Giulia Cangiano

Publications (5)12.74 Total impact

• Article: Evaluation of viral load in infants hospitalized with bronchiolitis caused by respiratory syncytial virus.

  Carolina Scagnolari, Fabio Midulla, Carla Selvaggi, Katia Monteleone, Enea Bonci, Paola Papoff, Giulia Cangiano, Paola Di Marco, Corrado Moretti, Alessandra Pierangeli, Guido Antonelli
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  ABSTRACT: The relationship between viral load, disease severity and antiviral immune activation in infants suffering from respiratory syncytial virus (RSV)-associated bronchiolitis has not been well identified. The main objective of this study was to determine the existence of a correlation between RSV load and disease severity and also between different clinical markers and mRNA levels of the interferon stimulated gene (ISG)56 in infants hospitalized for bronchiolitis. We also evaluated whether viral load tended to be persistent over the course of the RSV infection. The levels of RSV-RNA were quantified in nasopharyngeal washings, collected from 132 infants infected with RSV as a single (90.15%) or as a dual infection with other respiratory viruses (9.85%). Results indicated that viral load was positively related to the clinical severity of bronchiolitis, the length of hospital stay, the levels of glycemia and the relative gene expression of ISG56, whereas an inverse correlation was observed with the levels of hemoglobin. We also found that the RSV load significantly decreased between the first and second nasopharingeal washings sample in most subjects. These results suggest that infants with high RSV load on hospital admission are more likely to have both more severe bronchiolitis and a higher airway activation of antiviral immune response.
  Medical Microbiology and Immunology 03/2012; 201(3):311-7. · 3.83 Impact Factor
• Source

  Available from: Angelo G Solimini

  Article: Evaluation of interleukin 28B single nucleotide polymorphisms in infants suffering from bronchiolitis.

  Carolina Scagnolari, Fabio Midulla, Elisabetta Riva, Katia Monteleone, Angelo Solimini, Enea Bonci, Giulia Cangiano, Paola Papoff, Corrado Moretti, Alessandra Pierangeli, Guido Antonelli
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  ABSTRACT: The genetic diversity of the host is believed to be the key of the diversity in the clinical presentation of bronchiolitis. The aim of this study was to determine whether the known rs12979860 and rs8099917 single nucleotide polymorphisms (SNPs) in interleukin (IL)28B region, influence clinical features and natural history of bronchiolitis. Both SNPs showed no significant association with the risk of hospitalization for respiratory syncytial virus (RSV), viral load, disease severity, and other clinical features of patients. Interestingly infants carrying IL28B rs12979860 TT genotype had lower age at hospital admission than that of infants carrying CC/CT genotypes. Overall our results indicate that both IL28B SNPs had no impact on the clinical course of bronchiolitis with the only exception of the IL28B rs12979860 SNP which increased the risk of hospitalization for bronchiolitis at early age.
  Virus Research 02/2012; 165(2):236-40. · 2.94 Impact Factor
• Article: What could hemoptysis hide in an otherwise healthy child?

  Raffaella Nenna, Paola Papoff, Corrado Moretti, Giulia Cangiano, Valentina Ferro, Serena Salvadei, Giuseppe Soda, Maurizio Mennini, Fabio Midulla
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  ABSTRACT: We describe a previously healthy 12-year-old boy who attended our Department after a sudden episode of hemoptysis and recurrent consolidation. CT-scan revealed a mediastinal tumor. The biopsy specimens taken from the mass showed a mature teratoma. Hemoptysis is an unusual presenting symptom in an otherwise healthy child with a well capsulated, unruptured mature mediastinal teratoma. In this report, hemoptysis prompted us to undertake the diagnostic work-up that eventually disclosed the tumor.
  Pediatric Pulmonology 06/2011; 46(11):1146-8. · 2.53 Impact Factor
• Article: Incidence and predisposing factors for severe disease in previously healthy term infants experiencing their first episode of bronchiolitis.

  Paola Papoff, Corrado Moretti, Giulia Cangiano, Enea Bonci, Mario Roggini, Alessandra Pierangeli, Carolina Scagnolari, Guido Antonelli, Fabio Midulla
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  ABSTRACT: To determine the incidence and predisposing factors for severe bronchiolitis in previously healthy term infants <12 months of age experiencing their first episode of bronchiolitis. Epidemiological, clinical and virological data were prospectively collected. Severity was assessed by the need for ventilatory support. Of the 310 infants enrolled, 16 (5.1%) presented with severe bronchiolitis requiring ventilatory support (11 since admission). Compared with infants with less severe bronchiolitis, infants with severe disease presented with lower birth weight, gestational age, postnatal weight and postnatal age, and were more likely to be born by cesarian section. C-reactive protein positive results (>0.8 mg/dL) and pulmonary consolidation on chest X-ray were more common among infants with severe disease. Severity was independently associated with younger age on admission <30 days, respiratory syncytial virus (RSV) infection and lymphocyte counts < 3200/μL. No significant differences were found between epidemiologic variables. Severe bronchiolitis is uncommon in previously healthy term infants <12 months of age and when present develops soon after disease onset. Severity is predicted by young age and RSV carriage, whereas epidemiologic variables seem less likely to intervene.
  Acta Paediatrica 02/2011; 100(7):e17-23. · 2.07 Impact Factor
• Article: Old and new uses of surfactant.

  Camilla Gizzi, Paola Papoff, Caterina Silvia Barbàra, Giulia Cangiano, Fabio Midulla, Corrado Moretti
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  ABSTRACT: Exogenous surfactant has been the primary life-saving therapy for respiratory distress syndrome (RDS) of preterm infants for many years. More recently, early surfactant treatment administered less invasively by transient endotracheal intubation and combined to nasal ventilation has been shown to further improve neonatal outcome by reducing the need of mechanical ventilation. In addition to RDS, other neonatal and pediatric respiratory disorders characterized by surfactant inactivation or dysfunction, such as pulmonary hemorrhage, aspiration pneumonia, and viral lower respiratory tract infection, might also be amenable to surfactant replacement therapy. However, the nature of lung injury and the influence of co-morbidities may reduce the efficacy of surfactant in these conditions. Currently under investigation are new synthetic surfactant formulations which may be more effective and resistant to inactivation than natural ones and could be produced at a lower cost. The use of surfactants to deliver drugs directly to the lung also seems to be a promising technique worthy of study.
  The journal of maternal-fetal & neonatal medicine: the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 10/2010; 23 Suppl 3:41-4. · 1.36 Impact Factor