillator (ICD) system in 45 patients (mean age, 57+/-16 years). During the follow-up period of 27+/-17 months, 18 patients (40%) experienced one or more inappropriate therapies: sinus and supraventricular tachycardia (15 patients) and T wave oversensing (3 patients). In the 15 patients, re-programming of the tachycardia detection interval and/or additional treatment with beta-blocking agents were effective. In the 3 patients with T wave oversensing, the arrythmia was associated with an increase in T wave amplitude, change in T wave morphology and decreased R wave amplitude, and re-programming of the sensitivity of the local electrogram or changing the number of intervals to detect ventricular tachycardia decreased the number of inappropriate discharges in all 3 patients. In conclusion, inappropriate therapies are common problems in patients treated with the fourth generation ICD system, but most of them can be resolved using the dual-chamber ICD system. However, in patients with T-wave oversensing, it is difficult to avoid inappropriate discharge completely, even if the dual-chamber ICD system is implanted.
Japanese Circulation Journal 12/2001; 65(11):927-30.
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M Bannai,
T Kawamura,
T Naito,
H Kameyama,
T Abe,
H Kawamura,
C Tsukada, H Watanabe,
K Hatakeyama,
H Hamada,
Y Nishiyama,
H Ishikawa,
K Takeda,
K Okumura,
M Taniguchi,
T Abo
[show abstract]
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ABSTRACT: Natural killer T (NKT) cells are mainly present in the liver and thymus, and the majority of these T cells express either a CD4(+) or a double-negative (DN) CD4(-)8(-) phenotype. In the present study, we examined whether such NKT cells were present in the intestine. NKT cells were rare in all sites of the small intestine, including an intraepithelial site. However, a considerable number of NKT cells were found at an intraepithelial site in the large intestine. This result was confirmed by both immunofluorescence and immunohistochemistry. In contrast to conventional NKT cells, NKT cells in the large intestine were CD8(+) or DN CD4(-)8(-). In the case of conventional NKT cells, their existence is known to depend on non-classical MHC class I-like antigens (i. e. CD1d) but not on classical MHC class I antigens. However, the NKT cells in the large intestine were independent of the presence of both CD1d and classical MHC class I antigens. These results were obtained using knockout mice lacking the corresponding genes and molecules. NKT cells in the large intestine were mainly alpha betaTCR(+) (> 75 %) but did not use an invariant chain of Valpha14Jalpha281, which is preferentially used by conventional NKT cells. These NKT cells did not bias the TCR-Vbeta usage toward Vbeta8. These findings suggest that the large intestine is a site in which unconventional NKT cells carrying the CD8(+) phenotype (or DN CD4(-)8(-)) are abundant and that these cells are independent of MHC and MHC-like antigens.
European Journal of Immunology 11/2001; 31(11):3361-9. · 5.10 Impact Factor
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B Ruiz,
J Garay,
W Johnson,
D Li,
M Rugge,
M F Dixon,
R Fiocca,
R M Genta,
T Hattori,
J Lechago,
A B Price,
P Sipponen,
E Solcia, H Watanabe,
P Correa
[show abstract]
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ABSTRACT: As part of a multinational effort to reach a consensus in the definition and evaluation of atrophic gastritis, we applied morphometric techniques to 22 antral biopsy specimens examined visually by 12 experienced gastrointestinal pathologists.
Atrophy was defined as loss of glands. Each pathologist graded atrophy with both non-standardized and standardized approaches. Discriminant function analyses of morphometric measurements were conducted to validate and grade atrophy. Kappa statistics were used to compare the performance of each pathologist against the group mode and against the discriminant functions' grading of atrophy. Three morphometric indexes showed significant differences among categories of atrophy utilizing non-standardized as well as standardized visual atrophy grades: (i) the ratio of glandular length to total mucosal thickness; (ii) the proportion of the secretory compartment area occupied by glands; and (iii) the number of glandular cross sections per 40x microscopic field. The discriminant function analyses verified all cases classified visually as either non-atrophic, or moderately/severely atrophic; it verified as mildly atrophic 40% of the cases classified visually as mildly atrophic; and classified the remaining 60% as moderately or severely atrophic. The kappa statistics were good or excellent for the majority of pathologists.
The evaluation of antral atrophy, simply defined as loss of glands, can be reliable and reproducible. The visual grading of atrophy as absent, moderate and severe is entirely consistent with objective morphometric observations.
Histopathology 10/2001; 39(3):235-42. · 3.08 Impact Factor
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K Hayashi,
N Ando, H Watanabe,
H Ide,
K Nagai,
N Aoyama,
W Takiyama,
K Ishida,
K Isono,
H Makuuchi,
M Imamura,
M Shinoda,
S Ikeuchi,
T Kabuto,
H Yamana,
H Fukuda
[show abstract]
[hide abstract]
ABSTRACT: Surgery for advanced esophageal carcinoma has its limits as regards aggressiveness and therapeutic effect, therefore effective multimodality treatment is required to obtain better survival. The objective of this study was to evaluate whether daily continuous infusion of CDDP could achieve a higher clinical response rate with less toxicity than its drip infusion in the previous phase II study that we had conducted.
Patients with primary extensive or relapsed esophageal carcinoma after esophagectomy, which had distant organ metastasis and histologically proven SCC, were eligible for this study. A dose of 20 mg/m(2) of cisplatin and 800 mg/m(2) of 5-fluorouracil was given by continuous infusion for 24 h on days 1-5. This treatment was repeated every 4 weeks for up to four cycles. A total of 36 men and six women with a median age of 64 (range 39-75) years were registered and 36 patients were eligible.
The overall response rate of the registered patients was 33.3% (12/36) and the median response duration was 175 days. Median survival time was 201.5 days and the 1-year survival rate was 27.8%. Change from bolus to continuous infusion of cisplatin affected neither the type nor the degree of toxicity.
Daily continuous infusion of cisplatin was not associated with higher response or lower toxicity than those seen with the high-dose bolus or multibolus treatment regimens. We conclude that this regimen in this setting is not worthy of further phase III trials. JEOG is now evaluating other drug combination regimens.
Japanese Journal of Clinical Oncology 10/2001; 31(9):419-23. · 1.78 Impact Factor
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[show abstract]
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ABSTRACT: We have synthesized multi-walled carbon nanotubes (MWNTs) using a DC arc discharge method under organic molecular atmospheres.
This method allows us to synthesize about five times more MWNTs than are synthesized using the usual arc discharge method,
using discharge conditions of 100A and 20V. We have examined the synthetic yield of MWNTs at various pressures under different
organic atmospheres. The yield of MWNTs increases with the number of carbon atoms in the organic molecule.
Applied Physics A 09/2001; 73(4):451-454. · 1.63 Impact Factor
