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Jos J Westenberg,
Heynric B Grotenhuis,
Paul Steendijk,
Dennis Hendriksen,
J van der Rob Geest,
J van den Pieter Boogaard, Gerda Labadie,
Jeroen J Bax,
Wouter J Jukema,
Johan H Reiber,
Albert de Roos
Journal of Cardiovascular Magnetic Resonance 05/2012; 12:1-2. · 3.72 Impact Factor
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Jos J M Westenberg,
Arthur J H A Scholte,
Zuzana Vaskova,
Rob J van der Geest,
Maarten Groenink, Gerda Labadie,
Pieter J van den Boogaard,
Teodora Radonic,
Yvonne Hilhorst-Hofstee,
Barbara J M Mulder,
Lucia J M Kroft,
Johan H C Reiber,
Albert de Roos
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ABSTRACT: To study age-related change in aortic stiffness in patients with Marfan syndrome (MFS) versus healthy volunteers using velocity-encoded (VE) MRI.
Twenty-five MFS patients (age range, 18-63 years; mean age 36 ± 14 years, 13 men) and 25 age-/gender-matched healthy volunteers were examined with VE-MRI. Aortic stiffness was expressed by pulse wave velocity (PWV), assessed in the proximal and distal part of the aorta and in the total aorta. PWV was compared between patients and volunteers and age-relation was determined by linear regression.
PWV was significantly higher in all parts of the aorta in patients when compared with healthy volunteers (proximal aorta 5.7 ± 1.5 m/s versus 4.8 ± 0.9 m/s, distal aorta 6.4 ± 2.4 m/s versus 5.0 ± 1.2 m/s and total aorta 5.9 ± 1.7 m/s versus 4.9 ± 1.1 m/s, all P < 0.004). PWV correlated significantly with age (Pearson R between 0.45 and 0.94). Only in the proximal aorta, the increase in PWV with age was significantly higher in patients (7 ± 2 cm/s increase with age) than in volunteers (3 ± 1 cm/s increase, P = 0.03); in the distal or total aorta, the increase in PWV with age was not different between patients and volunteers.
Velocity-encoded MRI detects more pronounced age-related aortic stiffening in the proximal aorta in MFS patients versus healthy volunteers, suggesting more severe wall disease in MFS.
Journal of Magnetic Resonance Imaging 07/2011; 34(3):526-31. · 2.70 Impact Factor
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Jos Westenberg,
Heynric Grotenhuis,
Paul Steendijk,
Dennis Hendriksen,
Rob Geest,
Pieter Boogaard, Gerda Labadie,
Jeroen Bax,
Wouter Jukema,
Johan Reiber,
de Roos Albert
Journal of Cardiovascular Magnetic Resonance. 01/2010;
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Jos Westenberg,
Arthur Scholte,
Zuzana Vaskova,
Maarten Groenink,
Rob Geest, Gerda Labadie,
Pieter Boogaard,
Teodora Radonic,
Yvonne Hilhorst-Hofstee,
Lucia Kroft,
de Roos Albert,
Johan Reiber
Journal of Cardiovascular Magnetic Resonance. 01/2010;
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[show abstract]
[hide abstract]
ABSTRACT: A new method for quantifying the transvalvular flow through the mitral valve (MV) based on three-directional velocity-encoded magnetic resonance imaging (MRI) is presented. For thirty time phases during one cardiac cycle, the three-dimensional (3D) velocity vector field of the blood flow is reconstructed from the MRI measurement. Retrospectively, for each time phase, the MV-plane is indicated manually in the velocity data and the flow through this plane is determined, representing the MV flow. Measurements are performed in 10 healthy volunteers. The new method is compared to the conventional, one-directional velocity-encoded MRI method for which an acquisition plane is positioned at the mitral valve at end-systole and remains fixed during the acquisition. The flow measurements with the new method correlate very well with the flow measured in the aorta (r(p)=0.92, p<0.01), whereas the conventional method shows no statistically significant correlation (r(p)=0.15, p=0.68). The low differences between the flow measured at the MV and the flow in the aorta proves high accuracy of the new method. Also, the new method shows very low intra- and interobserver variation, proving the high reproducibility. Three-directional velocity-encoded MRI is a patient-friendly and easy-to-use method suitable for quantifying accurately and reproducibly the transvalvular MV flow.
Journal of Cardiovascular Magnetic Resonance 01/2004; 6(4):767-76. · 3.72 Impact Factor
