Emilia Condes

Publications (5)12.48 Total impact

• Article: [HIV infection in the adult: epidemiological changes over 25 years (1983-2008) in an area of the Community of Madrid].

  Emilia Condes, Carlos Barros, Francisco Merino, Julián Ruiz-Galiana
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  ABSTRACT: To describe the epidemiological characteristics and evolution of a cohort of HIV-infected patients in Madrid (Spain) over a period of 25 years. Longitudinal, prospective, cohort study of all patients diagnosed with HIV infection seen at the Hospital de Móstoles (1983-2008). Of the 2156 patients attended, 73% were men. In 68%, the route of infection was illicit drug use. There was a peak of new diagnoses in 1991 (188 patients) and a subsequent gradual decline. Sexual transmission increased over the time period studied, with a higher rise in heterosexual transmission. The percentage of immigrants with the infection also increased (more than 60% in the last 3 years). Sub-Saharan Africa remains the predominant region of origin of our immigrant patients. Over the period studied, 5% of patients were diagnosed during the acute infection, and 20% to 30% were diagnosed with AIDS within 1 year after detection of HIV infection. The estimated rate of new diagnoses of HIV infection in 2006 was 195 per million population (pmp), 269 pmp in men and 121 pmp in women. Many changes have occurred in the epidemiology of HIV infection in our area in the last 25 years. Routine serologic testing without waiting for warning signs would have an impact on early diagnosis and improving the prognosis of these patients.
  Enfermedades Infecciosas y Microbiología Clínica 09/2009; 28(3):156-61. · 1.49 Impact Factor
• Source

  Available from: Carlos Guijarro Herraiz

  Article: Effect of simultaneous use of highly active antiretroviral therapy on survival of HIV patients with tuberculosis.

  Maria Velasco, Virgilio Castilla, José Sanz, Gabriel Gaspar, Emilia Condes, Carlos Barros, Miguel Cervero, Rafael Torres, Carlos Guijarro
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  ABSTRACT: The optimal timing for initiation of highly active antiretroviral therapy (HAART) in patients with AIDS and tuberculosis (TB) is an unresolved question. To assess the effect of HAART on the survival of patients with TB, we designed this study. We selected all HIV patients included in the COMESEM cohort with TB diagnosis after 1996. Clinical and epidemiological data were registered. We compared patients who started HAART at the diagnosis of TB [simultaneous therapy (ST)] or not. Survival was assessed by Cox analysis. Among the 6934 HIV patients included in the cohort, 1217 patients had TB, 322 of them (26.5%) after 1996. At the time of TB diagnosis, 45% of them started HAART (ST). There were no differences between groups regarding basal characteristics, except for a lower viral load in ST patients. ST therapy was associated with improved survival (hazard ratio 0.38; 95% confidence interval 0.20 to 0.72, P = 0.003). By univariate analysis, survival was also associated with no endovenous drug use and a later year of TB diagnosis. After adjusting for other prognostic variables, by Cox multivariate analysis, ST remained robustly associated with improved survival (hazard ratio 0.37; 95% confidence interval 0.17 to 0.66, P = 0.001). Simultaneous HAART and TB treatment in HIV patients with TB is associated with improved survival.
  JAIDS Journal of Acquired Immune Deficiency Syndromes 02/2009; 50(2):148-52. · 4.43 Impact Factor
• Article: [Validation of a questionnaire to estimate satisfaction with antiretroviral treatment: CESTA questionnaire].

  Emilia Condes, Koldo Aguirrebengoa, David Dalmau, José Manuel Estrada, Luis Force, Miguel Górgolas, Xavier Badia, Daniel Podzamczer
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  ABSTRACT: Assessment of patient satisfaction with antiretroviral therapy is generating increasing interest in clinical practice, since the outcome is directly related with compliance with therapy and its effectiveness. Currently, there is no validated patient satisfaction questionnaire to evaluate this factor as related to control of the disease. An "ad hoc" questionnaire--Cuestionario Español de Satisfacción con el Tratamiento Antiretroviral (CESTA), Spanish Antiretroviral Treatment Satisfaction Questionnaire--was developed to evaluate satisfaction in patients switching to a simplified regimen. In a second phase, the questionnaire was validated in an observational study including 321 patients divided into two cohorts (patients switching to a simplified regimen and patients maintaining the same regimen). A total of 99% and 93% patients, respectively, completed the questionnaire at baseline and at the end-of-study visit. Cronbach's alpha coefficient for internal consistency and test-retest reliability were 0.82 and 0.69, respectively. Patients switching to a simplified regimen showed a statistically significant higher overall satisfaction score at the third-month visit than at baseline. The CESTA questionnaire is a valid instrument for use in clinical practice and provides valuable information on patient satisfaction with antiretroviral therapy.
  Enfermedades Infecciosas y Microbiología Clínica 01/2006; 23(10):586-92. · 1.49 Impact Factor
• Article: Lipid disorders in antiretroviral-naive patients treated with lopinavir/ritonavir-based HAART: frequency, characterization and risk factors.

