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ABSTRACT: The technique for robotic resection of the left colon and anterior resection of the rectum with total mesorectal excision is not well defined. In this study we describe a method that standardizes robot and trocar position, and allows for a complete mobilization of the left colon and the rectum, without repositioning of the surgical cart. Outcome and pathology findings are also reported.
From January 2007 to May 2008 a total of 55 consecutive patients affected by rectal and left colon cancer were operated on, with full robotic technique, using the Da Vinci robot. Data regarding outcome and pathology reports were prospectively collected in a dedicated database.
The following procedures were performed 27 left colectomies, 17 anterior resections, 4 intersphincteric resections, 7 abdominoperineal resections. There were 21 female and 34 male patients with a mean age of 63 +/- 9.9 years. Mean operative time was 290 +/- 69 minutes, ranging from 164 to 487 min., none were converted to open surgery. The median number of lymph nodes harvested was 18.5 +/- 8.3 (range 5-45), and circumferential margin was negative in all cases. Distal margin was 25.15 +/- 12.9 mm (range 6-55) for patients with rectal cancer, and 31.6 +/- 20 mm for all the patients in this series. Anastomotic leak rate was 12.7% (7/55); in all cases conservative treatment was successful.
Full robotic colorectal surgery is a safe and effective technique that exploits the advantages of the Da Vinci robot during the whole intervention, without the need to make use of hybrid operations. Outcome and pathology findings are comparable with those observed in open and laparoscopy procedures.
Annals of Surgical Oncology 03/2009; 16(5):1274-8. · 4.17 Impact Factor
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Antonio Chiappa,
Roberto Biffi,
Andrew P Zbar,
Emilio Bertani,
Fabrizio Luca,
Ugo Pace,
Francesca Biella,
Carmine Grassi, Giulia Zampino,
Nicola Fazio,
Giancarlo Pruneri,
Davide Poldi,
Marco Venturino,
Bruno Andreoni
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ABSTRACT: This study analyzed the results of treatment of rectal cancer (tumor within 12 cm of the anal verge) with different techniques.
Two hundred and sixty-four patients who had undergone elective curative surgical resection of rectal cancer within 12cm of the anal verge were evaluated. The operative data and follow-up data were collected prospectively. Comparisons were made between patients who had different surgical procedures.
The overall peroperative mortality rate was nil, and the morbidity 39.4%. Local recurrence occurred in 21 of the patients with a median follow-up of 34 months (range: 5-105 months). The 3-year actuarial local recurrence rates for double-stapled anastomosis, low straight anastomosis and APR were 25%, 6%, and 5%, respectively. The local recurrence rate was significantly higher for double-stapled low anterior resection than for the other types of operation (p = 0.013). On multivariate analysis reconstruction with Knight-Griffen anastomosis (p = 0.013) and tumor distance from the anal verge <6 cm (p = 0.001), were associated with local recurrence but only stage was a significant prognosticator of overall survival (p = 0.012).
Following total mesorectal excision, the local recurrence rate was higher in patients treated with double-stapled low anterior resection than in those with termino-terminal low anterior resection or APR; survival rates were similar in these groups.
Hepato-gastroenterology 04/2007; 54(74):400-6. · 0.66 Impact Factor
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New England Journal of Medicine 01/2007; 355(23):2487; author reply 2487-8. · 53.30 Impact Factor
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Journal of Clinical Oncology 10/2005; 23(25):6274-5; author reply 6275-6. · 18.37 Impact Factor
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Antonio Chiappa,
Roberto Biffi,
Andrew P Zbar,
Fabrizio Luca,
Cristiano Crotti,
Emilio Bertani,
Francesca Biella, Giulia Zampino,
Roberto Orecchia,
Nicola Fazio,
Marco Venturino,
Cristiano Crosta,
Gian Carlo Pruneri,
Carmine Grassi,
Bruno Andreoni
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ABSTRACT: This study reviewed the results of surgery for distal rectal cancer (where the tumour was within 6 cm of the anal verge) following the introduction of total mesorectal excision for rectal cancer in one institution.
