Fuming Xu

Publications (2)3.88 Total impact

• Article: Design, Synthesis and Preliminary Activity Evaluation of Novel L-Lysine Derivatives as Aminopeptidase N/CD13 Inhibitors

  Qiang Wang, Fuming Xu, Jiajia Mou, Jian Zhang, Luqing Shang, Yepeng Luan, Yumei Yuan, Yingzi Liu, Minyong Li, Hao Fang, Binghe Wang, Wenfang Xu
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  ABSTRACT: A novel class of L-lysine derivatives as aminopeptidase N (APN) inhibitors was designed and synthesized. Activity evaluation showed that compound C7 (IC50 = 9.6 ± 1.3 μM) and C20 (IC50 = 13.6 ± 1.9 μM) were equivalent to the positive control Bestatin (IC50 = 11.3 ± 1.6 μM).
  Protein and Peptide Letters 06/2010; 17(7):847-853. · 1.94 Impact Factor
• Article: Design, synthesis and preliminary activity evaluation of novel L-lysine derivatives as aminopeptidase N/CD13 inhibitors.

  Qiang Wang, Fuming Xu, Jiajia Mou, Jian Zhang, Luqing Shang, Yepeng Luan, Yumei Yuan, Yingzi Liu, Minyong Li, Hao Fang, Binghe Wang, Wenfang Xu
  [show abstract] [hide abstract]
  ABSTRACT: A novel class of L-lysine derivatives as aminopeptidase N (APN) inhibitors was designed and synthesized. Activity evaluation showed that compound C7 (IC(50) = 9.6 +/-1.3 microM) and C20 (IC(50) = 13.6 +/- 1.9 microM) were equivalent to the positive control Bestatin (IC(50) = 11.3 +/- 1.6 microM).
  Protein and Peptide Letters 02/2010; 17(7):847-53. · 1.94 Impact Factor