  Maria Luisa Montes, Federico Pulido, Carlos Barros, Emilia Condes, Rafael Rubio, Concepción Cepeda, Fernando Dronda, Antonio Antela, José Sanz, Enrique Navas, Pilar Miralles, Juan Berenguer, Susana Pérez, Angeles Zapata, Juan J González-García, Jose Ma Peña, J J Vázquez, Jose R Arribas
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  ABSTRACT: The aim of this study was to evaluate the frequency, characteristics and risk factors of lipid changes associated with lopinavir/ritonavir treatment in antiretroviral-naive patients. A prospective cohort of 107 antiretroviral-naive HIV-infected patients was followed for 12 months after starting lopinavir/ritonavir-based highly active antiretroviral therapy. At 12 months, percentages of patients with hypercholesterolaemia and hypertriglyceridaemia were 17.4% and 40%, respectively. Mean increases in total cholesterol and triglycerides were 40.7 and 73.3 mg/dL. There was a significant increase in both low-density and high-density (HDL) cholesterol, and no increase in the total cholesterol/HDL ratio (from 4.16 at baseline to 4.49 after 12 months). Baseline cholesterol > 200 mg/dL and triglycerides > 150 mg/dL were independent risk factors for dyslipidaemia, while hepatitis C coinfection appeared to be protective. Patients with elevated lipid values at baseline have the greatest risk of developing hypercholesterolaemia and hypertriglyceridaemia after starting lopinavir/ritonavir. Antiretroviral-naive patients coinfected with hepatitis C have a low risk of developing hyperlipidaemia after starting lopinavir/ritonavir.
  Journal of Antimicrobial Chemotherapy 05/2005; 55(5):800-4. · 5.07 Impact Factor
• Article: Validación del cuestionario de satisfacción con el tratamiento antirretroviral: cuestionario CESTA*

  Emilia Condes, Koldo Aguirrebengoa, David Dalmau Juanola
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  ABSTRACT: Antecedentes. La evaluación de la satisfacción con el tratamiento es una medida que centrada en el paciente está adquiriendo mayor importancia en la práctica clínica ya que podría incidir en el cumplimiento de los regímenes terapéuticos y por tanto en la efectividad del mismo. En la actualidad no existe ningún cuestionario validado de satisfacción con el tratamiento antirretroviral que permita valorar la importancia del control de la enfermedad. Pacientes y métodos. Se elaboró un cuestionario ad hoc (Cuestionario Español de Satisfacción con el Tratamiento Antirretroviral; CESTA) para evaluar la satisfacción de los pacientes que cambiaban a un régimen terapéutico de simplificación. Posteriormente se ha validado el cuestionario mediante un estudio observacional con 312 pacientes divididos en dos cohortes: pacientes que simplificaban su régimen terapéutico y pacientes estables que no variaban su pauta de tratamiento. Resultados. El cuestionario fue completado por más del 99% de los pacientes en la visita basal y por el 93% en la final. En los parámetros de consistencia interna se obtuvo un coeficiente a de Cronbach de 0,82 y una fiabilidad test-retest de 0,69. Los pacientes del grupo de simplificación obtuvieron puntuaciones significativamente más altas a los 3 meses de seguimiento respecto a los valores basales. Conclusiones. El cuestionario CESTA es un instrumento válido para su aplicación en el contexto de la práctica clínica proporcionando información sobre la importancia que cada paciente asigna a cada uno de los aspectos o cuestiones relacionadas con la satisfacción del tratamiento antirretroviral.
  Enfermedades infecciosas y microbiología clínica, ISSN 0213-005X, Vol. 23, Nº. 10, 2005, pags. 586-592.