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ABSTRACT: Immune-mediated blood diseases are organ-specific autoimmune disorders where one or more blood cell lineages are the target of the autoimmune process. They are classically divided into peripheral immune-mediated blood diseases when the immune attack occurs outside the bone marrow and autoimmune myelopathies. Overall they are the prototype of diseases that bridge immunology and hematology including blood malignancies. They also provide a fertile ground for new modalities of immunosuppression. The investigations of platelet autoimmunity as a model of peripheral immune-mediated blood diseases have confirmed that platelet disorders hover between hemorrhage and thrombosis and have led to develop the concept of autoimmune thrombophilia.
Recenti progressi in medicina 04/2002; 93(3):157-61.