G Ciavarella

Publications (2)2.66 Total impact

• Article: Coagulation contact phase factors and inhibitors in beta-thalassemia major children.

  F Schettini, D De Mattia, G Arcamone, V Sabato, M Altomare, M G Burattini, F Fedele, A Compagnone, G Ciavarella
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  ABSTRACT: Selected hemostatic parameters of 23 children affected by beta-thalassemia major were studied and compared to an age- and sex-matched group. Plasma prekallikrein level was reduced in all patients, splenectomized or not. In splenectomized patients, platelet count and in vitro platelet aggregability were significantly increased and Protein C was slightly increased. The activated partial thromboplastin time was prolonged and the normotest reduced. Finally, a reduction in the plasma levels of fibrinogen and of vitamin K-dependent proteins, including the antithrombotic Protein C, was observed in nonsplenectomized patients. Our data indicate that the hemostatic system in patients with thalassemia major may be altered. The relationship between these laboratory changes and clinical manifestations remains to be established.
  Pediatric Hematology and Oncology 02/1987; 4(3):231-6. · 0.89 Impact Factor
• Article: Post-natal development of protein C in full-term newborns.

  F Schettini, D De Mattia, M Altomare, O Montagna, G Ciavarella, M M Manzionna
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  ABSTRACT: The purpose of this study was to determine the concentration of Protein C in the blood of full-term healthy newborns. The levels of Protein C, evaluated by electroimmunoassay, were low in the first 5 days of life and lower than the critical adult thrombotic level. The antigenic activity increased progressively from the 2nd week of life and the adult values were reached after the 6th month. The reduction of Protein C levels may impair the ability of the newborn to control consumptive disorders, thus exposing the infants to the risk of thrombotic conditions in neonatal age.
  Acta paediatrica 04/1985; 74(2):226-9. · 1.77 Impact Factor