One hundred and fifty-three patients who had undergone elective curative surgical resection of rectal cancer within 6 cm of the anal verge were included. The demographic, operative and follow-up data were collected retrospectively. Comparisons were made between patients who had different surgical procedures.
The overall operative mortality rate was nil, and the morbidity 41%. With a mean follow-up of 37 months (range 5-100 months), local recurrence occurred in 18 of the patients. The 5-year actuarial local recurrence rates for double-stapled anastomosis, low-strength anastomosis and abdominoperineal resection (APR) were 39, 17 and 11% respectively. The local recurrence rate was significantly higher for double-stapled low anterior resection than for the other types of operation (P=0.007). On multivariate analysis type of surgery (P=0.025) and tumour stage (P=0.043), were associated with local recurrence, but only stage was a significant prognosticator of overall survival (P=0.0006).
With the practice of total mesorectal excision, APR was still necessary in 40% of patients with rectal cancer within 6 cm of the anal verge. The local recurrence rate was lower in patients treated with APR than in those with double-stapled low anterior resection; however, survival rates were similar in these two groups.
International Journal of Colorectal Disease 06/2005; 20(3):221-30. · 2.38 Impact Factor
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Antonio Chiappa,
Emilio Bertani,
Andrew P Zbar,
Roberto Biffi,
Francesca Biella,
Massimo Bellomi, Giulia Zampino,
Nicola Fazio,
Davide Poldi,
Ugo Page,
Bruno Andreoni
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ABSTRACT: To compare the short- and long-term outcome of older and younger patients with advanced colorectal cancer who underwent elective surgery.
Six hundred and ninety-two patients were analyzed. Four hundred and seventy-nine patients were < 70 years (group 1), and 213 were > or = 70 years (group 2).
The overall peroperative mortality rate in younger patients was 0.8% (n = 7), and 1.4% (n = 3) in the elderly (p = NS); morbidity was 35% and 42%, respectively (p = NS). On univariate analysis, elderly patients had a worse overall survival (OS) compared to younger, when only patients undergoing postoperative chemo-radiotherapy were considered (54% OS vs. 67% OS at 5 years; p = 0.03). Using logistic regression analysis, tumor stage (p < 0.0001) and radicality of surgery (p < 0.0001), were strongly associated with OS rates in the elderly.
Colorectal surgery for malignancy can be performed safely in the elderly. Clinical trials are necessary to understand the real advantage of adjuvant or palliative treatments in these patients.
Hepato-gastroenterology 54(75):740-5. · 0.66 Impact Factor
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Antonio Chiappa,
Andrew P Zbar,
Emilio Bertani,
Roberto Biffi,
Fabrizio Luca,
Ugo Pace,
Giuseppe Viale,
Giancarlo Pruneri,
Roberto Orecchia,
Roberta Lazzari,
Francesca Biella,
Carmine Grassi, Giulia Zampino,
Nicola Fazio,
Paolo Della Vigna,
Luca Andreoni,
Bruno Andreoni
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ABSTRACT: The aim of the study was to compare the short and long-term outcomes of older and younger colorectal cancer patients with advanced disease resected with a curative intent. Six hundred and ninety-two patients were analysed. Four hundred and seventy-nine patients were younger than 70 years (Group 1), and 213 were 70 years of age or above (Group 2). The overall perioperative mortality rate in the younger group was 0.8% (n = 7), as against 1.4% (n = 3) in the elderly group (p = NS). The morbidity rates were 35% and 42%, respectively (p = NS). At univariate analysis, the elderly patients had a worse overall survival compared to the younger group, when only patients undergoing postoperative chemo-radiotherapy were considered (54% vs 67% overall survival at 5 years; p = 0.03). Using logistic regression analysis, tumour stage (p < 0.0001) and radicality of surgery (p < 0.0001) correlated significantly with overall survival rates in the elderly. Colorectal surgery for malignancy can be performed safely in the elderly with acceptable morbidity and mortality rates and long-term survival.
Chirurgia italiana 57(5):589-96.
